Kamau, E.Campino, S.Amenga-Etego, L.Drury, E.Ishengoma, D.Johnson, K.Mumba, D.Kekre, M.Yavo, W.Mead, D.Bouyou-Akotet, M.Apinjoh, T.Golassa, L.Randrianarivelojosia, M.Andagalu B, B.Maiga-Ascofare, O.Amambua-Ngwa, A.Tindana, P.Ghansah, A.Macinnis, B.Kwiatkowski, D.Djimde, A.A.2018-11-152018-11-152015-01doi: [10.1093/infdis/jiu608]http://ugspace.ug.edu.gh/handle/123456789/25565Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be important determinants of artemisinin resistance in Southeast Asia. This study investigated the prevalence of K13-propeller polymorphisms across sub-Saharan Africa. A total of 1212 P. falciparum samples collected from 12 countries were sequenced. None of the K13-propeller mutations previously reported in Southeast Asia were found, but 22 unique mutations were detected, of which 7 were nonsynonymous. Allele frequencies ranged between 1% and 3%. Three mutations were observed in >1 country, and the A578S was present in parasites from 5 countries. This study provides the baseline prevalence of K13-propeller mutations in sub-Saharan Africa. © 2015 The Author. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.enartemisinin resistanceK13-propellersub-Saharan AfricaArticle