Perniola, T.Margari, L.Spina, A.Chindemi, A.Bello, A.De Iaco, M.G.De Giacomo, A.Galluzzi, R.Marzocco, P.L.Piscitelli, L.2013-06-282017-10-162013-06-282017-10-161997Perniola, T., Margari, L., Spina, A., Chindemi, A., Bello, A., De Iaco, M. G., . . . Piscitelli, L. (1997). Felbamate efficacy and tolerability in patients with refractory epilepsy: An open add-on multicentric study. [Studio multicentrico in aperto add-on sulla efficacia e tollerabilita del felbamato in soggetti con epilessia non controllata] Bollettino - Lega Italiana Contro l'Epilessia, (99), 149-151.http://197.255.68.203/handle/123456789/4277A multicenter study that evaluated felbamate efficacy and tolerability in 19 patients with refractory epilepsy was performed. One patient (5,3%) became seizure-free during felbamate treatment, 11 patients (57,9%) achieved a seizure reduction of 50% or more, 6 patients (31,6%) evidenced an unchanged seizure frequency and 1 patient (5,3%) had increase in seizure frequency. Of the 7 patients (36,8%) who had a diagnosis of Lennox-Gastaut syndrome, 5 (71,4%) had >50% reduction in seizure frequency, 1 (14,2%) had unchanged seizure frequency and 1 (14,2%) had an increase in seizure frequency.enAdolescentArticle