s("H(KIL m" PI'BLIC IIEALTII ('OU.u;.:o..- H.:ALTH SC,."n:s UNIV.:RStTY 0.- GHANA A.. ...... l.S.'M.:NT Ofi mE IMPACf OF PREGNAN('Y s(-UOOL ON PREGNANCY 01 I('OML'iANDSKILI.U) DELIVt:R\ IN N\8DAM DlSTIUCfOF t-PPt:R EAST REGION B\' KOl.oG TIMBllU: JU"'-IA.."t 10745155 nil,} DI~ER'rAll()" IS S(-B\UTnm TO THE I-~I\'.:RSITY OF GHANA. I.H~IO:"li IN .. ".K .....\ •.•- UI~.ll ....n N. .. OI; H''': R":QIIIK.:\1.:lIj'( tUK H''': AWARD OF MASTER OF SaofU'O"inlho_lJIOOPwasll .. hip ..... lhocontrolgroup. [9S% CI: 56-176; prding 10 Ihe 2018 Global NUlrilion Report, .bolll 20 million babies are born ~ith low birth weight every year (Development Initiative Poverty Reseaclt Ud. 201 8) Ilowever. the ineide~ of low bUtb weiaht met signif.cantly from COWlIly to country. For example. it is as low as 9% in Latin America and as high as 28% in South Amca (Weile. 20) 2a). It iii estimated that a female dies every minute in the globe as • result ofc hiklbirth complicatiuns mel it is unfortunate 10 mention that nearly half", million females die from matmlal. causes e.c:h year and about 99% of fl&alitics happen in developing nations. including Ghana(WHO. 2016). The challenae of decreasing maternal mortality remains a significant issue not only in Ghani,. but aJlO in lIeveral nations: such as Kenya. (Yaya. Bishwajit. Okonofua. &. Uthman. 2018) The 2014 Kenya Demoer-phic and Health Survey (KDHS) reported that there were about 525/100,000 live births in the malt'mlll monaJiry flllio (MMR). Other estimates plKed the ralio81 I.OOO/IOO,OOOlivebirths,whicbisonein2S lifetime riskofmaaernal death(Kenya National 8\U'eau of Statistics Nairobi & Ministry. 2015). In Sub--s.Mrao Africa, the )W'eVaIeace of low birth wei&bt is about 13% .ad this seems &ower in some areas due to under reporting resultinI from home deliverie5 and deliveries at Iowerhealtb facilities which may not be officially accounted for. Accordioa to G. ... Dcmop.ph.ic and Health Swvey (2014). the prevalence of LBW in Ghana wu 11% whilst the Upper East Region recorded about 9% in the same report. However, the situMion is very t.d in the Nabdam district In 2017 for instance. the district rcconIod 101 low birth weight babies out of94!i live births reprelCntina a hiaher rate of 10.7%%(0"'" Heolth Service. 2017). In 2018. thepn:volcnco increuedto 12'10(117 out 993). The prevalence is much higher tban both tbe regional andnationaJ average figures which are 11% and 9% respectively within the same period(Ghana Statistical Service/Ghana Health Service. 2017). With reprds to anaemia in pregnancy. the prevalence in 2012 was about 38% aIobally (Weise. 2012b). This is the same as the prevaleuce in Ghana according to the 2014 Ghana Demographic and Health Survey. which also pegged the prevalence at 380/,. Once aeain. the sihlltion was worse in the Nabdam district with over 45% prevalence of anaemia in prelfWlcy (Ghana Health Service. 2017). One of the sub-diltricll called Zanlerigu sub- diJlrict recorded over 7M"o of mild to severe anaemia in pregnancy which is largely due to iron detkiency anaemia. This is a cause to worry because a malnourished mother will give birth to a malnourished child. which coukl mult in chronic cycle of malnutrition. It is worth noting that, the World Health Organisation his classified the prevalence of IIDMmii u a problem of public health sipifica.ce IS follows: No public health problem (:54.9%), mild problem (5·19.9%). moderate (20.39"10) and severe public health problem (~40%) (WHO/CDC. 2012). This implies that any area or COWltry wicb the prevalence of auemia .-I to or ~ater thin 40% has a severe public health problan 10 deal with. In this regard, the higher prevalence of 45% anaemia iD pregnancy in the Nabdam distric:t i. a big iSiue In addition 10 the issues alreaIdy identified above, bome deliveries are"so COIIUDOD in catain parts of the district despite MNCHP intervention put in place to curb the menKC among. lntbefirstquartcrof2017a1ooe,IOhomcdeliverie5werercportedintwoofthe sub diaricts with the district rccordiat.lOtaI. of 34 home deliveries thal year. The number of home deliveries is believed 10 be an WlCIentatement due to Wlder reportina· The aim of the research .. to detennine whether the prevalence of anaemia in pregnancy, low birth weigM and skilled delivery were different among the intervention group and the control group. The study thus ISSeSICd whether the pregnancy ICbool concept was effective in reducing anaemia in pregnancy. low birth weiJht, and borne deliveries in the Nabdam district. 1.2 Tbe PregnaDey School fa N.bdam District The Pregnancy school stratelY was irnplemmtcd in the Nabdam district by the C.aholic Relief Services (CRS) in collaboration with Ghana Hcaith Service since 2014. The concept "..as called C-Press which means Community Pregnancy School Session. C-Press was supported by the maternal and child health project dubbed the "Rural Emergency Health Services aDd Transport (REST project). As the name suggests. the pcegnancy schools were organized at Ghana Health Service delivery points within eight (8) piloted communities where pregnant women received health educMion in the fonn of classes and group discussions. Dunna: the pregnancy school sessi005. several topics relaq to pre&nanCY Some of tbcK topics include &DOd maternal nutrition using of home delivery. importance of antennaJ c.re artcndance, Some facilities introduced. a local millet flour drink called Uzoomkom" that wu served to the pregnant women dwina the school JCIIions as a motivation for attcndance. Sealing arrangements were JUde in a boriesh.oe shape during C-Press sessions lad sessiOGl were managed by trained Health staff such as Midwives and Community Health Nurses. The horseshoe seatinB arrangemem wall 10 ensure visibility among each other durinl the discwsiOJlS or experience sharing. There were abo pregnancy school registen Cor record keeping beside the nonnal anlenllal anddclivay regislerSthat captured the necessary information on the women and their pregnancy outcomes. Some of the records that were docwnentcd in the register included demographic information. ANC and pregnancy school attendance. Anaemia status at registralion. anaemia at 36 weeks, as well as piKe of delivery and birth wcishl amonB othen were captured. The pregnancy school strategy did not consider health staff alone to be experti or "know it all" but it created an avenue for the women to share their personal experiences in pregnancy outcomes with other members. " ::"" ' 1 1.3 ProblelllStateratllt Since the impkmmlation oflbe preanancY school coocept in the Nabdml district. there has Dot beeo lay evaluation of the sttaICgy to critically examine whether it is yieldiDB the intended results or not. Without a scientifIC evaluation. it cannot be clearly ascertained wbether or not the prqnancy school approach is really contributing positively to maternal and child bealth indicators such as anemia in pregnancy. lew birth weight and home delivery. Meanwhile. a lot ofresourees have been invested and continues 10 be pumped into maternal and ehild health proif8llll. In 2014 for instance, the World Bank inVCiltcd about three million United States dollars on Maternal. Child Health and NUlrition Improvemeat project (MCHNP) all in the quest to improvinama&emal hcaJth 10 reduce malemal and child mortality(OECD. WID," Wocsot.cdcsognoflhen:seard\adesc:n. ..... of _ the """""'" - pcrlonncd rr-_ -. .. the end. h _the _ popuJoIion fo< IIIis _ . Ihe _of,,,,"phnr.the"'size.Ihe_lheilldl,,,,,,,,fo Centro, Zanlerigu CHPS, Loagre Heald> Centre, Pi .... CHPS, DasoblilO CHPS and A)WDfoya Clinic. However, there was no available data in Aymlfoya Clinic which was the onJy private health flCility in the district. The Nabdam district has five sub districts, 21 health facilities out of which only 9 conduct deliveries within the study period. Nabdam Diitrict had 85 commWlities and population of 39.789(Nabdam Oisttict Heald> 0_, 2017). The Nabdam Disui<:1 Asrcmbly woo estoblished in 2012 by L.l.210S. II WOI carved from TaIensi-Nabdam District into the Nabdam District with NlIlsodi as its capital. The district is situated in UpperEastregion.ltliesbetweenlltitudes 10047 adjacenland 100 57 adjaeent to the north oftbe equator; and longitudes 00 31 adjacent and 10 15 adjacent to the west Greenwicb meridian. It is bounded to the: north by the Bongo district. to the east by the Bawku West district 10 the south and to the west by the municipality of Bolgatanp.. The dUtric:lbII353km2ofterritory. fip,.4: M."ofN_ _' _hw_l.cililin~."'dmricl ~ NabdlllPl D,."ict Heall" [)'reclorJll~ In this study. the population lII'gcted wen: groups of pregnant women who detivercd. in Nabdam distnclm 2017. It included. revleW of all aVaJlable records of prqnanl WOIDCA whoanended antmaaal C3'C in the Nabdamdislrictand delivcn:d in the district in 2017 A rmewoflhc:dJ""ct2017 ___1 hol945 __d elivacddwi. the Rudy penod. However 769 records wert: .vaiIabIe for this study. Out of this, J9I wue In the mtcrvCPbon groupwlulsl 371 wtrelnlhem the control group 3.4lacluioa ..d Ent.lIioa Criteria Recon:b oran pregnant women from the district who delivered iD 2017 weft included in the study. Pl'ciQMI Women wbo attended lhe preenancy schoollDd delivered ... fllcility outside tbc dilaric:t bur whose delivery records could be obtained were included. 3.STbeEu. ..... Crite. ... ParticiPIDIS with incompIcac infonnatimt oa .,. of the 0UIC0me v.nlbln were excluded from Ihc-study. Also, prep.a& WOIDIII wbodid not.ncndANC in the district butonJyc.nr Ihere to deliver we~ excluded. from the srudy. Furthermore, pregnant women whole ANC and delivery records could not be tnICed at all did nol form part of this study. Ag, Aaeofmother independent Continuousbul categorised Education.Jlevel Educationa11evelofmotber ~-- Occupation Occupationoflhemother :~:~~~:~ Nommal Marital status Marital utus of the mother independent cateGorical Corwnunity The coIDnuUlity or ...ea where independent Nominal the woman stays - Facility Hcalthfacililywherethct:t.a independent Categorical wasextracled Subdistrict The sub district of the heallh independent Categorical facility ANCRegistcnxi Antenata1Careregistration independent Count Number number DateofANC Oatc of tirst ANC attendance independent categorical Rcgi5tration fortbepregnancywhichthe mother delivered 2017 10 Gat.ageal Oestalion age at ANC independent categorical registration registration in weeks 11 -Hbat, reais tration Haemoglobin concentration at independent Continuous ANCregistration 12 No.ofANe Nwnber of visiu by the independent Discrete woman went to the health facilityforantennalcare 13 Pregnancy school Whether the woman enrolled independent SinaI) enrolment for the pR:anancy school or DOt 14 Noofpregnanc) Number of pregnancy schoo! independent school's Ittendance of the motber attendance 15 Hb at 36 weeb Haemoglobin concentration Dependent Continuou! of mother at 36 weeks 16 Birth weight The weight of the baby at independent Continuous binh 17 Low birth Weight Any binh weight less than 2.5 Dependent Binary kg 18 PlKe of Delivery Skilled 0< wWcilled (Home Dependent Categorical delivery) Table 2: OretWtioaofindicatorsand lheirmeasurement INDICATOR , DEFINITION NUMERATOR DENOMINA DATA TOR SOURCE Lowbirthweigbt Binhweight No. of live: LBW All live births Odive:ry <2,5"" registers ANCregister and pregnancy schoolreister AMemiain Pregnanlwomen No.ofpresnant AlIprcgnant ANCregistet, Pregnanc)'at wilhHb< 11 gldl women whose HB womcnwbosc reports registrMion 3tJegiSiniion -.Hb or"rvCldJOO group a 16 weeks BasehOFHb"~ End IIhe'"" Hhaa36 wtUS lib: g/d1 <:-18.77 F~ 5: Vt.fIr:nttee Ulfllly.fl.t of Hh aJ 36 weeA:s hdween f..'fmlrul und ''''ervenIIlJn J:Y'oup l.ll Ma1dialt proc:eduret Mu::hing is any method that equates or try "'balance the dIStribution orcovana1C::S In the _ and controt _ . Propensity """" maId>"'8 (PSMJ and ........ "."gIIbow rnatdung proc:edwcs were used In several series of sensitIVity analysis 10 decrease the (."Ovariatc imbalancebcfween thec:onuol group and the Ifttavention group in the study. Propensity score (PS) (or an mdlV1dualts the conditional prob.tnlity orbeUIII.n::Med givca ~lly score for a prqpwtt woman bcoefittina from the 1nk:fVentlon ~ 64.8%. 1bis was dooe in STATA whic:tI mlmmlSedbias in the findingsofthlSstud)'. Propcn$lty score 28 replications were done to reduce random error in the estimate. The matching according to common suppan made the groups similar such thai any estimated difference could then be attributed to the pregnancy scbool intervention. Hence the impKt of the pregJWlcy school strategy on anaemia in ptCgJWlCY (at 36 weeks.). However, the kc:nnel matching with Regression Adjusted rtSuJts wm: reported because the adjustment made the model more robust in detennining the actuaJ imJ*1 of the intervention. J.1J QuaUty coDtrol In order to get quality data, omy heaJth staff such as Corrununity Health Nurses and midwives who an! very familiar with the data source registers were hired and trained to collect information. The data extraction instrument was also tested to guarantee that all correetionsand adjustments were made before the actual dataoollection processbcgan. 3.14 Expected outcomc oftbcstudy 1. The impact of pregnancy school 00 anaemia in pregnancy among pregnant women who attended pregnancy school and those who did not attend the pregnancy school in the Nabdam district 2. Proportion of Jowbirth weight between the intervention and control groups 3. Proportion ofsltilled delivery among the two groups in Nabdam district. _' .15 EthicalcoDsideration Prior to the conuncncement of the study, ethical clearance was sought from the Ghana Health Service Ethics Review committee with approval nwnber GHS-ERe 068104119. A formal pennission was also obtained from the Distric:t Direaor of Health Services to plve way for the study to be conducted. The data that were extracted from the records were solely used for the inlended purposcand the identity of participants was concealed by using codes instead of names in order ttl mainlalO confidentiality. Last but not the ~ the research team tnemben were poperIy trained and advised 10 be respectful8Ild responsive to all thole COQCc:med With the dMa required for this study. These techniques are all supported by • guide 10 filed daaa collection that ensured successful data coUection (Kathleen. Natasha Mack.Cynthia Woodsong. 2011) CHAPTER FOUR RESULn The reiUlts from the data analysis in this study arc plUmled in this chapter as follows: 4.0 Demojtraphic characterbtil::, ofprepaotwo.e. A total of 769 records of deliveries were reviewed durina the study. Majority oC lhe study participants in the intervcruiOD group 221 (S7.64%) and compuiJOll aroup 191 (53.8~) were between the ages 20-29 yean with a mean age of 24.7 and 25.1 respectively. More than Q{Wooftbe participults were married (91.1-10 versus 93.6%). About 99o/,ofthe women in each group had anactiveNHIS card (Table 3}. Note: Each var;Qb/~ hod ils own dntoinlnDlor Table 3: Association between Demognpbic ChanK:teristics and pregnancy school alt ... 56 • ~~-. . ~ .-..... 9. Kcmcldcmity_. .. pIol --------__-8 6-M' ----""---'" ___O Q"tJ4"Il --"""" [:=-1 (""I'M/1Ui "pre.fe1J/ /ho$e who duJ not aIIend the P't:gttuney $dtt}l()/ und fn '.}"''' ,Jrl' rh"" prexnonJ wOInt!n who tJllmded the pregnunq M:hotJI '-lIIg1Ire 10; Standlrdised cros.s covatlll&e betwo:D the two groo:pe. CHAPTER FIVE DISCUSSION OF FINDINGS 5.0 Introd\l~tioQ The main purpose ofthc pregnancy school project was to improve maternal and child health indicalon such anaemia io pregnancy. Low birth weight and home deliveries in the Nabdam district. 5.1 Summary or the study key rmdinp The study revealed that the pregnancy iChool intervention had II positive impact on pregnancy outcomes und skilled delivery in the Nabdam district. This include but not limited to the (ollowina: I. Anaemia in pregoalK)': Tbe pregnaney school strategy reduced the risk of anaemia at 36 weeks among the in1crvention group by 340/• . Thi. resulted from a difference of O.71gldlofHbconcenuationbetweentherwogroupsal36weeks 2. Birth weight: There: was a differences in mean birth weight between the intervention and COntrol group (116J.}The proportioQ of low binh weight was also found to be higher among the control group (17.2-10) compared to the intervention group (5.2"'11). J. Home delivery: The study also revealed that the proportion of home delivery was higher amonl the control group (7.5%) than the intervention lVouP which was only 0.30"-, This chaptcr lherefore gives a detailed discllSsion oflhc re:.:ulls from this study withreferenc:es to the relevant reviewed literature as well as the rese,m,;her opinion and interpretation of the results S. t. Aae ..i a i. pregnncy at J6 weeks Tbe results from the difference in difference anaJysis revealed thai there was a difference of 0.71 fldl in mean hemoatohin concentration between the two groups. This means there was a positive impact of the pregnmcy school interventioD on anaemia in pregnancy. The 34% reduction intberi,kofanaemiacowd be due to the fact that the intervention group had good nutrition edtK:ation on how to preserve and consume iron rich foods which improved their Hb levels at thiny 36 weeks. It could also be due 10 the fact that the lessonJ from the pregnancy school miam have increased their compliance in terms of taking iron 5uppiemeDlS duringtheirpregnancy_Thesefindinparesimilartoastudyinlndiawhichfound thatthere was a 35% reduction in the risk of anemia in the intervention group in that study (Mishra et aI., 2016). However. these findings contradict with a study which was conducted in Derunark on the effects of health cducationonpreSoanc:youtcornn(BrixvaletaJ.,2014) According to the World Health Organization. any prevalence of anamtia greater than 40% (40-59%) in 8 population is. severe public problem. This means, apart from Peluogu sub· district. aU the other sub-diSlrlcts per the results recorded prevalence: maher than the WHO recommend cut off point for anaemia. Though the intervention reduced the risk of anaemia by 34% in the intervention group. the overalJ district prevalence of anaemia was sHU high. This could be due to the fact that only about eight out of the 85 communities in the district organized the pregnant school. Nearly 52% of the pregnant women had anaemia which means by the WHO classification, the Nabdam district as a whole stilt has a public health problem in tenns of anaemia in pregnancy. (Challa a: Amirapu., 2016). 5.2 Low bir1b weipt The prevalence of low birth weight among the group of pregnant women who did DOl aHend the pregnancy school was about "'-0 rugher than the National prevalence of 9% and allO II the upper limit of the currenl World Heahh Orpnisation c1assificatioo of low birth "''eight (Gbona Statistical ServkclGIwla Health ServicdlCF Intemalional. 2014; Weise. 20120). Tbc 10.,. birth weight nile of 5.2 percent l1li008 the inlCtVCntion group was much smaller than the low binh weight incidence of 12 percent reported in the Nabdam District Health Directorate's 2018 annual report. This could be due to the fact that pregnant women who bc:oefiled from the prtgIlMCy school had good matenW nutrition which improved the birth weight of their babies. Thctewaadiffereoc:eo(abouIll-l, in the prevaIenceoflowbirth weight between prcgnant women who attended the pregnancy and thoie who did not. Almost 95°,4 of the women who attcnded the pregnancy school gave birth to normal weight babies against nearly 82% in the comparison group. These differences could be partly due to the preanancy school intervention which had a positive impact on Low birth weight in the district. Also. the mean birth wei&ht of women in the intervention croup wu 116 g higher t1wl those in the comparison group. 1bcse results IU'e consilient with • meta-analysis research conducted by (Grote et aI., 2010) wh~ the impact of antenatal care ranged from 1.02 to 4. 7S times higher among beneficiaries. These findings also means that. the impact of the pregnancy school was about five times more than whal was found in 3. study by Lima and coUeques in 2016 which was only two ~ .8°;0 ( 50g) lower in the inter:enlion group. Nearl)' 6% of women in the interVention group gave birth to low birth weight as compared to almost 18% in the conuol group. This means an increased risk ofmfant mortalily since low birth wciaht babies are three times more likely to die than oonnal babtes. The fUldings from thiJ study however disagree with 'Jb:angarantinnm stud)' in 2012 which showed thai there was no significant difference between the intervention and comparisou group in terms of birth weisht.(Thanpratinam. 2012). 43 5.3 Home chUve~ amoDg tbe two groups ACCOtdina 10 the 2017 GbIna Maternal Health survey, skilled delivery was 79% in the country and 91./. in the Upper East Region .Though the mults showed thai the prevalence of home deliveries among both the interVention and control group were lower the national figure of about 2ao", it was even much lo""'a' in the intervention group (0.3%) as compared to the control group (7.5%). This means the Nabdam district perfonncd better in terms of home deliveries than the Upper East Regional figurc of about 9%(Ghana Statistical Service/Ghana Health Service, 2017). The reduction In home deliveries to rates lower than both the regionaJ and national figures could be due to the pregnancy school intervention. Jt could also be due 10 uncieneportina since some of the victims of home deliveries in the villages may fail to report to a health faci lity for fear of blame from health staff. S.4 Impact of pregDlIncy school on anaemia in pregnancy at 36 weeks. Results from the propensity score matching revealed that pregnant women who actually attended the pregnancy school had a 34% reduced risk of suffering from anaemia al 36 weeks in pregnancy. Therefore. the pregnancy school strategy was found to really have a positive impact on anaemia in pregnancy in the Nabdam district in 2017. 1bese fmdings in the study wefe similar to a study in India which showed that the prevalence of anaemia was reduced by 350/. among preg:rwlt women who rtteived a similar intervention during pregnancy (Mishraetal.,2016). 5.5 Limitations ortheStudy Despite the findings mentioned above, the study had ~ limitations. One bed to do with unobserved factors which might not have been catered for in the model used in the impact estimates. For instance. a woman with Wldetected chronic condition could have developed anaemia or given birth to a low weight baby. Moreover. spillover effect coWd have affect the C'Sti1nlles. Abo, the paraJlel trend asswnptiOQ thai was used in the DID is very difficult to satisfy inrcal life situation and this was a limitation to the study. One priVak health facility out of the nine facilities in the disbict that conducted deliveries in 2017 COUld nol provide complete data for participants during the itudy. Hence, the teICIrcber cou&d not tell whether women wbo delivered in that privaae health facility had similar~oukomesoroot. CHAPTER SIX CONCLUSION AND RECOMMENDATIONS 6.1Conc1usMtlloftbestudy The main purpose of the study was to determine the differences in pregnancy outcomes and skilled delivery between pregnan! women who attended pregnancy school in Nabdam district and those who did not attend the pregnancy school. The study specifically focused on comparing the differences in anaemia and mean birth weight as well as proportion of home deliveries among the conb'Ot and intervention gfOUps. Impact estimates of the pregnancy school on anaemia at 36 weeks was also detennined among the intervention group. Kl!yFindings: 1. The mean Hb concentration at 36 is 0.71 aldl hiaher among the intervention group than the control group, 2. There is 34% reduced risk of anaemia among those who attended the pregnancy school than in the control group. 3. The proportion of low birth weight among women who attended the pregnancy was 5.2% compared with 17.2% in the control group. 4. The mean birth weight of women in the intervention group was 116g higher than those in the control group. S. Less than 1% of the pregnancy group delivered at home compued to 7.5% in the control group. FoIlowincu...c rmdio&1 from thc study, I can conclude that the prcgnancy school stralCg)' really itnpecl('d positively OD pregnancy outcomes and wiled deliveries in the Nabdam diSlrict. 6.2 RetO ••t bdaliou Based on the findillll above, the following recommendations are made 1 The pr"qnancy &ebooI stntcl)' should be scaled up to other convnunities in the Nabdam district. 2. QuaJilfltivc COUlpOocnl of this study shouJd be conducted to identify the lessons that were learnt during the implementalion of the pregnancy school for informed decisions to be m.dc on how to scale up and sustain the concept. 3. There 5bould be Cap.city buildina; for health staff e5peciaJly midwifes and community health nurses on the pregnancy school concept to enhance universal heaJlhcovcrage. REFERENCES Babies, A. R. C, for H. ofW. aDd. (2015). As.sesiing the efectivmess ofc:ommWlity based Intervention on pregnancy outcomes. SclUilo p. C. (2015). Birrh Outcomes 11. PT~ Wo"um Treated WifhA.rfemulnln-Based Combmatlon 1lt~rap;t$ At TemD G~t1I!TaJ Hospital. University afGhans. Retrieved fromhttp://ug5pace.ug.edu.gh Brix\'aJ, C. S. • Axelsen, S. F., Andersen. S. K• • Due. P. • & Koushede, V. (2014). The eff'ect of antenatal cducation in small classes on obstetric and psycho-social Outcomes: a S)'SlCmatic review and meta-analysis protocol, (February). hUps:J/doi.orglIO.118612046-4053_3_12 Challa, S., & Amirapu. P. (2016). Surveillance of Anaemia: Mapping and Grading the High Risk Tenitories IUId Populations. Journal o/Clinlcal and Diagnostic Rtsearch. J,I-6.https:lfdoi.org/IO.78601jcdrI2016/18107.7915 Darmstadt, G. L. • Lee, A. C. C., Cousens.. S., Sibley, L . Bhulta. Z. A. • Donnay, F., .. Lawn, J . E. (2009). 60 Million non-facility births: Who can deliver in community settings to reduce intrapartwn-related deaths? International Journal o/Gynecology and Ob","'c,. I07(SUPPL.). https:/ldoi.or&/10.1016/j';jao.2oo9.07.010 Development lnitiBtivt Poverty Reseacb Ltd . (2018). 2018 Global Nutrition Report: Shining a light 10 spur action on nutrition. Dijk, J. A. W. Van, Anderko, L.. &: Stetzer. F. (2010). The Impact ofPrenallil Care. Journal o/Obstelric GytJecoJog/c und Neof'IQtal Nursing. 40(1), 98-108. https:lldoi.oriVlO.lllllj .1552-6909.2010.01206.x Ghana Health Service. (2017). Ghana Health Service Annual Report 2016. Ghana Statistical Service/Ghana. Health ScrvicclICF International. (2014). Demographic aM Health Survey 2014. Rockville. Maryland, USA: GSS, GHS, and ICF International. Ghana Statistical Service/Ghana Health Service. (2017). Ghana Maternal Health SlIrvey Keyl""lcalors. Grote, N. K. • Gavin. A. R., Melville. J. L. Kalan, W. J., Bridge, J. A., & Iyengar. S. (20JO). A melli-analysis of depression during pregnancy and the risk ofpretenn birth. low birth weight. and intrauterine growth restriction. Archives a/General Psych/a".,.. 67(10). 1012-1024. https:lldoi.org/IO. I0 0 lIan:hgenpsychiatry.201 0.111 HoI1ain. N. • .t Triche. E. W. (2009). NIH Public Ac:cea. PM<. J/(4). 240-242 . hnpsJldoi.o'JII10.1053/j.sempcri.2001.01.013.EoviroM>ental hz;.,. G. R. • .t Bacigalupo. O. A. (2010). Childbirth Process in Spoin. (De