Seneadza, N.A.H.Kwara, A.Lauzardo, M.Prins, C.Zhou, Z.Se´raphin, M.N.Ennis, N.Morano, J.P.Brumback, B.Cook, R.L.2022-09-302022-09-302022Citation: Seneadza NAH, Kwara A, Lauzardo M, Prins C, Zhou Z, Se´raphin MN, et al. (2022) Assessing risk factors for latent and active tuberculosis among persons living with HIV in Florida: A comparison of self-reports and medical records. PLoS ONE 17(8): e0271917. https://doi. org/10.1371/journal.pone.0271917| https://doi.org/10.1371/journal.pone.0271917http://localhost:8080/handle/123456789/38305Research ArticlePurpose This study examined factors associated with TB among persons living with HIV (PLWH) in Florida and the agreement between self-reported and medically documented history of tuberculosis (TB) in assessing the risk factors. Methods Self-reported and medically documented data of 655 PLWH in Florida were analyzed. Data on sociodemographic factors such as age, race/ethnicity, place of birth, current marital status, education, employment, homelessness in the past year and ‘ever been jailed’ and behavioural factors such as excessive alcohol use, marijuana, injection drug use (IDU), substance and current cigarette use were obtained. Health status information such as health insurance status, adherence to HIV antiretroviral therapy (ART), most recent CD4 count, HIV viral load and comorbid conditions were also obtained. The associations between these selected factors with self-reported TB and medically documented TB diagnosis were compared using Chi-square and logistic regression analyses. Additionally, the agreement between self-reports and medical records was assessed. Results TB prevalence according to self-reports and medical records was 16.6% and 7.5% respectively. Being age 55 years, African American and homeless in the past 12 months were statistically significantly associated with self-reported TB, while being African American PLOS ONE PLOS ONE | https://doi.org/10.1371/journal.pone.0271917 August 4, 2022 1 / 12 a1111111111 a1111111111 a1111111111 a1111111111 a1111111111 OPEN ACCESS Citation: Seneadza NAH, Kwara A, Lauzardo M, Prins C, Zhou Z, Se´raphin MN, et al. (2022) Assessing risk factors for latent and active tuberculosis among persons living with HIV in Florida: A comparison of self-reports and medical records. PLoS ONE 17(8): e0271917. https://doi. org/10.1371/journal.pone.0271917 Editor: Wenping Gong, The 8th Medical Center of PLA General Hospital, CHINA Received: August 30, 2021 Accepted: July 10, 2022 Published: August 4, 2022 Peer Review History: PLOS recognizes the benefits of transparency in the peer review process; therefore, we enable the publication of all of the content of peer review and author responses alongside final, published articles. The editorial history of this article is available here: https://doi.org/10.1371/journal.pone.0271917 Copyright: © 2022 Seneadza et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: The data contain potentially sensitive patient information, but data can be obtained upon request. Information about homeless in the past 12 months and not on antiretroviral therapy (ART) were statistically significantly associated with medically documented TB. African Americans compared to Whites had odds ratios of 3.04 and 4.89 for self-reported and medically documented TB, respectively. There was moderate agreement between self-reported and medically documented TB (Kappa = 0.41). Conclusions TB prevalence was higher based on self-reports than medical records. There was moderate agreement between the two data sources, showing the importance of self-reports. Establishing the true prevalence of TB and associated risk factors in PLWH for developing policies may therefore require the use of self-reports and confirmation by screening tests, clinical signs and/or microbiologic data.enPersons Living with HIV (PLWH)active tuberculosisMedical ReportFloridaArticle