Huang, S.Tabudravu, J.Elsayed, S.S.Travert, J.Peace, D.Tong, M.H.Kyeremeh, K.Kelly, S.M.Trembleau, L.Ebel, R.Jaspars, M.Yu, Y.Deng, H.2018-09-112018-09-112015-07Volume 54, Issue 43,Pages 12697-12701https://doi.org/10.1002/anie.201502902http://ugspace.ug.edu.gh/handle/123456789/24051Pyrrolizidine alkaloids (PAs) are a group of natural products with important biological activities. The discovery and characterization of the multifunctional FAD‐dependent enzyme LgnC is now described. The enzyme is shown to convert indolizidine intermediates into pyrrolizidines through an unusual ring expansion/contraction mechanism, and catalyze the biosynthesis of new bacterial PAs, the so‐called legonmycins. By genome‐driven analysis, heterologous expression, and gene inactivation, the legonmycins were also shown to originate from non‐ribosomal peptide synthetases (NRPSs). The biosynthetic origin of bacterial PAs has thus been disclosed for the first time.enbiosynthesislegonmycinsmultifunctional enzymesnon-ribosomal peptide synthetasespyrrolizidine alkaloidsArticle