Adams, Y.Ofori, E.K.Asare-Anane, H.Amanquah, S.D.Ababio, G.K.Abendau, E.Nabia, R.2019-07-122019-07-122018-02https://doi.org/10.1186/s13104-018-3149-4http://ugspace.ug.edu.gh/handle/123456789/31418Objective This study aimed to evaluate serum leptin and high sensitivity C-reactive protein (hsCRP) concentrations in obese Ghanaians with or without type 2 diabetes and to find out the extent to which their levels are influenced by underlying disorders. Results Obese subjects with type 2 diabetes had lower leptin but higher hsCRP levels compared with obese non-diabetic controls. There were negative correlations within the control group for glucose vs % muscle mass (r = − 0.378, p = 0.016), leptin vs % muscle mass (r = − 0.555, p = 0.001) and within the obese diabetic group for leptin vs % muscle mass (r = − 0.602, p = 0.001). Obese persons without diabetes were about three times more likely to have higher leptin levels compared with their obese diabetic counterparts (Odds ratio = 3.315, p < 0.001). Obese females independently had a tenfold increase in leptin levels compared with obese males.enLeptinObesityC-reactive proteinType 2 diabetesArticle