University of Ghana http://ugspace.ug.edu.gh ASSESSMENT AND OPTIMIZATION OF OCCUPATIONAL RADIATION DOSES IN FLUOROSCOPY GUIDED PROCEDURE AT KORLE - BU TEACHING HOSPITAL, ACCRA, GHANA BY RUTH NANA NJANTANG (10633004) A THESIS SUBMITTED TO THE DEPARTMENT OF MEDICAL PHYSICS SCHOOL OF NUCLEAR AND ALLIED SCIENCES UNIVERSITY OF GHANA IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF MASTER OF PHILOSOPHY DEGREE IN NUCLEAR SCIENCE AND TECHNOLOGY JULY, 2018 i University of Ghana http://ugspace.ug.edu.gh DECLARATION “This thesis is a result of a research work undertaken by Ruth Nana Njantang in the department of Medical Physics, School of Nuclear and Allied Sciences, University of Ghana, under the supervision of Prof. Mary Boadu and Mr. Prince Kwabena Gyekye.” I hereby affirm that except for references which have been cited, this work is the product of my own research and it has not been presented in part or whole for any other degree in this University or elsewhere. ……..…………..…….. Date……….…………….. Ruth Nana Njantang Student Certified by: ……………….…………. Date…………………… Prof. Mary Boadu Principal Supervisor) …………………….… Date……………………. Mr Prince Kwabena Gyekye Co-Supervisor ii University of Ghana http://ugspace.ug.edu.gh ABSTRACT International Commission on Radiological Protection (ICRP) publication 85 of 2000 recommended the use of two dosimeters for the monitoring of staff performing fluoroscopically guided procedures. This study aimed to assess the dose to operators performing fluoroscopically guided procedures at Korle – Bu Teaching Hospital and evaluate possibility for dose reduction. Four Radiologists, the Interventional Radiologist and the assistant were monitored for a period of one month and four Cardiologists were monitored for two months. Two electronic dosimeters were used by each worker present in the room and the personal equivalent dose Hp (10) and Hp (0.07) were recorded after each procedure. The Kerma Area Product (KAP) and screening time were also recorded per procedure. The scattered radiation dose rate was measured using a water phantom at 1 m from the focal spot, 160 cm from the floor at 0°, 90°, 120° and 180° for 3 projection of the tube (RAO 30°, LAO 30° and AP 0°). The patient dose and screening time at Radiology Department (over couch tube) were [1.89 - 14.38] Gy.cm², (0.2 -2.5) min; [3.76 – 44.16] Gy.cm², (0.3 – 3.1) min and [8.7 – 60.77] Gy.cm², (1.9 – 10.9) min for Retrograde Urethrogram (RUG), Hysterosalpingography (HSG) and special cases respectively. The patient dose and screening time range at Cardiology (under couch tube) were [14.24 – 120.61] Gy.cm², (1.7 – 16.3) min, [42 – 237] Gy.cm², (9.70 – 43) min and [4.37 – 33.56] Gy.cm², (4.30 – 11.8) min for Coronary Angiogram (CA), Percutaneous Coronary Intervention (PCI) and Right Heart Catheterization (RHC) respectively. The dose range per procedure to Cardiologists was [0.1 – 42.15] µSv, [1.2 – 31.2] µSv and [0.1 – 2.75] µSv for the CA, PCI and RHC respectively. The range of the estimated monthly effective dose, and eye lens dose to Cardiologists and Radiologists were [0.01 – iii University of Ghana http://ugspace.ug.edu.gh 0.07] mSv, (0.15, 0.30) mSv and [0.03 – 0.12] mSv, (0.53 – 3.39) mSv respectively. The interventional procedures were found to be lengthier with exposure time of (52 – 76.4 min), and delivered relatively high dose (47.13 – 412.23 Gy.cm²) to patients. The Interventional Radiologist and the assistant received an effective dose of 0.09 mSv, 0.03 mSv respectively and eye lens dose of 1.2 mSv, 0.33 mSv respectively. A weak but significant relationship (R² = 0.32, p-value < 0.05) was found to exist between patient dose and staff effective dose, meaning that staff dose is influence by other factors. Generally, the staff effective dose and eye lens dose to Cardiologists and Radiologists were below the acceptable limits (1.67 mSv/month) excerpt for one Radiologist whose eye lens dose exceeded the limit by a factor of 2. Therefore, the use of a ceiling suspended screen is highly recommended in radiology to reduce the eye lens dose. Monte Carlo simulation of the distribution of radiation in the room highlighted the safest position that can be occupied by the staff as dose reduction technique to reduce the dose. The Implementation of the proposed radiation safety programme is encouraged for optimization of protection in both departments. iv University of Ghana http://ugspace.ug.edu.gh DEDICATION This work is dedicated to the Strength of my life, My Heavenly Father, the Almighty GOD. . v University of Ghana http://ugspace.ug.edu.gh ACKNOWLEDGEMENTS Special thanks go to the General Director of National Radiation Protection Agency of Cameroon Dr. Augustin Simo and Prof. Maurice Moyo Ndontchueng who offered me the opportunity to be trained in Ghana. I also want to express my gratitude to International Atomic Energy Agency (IAEA) for the sponsorship of this program. I would like to acknowledge the Director General of Ghana Atomic Energy Commission (GAEC) Prof. B. J. Nyarko, Dean, Prof. Yaw Serfor-Armah, the Head of International Programmes, Dr. Dennis Adotey, the Head of Medical Physic Department, Dr. Francis Hasford, all the staff and Nuclear Science and Technology Programme (NSTP) lecturers of the School of Nuclear and Allied Science. Also, I thank the Nuclear Regulatory Authority, Radiological and Medical Sciences Research Institute and Radiation Protection Institute of GAEC for the provision and calibration of the equipment. Special thanks go to my supervisors, Prof. Mary Boadu and Mr. Prince. K. Gyekye for their supportive and constructive criticism. Sincere gratitude goes to Prof. Cyril Schandorf for his useful advises and critical import which added value to this work. I would like to show my appreciation to the administration, Radiologists team, Radiographers, Nurses and Cardiologists team of Korle-bu Teaching Hospital for good collaboration. Particular thanks go to Mr. Bernard Botwe who facilitated my access to the facility and guided me throughout the data collection. Heartfelt gratitude goes to my family and friends for all their encouragement. I am indebted to Mr. Joseph and Mrs. Marian DADSON for their great love and support. vi University of Ghana http://ugspace.ug.edu.gh TABLE OF CONTENTS DECLARATION........................................................................................................ ii ABSTRACT ............................................................................................................... iii DEDICATION............................................................................................................ v ACKNOWLEDGEMENTS ..................................................................................... vi TABLE OF CONTENTS ........................................................................................ vii LIST OF FIGURES ................................................................................................ xiii LIST OF TABLES ................................................................................................... xv LIST OF ABBREVIATIONS ............................................................................... xvii CHAPTER ONE ........................................................................................................ 1 1.0. Introduction ................................................................................................... 1 1.1. Background to the study ................................................................................ 1 1.2. Statement of the Problem .............................................................................. 3 1.3. Research Objective ........................................................................................ 4 1.4. Relevance and justification ........................................................................... 5 1.5. Scope and Delimitation ................................................................................. 5 CHAPTER TWO ....................................................................................................... 7 2.0. Literature Review .......................................................................................... 7 2.1. Physics behind Fluoroscopy: X-ray Production and Interaction ................... 7 vii University of Ghana http://ugspace.ug.edu.gh 2.1.1. X-ray production .................................................................................... 7 2.1.2. X-ray Interactions with Matter............................................................... 8 2.2. Technology and Mode of Operation of the Fluoroscopy Machine ................. 10 2.2. Occupational Radiation Protection.............................................................. 13 2.3.1. Source of Occupational Radiation ....................................................... 14 2.3.2. Quantities used in Radiological Protection .......................................... 15 2.3.3. Operational Quantities for Individual and Area Monitoring ............... 17 2.3.4. Radiation Effects and Radiation Protection Principles ........................ 17 2.4. Strategies to Reduce Radiation Risk to Staff .................................................. 22 2.4.1. Practical Application of Optimization of Protection ................................ 24 2.4.2. Education and Training Programs ............................................................ 25 2.5. Individual Monitoring ..................................................................................... 25 2.5.1. Passive dosimeters .................................................................................... 26 2.5.2. Active Personal Dosimeters (APDs) ........................................................ 26 2.6. Assessment of Occupational Exposure ........................................................... 27 2.6.1. Effective Dose Assessment ...................................................................... 27 2.6.2. Assessment of Equivalent Dose to the Lens of the Eye ........................... 29 CHAPTER THREE ................................................................................................. 30 3.0. Material and Method ....................................................................................... 30 3.1. The Study Area................................................................................................ 30 viii University of Ghana http://ugspace.ug.edu.gh 3.1.1. Radiology Department of KBTH ............................................................. 31 3.1.2 National Cardiothoracic Centre (NCTC) ................................................... 32 3.2. Sample Size ..................................................................................................... 34 3.3. Materials .......................................................................................................... 34 3.3.1. Questionnaire ............................................................................................ 34 3.3.2. Piranha ...................................................................................................... 34 3.3.3. Kerma Area Product Meter ....................................................................... 36 3.3.4. Electronic Personal Dosimeter (EPD) ...................................................... 37 3.3.5. Dose Rate Meter ....................................................................................... 41 3.4. Software .......................................................................................................... 43 3.4.1. Microsoft Excell ....................................................................................... 43 3.4.2. Simple Geo ............................................................................................... 43 3.4.3. Monte Carlo N Particle (MCNP) .............................................................. 44 3.5. Methods ........................................................................................................... 45 3.5.1. Quality Control (QC) Tests ...................................................................... 45 3.5.2. Dose Monitoring ....................................................................................... 48 3.5.3. Scatter Radiation Study in the Examination Room .................................. 49 3.5.4. Data Analysis ............................................................................................ 50 3.5.5. Monte Carlo Simulation ........................................................................... 55 CHAPTER FOUR .................................................................................................... 56 ix University of Ghana http://ugspace.ug.edu.gh 4.0. Results and Discussions .................................................................................. 56 4.1. Basic Elements of Radiation Protection in Both Department ......................... 56 4.2. Quality control results ..................................................................................... 59 4.2.1. Over couch Fluoroscopy in Radiology Department ................................. 59 4.2.2. Under couch Fluoroscopy in Cathlab ....................................................... 62 4.3. Patients and Radiologists Dose in Radiology Department.............................. 65 4.3.1. Patient Dose and Fluoroscopy Time ......................................................... 66 4.3.2. Radiologist Dose and Workload ............................................................... 67 4.4. Patients and Cardiologists Dose in Cathlab .................................................... 74 4.4.1. Patient Dose and Fluoroscopy Time ......................................................... 75 4.4.2. Cardiologists Doses .................................................................................. 76 4.4.3. Risk Assessment to Cardiologists ............................................................. 81 4.4.4. Relationship between Effective Dose and Patient Dose ........................... 82 4.5. Investigation into other Factors affecting Workers Dose................................ 83 4.6. Scattered Radiation in the Examination Room (Cathlab) ............................... 85 4.6.1. Modelling of the room .............................................................................. 85 4.6.2. Distribution of Radiation in the Room for AP 0° of the Source .............. 86 4.6.3. Distribution of Radiation in the Room for LAO 30° and RAO 30° of the Source ................................................................................................................. 89 4.6.4. Measured Values of the Scattered Radiation ............................................ 90 x University of Ghana http://ugspace.ug.edu.gh 4.7. Limitations of the study................................................................................... 91 CHAPTER FIVE ..................................................................................................... 92 5.0. Conclusion and Recommendations ................................................................. 92 5.1. Conclusion ....................................................................................................... 92 5.2. Recommendations ........................................................................................... 93 5.2.1. Establishment of a Radiation Safety Programme ..................................... 94 5.2.2. Recommendation for Further Study ......................................................... 94 REFERENCES ......................................................................................................... 96 APPENDIX 1: Approval Letters .......................................................................... 105 APPENDIX 2: Data Collection Sheet ................................................................... 109 APPENDIX 3: Questionnaire ............................................................................... 110 APPENDIX 4: Calibration Certificates ............................................................... 112 APPENDIX 5: Quality Control Results from Pirhana ....................................... 115 APPENDIX 6: Radiation Safety Programme for Occupationally Exposed Workers in Fluoroscopy Guided Procedure ........................................................................ 118 1.0. Introduction ............................................................................................... 118 2.0. Responsibilities ......................................................................................... 118 3.0. Individual Monitoring ............................................................................... 119 4.0. Occupational Radiation Protection and Equipment .................................. 121 5.0. Education and Training ............................................................................. 122 xi University of Ghana http://ugspace.ug.edu.gh 6.0. Quality Assurance ..................................................................................... 123 7.0. Records for Quality Improvement............................................................. 123 8.0. Pregnant Workers .......................................................................................... 124 9.0. Emergency Plan and Procedures ............................................................... 124 APPENDIX 7: Typical Monte Carlo Input File .................................................. 126 APPENDIX 8: Raw Data of the Simulation Results ........................................... 133 xii University of Ghana http://ugspace.ug.edu.gh LIST OF FIGURES Figure 2.1: The X-ray tube ........................................................................................... 8 Figure 2.2: Photon interaction with the tissue www.e-radiography.net ...................... 9 Figure 2.3: Exponential attenuation of photon energy in the material ...................... 10 Figure 2.4: Schematic of the fluoroscopic imaging chain ......................................... 11 Figure 2.5: An image intensification tube.................................................................. 12 Figure 2.6: Sources of occupational radiation exposure ............................................ 14 Figure 3.1: Location of KBTH in Greater Accra Region ......................................... 30 Figure 3.2: Over couch fluoroscopy machine at the Radiology Department ............ 32 Figure 3.3: Outlook of the actual NCTC at KBTH .................................................... 33 Figure 3.4: Internal view of cathlab with Siemens biplane fluoroscopy unit. ........... 33 Figure 3.5: Setup of QC tools (Piranha and ocean 2014 installed on a computer) under the x – ray system ..................................................................................................... 35 Figure 3.6: (a) The kerma X – plus with the separated reader and (b) The ion chamber fixed on the X – ray tube in Radiology Department........................................... 37 Figure 3.7: Electronic Personal Dosimeters used for this study ................................ 38 Figure 3.8: Calibration setup in SSDL at GAEC ....................................................... 38 Figure 3.9: Typical personal dosimeter (source: www.helmholtz-muenchen.de) .... 39 Figure 3.10: Dose rate meter used in this study ......................................................... 41 Figure 3.11: Functional parts of the dose rate meter (source: www.polimaster.com)42 Figure 3.12: Microsoft excell 2010 running on window 7 ........................................ 43 Figure 3.13: Simple GEO interface with an example of geometry created (theis et al., 2006) ................................................................................................................... 44 xiii University of Ghana http://ugspace.ug.edu.gh Figure 3.14: Radiograph from the beam collimation check ...................................... 46 Figure 3.15: Cathlab dimensions ............................................................................... 49 Figure 3.16: Schematic of the side view of measurement set - up ............................ 50 Figure 3.17: Schematic of the top view of the measurement set-up showing the point of measurements at different angles at 1m from the isocenter. .............................. 50 Figure 4. 1: Estimated effective and eye lens dose compared with ICRP limit 73 Figure 4. 2: Frequency of procedures in the cathlab .................................................. 74 Figure 4. 3: Number of procedure conducted by Cardiologists monthly .................. 77 Figure 4.4: Estimated effective dose and eye lens dose to Cardiologists for different type of procedure ........................................................................................................ 78 Figure 4.5: Estimated annual effective dose and eye lens dose compared to ICRP limits ............................................................................................................................ 80 Figure 4.6: Estimated risk to Cardiologists................................................................ 81 Figure 4.7: Relationship between effective dose and patient dose ............................ 82 Figure 4.8. Source, patient table and phantom modeled with simple GEO software 85 Figure 4. 9. Top and side view of the cathlab modeled with simple GEO software. 85 Figure 4.10: Dose distribution in the room at 85 cm from the floor .......................... 86 Figure 4.11: Dose distribution in the room at 107 cm from the floor ........................ 86 Figure 4.12: Dose distribution in the room at 150 cm from the floor ........................ 87 Figure 4.13: Dose distribution in the room at 171 cm from the floor ........................ 88 Figure 4.14: Dose distribution (LAO 30°) at 171 cm from the floor ......................... 89 Figure 4.15: Dose distribution (RAO 30°) at 171 cm from the floor ........................ 90 xiv University of Ghana http://ugspace.ug.edu.gh LIST OF TABLES Table 2.1: Risk coefficients for stochastic effect proposed by ICRP (𝟏𝟎 − 𝟐 𝑺𝒗 − 𝟏). (ICRP, 2007) ....................................................................................................... 19 Table 2.2: ICRP’s recommendations for dose limits (ICRP, 2007; ICRP, 2013) ... 21 Table 2.3: Dose reduction techniques that are commonly used interventional cardiology procedures (miller et al, 2010) ........................................................................... 23 Table 3.1: Specifications of the black piranha for radiography / fluoroscopy 36 Table 3.2: EPD MK 2+ radiological specifications ................................................... 40 Table 3.3: EPD MK 2+ environmental specifications .............................................. 41 Table 3.4: Characteristic of the dose rate meter ........................................................ 42 Table 3.5: Some of the algorithm proposed for effective dose calculation with thyroid collar [adapted from jarvinen et al. (2008) and ICRP (2018)] ................................... 51 Table 3.6: Ratio (eye lens / thyroid) doses [adapted from carinou et al. (2015)] ...... 53 Table 4. 1: Status of radiation protection measure in both departments……...…….57 Table 4.2: kVp, time and output reproducibility test. ................................................ 60 Table 4.3: Tube voltage accuracy .............................................................................. 60 Table 4.4: mAs linearity ............................................................................................ 60 Table 4.5: Summary of the results ............................................................................. 62 Table 4.6: Voltage, time and output reproducibility test ........................................... 63 Table 4.7: Tube voltage accuracy .............................................................................. 63 Table 4.8: Summary of the results of QC test ............................................................ 64 Table 4.9: Summary of procedures and dose measurements ..................................... 65 xv University of Ghana http://ugspace.ug.edu.gh Table 4.10: Median and range values of KAP and fluoroscopy time for each procedure. ............................................................................................................................ 66 Table 4.11: Estimated daily effective dose (using three different methods) and eye lens dose to RAD 1 .................................................................................................... 68 Table 4.12: Estimated daily effective dose (using three different methods) and eye lens dose to RAD 2 for HSG procedures ................................................................... 69 Table 4.13: Estimated daily effective dose (using three different methods) and eye lens dose to RAD 3 for HSG procedures. .................................................................. 69 table 4.14: estimated daily effective dose (using three different methods) and eye lens dose to RAD 4. ................................................................................................... 70 Table 4.15: Estimated monthly workload, effective dose and eye lens dose to the Radiologists. ....................................................................................................... 71 Table 4.16: Number of procedures performed by cardiologists during the period of data collection. ........................................................................................................... 74 Table 4.17: Median and range values of KAP and fluoroscopy time for each procedure performed in Cathab. .......................................................................................... 75 Table 4.18: Effective dose per procedure to Cardiologists ........................................ 76 Table 4.19: Monthly effective dose and eye lens to the Cardiologists ...................... 79 Table 4.20: Dose records of interventional radiology procedures with overcouch and undercouch tube. ................................................................................................. 84 Table 4.21: Measured values of scattered radiation ................................................... 90 xvi University of Ghana http://ugspace.ug.edu.gh LIST OF ABBREVIATIONS IAEA International Atomic Energy Agency ICRU International Commission on Radiation Units and Measurements PET Positron Emission Tomography QA Quality Assurance WHO World Health Organization NCRP National Council on Radiation Protection CONRAD European Coordinated Network for Radiation Dosimetry HSG Hysterosalpingogram IVU Intraveneous Urogram MCUG Mituriting Urethrogram RUG Retrograde Urethrogram CT Computed Tomography MRI Magnetic Resonance Imaging NCTC National Cardiothoraxic Center QC Quality Control RTI Radiation To Information USB Universal Serial Bus RAMSRI Radiological and Medical Science Institute GAEC Ghana Atomic Energy Commission HVL Half Value Layer LCD Liquid Crystal Display xvii University of Ghana http://ugspace.ug.edu.gh EPD Electronic Personal Dosimeter MCNP Monte Carlo N - Particle LED Light Emitting Diode OEW Occupationally Exposed Worker NM Nuclear Medicine TLD Thermoluminescent Dosimeter OSL Optical Simulated Luminescence ICRP International Commission on Radiological Protection ALARA As Low As Reasonable Achievable KBTH Korle Bu Teaching Hospital CCD Charge – Coupled Device Cs I Cesium Iodine BSS Basic Safety Standard Gy Gray mA milli Ampere kVp kilo Voltage peak KAP Kerma Area Product DAP Dose Area Product Sv Sievert BEIR Biological Effect of Ionizing Radiation DDREF Dose and Dose Rate Effectiveness Factor LSS Life Span Study xviii University of Ghana http://ugspace.ug.edu.gh UNSCEAR United Nation Scientific Committee of the Effect of Atomic Radiation DD Doubling Dose IEC International Electrotechnical Commission APD Active Personal Dosimeter CA Coronary Angiography PCI Percutaneous Coronary Intervention RHC Right Heart Catheterization NRC National Research Council RSO Radiation Safety Officer LAO Left Anterior Oblique RAO Right Anterior Oblique AP Anterior Posterior LANL Los Alamos National Laboratory ISO International Organization for Standardization IRPA International Radiation Protection Association DNA Deoxyribonucleic Acid CathLab Catheterization Laboratory SSDL Secondary Standard Dosimetry Laboratory xix University of Ghana http://ugspace.ug.edu.gh AHA American Heart Association ACC American College of Cardiology NRA Nuclear Regulatory Authority xx University of Ghana http://ugspace.ug.edu.gh CHAPTER ONE 1.0. Introduction In the introductory part of this study, the background, the statement of the problem, justification, objectives and scope of the study are clearly defined. 1.1. Background to the study Medical exposure from X-rays and nuclear medicine is the largest man-made source of radiation exposure, representing a mean effective dose of 1.0–3.0 mSv per head per year (Mettler et al, 2009). The worldwide population exposure from medical radiation has been shown to increase, and the use of procedures (both diagnostic and therapeutic) with a high radiation dose has been growing steadily (Kim et al, 2008; Vano et al, 2009; Vassileva et al, 2013). Radiation exposure is a significant concern for interventional cardiologists and patients due to the increasing workloads and the complexity of procedures over the last decade (ICRP, 2013). With fluoroscopy the patient is imaged in real time to guide minimally invasive procedures that form part of the diagnostic and interventional procedures, and this requires medical and technical staff to directly participate in the procedures. Occupationally Exposed Workers (OEWs) in fluoroscopy procedures are likely to receive high exposure, especially for the unshielded parts of the body which are: the extremities and head (Vano et al, 2010; Vano et al, 2013). Rehani et al (2010) reported lens opacities detected among some Interventional Radiologists and Cardiologist. The primary operator who stays closer to the patient is the most exposed 1 University of Ghana http://ugspace.ug.edu.gh to radiation among all staff present in the room during interventional procedures (Kong et al, 2015). Many studies have been done so far concerning occupational exposure in fluoroscopy guided procedures around the world, mostly in Europe and America (Sanchez, 2011; Sandblom et al, 2013; Kostas et al, 2016; Szumska et al, 2016). A study performed in Netherlands, has estimated median occupational effective dose at 3 µSv per procedure for the interventional radiologist, 0.4 µSv per procedure for the assistant radiologist and maximum occupational effective dose for technologists 0.4 mSv (Joemai, 2009). Radiation safety in the practice of interventional cardiology has been addressed by several professional bodies. UNSCEAR in 2008 report states that fluoroscopic procedures represent the largest source of occupational exposure in medicine (UNSCEAR, 2008). In 2009, the American Heart Association (AHA) Science Advisory recommended the reference doses of common cardiology examinations (Gerber et al, 2009) and in 2010 the American College of Cardiology (ACC) committee also expressed the need for appropriate and optimal use of radiation techniques in cardiology (Brindis and Douglas, 2010). The continuous and systematic use of adequate protective equipment such as protective apron, thyroid shield, lead gloves, protective glasses, ceiling-suspended glass screen and lead curtain can significantly reduce exposure to the workers directly involved in interventional procedures. However, study on detailed monitoring of OEWs in fluoroscopy guided procedure in many facilities is still lacking. Botwe et al (2015) in a study carried out at the biggest referral hospital in Ghana showed that the radiation 2 University of Ghana http://ugspace.ug.edu.gh monitoring of staff was unsatisfactory and did not meet required standard and stated that workers were monitored by the means of TLD badges only. 1.2. Statement of the Problem Among all medical staff, those performing fluoroscopically guided procedures (such as Cardiologists and interventional radiologists.) are likely to receive the highest exposure to ionizing radiation. The eye’s lens, extremities and thyroid can receive high radiation doses (Ciraj-Bjelac et al, 2010; Vano et al, 2010; Ciraj-Bjelac et al, 2012; Vano et al, 2013). The eye lens exposure results in the prevalence of lens opacities and cataracts among Cardiologists, Radiologists. This indicates the relevance of optimization of radiological protection in fluoroscopically guided procedures (Sandblom et al, 2013). Unlike other activities involving ionizing radiation, for which the exposure of the staff is predictable (optimization can be performed in advance), optimization of radiation protection in interventional radiology is complex and has to be performed during the procedure under varying and sometimes difficult situation such as unstable patient who require individual care. The nature of the procedures, the high individual workload and the difficulties in radiation protection measures justify the need for detailed occupational dosimetry studies. Studies performed in Ghana on fluoroscopy examinations were focused on patient dosimetry (Gyekye et al. 2009; Gyasi et al. 2012). The survey of literature indicates that there is no empirical data available on dose estimation of individuals working in specific fluoroscopy guided procedures in Ghana. In National Cardiothoracic Center, according to the patient data available in book record, the number of procedures has grown from 15 procedures / year (2000 – 2010) to 25 – 30 procedures / year (2011 – 2015). With the installation of the new cathlab in October 3 University of Ghana http://ugspace.ug.edu.gh 2016 the number of procedures has increased up to (22 – 24) procedures monthly. This increasing number of procedures shows the importance of intensifying personal monitoring programme at the Center. In addition, the International Commission on Radiological Protection in the statement on tissue reactions on 21 April 2011 recommend for occupational exposure in planned exposure situations, the revised equivalent dose limits for the lens of the eye are 20 mSv in a year, averaged over 5 consecutive years (i.e. 100 mSv in 5 years), and 50 mSv in any single year. These limits replace the previous limit on equivalent dose of 150 mSv in a year and the threshold in absorbed dose is now considered to be 0.5 Gy (ICRP, 2011; IAEA, 2014). 1.3. Research Objective This study aims to estimate dose to medical staff during fluoroscopically guided procedures and evaluate possibilities for dose reduction. The specific objectives of the study include the following:  Estimate eye lens and effective dose to medical staff during selected fluoroscopy guided procedures.  Use Monte-Carlo simulation to investigate the radiation dose distribution in the room to evaluate the possibilities of dose reduction.  Investigate the factors that influence staff doses such as workload, type of procedure, patient dose, etc.  Assess detrimental risk to the workers and propose recommendations aimed at staff dose reduction for clinical routine. 4 University of Ghana http://ugspace.ug.edu.gh 1.4. Relevance and justification The purpose of routine monitoring for occupational exposure is to verify and demonstrate compliance with the regulatory or international dose limits, provide information on dose levels for the optimization of protection, to keep the dose as low as reasonably achievable (ALARA) and identify working practices that minimize the doses. The findings of this study on occupational doses will serve as a baseline data for future dose optimization efforts in fluoroscopically guided procedures in Ghana and may trigger the effective implementation of a radiation protection programme. Additionally, this study is going to help understand the influence of staff doses by the type of procedure performed, the individual workload, the use of radiation protection tools and the methodology of dose measurement. Lastly, staff dose reduction techniques suggested from this study for clinical trials will aid in the optimization of staff protection. 1.5. Scope and Delimitation This research covered staff performing fluoroscopically guided procedures whilst standing in the examination room in radiology and cardiology departments at the Korle- Bu Teaching Hospital (KBTH). For investigative studies, Monte Carlo N-Particle code was used to effectively experiment on possible staff dose reduction techniques. The radiation exposure to the staff’s whole body, eye lens and the study of the scatter radiation in the room of examination will be the dosimetry scope. This study is limited to the dosimetry of the staff and does not include patient protection. The dosimetry of the staff is also only limited to the whole body and eye lens exposures 5 University of Ghana http://ugspace.ug.edu.gh and does not include any other organs. Only fluoroscopically guided procedures in the radiology and cathlab of the KBTH were considered. 6 University of Ghana http://ugspace.ug.edu.gh CHAPTER TWO 2.0. Literature Review This chapter present the general physics behind fluoroscopy: basic science, optimal use, Patient and operator protection. The principle of dose measurements and risk associated with radiation is described. 2.1. Physics behind Fluoroscopy: X-ray Production and Interaction X-ray was discovered in 1895 when Wilhem Conrad Roentgen noticed that a screen coated with a barium-compound glowed when it was subjected to what would later me named X-rays. It is a form of electromagnetic waves generating enough radiation to be ionizing. Other electromagnetic waves include visible light, radio waves and gamma rays (Davros, 2007). 2.1.1. X-ray production X-rays are generated when the energy state of an electron change. This is achieved when a heated filament (cathode) produces electrons which are accelerated to a tungsten target (anode) by applying a high voltage (50 – 150 kVp) to the tube. The electron creates an electric field that interacts with other atomic particles of the anode material. This result in the release of energy in the form of X-ray as shown in figure 2.1. 7 University of Ghana http://ugspace.ug.edu.gh Figure 2.1: The X-ray tube (Source: www.radiologymasterclass.co.uk) 2.1.2. X-ray Interactions with Matter When photons pass through a material, some interacts with particle in the medium and their energy can be totally absorbed or scattered. Other photons travel completely through the medium without any interaction resulting in an image. This is called “complete penetration”. In diagnostic radiology, the two most important interaction of X-ray with tissue are: the photoelectric effect and Compton Effect. Depending on the type of interaction of electron with the target material, continuum and characteristic x-rays are produced. 2.1.2.1. Total absorption or photoelectric effect This occurs when a low energy (low kVp) photon transfers the totality of its energy to the inner shell electron of the atom. This electron is ejected from the atom leaving a vacancy on the shell. An electron from an outer shell (more energetic) drops down to fill the vacancy. This results in an emission of characteristic X-ray. Photoelectric effect represents anatomic structures with high X-ray absorption characteristics, radiopaque structures, tissue with high atomic number, or with high mass density (bone). It contributes in no image and increases patient dose. 8 University of Ghana http://ugspace.ug.edu.gh 2.1.2.2. Compton Scattering Partial absorption with scatter also called Compton scatter means that part of the energy is absorbed by the tissue and part is scattered. Compton Effect increases with photon’s energy, and is likely to occur with soft tissue and fairly high energy (high kVp) photons. It doesn’t depend on the atomic number (probability for bone an atom is the same with soft tissue). Scattered radiation tends to degrade image quality and is the primary source of staff radiation exposure. Interaction of radiation with patient is presented in figure 2.2. Figure 2.2: Photon interaction with the tissue (www.e-radiography.net) The number of photons transmitted through the material depends on the tissue thickness, tissue electron density and the photon’s energy (kVp). Photon attenuation passing through the matter is presented in figure 1.3 below. 9 University of Ghana http://ugspace.ug.edu.gh Figure 2.3: Exponential attenuation of photon energy in the material (Schuler, 2000) The formula that describes this curve is Beer–Lambert’s Law defined as follow equation (2.1): 𝐼(𝑥) = 𝐼 𝑒−𝜇𝑥0 (2.1) Where I is the initial intensity of the photon, µ is the linear absorption coefficient and x is the distance travelled. 2.2. Technology and Mode of Operation of the Fluoroscopy Machine 2.2.1 Fluoroscopic Imaging Chain Fluoroscopy can be defined as a general method of radiographic examination by which real time image is produced on the fluorescent screen when the part to be examined is placed between the X-ray tube and fluoroscopic screen (schueler, 2000). It allows observation of gross physiology, which is concerned with motion of the heart, diaphragm and alimentary traction, follow through and so forth. The schematic of fluoroscopy chain is presented in figure 2.4. 10 University of Ghana http://ugspace.ug.edu.gh The principal components required for the production and management of the fluoroscopic images are as follows:  X-ray generator: produce electrical energy to the X-ray tube.  X-ray tube: is located under the patient table for under couch fluoroscopy unit and above the table for over couch fluoroscopy unit. It is fixed to the fluoroscopic tower and convert electrical energy from the X-ray generator to X-ray Monitor Video Camera Optical Coupling Image Intensifier Grid Patient Table Filtration Collimator X-ray Tube X-ray Generator Figure 2.4: Schematic of the fluoroscopic imaging chain  Collimation: is a device made of sets of shutters which is use to define with precision the area that will be irradiated. Collimation fundamental purpose is to prevent unwanted region of the body from being irradiated by coning down the area of interest. 11 University of Ghana http://ugspace.ug.edu.gh This action thus reduces the overall patient and staff radiation dose. Proper collimation is important for high image quality.  Patient table and pad: It is used to support the patient safely during the examination period.  Image intensifier The image intensification tube shown in figure 2.5 receives a small portion of the remaining X-ray beam, converts it into a visible light image and increases the image’s brightness without increasing the patient dose. Figure 2.5: An image intensification tube (Source: http://www.usapa.army.mil/pdffiles/p350-59.pdf.) An image intensification tube has four basic components: - An input phosphor and photocathode: used to stop high X-ray energy that exit from patient and convert it into a darkish visible light image. Then convert the visible light photon image into free electron. 12 University of Ghana http://ugspace.ug.edu.gh - Set electrostatic focusing lenses: Focus the photoelectron comprising image by a low potential on the inside metallic coating of the tube so that it passes through the anode aperture. And secondly, provide different magnification levels for viewing. - An accelerating anode: Accelerate the electron image to high speed by applying high voltage. - An output phosphor also made of CsI The electron image strikes the output phosphor and releases their kinetic energy in the form of massive amount of visible light photons. Thus, the output layer converts the electron to light necessary for visualization of the image. 2.2. Occupational Radiation Protection Occupational exposure to ionizing radiation can occur in a range of industries, in mining and milling, in medical institutions, in educational and research establishments and in nuclear fuel cycle facilities. The term occupational exposure‟ refers to the radiation exposure incurred by a worker which is attributable to the worker’s occupation and received or committed during a period of work (IAEA, 2003). Persons potentially exposed to radiation as a result of work to more than three tenths of the occupational dose limit are occupationally exposed workers (OEWs) or radiation workers. 13 University of Ghana http://ugspace.ug.edu.gh 2.3.1. Source of Occupational Radiation In diagnostic and interventional radiology, workers are most likely exposed to three sources of radiations: scattered radiation, leakage radiation and direct beam show in figure 2.6. Figure 2.6: sources of occupational radiation exposure (Source: https://images.search.yahoo.com/scattered and leakage from x-ray.)  Primary radiation or useful beam: produce in the X-ray tube and it is used to irradiate the patient. For specific procedures worker’s hands are exposed to the direct beam in the case of over couch fluoroscopes.  Leakage radiation: are coming from the source assembly (including collimators). It should not exceed 1 µSv per hour at one meter when the maximum kiloVoltage peak (kVp) is 125 – 150 kV and maximum milli Ampere (3 – 5 mA) or at every power rating specified by the manufacturer.  Scattered radiation: arises from any object within the X-ray beam (including but to very limit extent, the air through which the primary X-ray beam passes). The patient is the most significant source of scatter radiation. The intensity of scatter is dependent on a number of factors, including the intensity of primary X-ray beam, the area of the X- 14 University of Ghana http://ugspace.ug.edu.gh ray beam incident on the patient (patient entrance skin area) and the angle from which the primary beam at which scatter is assessed. Scattered radiation contributes to the majority of occupational exposure, especially during fluoroscopy. 2.3.2. Quantities used in Radiological Protection In radiation measurement, three main categories of quantities are used. The quantities used to describe the radiation field called radiometric quantities, include energy fluence (rate), fluence (ф). The dosimetric quantities which includes, absorbed dose (D), exposure (X), and kerma (K) and the protection quantities are equivalent dose (H), effective dose (E), directional dose equivalent, etc. 2.3.2.1. Dose Quantities and Units used for Patient Dosimetry  Absorbed dose: The absorbed dose is the amount of energy imparted to the matter per unit mass of the irradiated material. The conventional unit is rad (Radiation Absorbed Dose) and the SI unit is the gray (Gy). 1Gy = 1J/kg = 100 rad. The rate at which an absorbed dose is received is called dose rate. The units are Gy/s, mGy/h and the most used is µGy/h. the gray cannot be used to measure the relative biological effect on the body.  KAP (Kerma Area Product) for patient dosimetry Sometimes called DAP (Dose Area Product), is the dose integrated across the entire exposed field (dose multiplied by the area irradiated), usually expressed in Gy.cm². It is 15 University of Ghana http://ugspace.ug.edu.gh measured by fixing the KAP meter on the X-ray set. The KAP is independent of the distance from the source. 2.3.2.2. Dose Quantities for Occupational Exposure The quantities recommended by ICRP for occupational dosimetry are protection quantities expressed in term of effective dose and equivalent dose (ICRP, 2007).  Equivalent Dose The equivalent dose is a quantity used to indicate the relative health effect caused by a specific type of radiation. It is the product of the absorbed dose in the volume of organ or tissue (T) 𝐷𝑇,𝑅 and radiation weighting factor 𝑊𝑅 and is expressed in equation (2.2). 𝐻𝑇 = ∑𝑅 𝑊𝑅 𝐷𝑇,𝑅 (2.2) The sum is performed over all types of radiation involved. The SI Unit of equivalent dose is Sievert (Sv). For diagnostic radiology (𝑊𝑅 = 1) effective dose is numerically equal to absorbed dose.  Effective dose Defined by ICRP publication 60 as a weighted sum of tissue equivalent doses and is expressed in equation (2.2). 𝐸 = ∑𝑇 𝑊𝑇 𝐻𝑇 = ∑𝑇 𝑊𝑇 ∑𝑅 𝑊𝑅 𝐷𝑇,𝑅 (2.3) 𝑊𝑇 is the tissue weighting factor and represent also the contribution of individual organs and tissues to the overall radiation detriment ∑𝑇 𝑊𝑇 = 1 . 16 University of Ghana http://ugspace.ug.edu.gh The effective dose is expressed using the Sv. It is the average over all the tissues of the human body and is probably the most useful way to express and compare the dose delivered by different imaging procedures. These are not measurable quantities. The effective dose and equivalent dose for occupational exposure are assessed by using the operational quantities (ICRP, 2007a). 2.3.3. Operational Quantities for Individual and Area Monitoring The operational quantities used for area monitoring of external exposure are: ambient dose equivalent 𝐻∗(10) and directional dose equivalent 𝐻′(0.07, Ω). The quantity used for individual monitoring is personal dose equivalent 𝐻𝑃(𝑑) which is defined as the dose equivalent in International Commission on Radiation Units and Measurements (ICRU) sphere (soft tissue) at an appropriate depth d below a specified point on the human body. To assess the effective dose, 𝐻𝑃(10) with d = 10 mm is used, 𝐻𝑃(0.07) with depth d = 0.07mm for the dose to skin, the hands and the feet, and a depth d = 3mm is used for monitoring the dose to the lens of eye (𝐻𝑃(3). Operational quantities are measurable using radiation monitoring devices, which are calibrated in terms of 𝐻𝑃(10) and 𝐻𝑃(0.07). 2.3.4. Radiation Effects and Radiation Protection Principles 2.3.4.1. Radiation Effects X – ray is a form of ionizing radiation which once in the human body can interact with atoms and cause ionization in cells which may produce free radicals or direct effect that 17 University of Ghana http://ugspace.ug.edu.gh can damage the Deoxyribonucleic Acid (DNA) or cause cell death. The adverse health effects of radiation exposure are classified into two types:  Deterministic effects Deterministic effect is defined as an outcome for which severity of the effect increases with dose and for which a threshold exists and are typically quite high. It is the result of a large part of cells kills/malfunction following high doses. Some examples are: skin erythema, hair loss, cataract, etc.  Stochastic effects Stochastic radiation effects involve either cancer in exposed individuals due to mutual of somatic cells or heritable diseases in their offspring due to mutation of reproductive (germ) cells. It is considered as chronic effect and caused by longer exposure relatively lower doses. The dose response model for stochastic effect is the linear-non-threshold (LNT) at low dose. The probability that cancer and heritable effects caused by radiation can occur increases with increment in the equivalent dose. - Risk of cancer The ICRP in publication 60 estimated cancer risk coefficient based on direct human epidemiological data (ICRP, 1990). Years later, the cancer risk coefficient at low dose and low dose rate were estimated based on many data such as occupational exposure (early Radiologist and Medical Physicist), medical overexposure, bomb victims, Inhabitants of high natural background areas, accidents, etc. Biological Effects of Ionizing Radiation (BEIR VII) committee combined radiobiological and epidemiological evidence concerning the Dose and Dose Rate Effectiveness Factor (DDREF) using data on solid cancer in Life Span Study (LSS) and life shortening in animals to choose the 18 University of Ghana http://ugspace.ug.edu.gh modal value of DDREF as 1.5 with probabilistic uncertainties (BEIR, 2006). ICRP (2007) adopted the risk reduction factor of 2 for radiological protection to derive the nominal risk coefficient for all cancer given in table 2.1 below (ICRP, 2007a). - Risk of heritable effect The framework for the estimation of heritable risk adopted by ICRP was based on data from human and mouse. In publication 60, ICRP use another approach to heritable risk based on the concept of Doubling-Dose (DD) for disease – associated mutation (ICRP, 1990). In agreement with United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR, 2008) and BEIR VII, ICRP gives an estimation of the genetic risk up to the second generation of about 0.2% per Gray (BEIR, 2006). - Nominal risk coefficients for cancer and heritable effects ICRP in publication 103 (2007) proposed risk coefficients values for human health effects (cancer and heritable effects) based on calculation of sex – averaged nominal risk coefficient seen in table 2.1 (ICRP, 2007a). Table 2.1: Risk coefficients for stochastic effect proposed by ICRP (𝟏𝟎−𝟐 𝑺𝒗−𝟏). (ICRP, 2007a) Exposed Cancer Heritable effects Total detriments population 2007 1990 2007 1990 2007 1990 Whole 5.5 6.0 0.2 1.3 5.7 7.3 Adult 4.1 4.8 0.1 0.8 4.2 5.6 19 University of Ghana http://ugspace.ug.edu.gh 2.3.4.2. Radiation Protection Principle The purpose of radiation protection is to control exposure to ionizing radiation in order to avoid deterministic effects and ensure that the likelihood of stochastic effects is kept below the unacceptable level. To achieve this objective, ICRP (2007a) recommended three basic principles of radiological protection which are: justification of the practice, optimization of protection and application of dose limitation.  Justification of practice: for any procedure that involves ionizing radiation, the benefits must be well established and accepted by both medical practitioner and society at large. ICRP publication 103 ICRP, (2007a) state as a principle of justification that “any decision that involves the radiation exposure situation should do more good than harm” and (ICRP, 2007b) in publication 105 said that, “in the case of the individual patient, justification normally involves both the referring medical practitioner who refers the patient (example of patients physician/surgeon) and the radiological medical practitioner under whose responsibility the examination is conducted”. In fluoroscopy guided intervention the responsibility rest with the interventionist.  Optimization: find a way to do the examination at a lower dose while maintaining efficacy and accuracy. In optimization process the likelihood of incurring exposures, the number of people exposed and their individual doses should be kept as low as reasonably achievable. It should be considered from the design stage of equipment and installation, through operation to decommissioning and waste management.  Dose limits: Dose limitation is defined in the BSS as “the value of effective dose or equivalent dose to individual from controlled practices that shall not be exceeded”. For occupational 20 University of Ghana http://ugspace.ug.edu.gh exposure, it is applied to the sum of effective dose from external sources. Table 2.2 present the new dose limits for individuals occupationally exposed. Table 2.2: ICRP’s recommendations for dose limits (ICRP, 2007; ICRP, 2013) Effective Dose Limits 20 mSv per year averaged over 5 years 50 mSv in a single year Equivalent Dose Limits Lens of the eye 20 mSv per year averaged over 5 years 50 mSv in a single year Skin 500 mSv per year averaged over 1 cm² area of skin regardless of the area exposed Extremities 500 mSv per year 2.3.4.3. Dose Constraint The use of dose constraint is highly recommended in optimization of protection. For occupational exposure, dose constraint is that value of individual dose from a source (always lower than annual dose limit) serving as upper bound on the predicted dose in optimization of protection for that source. In the case that the boundary is exceeded, meaning that protection is not optimized, an investigation should be conducted. For better optimization, an investigation level should be established in term of effective dose or equivalent dose received monthly. The monthly investigation level will serve as an alert to review the level of protection to that period of time and it should not exceed annual dose limit or dose constraint when it is extrapolated to a year. 21 University of Ghana http://ugspace.ug.edu.gh In 2000, the World Health Organization (WHO) recommended an investigation to be carried out when monthly exposure reaches 0.5 mSv for effective dose, 5 mSv for eye lens, or 15 mSv for the extremities (WHO, 2000). With the review of annual eye lens dose, Duran et al (2013) proposed for interventional cardiologists a new investigation level of 2 mSv per month. 2.4. Strategies to Reduce Radiation Risk to Staff It is the responsibility of all staff members working in radiation to take measures that will enhance radiation protection and safety in the department. Techniques used to reduce patient dose, will reduce the scatter radiation to operators and thus decrease occupational radiation dose. Cardiovascular and Interventional Society of Europe summarized dose reduction techniques generally applied in interventional cardiology procedures in table 2.3 below (Miller et al, 2010). 22 University of Ghana http://ugspace.ug.edu.gh Table 2.3: Dose reduction techniques commonly used fluoroscopy procedures (Miller et al, 2010) Techniques used in interventional cardiology Corresponding functions Minimize use of fluoroscopy time and use low Reduce staff and patient dose fluoroscopy mode Number of fluorographic images Reduce staff and patient dose Image-chain geometry Reduce patient dose Collimation of the radiation field Decrease the level of scatter dose Medical staff position in a low-scatter area Reduce staff dose Wear protective shielding Reduce radiation dose to eye lens and other organs Fluoroscopic imaging equipment comply with Dose-reduction technology is International Electrotechnical Commission incorporated into the imaging (IEC, 2010) systems Obtain appropriate training provided by Increase awareness of radiation professional bodies protection and dose reduction Wear personal dosimeter Know and monitor your own dose Diagnostic reference levels Monitor clinical practice and radiation dose 23 University of Ghana http://ugspace.ug.edu.gh 2.4.1. Practical Application of Optimization of Protection The basics tools of occupational radiation protection are time, distance and shielding. 2.4.1.1. Time Fluoroscopy time should be minimized by screening only when necessary. The health care personnel should limit the amount of time spent close to the radiation source. 2.4.1.2. Distance The shorter the distance, the higher is the exposure. The longer the distance, the lesser is the exposure. The health care professional should avoid direct beam and keep the maximum distance from the patient. 2.4.1.3. Shielding Shielding is the key for staff dose reduction and it is applied at three levels: architectural shielding, equipment – mounted shields and personal protective shield (Christopoulos et al., 2015). The most important component of personal protective shielding is the lead apron which must be worn by all staff present in the fluoroscopy room. The common thickness of lead apron used in fluoroscopy room is 0.25 mm on the back and 0.35 mm on the front or 0.25 mm on the back and 0.5 mm on the front. Depending on the X – ray energy (kV setting) and the lead equivalent thickness of the apron, the lead apron may reduce the dose by 85% - 99% (Bushberg et al., 2012). The use of lead glasses is strongly recommended to interventional Cardiologists and Radiologists and can reduce the eye exposure of the operator by 85% to 90% (Kim et al., 2009). A separated thyroid shield is 24 University of Ghana http://ugspace.ug.edu.gh also recommended for workers in X – ray room. Most catheterization laboratories is equipped with a ceiling suspended screens which contain lead impregnated in plastic or glass and a table mounted lead curtain which provide effective attenuation. Roguin et al (2012) and Reeves et al (2015) reported brain tumor at the left side of the head of interventional cardiologists, saying that it was caused by radiation exposure. 2.4.2. Education and Training Programs Training is a basic requirement for healthcare professional in terms of optimization of radiation protection. It increases awareness of the risk of radiation and enhance the use of protective measures in order to reduce exposure. In interventional procedures where, high dose of radiation is used, proper education and training is highly recommended for all staff (cardiologists, nurses, technologist, etc.) at the time of employment and as part of continuing education program. In 2009, Vano et al (ICRP publication 113) included training in radiological protection as part of Quality Assurance (QA) program, highlighted its importance and give specific recommendations for interventional procedures (Vano et al., 2009). Georges et al (2009) provided training materials to improve radiation protection and safety in interventional procedures showing the successful impact of training program on dose reduction. 2.5. Individual Monitoring Personal monitoring is considered as the gold standard for radiation surveillance in intervention procedures (Christopoulos et al., 2015). Personal dosimeters must be adequately accurate in different exposure conditions, small and lightweight for the 25 University of Ghana http://ugspace.ug.edu.gh convenience in use such that it will not affect staff performance in exercising their task. The individual monitoring of health professional can be achieved using two types of dosimeters: passive dosimeters and active dosimeters. 2.5.1. Passive dosimeters They give information on the personal dose after processing. Film, thermo luminescent dosimeters (TLDs), optically stimulated luminescent (OSLs) badges are some examples. They are small, lightweight, do not require power and well package for the comfort of staff. These are the most used in personal dosimetry around the world. The reading process makes the dosimetry system suitable to verify compliance and not convenient for optimization (ICRP, 2018). 2.5.2. Active Personal Dosimeters (APDs) They are also called electronic dosimeters. They provide instant information of the dose when it is exposed to radiation. It is suitable for optimization and analysis of dose by procedure. The direct feedback on the dose give opportunities to staff to take actions within a procedure if needed and evaluate the effectiveness of the protective action taken. It also facilitates auditing of the wearing of APDs during procedures and the study the correlation between occupational and patient exposure (ICRP, 2018). For photon energies between 20 and 150 keV and spectra used for fluoroscopy procedures, the dosimetry system must meet IEC standard (IEC, 2012) and internationally accepted guidance (ICRP, 2010; IAEA, 2014). It must be simple, reliable and efficient to execute required action (ICRP, 2018). 26 University of Ghana http://ugspace.ug.edu.gh 2.6. Assessment of Occupational Exposure 2.6.1. Effective Dose Assessment The accuracy and precision on the dose assessment depend on the location of the dosimeter on the body. In fluoroscopy guided procedures, workers are partly shielded. Therefore, single dosimeter placed over the lead apron will overestimate the dose, the same way a single dosimeter placed under the lead apron will underestimate the dose because it doesn’t consider the unshielded part of the body such as head, hands, legs etc. therefore a correction factor should be applied to the reading of the dosimeters for better estimation of effective dose (Siiskonen et al., 2007). 2.6.1.1. Double Dosimetry Approach All personnel working in radiation area must be monitored. In interventional procedures, ICRP (2000) recommends the use of two dosimeters (one worn on the trunk of the body inside the lead apron and another outside the lead apron on the thyroid collar at the left side). This has been approved by the National Council on Radiation Protection (NCRP, 2010) as it provides the best estimation of the effective dose. The algorithm used to combine the reading of the two dosimeters is in the form of equation 2.4. 𝐸 = 𝛼 𝐻𝑈 + 𝛽 𝐻𝑂 (2.4) Where E is the effective dose, 𝐻𝑈 and 𝐻𝑜 are the personal dose equivalent Hp (10) measured under the apron and over the apron on the collar respectively, 𝛼 and 𝛽 are the factors to be applied to the dosimeter reading. Over the years many couples of 𝛼 and 𝛽 has been proposed by many authors, but there is not international agreement on which one should be used. Among the entire double dosimetry algorithm tested by Jarvinen et 27 University of Ghana http://ugspace.ug.edu.gh al. (2008) within the European Coordinated Network for Radiation Dosimetry (CONRAD), ICRP (2018) found 𝛼 and 𝛽 combination proposed in the Swiss Ordinance (2008) to be the best to estimate the effective dose. 2.6.1.2. Single Dosimetry Approach Although the double – dosimetry approach provides better accuracy, it has some disadvantages:  No international agreement on the algorithm that should be use. This makes the comparison of the effective dose difficult to interpret.  No reliability in wearing two dosimeters correctly and consistently by the interventionists.  The higher cost of two dosimeters. A single dosimeter worn under the lead apron gives the dose received by radiosensitive organs at the trunk. the monthly reading of these dosimeters is often below the detection level, making this monitoring technique poor and limited in providing information. Many studies have shown that there is no significant difference between double – dosimetry and one dosimeter worn over the lead apron corrected by a factor (ICRP, 2018). Based on studies of the relationship between Hp (10) from the over apron dosimeter and Monte Carlo simulation or direct measurements using an anthropomorphic phantom, Martin and Magee (2013) proposed an algorithm of effective dose for staff performing fluoroscopy procedures in radiology, cardiology and interventional radiology. The algorithm defines in equation 2.5 was accepted and proposed by ICRP publication 139 in 2018. 28 University of Ghana http://ugspace.ug.edu.gh 𝐸 = 0.1 𝐻0 (2.5) 2.6.2. Assessment of Equivalent Dose to the Lens of the Eye Before ICRP (2011) new recommendation of eye lens dose limit, the eye lens dosimetry was hardly performed by clinicians, who were assuming that the limit was too high (150 mSv) and that the whole-body monitoring was enough to provide reliable eye lens dose. In 1992, ICRU recommended the use of the personal dose equivalent Hp (3) to assess the eye lens dose (ICRU, 1992). This operational quantity was found suitable for the eye lens dosimetry, but dosimeters calibrated in term of Hp (3) are non-available in many countries. ICRP in publications 103 and 117 recommended the use of Hp (0.07) for monitoring of the lens of the eye for photon exposures (ICRP, 2007; ICRP, 2010). IAEA (2013) suggested that Hp (0.07) can be used to approximate Hp (3) for photon radiation field and Hp (10) can only be considered when the mean energy of the photon spectrum reaching the dosimeter is more than 40 keV. IAEA (2014), ISO (2015) and International Radiation Protection Association in Paris (IRPA, 2017) have provided the monitoring procedure for the lens of eye. Clerinx et al (2008) and Martin (2009) based on Monte Carlo study, proposed a factor between the equivalent dose Hp (0.07) read from a dosimeter worn at the collar level and eye lens dose. Personal monitoring program consist in monitoring, recording, evaluating and reporting the radiation dose received by individuals occupationally exposed to radiation in a department. All the staff exposed to radiation must be monitored at the international standard, especially those performing fluoroscopic procedures. 29 University of Ghana http://ugspace.ug.edu.gh CHAPTER THREE 3.0. Material and Method This chapter will focus on the description of the study area, sample size, materials and methods used for data collection and analysis. 3.1. The Study Area This study was conducted in the biggest referral hospital in Ghana. KBTH is situated at 5° 32′ 16.2″ north, 0° 13′ 38.67″ west, 5.5374 latitude and – 0.2274 longitude, Guggisberg Avenue of Ablekuma Sub – locality in Accra Metropolis District, Greater Accra Region of Ghana. Figure 3.1 present the location of KBTH in Ghana. Figure 3.1: Location of KBTH in Greater Accra Region Korle Bu means the valley of the Korle lagoon. It was founded on 9th October 1923 as a general hospital to address health issues of the population. KBTH leads three centers of excellence, the National Cardiothoracic Centre (NCTC), the National Plastic and Reconstructive Surgery and the National Centre for Radiotherapy and Nuclear Medicine 30 University of Ghana http://ugspace.ug.edu.gh and has 17 clinical and diagnostic departments/units. Because of sophisticated procedures provided in various field, KBTH attract patients from all over Ghana and West Africa Sub-region and sometimes from other countries in Africa. In KBTH, fluoroscopy guided procedures are conducted in the Radiology Department, Accident Department and NCTC. Because of some factors such as the limited time allocated for the study, limited number of equipment available and the limited access to the departments, this study was focused in the Radiology Department and NCTC. 3.1.1. Radiology Department of KBTH The Radiology Department is well equipped with different modalities system to attend to in and out patients. The systems include X-ray machines used for general radiography such as chest, pelvis and spine etc., one over couch fluoroscopy unit for special diagnostic examination like barium studies, Hysterosalpingogram (HSG), Intravenous Urogram (IVU), myelogram sometime for interventional procedure (biliary drainage) etc., three ultrasound machine, X-ray machine for emergency cases, one Computed Tomography (CT) scanner, Magnetic Resonance Imaging (MRI) scanner and portable X- ray at surgical department. The department transfers nine (9) Consultant Radiologists and 18 in training, among whom four (4) are assigned for fluoroscopy examinations on the monthly basis. The fluoroscopy room has two trained radiographers and two nurses. Fluoroscopy examination room is very spacious 6 m x 6.8 m (40.8 m2). The walls are made up of concrete material of about 30 cm width. Console room is separated from examination room by wall of 28.5 cm width and 220 cm height and had a glass screen lead equivalent. The entrance door to the room is made up lead sheet of 3 mm and had a warning light on top of the door which illuminate when the X-ray is on. The room is 31 University of Ghana http://ugspace.ug.edu.gh equipped with two screens (one in the examination room for Radiologists and one in the console room for Radiographers) and functional air conditioner The fluoroscopy unit is SHIMADZU FLEXAVISION (CE 0197) over couch as shown in figure 3.3. It was manufactured in Japan in February 2012. Model: Collimator type R – 30 H and serial number 3Z0FF7D22045, the maximum tube kVp 150 and Al equivalent is 1.0 mm. The unit is powered by one generator model Servo – REG with serial number 130451, manufactured the 24th April 2013. The standard distance from the source to bed is one meter. Figure 3.2: Over couch fluoroscopy Machine at the Radiology Department, KBTH 3.1.2 National Cardiothoracic Centre (NCTC) The NCTC shown in figure 3.3 was founded in January 1989 by Dr. Frimpong – Boateng. It is a very dedicated center with a 30 beds ward, 2 operating theatres, a laboratory, radiology, echocardiography services, cardiac catheterization laboratory and a renal dialysis unit. Staff members comprise a team of seven cardiothoracic surgeons assisted by Cardiologists, Anesthetists, cardiovascular Perfusionists, nurses, Technologists etc. 32 University of Ghana http://ugspace.ug.edu.gh NCTC offer their services to patients from all over the country and receives regular referrals from Nigeria, Sierra Leone, Gambia, Liberia, Togo etc. (Edwin et al, 2011). Figure 3.3: Outlook of the actual NCTC at KBTH Cardiac Catheterization Laboratory (Cathlab) is used in modern cardiology and cardiac surgery for diagnostic and treatment of many heart diseases without opening the heart of the patient. The new cathlab was installed in October 2016 and inaugurated on Wednesday 4th January 2017 by the former Ghana President John Mahama. The fluoroscopy unit at the cathlab in figure 3.4 is the type Siemens (Artis Zee/Zeego) Megalix catplus 125/40/90 – 121 GW, model N° 10144181 and serial number 640041673. The maximum tube voltage is 125 kV – IEC 60613 and total filtration is 0.8 mm Al/80 kV. It was manufactured in February 2016 in Germany. Examination room Console room Figure 3.4: Internal view of Cathlab with Siemens biplane fluoroscopy unit. 33 University of Ghana http://ugspace.ug.edu.gh 3.2. Sample Size All operators who conducted fluoroscopically guided procedure during the period of data collection in Radiology Department and NCTC were the sample size of this study. A total of four (4) Radiologists and four (4) Cardiologists were monitored. 3.3. Materials A questionnaire was been issued to assess the level of radiation protection practices in the cathlab. The Pirhana was used for Quality Control (QC) on equipment, KAP meter was used to record patient dose for fluoroscopy procedures conducted in radiology department, electronic dosimeters for personal monitoring, survey meter for area monitoring. 3.3.1. Questionnaire A set of questions were prepared for the purpose of interview. Based on these questions, an interview was done between the investigator and the chief nurse (who is in charge of the cathlab), Cardiologists and Radiologists. This was done in order to collect information on radiation protection and safety measures practice in the laboratory to prevent the risk of ionizing radiation both for patient and workers. The questions had two main parts: the first part was about the general information on the equipment and the second focused on the information regarding the radiation protection of the personnel. 3.3.2. Piranha Pirhana is a Radiation to Information (RTI) package used for an instant X – ray Quality Assurance (QA) solution. It is an all in one multimeter that can be connected to a 34 University of Ghana http://ugspace.ug.edu.gh computer wireless or via Universal Serial Bus (USB). It works with the diagnostic RTI software ocean 2014, which is used to display, record and report all the measurements, waveforms and facilitate the reading on a screen. The Piranha was used in this work for the quality control test of the fluoroscopy units at Radiology Department and NCTC. The Piranha version 5.5 with serial number CB2 – 15020088, was manufactured in Sweden and calibrated the 11th March 2015 by SWEDAC. ACKREDICTERING. The Piranha was connected to a computer with an Ocean 2014 software installed on the window 7 systems for reading (Figure 3.5). Table 3.1 presents the specifications of the piranha used. Figure 3.5: Setup of QC tools (piranha and ocean 2014 installed on a computer) under the X – ray system 35 University of Ghana http://ugspace.ug.edu.gh Table 3. 1: Specifications of the Piranha for radiography / fluoroscopy Elements Specifications Dose Range: 0.1 nGy–1500 Gy*, Inaccuracy: 5% Dose Rate Range: 1 nGy/s*–320 mGy/s, Resolution: 0.2 nGy/s*, Inaccuracy: 5% or 0.25 nGy/s Total Filtration 60–120 kVp, 1–90 mm Al or 2 mm Cu . kVp Range: 35–160 kVp, Minimum Dose Rate: 0.1 µGy/s, Inaccuracy: 1.5% HVL Range: 0.72–13 mm Al, Minimum Peak Dose Rate: 0.1 µGy/s, Inaccuracy: 10% or 0.2 mm Al. Quick HVL in one exposure Total filtration Range: 1.0–90 mm Al, Minimum Dose Rate: 0.1 µGy/s Inaccuracy: 10% or 0.3 mm Al Time Range: 0.1 ms–2000s, Resolution: 0.5 ms, Inaccuracy: 1% or 0.5 ms 3.3.3. Kerma Area Product Meter The Kerma X – plus is made of a transparent ion chamber, model 120 – 131 and serial number 01A04042 (50 – 150 kVp, Class II – type B), with a separated reader with “10 – digit LCD “Single Line Display”, model 120 – 210 with serial number o1E004774. It was manufactured by IBA dosimetry service. The ion chamber was fixed on the collimator of 36 University of Ghana http://ugspace.ug.edu.gh the X – ray unit at the radiology department to measure DAP for patient dose monitoring. Figure 3.6 below shows the Kerma X – plus package used for this study. (a) (b) Figure 3.6: (a) The Kerma X – plus with the separated reader and (b) the ion chamber fixed on the X – ray tube in radiology department. 3.3.4. Electronic Personal Dosimeter (EPD) Four (4) labeled EPD of type EPD MK 2.3 manufactured by Thermo Electron Corporation were used for this study to measure the dose to the personnel. The corresponding serial numbers of the EPDs were 00179975, 00178174, 00070491, 00179958. The EPD is a direct reading dosimeter suitable to use in occupational dosimetry according to the Radiation Protection and X – ray ordinance (FO75KOM06A/Datasheet EPD MK, 2014). Personal dosimeters is used to measure personal depth dose equivalent Hp (10) and the personal surface dose equivalent Hp (0.07) both from photons (X-rays and gamma radiation) and beta radiation. It can be attached to the clothing with a clip mounted on the housing well display in figure 3.7 below. 37 University of Ghana http://ugspace.ug.edu.gh Figure 3.7: Electronic Personal Dosimeters used for this study These dosimeters were calibrated at the Secondary Standard Dosimetry Laboratory (SSDL) of GAEC to check the accuracy on the reading during the study. The Calibration set up is shown in figure 3.8 below. Cesium source EPD Figure 3.8: Calibration setup in SSDL at GAEC 3.3.4.1. Measurement Method The radiation detector is made of PIN diodes in which charges are induced by radiation (electron – hole –pairs). The measurements of charges in terms of electric current constitute the measurement of the dose rate from which the value of the dose can be derived by adding the time (is stored in the dosimeter and can be read out via an infrared 38 University of Ghana http://ugspace.ug.edu.gh interface). The thin beta - window is used to measure beta radiation because of its low penetrating power. The detailed picture of the EPD used for this study is shown in figure 3.9 below. Figure 3.9: Typical personal dosimeter (Source: www.helmholtz-muenchen.de/awst) 3.3.4.2. EPD MK 2+ Radiological and Environmental Specifications The Thermo Scientific Mk2+ EPD is perfect for organizations, utilities, agencies, and research laboratories to monitor employee dose and dose rates. The radiological and environmental key features of these instruments as stipulated in the user manual are presented in tables 3.2 and table 3.3 respectively. 39 University of Ghana http://ugspace.ug.edu.gh Table 3.2: EPD MK 2+ Radiological Specifications Components Details Display Units Sv and rem OR scaled in Sv and cGy (with prefixes) Dose Display and Storage 0 μSv to > 16 Sv (0 mrem to > 1600 rem) Display Resolution 1 μSv (0.1 mrem), up to 10 Sv Storage Resolution 1/64 μSv (=1.5 μrem) Photon: Hp(10): [All ref. 137Cs]: ±50% 15 keV to 17 keV; ±20% 17 keV to 1.5 MeV; ±30% 1.5 MeV to 6 MeV; ±50% 6 MeV to 10 MeV Energy Response Photon: Hp(0.07): [All ref. 137Cs]: ±30% 20 keV to 6 MeV; ±50% 6 MeV to 10 MeV Beta: Hp(0.07): ±30% 250 keV to 1.5 MeV (ref. 90Sr/90Y) Angular Response Hp(10) 137Cs ±20% up to ±75º; Hp(10) 241Am ±50% up to ±75º; Hp(0.07) 90Sr/90Y ±30% up to 55º Accuracy Hp(10) 137Cs ±10%; Hp(0.07) 90Sr/90Y ±20% Hp (10) 137Cs: ±10% <0.5 Sv/h (<50 rem/h); ±20% 0.5 to 1 Sv/h (50 to 100 rem/h); ±30% 1 to 2 Sv/h (100 to 200 rem/h); ±50% 2 to 4 Sv/h (200 to 400 rem/h); Between 4 and 50 Sv/h continues to accumulate dose at Dose Rate Linearity a rate > 1 Sv/h Hp (0.07) 90Sr/90Y: ±20% <1 Sv/h (<100 rem/h); Between 1 Sv/h and 50 Sv/h continues to accumulate dose at a rate > 1Sv/h 40 University of Ghana http://ugspace.ug.edu.gh Table 3.3: EPD MK 2+ Environmental Specifications Components Details Operating Temperature -10ºC to +50ºC (+14ºF to +122ºF) Humidity 20% to 90% RH, non-condensing Vibration IEC 1283: 2g, 15 minutes, 10 to 33 Hz 3.3.5. Dose Rate Meter The dose rate meter presented in figure 3.10 is the type PM1703MO – 2. It is a personal combined radiation detector/dosimeter manufactured by Polymaster with serial number 2160498. Figure 3.10: Dose rate meter used in this study This instrument is designed to measure ambient Dose Equivalent Rate (DER) 𝐻∗(10) of gamma and X – ray radiation, to detect and locate radioactive materials and alerting the user with audible, visual and vibration alarms. Figure 3.11 and table 3.4 show the design and characteristics of the dose rate meter respectively according to the operational manual. 41 University of Ghana http://ugspace.ug.edu.gh Figure 3.11: Functional parts of the dose rate meter (Source: www.Polimaster.com) Table 3.4: Characteristics of the dose rate meter Specifications PM 1703MO – 2 Detector - gamma search CsI(Tl) - gamma measurement GM tube Sensitivity - for 137Сs , ± 20 % 85 (s-1)/( Sv/h) (1.0 (s-1)/( R/h)) - for 241Am , no less 130 (s-1)/(μSv/h) (1.3 (s-1)/(μR/h)) Energy range 0.033 - 3.0 MeV Time of measurement 0.25 s Dose Rate 0.01 Sv/h - 10 mSv/h (1 R/h - 1000 mR/h) Maximum permissible intrinsic ±30% in measurement range relative error of DER measurement in 0.1 μSv/h - 10 Sv/h (10 μR/h - 1000 R/h) measurement range Alarm type visual, audio, vibration Operating temperature -30°C to 50°C (-22°F to 122°F) 42 University of Ghana http://ugspace.ug.edu.gh 3.4. Software 3.4.1. Microsoft Excell The software used for the data analysis in this study was Microsoft excel 2010 version 14.0 included in Microsoft office 2010 installed on a window 7 system. Excel provides functions to solve statistical, engineer and financial problems and it is used to display data as line graphs, histograms and charts. It supplies pivot tables and scenario manager that can be used to section data in order to view dependencies between variables (Greg, 2007). It can also be used for numerical methods to solve differential equations in mathematics and physics. Figure 3.12 shows the interface of excel 2010 running on window 7. Figure 3.12: Microsoft excell 2010 running on window 7 3.4.2. Simple Geo Simple Geo version 4.3.3 was used in this work. It is an interactive solid modeler used to implement geometries for particles transport problems. It provides a flexible and easy platform to create modes via drag and drop, and also debugging facilities based on stochastic and deterministic methods for validation of the created geometry. In other 43 University of Ghana http://ugspace.ug.edu.gh word Simple Geo offers an interface where the created geometry is visualized so that corrections and modifications can be immediately done. The created geometry in Simple Geo can be exported to ray tracing packages such as FLUKA, Monte Carlo N particle (MCNP), etc. (Theis et al., 2006). The following figure 3.13 presents a geometry creates with Simple Geo. Figure 3.13: Simple Geo interface with an example of geometry created (Theis et al., 2006). 3.4.3. Monte Carlo N Particle (MCNP) MCNP is a general purpose, continuous energy, generalized – geometry and time dependent code developed by Los Alamos National Laboratory (LANL). It is designed to simulate fission and particle interaction (neutron, photon, electron or coupled neutron / electron / photon) over a broad range of energies. It found its application in many areas such as radiation shielding, medical physics, dosimetry and radiation protection, nuclear reactor modeling, etc. it is a three-dimensional geometry with flexible source and tally options, interactive graphics, and support for both sequential and multi – processing computer platforms. The latest version is MCNP 6 package which gives abilities to 44 University of Ghana http://ugspace.ug.edu.gh import unstructured mesh geometries from the finite element code, to model complete atomic relaxation emissions, etc. 3.5. Methods Approval letter to conduct this research were provided by the College of Basic and Applied Science and also the KBTH Scientific and Technical Committee (KBTH-STC). The ethical clearance was obtained from the Institutional Review Board (IRB) of KBTH. 3.5.1. Quality Control (QC) Tests In order to verify that the fluoroscopy equipment was performing consistently, standard QC tests were undertaken before all measurements. The following are the parameters which were checked: beam collimation, kVp accuracy and reproducibility, time reproducibility, half value layer, leakage test, mAs linearity and exposure reproducibility and compared with the standard limits provided by Nuclear Regulatory Authority of Ghana (NRA, 2016). The room size has been measured using the tape meter. The distance between the X –ray source and the table were 1 m. 3.5.1.1. Beam Collimation This test is performed to check if the X – ray beam coincides with the light field, because the radiation field may be shifted away from the area of clinical interest. This was achieved by placing a sheet of paper under the radiation field and height (8) coins of 20 pesewas were positioned strategically on the corners (in and out) of the sheet of paper and some images were taken. The accuracy on the collimation was checked by measuring the distance of the shifting of coins on the image using the meter provided at the 45 University of Ghana http://ugspace.ug.edu.gh computer screen. Figure 3.14 shows one image of the collimation check. The distance measured was subtracted from the diameter of the coin (23 mm). Figure 3.14: Radiograph from the beam collimation check 3.5.1.2. Reproducibility Test For every X – ray machine, some parameters such as kV, exposure time and exposure should be reproducible. To assess the reproducibility, the machine was set at 80 kV and 10 mAs. The exposure was repeated three (3) times and the results were registered in the Ocean 2014 software. For all these parameters, the coefficient of variation should be less than 5% and this was calculated as follows (NRA, 2016): Standard deviation Coeficient of Variation (COV) = × 100% (3.1) Average 3.5.1.3. kVp and Exposure Time Accuracy For kV, the test was performed at tube voltage 70 kV up to 115 kV at the highest tube current (250 mA and 110 ms). The readings were registered and the percentage of error was automatically calculated by Ocean 2014 according to equation (3.2) (find the results on Appendix 5). (V − V ) Percentage kVp error = 0 S × 100 (3.2) VS 46 University of Ghana http://ugspace.ug.edu.gh Where V0 is the measured value and VS is the set value. The percentage kVp error should lie within ±6% (NRA, 2016). The machine was set at 80 kVp, 250 mA and the first time at 8 ms. The procedure was repeated for different time 63 ms, 100 ms, and 0.125 s. The percentage error should lie within ±10 % (NRA, 2016). It has been calculated according to equation (3.3) below. (T − T Percentage timer error = 0 S × 100 (3.3) TS Where T0 is the measured value and TS is the set value. 3.5.1.4. mAs Linearity To perform this test, the parameters of the machine were set at 80 kV and at first 2.5 mAs. The exposure, time kV was recorded and the value of exposure / tube current (mGy / mAs) was calculated. This procedure was repeated for 20 mAs, 32 mAs, and 40 mAs. The maximum and minimum values of (mGy / mAs) were recorded and the linearity was found according to equation (3.4). It should be less than 10% (NRA, 2016). 𝑀𝑎𝑥−𝑚𝑖𝑛 ≤ 10% (3.4) 𝑀𝑎𝑥+𝑚𝑖𝑛 3.5.1.5. Half Value Layer (HVL) The determination of HVL was obtained directly from the Piranha at one exposure when the setting of the machine was 80 kVp and 250 mA, and 0.11 s. this value should be more than 2.3 mm Al (NRA, 2016). 47 University of Ghana http://ugspace.ug.edu.gh 3.5.1.6. Leakage Test The tube output rate free in air was measured using the dose rate meter (survey meter) at one-meter distance from focal spot to front, back, right and left of the X – ray tube when the collimator is completely shut at maximum kVp (125 kVp) and 25 mAS. The values should be less than 1 mGy/h. 3.5.2. Dose Monitoring The four dosimeters used for measurements were labeled (chest 1, chest 2, neck 1, and neck 2) in order to reduce errors during the readings. All measurements were performed within one month at Radiology Department and two months at the Cathlab. For every type of procedures requiring the presence of the operator near the patient, dose to the workers were measured. Two electronic dosimeters (thermo fisher) were issued for every operator conducting the procedure. One dosimeter was fixed under the lead apron at chest level and the second one, over the lead apron on the thyroid shield at neck level. For patient dose, the KAP meter was fixed on the X-ray tube (Radiology). The following parameters were recorded in both departments: - The type and the number of the procedure performed by each operator. - The patient dose (DAP) per procedure. - The screening time of each procedure. - The personal equivalent dose Hp (10) from each dosimeter was recorded daily and Hp (0.07) for the dosimeter worn over the lead apron at neck level. - The protective equipment available in the room and the protective actions. 48 University of Ghana http://ugspace.ug.edu.gh 3.5.3. Scatter Radiation Study in the Examination Room Cathlab was modeled according to the measured parameters using Simple Geo. Height 290 cm, length 740 cm, breadth 400 cm and size of the lead glass 100 cm x 315 cm are presented in figure 3.15. 740 cm 370 S ource Lead glass Contro l panel Figure 3. 15: CathLab dimensions Scattered radiation dose was measured by irradiating an improvised plastic rectangular shape container with rounded corners filled with water used as phantom to simulate a standard patient (50 Cm length, 30 cm width and 22 cm height). This is a good representative of human trunk. Dose rate was measured at 160 Cm height from the floor at each strategic angles (0°, 90°, 180°, 270°) as illustrated in figure 3.16 at 1m from the isocenter. The projection angles of the tube at which the data were collected were Left Anterior Oblique (LAO) 30°, Right Anterior Oblique (RAO) 30° and Antero Posterior (AP) 0° presented in figure 3.17. At each point three measurements were taken and the average was calculated in order to reduce errors. 49 200 cm 400 cm University of Ghana http://ugspace.ug.edu.gh 160 I 100 Phanto Patient bed C- arm Tub e Focal spot Figure 3.16: Schematic of the side view of measurement set - up LAO 30° RAO 30 AP 0° Figure 3.17: Schematic of the top view of the measurement set-up showing the point of measurements at different angles at 1m from the isocenter. 3.5.4. Data Analysis Microsoft excel was used to analyze data and presented them in tables and graphs. The correlation between the KAP values recorded and staff dose was done by regression analysis to determine the P-value, R² and the possible equation which can be used for prediction. 50 University of Ghana http://ugspace.ug.edu.gh 3.5.4.1. Whole – Body Dose Calculation In agreement with regulatory requirement, staff dose monitoring is mostly done by the use of one dosimeter worn at chest/waist level under the lead apron and the recorded value from the dosimeter represents the effective dose (ICRP, 2000). The methodology for personal monitoring used in this study is the double dosimetry (one dosimeter worn in lead at waist level and another out lead at neck level on the thyroid collar) method recommended by NCRP (1995) and ICRP (2000) for both Radiologists and Cardiologists. Many algorithms have been developed combining dose recorded from the two dosimeters, but there is no yet an international consensus about which algorithm to use. The table 3.5 presents some algorithm proposed by different authors for effective dose calculation both for single dosimeter and double dosimeters. Table 3.5: Algorithm proposed for effective dose calculation with thyroid collar [adapted from Jarvinen et al. (2008) and ICRP publication 139 (2018)] Source Dosimetry Effective dose estimation Type NCRP Report 122 Single 𝟏 𝑯𝒑(𝟏𝟎) 𝑶𝒗𝒆𝒓 × 𝟐𝟏 (NCRP, 1995) Martin and Magee (2013) Single 𝟎. 𝟏 × 𝑯𝒑(𝟏𝟎)𝑶𝒗𝒆𝒓 * NCRP Report 122 Double 𝟎. 𝟓𝑯𝒑(𝟏𝟎)𝑼𝒏𝒅𝒆𝒓 + 𝟎. 𝟎𝟐𝟓𝑯𝒑(𝟏𝟎)𝑶𝒗𝒆𝒓 (NCRP, 1995) Swiss Ordinance (2008) Double 𝑯𝒑(𝟏𝟎) 𝑼𝒏𝒅𝒆𝒓 + 𝟎. 𝟎𝟓 𝑯𝒑(𝟏𝟎)𝑶𝒗𝒆𝒓 * Clerinx et al, 2008 Double 𝟏. 𝟔𝟒𝑯𝒑(𝟏𝟎) 𝑼𝒏𝒅𝒆𝒓 + 𝟎. 𝟎𝟕𝟓𝑯𝒑(𝟏𝟎)𝑶𝒗𝒆𝒓 Chida et al, 2013 Double 0.89 𝑯𝒑(𝟏𝟎)𝑼𝒏𝒅𝒆𝒓 + 𝟎. 𝟎𝟕𝟓𝑯𝒑(𝟏𝟎)𝑶𝒗𝒆𝒓 51 University of Ghana http://ugspace.ug.edu.gh (*) represent the algorithms used in this work which was recommended in publication 139 (ICRP, 2018) for single and double dosimetry using the protective collar. 𝐻𝑝(10) 𝑈𝑛𝑑𝑒𝑟 is the deep dose calculated from the dosimeter worn at waist level under the lead apron and 𝐻𝑝(10) 𝑜𝑣𝑒𝑟 is the dose calculated from the dosimeter worn at neck level above the apron. The value of equivalent dose used in this calculation was obtained by the following equation 3.5. 𝐻𝑝(10) 𝑟𝑒𝑎𝑙 = k * 𝐻𝑝(10) 𝑟𝑒𝑎𝑑 (3.5) Where k is the calibration factor, 𝐻𝑝(10) 𝑟𝑒𝑎𝑑 is the value read from dosimeters. The same equation was applied for 𝐻𝑝(0.07) 3.5.4.2. Eye Lens Dose Calculation The international recommendation of the eye lens monitoring is the use of personal dosimeters calibrated in terms of 𝐻𝑝(3). Because of the non – availability of such dosimeters, many authors established the correlation between 𝐻𝑝(0.07) read on the dosimeter worn on the thyroid collar and the eye lens dose. Some coefficients found in literature are presented in the following table 3.6. 52 University of Ghana http://ugspace.ug.edu.gh Table 3.6: Ratio (eye lens / Thyroid) doses [adapted from Carinou et al. (2015)] References Ratio (eye lens/Thyroid) Geometry Equipment Covens et al (2007) 0.73 Lie et al (2008) 0.75 * under couch tube Clerinx et al (2008) 0.75 * Hausler et al (2009) 0.68 Buls et al (2002) 1.22 Over couch tube Sulieman et al (2008) 1.46 * (*) are the equations used for eye lens dose estimation for both Radiologists and Cardiologists depending on the geometry of the equipment used in this work. Monthly dose received by each worker monitored was calculated by summing the daily dose over the whole month using equation (3.6). 𝐸 𝑛𝑀 = ∑𝑖 =1 𝐸𝑖 (3.6) Where 𝐸𝑀 is the monthly dose, 𝐸𝑖is dose received per procedure. For cardiologists the annual dose was estimated by calculating the mean of three-monthly dose and multiply by twelve (12). ∑3 𝐸 𝐴𝑛𝑛𝑢𝑎𝑙 𝑒𝑓𝑓𝑒𝑐𝑡𝑖𝑣𝑒 𝑑𝑜𝑠𝑒 = 𝑖=1 𝑀𝑖 × 12 (3.7) 3 3.5.4.2. Workload The workload is defined differently depending on whether it is for a device or an individual. For a device, it is the weekly radiation output expressed in mA-minute per 53 University of Ghana http://ugspace.ug.edu.gh week. It can also be defined in term of working time or amount of work that is expected or assigned to an individual for a period of time. This gives an idea of the time a worker spends under radiation whether weekly, monthly or annually. It can also be expressed in term of number of procedures. In this study, the workload has been calculated in term of total time spent under the radiation and also the number of procedures performed by each Cardiologist over a period of 2 months in cathlab. The monthly average workload was calculated in order to estimate the annual workload for each worker. 3.5.4.3. Risk Assessment The risk assessment was calculated using the risk coefficient values provided by ICRP 2007 recommendations given in table 2.1 in the previous chapter. The cancer, heritable effect, total detriment and lifetime risk have been estimated for each Cardiologist working with radiation. The general equation used for cancer and heritable effect risk is expressed as follow in equation 3.8: Annual Risk (AR)= Eannual (Sv) X Nominal Risk Coefficient (3.8) Where E is the annual effective dose in Sievert (Sv) and the nominal risk coefficient in Sv-1 The total detrimental effect can be estimated by summing the annual cancer risk and annual heritable effect risk. 54 University of Ghana http://ugspace.ug.edu.gh 3.5.5. Monte Carlo Simulation The dimensions of the examination room were taken using tape measure. The location of the couch, X-ray tube with respect to the room was located. Dose rate measurement at a distance of 100 cm from the couch to the focal spot of the tube was measured using a survey meter for verification of the computational model. Simple Geo was used to model the X-ray room, phantom and the X-ray source using the already taken dimensions. The model was out put into Monte Carlo input file for simulation as shown in Appendix 7. The model was verified for accuracy using the measured dose rate in air at 100 cm. An X-ray spectrum was generated for the simulation at 100 kVp, 12 degree tungsten anode and 2.5 mm Al using SpekCalc (spectrum generation software). The Monte Carlo input file was simulated on a computer with a processing speed of 3 GHz. 1.9 x 109 photon particles were tracked for a reasonable computational time and output accuracy. Photon dose rate deposited per particle mesh in the X-ray room was tallied for the output results. The output of radiation dose rate/particle in the room was plotted in a contour to illustrate the spread of radiation using GNUPlot (plotting software version 5.2, patchlevel 4). 55 University of Ghana http://ugspace.ug.edu.gh CHAPTER FOUR 4.0. Results and Discussions This chapter presents the QC results of the equipment and the compliance with the regulatory standard in Ghana. It also presents the overall research finding from the assessment done and comparison of workers parameters between the two departments, two X-ray tube geometry. The finding was also compared with other studies and recommendations of ICRP, IAEA and NCRP. 4.1. Basic Elements of Radiation Protection in Both Department At the Radiology Department among the six (6) staff members working in fluoroscopy room, four (4) responded to the questions (one radiographer and three radiologists) and in cathlab, the chief nurse, the chief cardiologist and three other cardiologists were the respondents. Table 4.1 presents the summarized results of the interview made showing the actual state of radiation protection in both departments. 56 University of Ghana http://ugspace.ug.edu.gh Table 4.1: Status of radiation protection measure in both departments Protective measures Radiology Cardiology In Tube Geometry Over couch Under couch Presence of warning light Yes Yes Lead apron Yes (100%) Yes (100%) Thyroid shield (0.35 mm) Yes (100%) Yes (100%) Lead glasses Yes (25%) No Lead gloves No No Other protective equipment Not available Yes (full use) (ceiling suspended screen and lead drap) Use of collimation No No Medical physicist Yes No Refresher training of workers No No Quality assurance program No No Radiation Protection Officer No No Regular QC on the machine No No radiology department, no personnel had received refresher training on radiation 57 University of Ghana http://ugspace.ug.edu.gh protection. They have acknowledged the presence of a Medical Physicists. Survey on radiation protective clothing showed the availability of six (6) lead aprons: two (2) one side aprons (0.35 mm), two wraps around apron (0.35 mm front and 0.25 mm back), two (2) one side aprons (0.5 mm), and one skirt and one shirt (0.35 mm front and 0.25 mm back). Other available protective clothing includes three (3) thyroid collar of 0.5 mm, two (2) pairs of lead glasses and one pair of lead gloves are for Radiologists. The ceiling suspended screen and lead drape were not available. Radiologists expressed the inconvenience in using lead gloves due to the small size of catheter and syringes used during procedures even though their hands are most often exposed to the direct beam. The radiation protection measures to reduce patients and operator doses such as (use of collimation, reduce number of images and frame, etc.) were not applied. The record keeping in Radiology Department needs more attention. At the NCTC, Cardiologists and Nurses affirmed that they have received training on radiation protection during their general training, but they have not received any refresher training in course of their work. This may be due to the absence of a Radiation Protection Officer (RPO) or Medical Physicist, Quality Assurance program in the department. Therefore, no frequent QC test is performed on the equipment. In term of personal protection equipment, the department is well equipped with one lead curtain (0.5 mm) fixed on patient bed, the ceiling suspended screen lead equivalent (0.5 mm), eight (8) thyroid collar of 0.5 mm and a total of ten (10) lead apron: four (4) one side apron of 0.5 mm use by nurses, four (4) wrap around apron of 0.5 mm front and 0.25 mm back, one side apron of 0.35 mm and one wrap around skirt and shirt of 0.5 mm front and 0.25 mm back. But no lead glasses or gloves were available. Every worker has a well labeled TLD 58 University of Ghana http://ugspace.ug.edu.gh badge provided by Lumina Dosimetry Services. They wear inside the lead apron at waist level. But these TLDs had never been read since the starting of the new cathlab in October 2017 till the end of this study. Thus, there was not personal dose record in the department. Patient’s information and doses details are well recorded and well kept on digital form (computer, CDs and external hard disk) and also hard copies. In general, table 4.1 reveals the critical aspects of radiation safety program are not practiced in both departments. These departments require the presence of a radiation protection officer to assure continuous training of workers on radiation protection. The QC and radiation survey around the workplace are performed by the regulatory authority during their inspection. This study has been useful both for workers and at the departmental level in the way that it has brought awareness of radiation exposure to the workers. This leads to some practice of protective measures at worker level and will contribute to the implementation of continuous personal monitoring in both departments. 4.2. Quality control results 4.2.1. Over couch Fluoroscopy in Radiology Department Peak tube voltage, screening time and tube outputs measured when set tube voltage and mAs are 80 kV and 2.5 mAs respectively are shown in table 4.1 with the calculated deviations. 59 University of Ghana http://ugspace.ug.edu.gh Table 4.2: kVp, time and output reproducibility test. Measuring quantities 80 kV, 2.5 mAs Mean COV% Actual kV 75.21 75.79 75.62 75.54 0.30 Time (ms) 31.60 31.61 31.61 31.60 0.03 Output (µGy) 363.40 363.70 365.30 364.13 0.20 Peak tube voltage sets and measured together with calculated deviations used to assess accuracy are shown in table 4.3. Table 4.3: Tube voltage accuracy kV accuracy Set kV 70 80 90 100 110 115 Actual kV 69.19 77.9 87.25 97.46 106.89 111.55 D kV 0.81 2.1 2.75 2.54 3.11 3.45 % DkV 1.16 2.63 3.06 2.54 2.83 3 For tube voltage set at 80 kV, the set values of mAs, measured values of exposure and calculated values of exposure / mAs are presented in table 4.4. Table 4.4: mAs linearity mAs linearity (80 kV) m A s 2.5 20 32 40 Exposure (mGy) 0.1085 0.8409 1.307 1.652 mGy / m A s 0.0434 0.042045 0.04084375 0.0413 60 University of Ghana http://ugspace.ug.edu.gh From the values calculated in table 4.4, the mAs linearity is calculated as indicated in equation 4.1: 𝑀𝑎𝑥−𝑚𝑖𝑛 0.0434−0.04084375 The mAs linearity = = = 0.03 (4.1) 𝑀𝑎𝑥+𝑚𝑖𝑛 0.0434+0.04084375 A total of seven (7) QC tests were performed on the over couch fluoroscopy tube used at the Radiology Department. The calculated deviations for each test and the standard acceptable deviations provided by Ghana Nuclear Regulatory Authority are presented in the following table 4.5. The room size of 40.8 m² is far greater than the minimum required. The beam collimation deviation was found between 5 – 6.10 mm which was below the acceptable deviation of 10 mm. The tube voltage accuracy (3.10 %), mAs linearity (0.03) are both below the tolerance ±6% and 0.1 respectively. The reproducibility of tube voltage, time and exposure were 0.3%, 0.03%, and 0.2% respectively. These are less than the tolerance ±5%. The HVL measured at 80 kV was 3.17 mm Al which is greater than the minimum (2.3 mmAl) recommended and the leakage was not detectable by the measuring instrument meaning that is was less than 1.00 mGy /h. 61 University of Ghana http://ugspace.ug.edu.gh Table 4.5: Summary of the results Deviation of Acceptable Parameter Fluoroscopy Deviation Remarks Machine (NRA, 2016) (Measurement) Room Size (Sq. metre) 40.8 m2 ≥ 25.0 m2 Pass kVp Accuracy 3.10 % ≤ ±6.0 % Pass mAs Linearity 0.03 ≤ 0.10 Pass Collimation Accuracy 6.10 mm ≤ 10.0 mm Pass HVL (mm Al ) @ 80kV 3.17 mm Al ≥ 2.3 mm Al Pass Tube Leakage at 1m - < 1.00 mGy/h - Tube Voltage Reproducibility @ 0.30 % COV ≤ 5.0 % Pass (10mAs,80 kV) Exposure Reproducibility 0.2. % COV ≤ 5.0 % Pass @ (10 mAs,80 kV) Exposure Time Reproducibility @ 0.03 % COV ≤ 5.0 % Pass (10 mAs,80 kV) (-) means that, radiation no detectable. 4.2.2. Under couch Fluoroscopy in Cathlab The measured tube voltage, time, output and the calculated deviations are presented in table 4.6 below. 62 University of Ghana http://ugspace.ug.edu.gh Table 4.6: Voltage, time and output reproducibility test Measuring quantities Values Mean COV(%) Actual kV 77.38 77.55 77.38 77.49 77.45 0.10% Time (ms) 270.00 270.00 270.50 270.50 270.25 0.10% Output (µGy) 467.20 464.70 469.60 469.60 467.77 0.43% The console reading, measured tube voltage and the deviation are given on table 4.7 below. Table 4.7: Tube voltage accuracy kVp accuracy Console kV 77.30 78.70 81.00 81.00 93.80 94.40 Actual kV 77.77 75.79 80.54 84.10 98.57 100.10 D kV -0.47 2.91 0.46 -3.10 -4.77 -5.70 % DkV -0.61 3.69 0.57 -3.83 -5.09 -6.04 A summary of five (5) QC tests was performed on the under couch (C-arm) used in cathlab. The measured room size, the calculated deviations and the standard acceptable deviations by Ghana Nuclear Regulatory Authority are presented in the following table 4.8 (NRA, 2016). 63 University of Ghana http://ugspace.ug.edu.gh Table 4.8: Summary of the results of QC test Deviation of Acceptable Parameters X-ray Machine Deviation Remarks (Measurement) (NRA, 2016) Room Size (Sq. metre) 29.30 m2 ≥ 25.0 m2 Pass kVp Accuracy 6.04 % ≤ ±6.0 % acceptable HVL (mm Al ) 3.64 mm Al ≥ 2.3 mm Al Pass Tube Leakage at 1m No detectable < 1.00 mGy pass Tube Voltage 0.10 % COV ≤ 5.0 % Pass Reproducibility Exposure Reproducibility 0.10 % COV ≤ 5.0 % Pass Exposure Time 0.43 % COV ≤ 5.0 % Pass Reproducibility The room size of about 30 m² is greater than the minimum required. The tube voltage accuracy (±6.04%) was slightly higher than the requirement (±6%)but is acceptable. The reproducibility of tube voltage, time and exposure were 0.1%, 0.43%, and 0.1% respectively. These are less than the tolerance ±5%. The HVL measured at 80 kV was 3.64 mm Al which is greater than the minimum (2.3 mmAl) recommended and the leakage were not detectable by the measuring instrument meaning that is was less than 1.00 mGy /h. These results show that, the two fluoroscopy machines are functioning well and the measurement taken can be reliable. 64 University of Ghana http://ugspace.ug.edu.gh 4.3. Patients and Radiologists Dose in Radiology Department Radiation dose to radiologist was evaluated for 8 different types of diagnostic procedures carried out on 118 patients. The number of patients per type of procedure is presented in table 4.9. Table 4.9: Summary of procedures and dose measurements Procedures Abbreviations Number of Frequency of (performed by) procedures procedures Hysterosalpingography HSG 74 63.8 (RAD 2 &3) Retrograde Urethrogram RUG 26 22.4 (RAD 1) Mituriting Cysto-Urethrogram MCUG 9 7.7 (RAD 1) Fistulogram FIST 3 2.6 (RAD 4) Myelogram 1 0.9 (RAD 4) Sialogram 1 0.9 (RAD 4) Barium Meal BM 2 1.7 (RAD 4) TOTAL 116 100 *RAD 1, 2, 3 & 4 means Radiologist 1, 2, 3 & 4 Table 4.9 shows that the most performed procedure was HSG with 63.8 % followed by RUG (22.4 %) and MCUG (7.7 %). Because of the high number of procedures, HSG procedures were conducted by two radiologists (RAD 2 and RAD 3). RUG and MCUG procedures were performed by one radiologist (RAD 1) and other procedures such as 65 University of Ghana http://ugspace.ug.edu.gh barium meal, barium enema, myelogram, sialogram and fistulogram also called special cases in the department were conducted by one Radiologist (RAD 4). These procedures however, are not frequent. 4.3.1. Patient Dose and Fluoroscopy Time The mean, median and range of patient dose (KAP) and fluoroscopy time of each type of procedure performed in radiology department are presented in table 4.10. Table 4.10: Mean, median and range values of KAP and fluoroscopy time for each procedure. Procedures KAP (Gy.cm²) Time (min) Mean Median Range Mean Median Range RUG 6.7 5.6 3.5 – 16.8 0.7 0.6 0.3 – 1.6 MCUG 13.9 13.4 2.2 – 23.7 1.8 2.0 0.4 – 3.1 RUG +MCUG 40.7 41.0 37.1 – 44.1 1.5 1.5 1.2 – 1.9 H S G 6.0 5.7 1.9 - 14.4 0.7 0.6 0.2 - 2.5 FIST 35.0 30.2 8.7 – 66.1 1.9 1.4 1.4 – 3.0 Myelogram 25.6 10.3 10.3–40.8 3.4 1.9 1.9 – 4.8 and Sialogram Baruim meal 41.1 21.5 21.5–60.8 7.2 3.5 3.5– 10.9 The lowest fluoroscopy time range are [0.3 – 1.6] min and [0.2 – 2.5] min and the corresponding patient dose range are [3.5 – 16.5] Gy.cm² and [1.9 – 14.4] Gy.cm² were recorded for RUG and HSG procedures respectively. This can be attributed to the fact that those procedures are simple, fast and require the lowest number of image acquisition 66 University of Ghana http://ugspace.ug.edu.gh (between 2 – 4 images). This observation is contrary to combined RUG + MCUG, FIST, myelogram and sialogram procedures which have almost the same time range and with high patient dose. The high patient dose recorded can be the result of the high number of image acquisition obtained during these procedures. Barium meal was found to be the lengthier procedure administering the highest dose to the patients. This procedure is performed on babies, so the length depends on how stable the baby is and require many image acquisitions than screening mode. A good example shown in this table was performed in 10.9 minutes and the recorded KAP was 60.7 Gy.cm² on a ten months baby female. A total of 16 images and 95 frames were recorded for this specific procedure without collimation. In general, patient dose and fluoroscopy time are not uniformly distributed. Table 4.10 shows that patient dose varies with different type of procedures, not necessary with the fluoroscopy time. Also, for the same procedures, these two quantities vary for different patient. This observation lets conclude that patient dose depends on many other factors such as the complexity in patient anatomy, patient size, etc. 4.3.2. Radiologist Dose and Workload Table 4.11, 4.12, 4.13 and 4.14 represent the daily number of procedures, fluoroscopy time, the estimated effective dose using three (3) different methods (one dosimeter out leads, one outside lead and double dosimetry) and the eye lens dose of RAD1, RAD2, RAD3 and RAD4 respectively. It also represents the number of days each radiologist performed procedures during the data collection. 67 University of Ghana http://ugspace.ug.edu.gh Table 4.11: Estimated daily effective dose (using three different methods) and eye lens dose to RAD 1 Procedures Number Time Single in Single Double E of cases (min) E1 (µSv) out E3 eye E1(µSv) (µSv) (µSv) Day 1 RUG 2 2 1 6.6 4.3 96.4 MCUG 1 1.1 Day 2 RUG 3 1.2 1 5.8 3.9 84.7 RUG+MCUG 1 1.5 MCUG 1 2.2 Day 3 RUG 2 2.4 1 2.9 2.5 42.3 Day 4 RUG 3 1.2 1 3.2 2.6 46.7 RUG+MCUG 1 1.2 Day 5 RUG 2 1.7 0 6.3 10.2 92.0 MCUG 1 3.1 Day 6 RUG 2 1.7 0 1.3 0.7 19.0 Day 7 RUG 1 0.7 1 1.8 1.9 26.3 MCUG 1 1.9 0 1.7 0.9 24.8 Day 8 RUG 3 2.4 2 8.1 6.1 118.3 MCUG 2 2.9 68 University of Ghana http://ugspace.ug.edu.gh Table 4.12: Estimated daily effective dose (using three different methods) and eye lens dose to RAD 2 for HSG procedures Number Time Single in Single out Double E2 E eye of cases (min) E1 (µSv) E2 (µSv) (µSv) (µSv) DAY 1 3 1.2 3 4.7 5.4 68.6 DAY 2 4 2.5 6 12.7 12.4 185.4 DAY 3 5 2.7 1 5.8 3.9 84.7 DAY 4 4 2.1 1 3.6 2.8 52.6 DAY 5 2 0.7 1 3.2 2.6 46.7 DAY 6 5 2.9 2 8.9 6.5 129.9 Table 4.13: Estimated daily effective dose (using three different methods) and eye lens dose to RAD 3 for HSG procedures. Number Time Single in Single out Double E eye of cases (min) E1 (µSv) E1 (µSv) E2 (µSv) (µSv) DAY 1 3 1.2 3 3.1 4.5 45.3 DAY 2 1 0.9 1 4.2 3.1 61.3 DAY 3 6 1.9 1 4.4 3.2 64.2 DAY 4 3 2.5 1 10.3 6.2 150.4 DAY 5 2 0.6 1 7.1 4.5 103.7 DAY 6 3 2.2 4 14.4 11.2 108.0 69 University of Ghana http://ugspace.ug.edu.gh Table 4.14: Estimated daily effective dose (using three different methods) and eye lens dose to RAD 4. Procedures Time Single in Single out Double E eye (min) E1 (µSv) E2 (µSv) E3 (µSv) (µSv) Barium meal 10.9 13 116.2 71.1 1696.5 Sialogram 1.9 1 1.10 1.6 16.0 Fistulogram 5.1 7 87.6 50.8 1279.0 Follow through 3.5 1 7.4 4.7 108.0 Barium enema 4.7 1 7.4 4.7 108.0 Myelogram 4.8 1 12.3 7.2 179.6 The number of days in tables 4.12 and 4.13 is less because HSG procedures were conducted by two radiologists who were working together in the room at the same time. The dose recording of the first day of the data collection brought awareness on their radiation exposure. Therefore, for optimization purpose, RAD 2 and RAD 3 divided themselve in such a way that one conducts procedure while the second one observe from the console room daily. According to table 4.11, the average number of procedures performed by RAD 1, RAD 2 and RAD 3 was found between 2 – 3 per day. In these cases only the double dosimetry method of estimation of the effective dose is considered for the discussion. The lowest dose recorded by RAD 1 were observed on day 6 with the corresponding values 0.7 µSv and 19 µSv for effective dose and eye lens dose. These dose were recorded performing two RUG procedures in 1.7 minutes. The highest doses were 6.1 µSv and 118.3 µSv 70 University of Ghana http://ugspace.ug.edu.gh recorded for five procedures (3 RUG and 2 MCUG) performed in 5.3 minutes. The trend of this results shows that worker dose increases with the number of procedures and the fluoroscopy time. This assumption is not verified for RAD 2 and RAD 3 and RAD 4. The dose to RAD 2 performing four procedures in day 2 and day 4 were 12.4µSv and 1.8 µSv respectively, for five procedures on day 3 and day 6 were 4.0 µSv and 6.6 µSv. This same scenario where observed with RAD 3 and RAD 4. Generally, it was observed that dose to RAD 2, RAD 3 and RAD 4 were not uniformly distributed in function of number of procedures performed or the screening time.This shows that the dose to the worker is influenced by many other factors related the worker. Table 4.15 represents the monthly workload (in terms of time and number of procedures performed), the effective dose estimated by three (3) different methods and eye lens dose to radiologists. Table 4. 15: Estimated monthly workload, effective dose and eye lens dose to the Radiologists. Total Time N° of Single in Single out Double E eye (min) procedures E1 (mSv) E2 (mSv) E3 (mSv) (mSv) RAD 1 32.10 32 0.01 0.04 0.03 0.55 RAD 2 36.30 69 0.02 0.04 0.03 0.57 RAD 3 37.67 69 0.01 0.04 0.03 0.53 RAD 4 30.90 8 0.02 0.23 0.14 3.39 Table 4.15 shows a great variation in the number of procedures performed by Radiologists: 32, 69, 69 and 8, but the screening time almost the same 32.10, 36.30, 71 University of Ghana http://ugspace.ug.edu.gh 37.70 and 30.90 minutes respectively. this imply that the screening time is not figured by the number of procedure, it depend on the type of procedure and the anatomy of the patient. RAD 4 has recorded the highest effective dose and eye lens dose (0.11 mSv and 3.39 mSv) even though having the smallest workload. This can be attributed to the poor application of protective measures and also the position occupied (very close to the patient and to the direct beam) when performing the procedure. But RAD 1, RAD 2 and RAD 3 recorded the same amount of effective dose and eye lens dose . This was predictible from the patient dose and fluoroscopy time analysis done in section 4.3.1. Where it was found that dose delivered to patients and fluoroscopy time were almost similar RUG, MCUG and HSG were in the same range. The result of the estimated effective dose using three differents methods agree with ICRP assumption saying that, “dose monitoring with one dosimeter placed inside lead apron underestimate the dose (ICRP, 2000). A dosimeter worn outside lead will overestimate the dose and the best way to monitor the workers conducting fluoroscopy procedures is the double dosimetry in case of hight radiation exposure.” The monthly dose compared with ICRP recommendation (ICRP, 2007) is presented in figure 4.1. 72 University of Ghana http://ugspace.ug.edu.gh 4 3.5 3 2.5 E1 2 ICRP Limit = 1.667 mSv E2 E3 1.5 E (eye) 1 0.5 0 RAD 1 RAD 2 RAD 3 RAD 4 Figure 4.1: Estimated effective and eye lens dose compared with ICRP limit Both effective dose and eye lens dose to RAD 1, 2 and 3 were found far below (42 times less for effective dose, 3 times less for eye lens) the limit regardless the method used for estimation. In the same line, effective dose to RAD 4 was below the limit (by a factor 12) but the dose to the lens of eye has double the limit. It has exceeded to the investigation level (2 mSv/ month) proposed by Duran et al (2013). An investigation should be carrying out to this particular worker to check the circumstances that lead to that high eye dose. The purpose of which is to keep the dose As Low As Reasonable Achievable (ALARA). Because of the proximity of Radiologists to the patient, for some procedures the hands of some radiologists were exposed to the direct beam. Therefore, are likely to received high radiation doses. The monitoring of Radiologists hands is required 73 Effective dose (mSv) University of Ghana http://ugspace.ug.edu.gh 4.4. Patients and Cardiologists Dose in Cathlab Table 4.16 shows the number of procedures that have been carried out by Cardiologists in cathlab of KBTH during the period of data collection (two months). Figure 4.2 presents the frequencies of procedures in the laboratory. Table 4. 16: Number of procedures performed by cardiologists during the period of data collection. Procedures Abbreviations N° cases Coronary Angiogram CA 30 Right Heart Catheterization RHC 6 Percutaneous Coronary PCI 14 Angiogram TOTAL 50 CA 14 18 RHC 54 PCI 14 CA + PCI Figure 4.2: frequency of procedures in the cathlab Coronary Angiogram is a diagnostic procedure and is the most performed in the cathlab. It is sometime associated with intervention procedures (PCI). RHC is a procedure used to 74 University of Ghana http://ugspace.ug.edu.gh check heart pressure of patients and it is done only for few patients who are programmed for surgery. 4.4.1. Patient Dose and Fluoroscopy Time The KAP and fluoroscopy time were recorded by means of integrated KAP meter. The median, range values for investigated procedure are presented in table 4.17. Table 4.17: Median and range values of KAP and fluoroscopy time for each procedure performed in cathab. KAP (Gy/cm²) Time (min) A Procedures Median Range Median Range CA 27.2 14.2 - 120.6 3.9 1.7 - 16.3 PCI 112.5 60.0 - 117.2 26.9 13.5 - 43.0 CA + PCI 134.8 42.0 – 237.0 19.9 9.7 - 37.5 RHC 5.8 4.4 - 33.6 4.8 4.3 - 11.8 large variation of DAP and screening time among procedures are observed. KAP ranges from 4.4 Gy.cm² (Right heart catheterization) to 237.0 Gy.cm² (combined CA + PCI). Fluoroscopy time ranges from 1.7 minutes (CA) to 43 minutes (PCI). Significant variation was also observed for different types of procedures for example, for CA procedure the minimum and maximum values of DAP and fluoroscopy time are 14.2 Gy.cm², 1.7 minutes and 120.6 Gy.cm², 16.3 min respectively. This large variation is observed for other type of procedure. This could be attributed to the complexity of patient 75 University of Ghana http://ugspace.ug.edu.gh anatomy, the technique of the doctor, the number of cine and the patient – tube distance and angulation used. Patients undergoing PCI and CA + PCI procedures are likely to receive the highest dose, median DAP are 11.47 Gy.cm² and 134.8 Gy.cm², median fluoroscopy time are 26.9 minutes and 19.9 minutes respectively. 4.4.2. Cardiologists Doses Contrary to Radiologists to whom is allocated specific type of procedures, Cardiologists are performing every type of procedure depending on their availability when patients are ready. Every procedure is performed by two Cardiologists present near the patient. The range of dose per procedures for different type of procedure conducted by Cardiologists is given in table 4.18. Table 4.18: Effective dose per procedure to Cardiologists CA (µSv) PCI (µSv) RHC (µSv) Card 1 0.3 – 2.1 1.8 – 6.9 - Card 2 0.15 – 21.1 1.2 – 57.6 2.3 – 2.5 Card 3 0.85 – 15.9 0.9 – 6.4 0.1 – 1.9 Card 4 0.05 – 5.7 0.8 – 2.5 0.3 – 2.8 Combined 0.05 – 21.1 0.8 – 57.6 0.1 – 2.8 As expected, owing to patient dose presented in section 4.4.1, the dose range for RHC procedures is very lower (minimum 0.1 µSv, Maximum 2.8 µSv) than the dose range for other procedures. Morrish and Goldstone in (2008) estimated the dose to Cardiologists and found a range of (0.02 – 30.2) µSv per procedure for CA examinations and (0.17 – 76 University of Ghana http://ugspace.ug.edu.gh 31.2) µSv per procedure for PCI. In the same line Fardid et al in (2013) found the dose range per procedure to cardiologists for CA (0.3 – 14.3) µSv and (1.3 – 27.5) µSv for PCI. In general, the dose range received by all Cardiologists per procedures was 0.05 µSv to 21.1 µSv which is comparable to the range value of (0.2 – 18.8) µSv and (0.02 – 38.0) µSv obtained by Padovani and Rodella in (2001), Kim et al in (2008) respectively. The wide range of dose for each Cardiologist is attributed to the position of the Cardiologist from the patient, whether the Cardiologist is acting as an assistant or principal operator and the protective equipment used. The number of cases per type of procedure conducted by each Cardiologist is presented in figure 4.3. 8 7 6 5 4 3 2 1 0 Card 1 Card 2 Card 3 Card 4 Figure 4. 3: Number of procedures conducted by Cardiologists Monthly PCI and CA + PCI are mostly performed by Card 1 and CA by Card 2 and Card 3. Card 1 because of the expertise was always working as the principal operator and Card 4 as the assistant. From figure 4.3, Card 2 and Card 4 were the most frequent in the room with 12 procedures conducted by each, following by Card 1 with 10 procedures and lastly Card 3 with 7 procedures. To investigate the impact of each type of procedure on workers dose, 77 Number of procedures CA PCI CA + PCI RHC CA PCI CA + PCI RHC CA PCI CA + PCI RHC CA PCI CA + PCI RHC University of Ghana http://ugspace.ug.edu.gh the dose received by Cardiologists for each type of procedure was estimated and is presented in figure 4.4 below. 180 160 140 120 100 80 Effective dose 60 Eye lens dose 40 20 0 Card 1 Card 2 Card 3 Card 4 Figure 4.4: Estimated effective dose and eye lens dose to Cardiologists for different type of procedure Figure 4.4 shows that the dose received by Card 4 for every type of procedure is far lower than the dose received by Card 2 even though they performed the same number of procedures. In the same perspective, the dose received by Card 1 conducting two procedures of CA +PCI, is lightly the same received by Card 2 conducting only one procedure. For the same number of RHC procedures conducted, it is observed that the dose received by Card 4 is almost two time the dose received by Card 3. Generally, all the great variation of dose to each Cardiologist per type of procedure owned to the fact that there is an inconsistency in the position occupied by different operators in the examination room. The most important observed fact is that most of RHC procedures were performed by Card 4 as principal operator and other were working as assistant. For 78 Effective dose (µSv) CA PCI CA + PCI RHC CA PCI CA + PCI RHC CA PCI CA + PCI RHC CA PCI CA + PCI RHC University of Ghana http://ugspace.ug.edu.gh Card 1, PCI procedure is the most contributors in terms of dose (both effective and eye lens dose) because the complexity of the procedure and to the fact that, this particular Cardiologist always work as principal operator. For other Cardiologists, the CA procedures are the most contributors to the dose. An average of 22 procedures was performed in the cathlab per month. The monthly workload (time and number of procedures) effective dose and eye lens dose to Cardiologists has been estimated and is presented in table 4.19. Table 4.19: Monthly effective dose and eye lens to the Cardiologists Fluoroscopy N° of Double Eye lens Time (min) procedures E (mSv) Dose (µSv) Card 1 177.0 10 0.02 0.30 Card 2 129.0 12 0.07 0.25 Card 3 77.1 7 0.02 0.20 Card 4 109.2 12 0.01 0.15 Because of various types of procedures, some are lengthier and complex than other. An example is the comparison between the fluoroscopy time and the number of procedures performed by Card 1 (10 procedures, 177 minutes) and Card 4 (12 procedures, 109.15 minutes). Comparing the screening time to the effective dose, Card 1 has the highest workload, but effective dose is half of the dose to Card 2 who has a workload of 129 minutes and the same with Card 3 who has a workload of 77.1 minutes. But the eye dose to Card 1 were found to be the highest (0.3 mSv) among all the Cardiologists. Highest 79 University of Ghana http://ugspace.ug.edu.gh eye dose and low effective dose show an adequate lead apron wear by Card 1. Card 2 record the highest effective dose because of his proximity to the patient during procedure. The lowest value of doses (0.01 µSv for effective dose and 0.15 µSv for eye lens) was recorded by Card 4 can due to the fact that mostly working as assistant operator. In general, the low values obtained in this can be attributed to the small number of procedures conducted in this particular cathlab. The amount of radiation received by every worker depends also on the level of protective measure taken individually. The estimated annually dose was compared to the limit recommended by ICRP and is presented in figure 4.5 below (ICRP, 2007). 20 18 16 14 12 Eye lens dose 10 8 Effective dose 6 3.81 4 3.05 2.43 1.85 2 0.23 0.81 0.26 0.16 0 Card 1 Card 2 Card 3 Card 4 Figure 4.5: Estimated annual effective dose and eye lens dose compared to ICRP limits The annually estimated effective dose and eye lens dose to the Cardiologists was found very low to ICRP recommended annual dose limit of 20 mSv (ICRP, 2007). These results are high compared the one obtained by Efstathopoulos et al (2003) who obtained a range of (0.04 – 0.03) mSv per year for principal operator considering a workload of 240 procedures. On the other hand, the estimated effective dose (0.16 – 0.81) mSv was 80 Effective dose (mSv) University of Ghana http://ugspace.ug.edu.gh comparable to those published by UNSCEAR 2000 (0.4 mSv per year). The reported dose by Dendy (2008) was 2 – 4 mSv per year considering a workload of 1000 procedures. In 2009 Martin reviews the dose to cardiologists and found the dose per procedure between 0.2 and 4 µSv (few were found at 19 µSv) to the whole body and around 20µSv for the lens of eye. He assumed that for 500 procedures each year, Cardiologists are likely to receive between 0.1 and 4 mSv per year. The projected number of procedures per Cardiologists in this study is averaged at 123 procedures per year, which is the quarter of what proposed by Martin. This can be the reason for low dose obtained in this study. 4.4.3. Risk Assessment to Cardiologists The probability of cancer induced and heritable effect (or total detrimental risk) due to radiation exposure received by Cardiologists in this study was calculated using ICRP 2007 for individual risk coefficient and is presented in figure 4.6 below. 0.04 0.035 0.03 0.025 0.02 0.015 0.01 0.005 0 Card 1 Card 2 Card 3 Card 4 Cancer Heritable effects Total Detriments Risk Figure 4.6: Estimated risk to Cardiologists 81 Estimated risk (%) University of Ghana http://ugspace.ug.edu.gh Due to the fact that the dose to Cardiologists was estimated for only one year, the risk estimation done in this study is very negligible. In addition, the workers are exposed to radiation during their life time. In general, the estimated probability of health effect due to radiation to Cardiologists is not significant but should not be ignored. The LNT model assume that every amount of radiation (as small it can be) carries with it risk of cancer or heritable effect. Therefore, there is the need to enhance radiation protection actions in other to keep the dose As Low As Reasonably Achievable and reduce the likelihood of stochastic effects. 4.4.4. Relationship between Effective Dose and Patient Dose The investigation into the relationship between patient dose (DAP) and Effective dose is given in figure 4.7. 70 y = 0.6487e0.0159x 60 R² = 0.3289 50 40 30 20 10 0 0 50 100 150 200 250 KAP (Gy.cm²) Figure 4.7: Relationship between Effective dose and patient dose The plot of exponential relationship between KAP and effective dose gave the following equation 4.3: 82 Effective Dose (µSv) University of Ghana http://ugspace.ug.edu.gh 𝑌 (𝑒𝑓𝑓𝑒𝑐𝑡𝑖𝑣𝑒 𝑑𝑜𝑠𝑒) = 0.6487 × 𝑒0.0159 × 𝐷𝐴𝑃 With R² = 0.32 (4.3) Figure 4.7 shows that below KAP value of 150, the relationship between KAP and effective dose is likely to be linear. Looking at the previous equation 4.3, the value of R² shows that the relationship in general is weak, showing that the effective dose is influenced by other factors which have been stated in previous sections. The regression analysis of these two parameters gives a significant level (P – value = 0.012 < 0.05) meaning that this relationship is statistically significant, and the probability that it is related to chance is 0.012 which is very small. The linear relationship derived from the statistical analysis is following equation 4.4. 𝑌 (𝑒𝑓𝑓𝑒𝑐𝑡𝑖𝑣𝑒 𝑑𝑜𝑠𝑒) = 0.073 × 𝐷𝐴𝑃 + 0.2962 with R² = 0.15. (4.4) The p – value of the intercept is 0.89 which is greater than 0.05. This means that the intercept is more related to chance, so not reliable. This may be attributable to the non - uniform distribution of effective dose caused by the influence of another factor such as shielding, etc. 4.5. Investigation into other Factors affecting Workers Dose A comparison of Cardiologists and Radiologists effective dose and eye lens dose against the workload presented in tables 4.15 and 4.19 in the previous sections shows that the workers are most exposed to radiation with over couch fluoroscopy tube than under couch tube. To support this statement, the Interventional Radiologist (IR) and the Assistant have been monitored during two procedures using the two configuration of the fluoroscopy tube and the results are given in table 4.20. The biliary drainage was 83 University of Ghana http://ugspace.ug.edu.gh performed with over couch tube in radiology department and biliary stenting was performed with under couch tube at the cathlab. Table 4.20: Dose records of interventional radiology procedures with overcouch and undercouch tube. IR Assistant IR Procedures DAP Time Effective Eye Dose Effective Eye Dose Gy.cm² (min) Dose (mSv) (mSv) Dose (mSv) (mSv) Biliary 47.13 14.3 0.04 0.53 0.02 0.22 drainage Biliary 412.23 76.4 0.05 0.67 0.01 0.11 stenting Biliary drainage procedure performed in the radiology department with fluoroscopy time of 14.3 minutes, the IR received 0.04 mSv and 0.53 mSv for effective dose and eye lens dose respectively. These values are lower (with a factor 1.25) than the dose received by the same IR (0.05 mSv and 0.67 mSv for effective dose and eye lens dose respectively) during 76.4 minutes (five times the screening time of biliary drainage). This high dose received in short time in the radiology department may be attributable to the geometry of the tube and the absence of additional shielding (lead glass and lead curtain) in radiology department. The assistant recorded half of the dose received in the radiology department owing to his position from the patient in the cathlab. The variation in staff effective doses for the same procedure can be attributed to the expertise of the worker and the protective garment used. The effect of the worker position in the room and the tube angulation during examination would be further explained in the following section. 84 University of Ghana http://ugspace.ug.edu.gh 4.6. Scattered Radiation in the Examination Room (Cathlab) 4.6.1. Modelling of the room The X-ray source was modeled in a capsule made up of lead and placed under the patient couch. The modeled phantom was placed on the couch. It is shown in figure 4.8 below. Patient couch a) b) Figure 4.8. Source, patient table and phantom modeled with Simple Geo software The room was modeled in respect with the measures taken at the real cathlab. The top and side views are presented in figure 4.9. Figure 4. 9. Top and side view of the cathlab modeled with Simple Geo software 85 University of Ghana http://ugspace.ug.edu.gh 4.6.2. Distribution of Radiation in the Room for AP 0° of the Source The file created by the Simple Geo was exported in MCNP 6 for simulation. Results were plotted using GnuPlot at different height from the floor of the source. The plots are presented in figures 4.10 and 4.11 below. y x Figure 4.10: Dose distribution in the room at 85 cm from the floor y x Figure 4.11: Dose distribution in the room at 107 cm from the floor 86 University of Ghana http://ugspace.ug.edu.gh Figure 4.10 represents radiation distribution under the patient couch before any interaction, it shows that radiation is more concentrated around the patient couch and is spread all over the room. The safest place is negligible. This is the reason why a lead curtain must be always used to protect the operator’s legs. Figure 4.11 is the scattered radiation distribution at the level of the patient couch which is likely to be the trunk level of the operator. At this level the direct beam has interacted with the patient table and other materials on the patient couch. It can be observed that the safest place at the back of the room, behind the equipment is larger than the distribution at 85 cm. Also, the area of maximum radiation is smaller than the one at 85 cm, but it is around the table where the operator stays. It shows the importance of wearing lead apron properly. In both cases the nurses and any other person staying in the room are exposed to radiation. Therefore, they should also wear the protective garment. The head of the operator is the unshielded part of the body exposed to radiation. Figures 4.12 and 4.13 represent the distribution at the head level of the operator (150 cm and 171 cm) y x Figure 4.12: Dose distribution in the room at 150 cm from the floor 87 University of Ghana http://ugspace.ug.edu.gh y x Figure 4.13: Dose distribution in the room at 171 cm from the floor At 150 cm in figure 4.12, the safer place in the room is larger than at 171 cm on figure 4.13. The more it goes higher the more radiation is spread all over in the room and the maximum region is directed toward the entrance of the room where the nurse are likely to stay. Therefore, the taller nurses are likely to receive more radiation to the head (eye lens) than the operators staying near the patient. In general, everyone staying in the examination room is not safe. Thus, the safety measures must be applied by the operators and the nurses at the same level. The lead glass screen is one of the protective measures taken to reduce radiation to the head and hands of the operators. 88 University of Ghana http://ugspace.ug.edu.gh 4.6.3. Distribution of Radiation in the Room for LAO 30° and RAO 30° of the Source The staff exposure is more influenced by the tube angulation used during procedures. Figures 4.14 and 4.15 represents the distribution at LAO 30° and RAO 30° of the source. y x Figure 4.14: Dose distribution (LAO 30°) at 171 cm from the floor Figure 4.15 shows that, there is no safe area in the room and the highest radiation is concentrated on the operator side. Therefore, the operators are more exposed to radiation when using the LAO anterior position of the tube. 89 University of Ghana http://ugspace.ug.edu.gh y x Figure 4.15: Dose distribution (RAO 30°) at 171 cm from the floor For RAO 30° positions shown in figure 4.15, radiation is more concentrated at the opposite side of the operator. 4.6.4. Measured Values of the Scattered Radiation The measured values of scattered radiation are presented in table 4.21 below. The operator’s position is 180° at the right side of the patient. Table 4.21: Measured values of scattered radiation 0° (mSv/h) 90° (mSv/h) 180° (mSv/h) 270° (mSv/h) AP 0° 0.48 0.36 0.52 0.48 RAO 30° 1.08 0.60 0.54 1.56 LAO 30° 0.42 0.72 1.50 1.14 90 University of Ghana http://ugspace.ug.edu.gh Table 4.21 shows that operators are more exposed to the radiation when the tube is at the position LAO 30°. These results agree with the computation in term of the most exposed and the safest area in the room. Generally, every staff present in the room during the procedure is exposed to radiation especially to the head. Therefore, more protective actions (such as: additional shielding, stay at the safer position, etc) should be applied to keep the dose As Low As Reasonably Achievable. 4.7. Limitations of the study The data was intended to be collected at least for two months in the Radiology Department but because of the delay in acquiring the ethical clearance and the dosimeters, the data was collected for only one month. An improvised water phantom was used for the scatter radiation measurement because of the unavailability of anthropomorphic phantom. The time allocated for the study was very limited to conduct a comprehensive risk assessment. Thus, a significant value of risk to the worker could be found in a study accounting for many years. 91 University of Ghana http://ugspace.ug.edu.gh CHAPTER FIVE 5.0. Conclusion and Recommendations Recent progresses in technology have resulted in the development and increased use of ionizing radiation for the purpose of diagnostic and treatment particularly in fluoroscopy. However, the awareness of the health effect of ionizing radiation should be considered and actions must be considered to reduce patient and staff dose. This chapter presents the general conclusion of this study and some recommendations emanating from the findings. 5.1. Conclusion In this study, the effective dose and eye lens dose to four Radiologists using over couch fluoroscopy tube and four Cardiologists using under couch fluoroscopy tube was estimated using the double dosimetry method at KBTH and compared to other study using the same monitoring methods. The effective dose and eye lens dose to the Radiologists were found lower than the limits recommended by ICRP except the eye lens dose to Rad 4 that was found higher by the factor 2. Therefore, monitoring of Radiologists eye lens for the identified specific procedures need more attention. The use of ceiling suspended glass and lead curtain would reduce the dose to the unshielded part such as eye, head, etc. therefore it is highly recommended for use in this department. Dose to Cardiologists were comparable to other study, but were found far lower than ICRP dose limit (1.667 mSv). The effective dose and eye lens dose were not uniformly distributed. The interventional procedures were found to be lengthier, delivering 92 University of Ghana http://ugspace.ug.edu.gh relatively high doses to patients. Therefore, the dose per procedure to the Interventional Radiologist was higher than other staff working in the same environment.  The main factors that influence staff dose were observed to be: procedure types due to the access route used, geometry of the X-ray tube (staff are more exposed to radiation using over couch tube than under couch tube), position of the operator in the room during procedures, the tube angulation, and the experience of the staff. The most critical factor is the use of protective garment used by each operator. Occupational exposure is significantly influenced by patient exposure. Therefore, actions to reduce patient dose will also contribute to operator protection.  The risk assessment shows that, no dose should be considered safe because any amount of radiation carries with it a risk.  The Monte Carlo simulation of dose distribution in the room shows that, at certain height, the nurses are more exposed to the eye lens than the operators for AP0° and there is no safe position in the examination room. On other hand the operators are exposed to high radiation for LAO position of the tube and are safe for RAO position of the tube. Therefore, staffs are advised to wear protective equipment at all times dring procedures. Optimization of protection (describe in the radiation safety programme proposed in appendix 6) should be considered by the operator to maximize patient safety keeping the dose ALARA without compromising the clinical outcome of the procedure. 5.2. Recommendations Optimization in fluoroscopy is complex due to the complexity of procedures and the many technical factors that influence the dose. Therefore, training and quality assurance are indispensable. Because of the complexity of equipment used, quality control of the 93 University of Ghana http://ugspace.ug.edu.gh many parameters involved is time consuming and a careful selection of the parameters to be controlled in constancy checks and frequency are essential part of the programme. 5.2.1. Establishment of a Radiation Safety Programme The results of the investigation performed in both departments concerning radiation protection practice in section 4.1 shows insufficient radiation protection and safety measure considerations. The risk associated with low radiation exposure emphasizes the need for adequate measures to minimize patient and staff dose. This can be possible through the development and implementation of a radiation safety programme. This study recommends the implementation of the proposed radiation safety program (Appendix 6). It is adopted from ICRP publication 139, Chamber et al (2011) and the purpose of this program is to increase the awareness of safety related to procedures involving radiation in other to provide to patient and all staff involved with radiation a safest environment possible for the best clinical outcomes. 5.2.2. Recommendation for Further Study This study was limited by the duration, the type of dosimeter used and the collaboration with the administration and personnel. Therefore, the following are proposed for further study.  This study was limited to occupational radiation exposure. However, high patient dose and long fluoroscopy time were recorded especially for interventional procedures. This shows the necessity to carry out a detailed and complete study on patient dose assessment in the catheterization laboratories in Ghana. In 94 University of Ghana http://ugspace.ug.edu.gh addition, the growing number of procedures and the new operating cathlab created show the importance of establishing the dose reference level for the most performed cardiac catheterization procedures (CA and PCI) in Ghana.  A study base measurements and Monte Carlo simulation aiming to develop an algorithm to accurately estimate effective dose to operators in Ghana using double dosimetry method. 95 University of Ghana http://ugspace.ug.edu.gh REFERENCES Balter, S., and Moses, J. “Managing patient dose in interventional cardiology, Catheterization and Cardiovascular Interventions.” vol. 70, no. 2, pp. 244–249, 2007. BEIR, Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation. “Health risks from exposure to low levels of ionizing radiation: BEIR VII Phase 2,” The National Academies Press, Washington, DC, 2006 Botwe, B. O., Antwi, K. W., Adesi, K. K., Anim – Sampong, S., Dennis, M. E., Sarkodie, B. 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Sanchez, R., "A national programme for patient and staff dose monitoring in interventional cardiology", Radiation Protection Dosimetry, 09/01/2011. Sanchez, R. M., Vano, E., Fernandez, J. M., Ginjaume, M., Duch, M.A., "Measurements of eye lens doses in interventional cardiology using OSL and electronic dosimeters.” Radiat. Prot. Dosim, 162, 569–576. 2014. Sandblom, V., Mai, T., Almén, A., Rystedt, H., Cederblad, A., Båth, M., and Lundh, C. "Evaluation of the impact of a system for real-time visualisation of occupational radiation dose rate during fluoroscopically guided procedures", Journal of Radiological Protection, 2013. 102 University of Ghana http://ugspace.ug.edu.gh Siiskonen, T., Tapiovaara, M., Kosunen, A., Lehtinen, M. and Vartiainen, E. "Monte Carlo simulations of occupational radiation doses in interventional radiology. " Brit. J. Radiol. 80, 460–468, 2007. Szumska, A., Renata, K., Maciej B. "Occupational doses of medical staff and their relation to patient exposure incurred in coronary angiography and intervention," Radiation Measurements, 2016. Sulieman, A., Theodorou, K., Vlychou, M., Topaltzikis, T., Roundas, C., Fezoulidis, I., and Kappas, C., "Radiation dose optimisation and risk estimation to patients and staff during hysterosalpingography." Radiat. Prot. Dosim, 2008. Sun, Z., AbAziz, A., Yusof, A. K. “ Radiation-induced noncancer risks in interventional cardiology: Optimisation of procedures and staff and patient dose reduction.” Biomed Res Int 2013. Swiss Ordinance, “ Eidgenossisches Departement des Inneren und Eidgenossisches Departement fur Umwelt, Verkehr, Energie und Kommunikation: Verordhung uber die Personendosimetrie (Dosimetrieverordnung).” vom 07.10.1999. SR 814.501.43. Swiss Ordinance, Bern (in German), 2008. Theis, C., Buchegger, K. H., Brugger, M., Forkel-Wirth, D., Roesler, S., Vincke, H., "Interactive three dimensional visualization and creation of geometries for Monte Carlo calculations." Nuclear Instruments and Methods in Physics Research A 562, pp. 827-829 (2006). Tsapaki, V. "Correlation of patient and staff doses in interventional cardiology." Radiation Protection Dosimetry.02/03/2006. UNSCEAR. Sources and effects of ionizing radiation: volume I, sources: annex D, medical radiation exposure. Report to the General Assembly of the United Nations; 2000; New York, NY Available at: http://www.unscear.org/unscear/en/publications/2000_1.html Accessed December 31, 2010. United Nations Scientific Committee on the Effects of Atomic Radiation. Sources and effects of ionizing radiation, “UNSCEAR 2008 report to the General Assembly,” vol 1. Annex A. Medical Radiation Exposures, United Nations, New York, NY, USA, 2008, http://www.unscear.org/. Uwe Häusler. "Radiation exposure of medical staff from interventional X-ray procedures: a multicentre study", European Radiology, 04/07/2009. Vanhavere, F., Carinou, E., Domienik, J., Donadille, L., Ginjaume, M., Gualdrini, G., Koukorava, C., Krim, S., Nikodemova, D., Ruiz-Lopez, N., Sans-Merce, M., and Struelens, L. "Measurements of eye lens doses in interventional radiology and 103 University of Ghana http://ugspace.ug.edu.gh cardiology: final results of the ORAMED project." Radiation Measurements, vol. 46, pp. 1243-1247, 2011. Vano, E., "Radiation exposure to cardiologists: how it could be reduced." Heart. 2003; 89(10):1123-4. Vano, E., Gonzalez, L., Fernandez, J. M., Prieto, C., Guibelalde, E. “Influence of patient thickness and operation modes on occupational and patient doses in interventional cardiology.” Radiat Prot Dosim 2006. Vano, E., Rosenstein, M., Liniecki, J., Rehani, M., Martin, C. J. and Vetter, R. J. “ICRP publication 113: education and training in radiological protection for diagnostic and interventional procedures.” Annals of ICRP, vol. 39, 2009. Vano, E., Kleiman, N. J., Duran, A., Rehani, M. M., Echeverri, D. and Cabrera, M. “Radiation Cataract Risk in Interventional Cardiology Personnel.” Radiat. Res, vol. 174, no. 4, pp. 490-495, Oct. 2010 Vano E, Cossett JM, Rehani MM. Radiological protection in medicine: work of ICRP Committee 3. Ann ICRP. 2012;41:24. Vano, E., Fernandez, J. M., Sanchez, R., Dauer, L. T. “Realistic Approach to Estimate Lens Doses and Cataract Radiation Risk in Cardiology When Personal Dosimeters Have not Been Regularly Used,” Health Phys., vol. 105, no. 4, pp. 330-339, Oct. 2013. Vassileva, J., Vano, E., Ubeda, C., Rehani, M., and Zotova, R. “Impact of the X-ray system settings on patient dose and image quality; a case study with two interventional cardiology systems,” Radiation Protection Dosimetry, 2013. WHO, 2000. “Efficacy and Radiation Safety in Interventional Radiology. World Health Organization,” Geneva, Switzerland. 104 University of Ghana http://ugspace.ug.edu.gh APPENDIX 1: Approval Letters 105 University of Ghana http://ugspace.ug.edu.gh 106 University of Ghana http://ugspace.ug.edu.gh 107 University of Ghana http://ugspace.ug.edu.gh 108 University of Ghana http://ugspace.ug.edu.gh APPENDIX 2: Data Collection Sheet 1. Patient’s Data Procedures DAP Exposure time Field size 2. Worker’s Data Procedures workers Neck Neck Chest Hp(10) Hp(0.07) Hp(10) 3. Availability of Radiation Protection Equipment  Identification of the X-ray unit (characteristic and parameters)  Availability of personal protection - Lead apron - Thyroid collar - Gloves - Lead glasses  Presence of additional protection 4. QC data Parameters  Beam quality (HVL)  Tube voltage, accuracy and reproducibility  Tube current exposure time product (mAS)  collimation  Output consistency and linearity 5. Scatter dose measurement 0° (µSv/h) 90° (µSv/h) 180° (µSv/h) 270° (µSv/h) AP 0° RAO 30° LAO 30° 109 University of Ghana http://ugspace.ug.edu.gh APPENDIX 3: Questionnaire PART A: General Information 1. Name of Department: 2. a. Responsibility of respondent: b. For how long have you worked in radiology service? 3. Are you aware of radiation protection of workers? 4. What practices of staff protection do you know? 5. What practices does the department undertake? PART B: Department Information 6. Information of fluoroscopy X-ray tube used: 7. Date of installation_____________________________ 8. a. Is there a Quality Assurance Program in the Department? b. How frequent do you perform QC tests? 9. Is there a radiation safety committee or a radiation protection officer (RPO) in the department? 10. Is there any external expert who offers advice on radiation protection to the department? 12. Are areas in your facility designated as controlled and supervised areas? 13. Are there local rules in the department? 14. Are there radiation warning signs in the facility? 15. Are there warning lights at the entrance door to the X-ray room? 110 University of Ghana http://ugspace.ug.edu.gh PART C: Personnel Protection 16. How many workers are in this department? Radiologists: _______________ Radiographers:______________ Medical Physicists____________ Nurses:_____________ 17. How many female workers are in the department? 18. Any rules for pregnant workers? 19. What protective wear are workers given? a. Lead aprons b. Lead gloves c. Gloves, lead glasses 20. Number of working days per week: 21. Average working hours (in the X-ray room) per day. 22. a. Are occupational doses monitored? b. How are occupational doses monitored? c. How frequent are they monitored? 23. How many workers have ever attended radiation protection training? 24. Are there staff exposure and health surveillance records? 25. a. Do you conduct radiation surveys or assessments around the working area? b. How frequent? 28. Any emergency response mechanisms in place at the facility? 111 University of Ghana http://ugspace.ug.edu.gh APPENDIX 4: Calibration Certificates 112 University of Ghana http://ugspace.ug.edu.gh 113 University of Ghana http://ugspace.ug.edu.gh 114 University of Ghana http://ugspace.ug.edu.gh APPENDIX 5: Quality Control Results from Pirhana 115 University of Ghana http://ugspace.ug.edu.gh 116 University of Ghana http://ugspace.ug.edu.gh 117 University of Ghana http://ugspace.ug.edu.gh APPENDIX 6: Radiation Safety Programme for Occupationally Exposed Workers in Fluoroscopy Guided Procedure 1.0. Introduction The improvement in technology results in the increase of number of procedure and number of facilities performing fluoroscopy procedures (for diagnostic and treatment). Thus, it is important that everyone involve with radiation receives radiation as low as possible. Therefore, it is a mandate for every x – ray department to have an implemented Radiation Safety Program for the safeguard of personnel and public from radiation exposure. The following radiation safety program provides guidelines designed to ensure staff awareness on radiation health risk, also tools and knowledge for the best practice in radiation dose management. It will help the administration and staff to have knowledge and education in place to maintain safe radiation dose. Establishing this program should be a collective effort involving hospital administration and all staff involve with radiation. The target groups of this program are: the Medical Director of the hospital, the Director of NCTC, the Head of radiology department, Radiologists, Cardiologists, Nurses, Radiation Safety Officer (RSO), personnel dosimetry services, Radiographers, everyone interested with occupational exposure in fluoroscopy guided procedures. 2.0. Responsibilities The Medical Director of the hospital has the overall responsibility for protection and safety of the member of staff involve with radiation. He must be part of the effective 118 University of Ghana http://ugspace.ug.edu.gh implementation of radiation safety program and provides financial and adequate support to sustain a reasonable program while ensuring all regulatory requirements for patient and staff safety. He should appoint a Radiation Safety Officer who will work together with staff members and supervises all radiation safety issues in the department. Some of his responsibilities are:  Authorize and register the safety program  Review radiation safety policies and procedures  Monitor and review equipment and radiation warning signs  Evaluate individual monitoring and perform the risk assessment  Survey all radiation areas for safety hazards  Implements QA policies and procedures for X-ray equipment and personnel  Review and submit report of RSP annually  Education and training of all personnel involve with radiation  Establish emergency plan and procedures 3.0. Individual Monitoring Occupational dose monitoring is a critical element of radiation surveillance and is performed to verify compliance and optimize protection. All staff whose work is associated with radiation must adequately and consistently wear their dosimeter. ICRP recommends the use of two dosimeters for operator in fluoroscopy. One dosimeter should be worn at waist level inside lead apron and one worn at neck level outside the apron. In case of the non-availability of two dosimeters for each operator, one should be worn outside the lead apron taking in account the unshielded part (head, 119 University of Ghana http://ugspace.ug.edu.gh extremities). A separated dosimeter should be used for those personnel who work in more than one facility in other to identify the source of highest exposure. In case that the hands are exposed or work close to the direct beam, a wrist dosimeter should be considered for hand monitoring. The recommended dose limits are given in the following table. Table 1: ICRP dose limits (ICRP, 2007) Effective Dose Limits 20 mSv per year averaged over 5 years (1.67 mSv / month) 50 mSv in a single year Equivalent Dose Limits Lens of the eye 20 mSv per year averaged over 5 years (1.67 mSv / month) 50 mSv in a single year Skin 500 mSv per year averaged over 1 cm² area of skin regardless of the area exposed Extremities 500 mSv per year (hands and feets) In case of high exposure an investigation should be carried out to know the elements causing the high exposure for optimization. The investigation level proposed by WHO is 0.6 mSv / month for effective dose. Variety of dosimeters can be used in personnel dose monitoring include TLDs, film dosimeters, etc. but for the purpose of optimization and for detailed study on dose per procedures, APDs are highly recommended. The calibration of the APDs should include the radiation field representative of those encountered in fluoroscopy including tests in 120 University of Ghana http://ugspace.ug.edu.gh pulsed mode with high dose rates. The quantities used in personnel dose monitoring are Hp (0.07), Hp (3) and Hp (10). In case that a dosimeter calibrated in term of Hp (3) in not available, Hp (0.07) can be used as an approximation of Hp (3) and Hp (10) can also be used only for photon spectrum with mean energy above 40 keV. The assessment of Scatter radiation field should be performed to verify the non – compliance with the procedure for wearing individual dosimeters by comparing with individual dosimeter readings. Audits of occupational doses, investigation of abnormal exposure, recording, reporting results and corrective action if appropriate should also be considered. 4.0. Occupational Radiation Protection and Equipment The action toward occupational protection is optimizing patient protection. Other means and actions include: the use of lead apron and thyroid collar, ceiling suspended screen shield and lead glasses, lead caps (if available), table suspended lead curtains and keeping distance from patient. A leaded drape and pad attached to the ceiling screen and be a mean of protection for operator hands for some specific procedures. The protective equipment should be characterized base on the radiation beam used to measure attenuation. Protective apron should never be folded, to avoid crack in the lining and should be inspected using X-ray for any defects. The integrity of lead apron should be assessed annually. The hospital administration should ensure that adequate resources are available to purchase, test and replace them. The following figures are example of a well-equipped cathlab and operator. 121 University of Ghana http://ugspace.ug.edu.gh Figure 1: Protective cathlab an equipped personnel 5.0. Education and Training Every staff member should receive radiation dose management and adequate training in line with their responsibilities. The RSO should coordinate in collaboration with m staff member initial and periodic training of newly employed and operating workers. Training program can be a series of online or standard classroom lectures focusing on:  Physics of X-ray production and interaction  Mode of operation of fluoroscopy machine  Technical factors affecting image quality in fluoroscopy  Dosimetry quantities and unit, biological effects of radiation  Principle of radiation protection , local rules and requirements  Techniques to minimize patient and staff dose Because of the relationship between patient and operator protection in fluoroscopic procedures, the RSO, the personnel in charge of dosimetry services, clinical application specialist from suppliers and regulators also require training on clinical practice and specifications of X-ray equipment used in addition to general radiation protection. The 122 University of Ghana http://ugspace.ug.edu.gh RSO or Medical Physicist should have the highest level of training because they are responsible to train other staff member. 6.0. Quality Assurance A well establish QA program maintain best radiation protection practices and ensure adequate occupational exposure control. It should include, appropriate audit, to ensure that personnel adhere to procedures, especially related to wearing of dosimeter, protective devices and method to optimize occupational protection. It should establish the components of performance testing which are:  Test to be performed, how often they are performed and acceptable limits for each test.  A brief description of be used for testing and sample forms to be used. Some X-ray tube and generator test that can be carried out are: filtration (HVL), focal spot size, kVp accuracy and reproducibility, mAs linearity, output waveforms, beam uniformity and alignment. The fluoroscopic system also requires visual and environmental inspection and performance testing. 7.0. Records for Quality Improvement A quality program depends on good record keeping, therefore should be well documented, evaluated and updated. The following elements should be properly documented: Shielding calculations, inspections details and corrective actions. Record on occupational dose consists of: 123 University of Ghana http://ugspace.ug.edu.gh - The nature of the work - Exposure from work for other facilities - Outcomes of health surveillance - Education and training of the workers - Results of exposure monitoring and dose assessments including results of investigation of abnormal exposure values. The member of staff should have access on the record of their own dose. Another important aspect of quality improvement is review which includes: policies and procedures, dose reports, inspections, repairs, audits, personnel consultations, unmet goals from previous years and non-compliance with maintenance. 8.0. Pregnant Workers Ionizing radiation is one of the most agents that cause defects on embryo. Therefore the protection of pregnant workers needs a special consideration. Additional protection of the foetus should be considered immediately the pregnancy is known. On the other hand, pregnancy of a worker should not be a reason to perform procedures. A dosimeter placed inside the lead opron on the abdomen should be < 0.2 mSv/month. 9.0. Emergency Plan and Procedures Emergency plan is an important component of a radiation safety program. It should help the personnel how to adequately identify, evacuate and react to emergency situations. The main goal is to protect the member of staff patient and public against potential accidents and it should include: plan of action, people involve in case of emergency (fire service, 124 University of Ghana http://ugspace.ug.edu.gh police personnel, etc.) and placement of exit signs (such as illuminated warning signs for beam on/of, evacuation plan, location and use of fire extinguisher and pull station). 125 University of Ghana http://ugspace.ug.edu.gh APPENDIX 7: Typical Monte Carlo Input File c c ------------------------------------------------------------------------------ c --- Cells -------------------------------------------------------------------- c ------------------------------------------------------------------------------ c 1 1 -2.3 -1 $ WALLB (CathLab_0 # WALLC) 2 1 -2.3 -2 $ WALLC (CathLab_0 # WALLC) 3 1 -2.3 -3 $ WALLA (CathLab_0 # WALLC) 4 1 -2.3 -4 $ WALLD (CathLab_0 # WALLC) 5 2 -7.874 -5 $ COUCH (CathLab_0 # WALLA) 6 1 -2.3 (-6) $ floor (CathLab_0 # WALLC) 7 1 -2.3 (-7) $ ceiling (CathLab_0 # WALLC) 8 3 -0.001205 (-8) $ Dr1Space (CathLab_0 # WALLD) 9 3 -0.001205 (-9 #10 #11 #12 #14 #5) $ XrSpace (CathLab_0 # WALLD) 10 3 -0.001205 -10 $ source (CathLab_0 # WALLD) 11 4 -11.35 (-11 (+12)) $ collimator (CathLab_0 # WALLB) 12 5 -1.19 -13 $ Phantom (CathLab_0 # COUCH) 13 4 -11.35 -14 $ Door (CathLab_0 # WALLB) 14 4 -11.35 -15 $ Divide (CathLab_0 # WALLB) 15 0 +17 $ Void c ------------------------------------------------------------------------------ c --- Surfaces ----------------------------------------------------------------- c ------------------------------------------------------------------------------ 1 rpp 0 45 0 830 0 300 $ WALLB (CathLab_0) 2 rpp 45 490 0 45 0 300 $ WALLC (CathLab_0) 3 rpp 445 490 165 785 0 300 $ WALLA (CathLab_0) 126 University of Ghana http://ugspace.ug.edu.gh 4 rpp 45 490 785 830 0 300 $ WALLD (CathLab_0) 5 rpp 150 224 300 483 88.92 95 $ COUCH (CathLab_0) 6 rpp 0 490 0 830 -50 0 $ FLOOR1 (CathLab_0) 7 rpp 0 490 0 830 300 350 $ Ceiling1 (CathLab_0) 8 rpp 445 485 45 165 0 300 $ 1_1 (CathLab_0) 9 rpp 45 445 45 785 0 300 $ 4_1 (CathLab_0) 10 s 200 370 30 0.01 $ source (CathLab_0) 11 rpp 198 202 368 372 26.5 30.5 $ 5_1 (CathLab_0) 12 rpp 199.92185 200.07815 369.094 370.094 29.594 30.5 $ 5_2 (CathLab_0) 13 rcc 180 375 115 0 -15 9.184547654e-16 16 $ Phantom (CathLab_0) 14 rpp 485 490 45 165 0 300 $ Door (CathLab_0) 15 rpp 350 355 165 785 0 300 $ Divide (CathLab_0) 17 rpp 0 490 0 830 -50 350 $ box around building c c ------------------------------------------------------------------------------ c --- Mode --------------------------------------------------------------------- c ------------------------------------------------------------------------------ c mode p c imp:p 1 13r 0 c c ------------------------------------------------------------------------------ c --- Materials ---------------------------------------------------------------- c ------------------------------------------------------------------------------ c m1 $ Concrete (CathLab_0) 127 University of Ghana http://ugspace.ug.edu.gh 1000 -0.0221 6000 -0.002484 8000 -0.57493 11000 -0.015208 12000 -0.001266 13000 -0.019953 14000 -0.304628 19000 -0.010045 20000 -0.042951 26000 -0.006435 c m2 $ Steel (CathLab_0) 26000 +1 c m3 $ Air (ct_room_accra) 6000 -0.000124 7000 -0.755268 8000 -0.231781 18000 -0.012827 c m4 $ Lead (CT Gantry Accra) 82000 +1 c m5 $ PMMA (PMMA_0deg) 1000 -0.080541 6000 -0.599846 8000 -0.319613 128 University of Ghana http://ugspace.ug.edu.gh c ------------------------------------------------------------------------------ c --- Source ------------------------------------------------------------------- c ------------------------------------------------------------------------------ sdef par=p wgt=1 erg=D1 cel=10 x=200 y=370 z=30 rad=d2 c ------------------------------------------------------------------------------ c --- Source Distributions ----------------------------------------------------- c ------------------------------------------------------------------------------ sc1 Point Source Distribution: # head si1 H 0.0005 0.0010 0.0015 0.0020 0.0025 0.0030 0.0035 0.0040 0.0045 0.0050 0.0055 0.0060 0.0065 0.0070 0.0075 0.0080 0.0085 0.0090 0.0095 0.0100 0.0105 0.0110 0.0115 0.0120 0.0125 0.0130 0.0135 0.0140 0.0145 0.0150 0.0155 0.0160 0.0165 0.0170 0.0175 0.0180 0.0185 0.0190 0.0195 0.0200 0.0205 0.0210 0.0215 0.0220 0.0225 0.0230 0.0235 0.0240 0.0245 0.0250 0.0255 0.0260 0.0265 0.0270 0.0275 0.0280 0.0285 0.0290 0.0295 0.0300 0.0305 0.0310 0.0315 0.0320 0.0325 0.0330 0.0335 0.0340 0.0345 0.0350 0.0355 0.0360 0.0365 0.0370 0.0375 0.0380 0.0385 0.0390 0.0395 0.0400 0.0405 0.0410 0.0415 0.0420 0.0425 0.0430 0.0435 0.0440 0.0445 0.0450 0.0455 0.0460 0.0465 0.0470 0.0475 129 University of Ghana http://ugspace.ug.edu.gh 0.0480 0.0485 0.0490 0.0495 0.0500 0.0505 0.0510 0.0515 0.0520 0.0525 0.0530 0.0535 0.0540 0.0545 0.0550 0.0555 0.0560 0.0565 0.0570 0.0575 0.0580 0.0585 0.0590 0.0595 0.0600 0.0605 0.0610 0.0615 0.0620 0.0625 0.0630 0.0635 0.0640 0.0645 0.0650 0.0655 0.0660 0.0665 0.0670 0.0675 0.0680 0.0685 0.0690 0.0695 0.0700 0.0705 0.0710 0.0715 0.0720 0.0725 0.0730 0.0735 0.0740 0.0745 0.0750 0.0755 0.0760 0.0765 0.0770 0.0775 0.0780 0.0785 0.0790 0.0795 0.0800 0.0805 0.0810 0.0815 0.0820 0.0825 0.0830 0.0835 0.0840 0.0845 0.0850 0.0855 0.0860 0.0865 0.0870 0.0875 0.0880 0.0885 0.0890 0.0895 0.0900 0.0905 0.0910 0.0915 0.0920 0.0925 0.0930 0.0935 0.0940 0.0945 0.0950 0.0955 0.0960 0.0965 0.0970 0.0975 0.0980 0.0985 0.0990 0.0995 0.1000 sp1 D 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.56162E-08 1.47956E-07 9.30689E-07 3.8289E-06 1.58249E-05 4.52987E-05 0.000129956 0.000296961 0.000684586 0.001280192 0.002409286 130 University of Ghana http://ugspace.ug.edu.gh 0.003937936 0.006475987 0.009475574 0.013922641 0.01875253 0.025350137 0.032254988 0.041145166 0.049918449 0.060709287 0.071005743 0.083179034 0.094405477 0.10732336 0.119009585 0.132093088 0.14366044 0.1564176 0.166925401 0.178242096 0.188618685 0.19976588 0.208933707 0.218600813 0.226728106 0.235389214 0.242225636 0.249402647 0.254675851 0.260193097 0.264697476 0.269314622 0.27281472 0.276475796 0.279061166 0.28168915 0.283381798 0.285188167 0.286007238 0.286834259 0.286851368 0.286957138 0.286563567 0.286166816 0.28525584 0.284425957 0.282974298 0.28151876 0.279744891 0.278050208 0.276053731 0.274055474 0.271696464 0.269417085 0.266906257 0.264398863 0.261714146 0.259108486 0.256298346 0.253495901 0.250630553 0.24784261 0.244876198 0.241920344 0.238826665 0.235811724 0.232818918 0.22983756 0.226726516 0.223691478 0.220607656 0.217538782 0.214439377 0.211413434 0.208407462 0.2054158 0.202395708 0.199445324 0.196459959 0.193490113 0.190496098 0.187620892 0.184663766 0.181773169 0.178946809 0.653478728 0.17337035 0.17057293 1 0.165048115 0.162332933 0.159632506 0.156990148 0.154404205 0.151768844 0.14914792 0.146632385 0.144169386 0.141627201 0.139099073 0.136670483 0.134292075 0.131880402 0.404127408 0.127122886 0.124813486 0.122522786 0.191832891 0.117964345 0.104517736 0.102758686 0.1010011 0.099250447 0.097531022 0.095837356 0.09414369 0.092442074 0.090769842 0.089085717 0.087402609 0.085709961 0.084046951 0.082394245 0.080742748 0.07911949 0.077523644 0.075877362 0.074233242 0.072617807 0.07103023 0.069421982 0.067815452 0.066252425 0.064715793 0.063126988 131 University of Ghana http://ugspace.ug.edu.gh 0.061539926 0.059960026 0.058407913 0.056840066 0.055273821 0.053732228 0.052217221 0.050660936 0.049105942 0.04757569 0.046071705 0.044499297 0.042929211 0.041400911 0.039898764 0.03831653 0.036736457 0.035195094 0.033680265 0.032072774 0.030467407 0.028889796 0.027340291 0.025594236 0.023849142 0.022126359 0.020434493 0.018722052 0.017012053 0.015332774 0.013683909 0.010210753 0.006742792 0.003340765 0 si2 h 0 0.01 $ inner and outer radii of sphere sp2 d 0 1 $ sampling range c ------------------------------------------------------------------------------ c --- Mesh Tally $ units (sieverts/h/source_particle) and MeV/cm3/particle------ c ------------------------------------------------------------------------------ TMESH RMESH1:p DOSE 30 1 2 1.0 CORA1 45 6i 445 CORB1 45 9i 785 CORC1 0 10i 300 ENDMD c ------------------------------------------------------------------------------ c --- Control ------------------------------------------------------------------ c ------------------------------------------------------------------------------ stop nps=1900000000 prdmp j -60 1 1 100000 132 University of Ghana http://ugspace.ug.edu.gh APPENDIX 8: Raw Data of the Simulation Results 1. Distribution for the tube position AP 0° at different height Z x y Z Value/Sv/h/particles error 45 45 85.7143 9.61E-20 0.5383 102.143 45 85.7143 8.01E-17 0.0197 159.286 45 85.7143 1.14E-16 0.0158 216.429 45 85.7143 1.37E-16 0.0141 273.571 45 85.7143 1.25E-16 0.015 330.714 45 85.7143 9.45E-17 0.0177 387.857 45 85.7143 6.03E-17 0.0226 45 119 85.7143 3.27E-17 0.0309 102.143 119 85.7143 1.18E-16 0.0156 159.286 119 85.7143 1.91E-16 0.0121 216.429 119 85.7143 2.65E-16 0.0102 273.571 119 85.7143 2.27E-16 0.0111 330.714 119 85.7143 1.42E-16 0.0141 387.857 119 85.7143 6.25E-17 0.0201 45 193 85.7143 2.70E-17 0.029 102.143 193 85.7143 1.51E-16 0.014 159.286 193 85.7143 2.88E-16 0.01 216.429 193 85.7143 2.01E-14 0.001 273.571 193 85.7143 4.66E-16 0.0078 330.714 193 85.7143 1.85E-16 0.0125 387.857 193 85.7143 4.22E-17 0.0197 45 267 85.7143 8.64E-18 0.0512 102.143 267 85.7143 1.71E-16 0.0132 159.286 267 85.7143 3.12E-16 0.0093 216.429 267 85.7143 5.47E-14 0.0005 273.571 267 85.7143 7.69E-16 0.0056 330.714 267 85.7143 2.29E-16 0.0112 387.857 267 85.7143 4.43E-17 0.0188 45 341 85.7143 1.18E-18 0.1606 102.143 341 85.7143 1.54E-16 0.0142 159.286 341 85.7143 2.43E-16 0.0102 216.429 341 85.7143 2.93E-14 0.0003 273.571 341 85.7143 6.70E-16 0.0056 330.714 341 85.7143 2.09E-16 0.0116 387.857 341 85.7143 3.96E-17 0.0197 45 415 85.7143 6.48E-19 0.2517 133 University of Ghana http://ugspace.ug.edu.gh 102.143 415 85.7143 1.03E-16 0.0179 159.286 415 85.7143 1.14E-16 0.016 216.429 415 85.7143 5.71E-17 0.0158 273.571 415 85.7143 1.78E-16 0.0129 330.714 415 85.7143 1.26E-16 0.016 387.857 415 85.7143 2.92E-17 0.0244 45 489 85.7143 3.32E-19 0.3781 102.143 489 85.7143 6.38E-17 0.0231 159.286 489 85.7143 6.91E-17 0.0221 216.429 489 85.7143 6.68E-17 0.0232 273.571 489 85.7143 7.76E-17 0.0209 330.714 489 85.7143 7.29E-17 0.0223 387.857 489 85.7143 1.94E-17 0.0331 45 563 85.7143 1.42E-19 0.4149 102.143 563 85.7143 3.93E-17 0.0303 159.286 563 85.7143 4.45E-17 0.0294 216.429 563 85.7143 4.68E-17 0.0285 273.571 563 85.7143 4.62E-17 0.0289 330.714 563 85.7143 4.59E-17 0.0291 387.857 563 85.7143 1.31E-17 0.042 45 637 85.7143 1.05E-19 0.4706 102.143 637 85.7143 2.80E-17 0.036 159.286 637 85.7143 2.95E-17 0.0367 216.429 637 85.7143 3.20E-17 0.0353 273.571 637 85.7143 2.99E-17 0.0361 330.714 637 85.7143 3.02E-17 0.0357 387.857 637 85.7143 8.94E-18 0.0543 45 711 85.7143 2.94E-20 0.5214 102.143 711 85.7143 2.14E-17 0.0432 159.286 711 85.7143 2.07E-17 0.0439 216.429 711 85.7143 2.21E-17 0.0422 273.571 711 85.7143 2.21E-17 0.0423 330.714 711 85.7143 2.35E-17 0.0423 387.857 711 85.7143 6.42E-18 0.0659 45 45 107.143 5.75E-20 0.4758 102.143 45 107.143 8.83E-17 0.0179 159.286 45 107.143 1.41E-16 0.0139 216.429 45 107.143 1.79E-16 0.0121 273.571 45 107.143 1.60E-16 0.0131 330.714 45 107.143 1.04E-16 0.0163 387.857 45 107.143 6.16E-17 0.0216 45 119 107.143 3.19E-17 0.0295 102.143 119 107.143 1.31E-16 0.0145 134 University of Ghana http://ugspace.ug.edu.gh 159.286 119 107.143 2.32E-16 0.0109 216.429 119 107.143 4.41E-16 0.0072 273.571 119 107.143 2.96E-16 0.0094 330.714 119 107.143 1.59E-16 0.013 387.857 119 107.143 6.46E-17 0.0191 45 193 107.143 3.05E-17 0.0283 102.143 193 107.143 1.53E-16 0.0135 159.286 193 107.143 3.05E-16 0.0093 216.429 193 107.143 5.20E-14 0.0007 273.571 193 107.143 5.70E-16 0.0068 330.714 193 107.143 2.00E-16 0.0117 387.857 193 107.143 4.57E-17 0.019 45 267 107.143 8.82E-18 0.0516 102.143 267 107.143 1.55E-16 0.0133 159.286 267 107.143 1.71E-16 0.0122 216.429 267 107.143 3.79E-15 0.0015 273.571 267 107.143 4.59E-16 0.007 330.714 267 107.143 2.26E-16 0.0106 387.857 267 107.143 4.51E-17 0.0185 45 341 107.143 7.99E-19 0.1719 102.143 341 107.143 1.31E-16 0.0142 159.286 341 107.143 1.14E-16 0.0148 216.429 341 107.143 5.77E-17 0.022 273.571 341 107.143 3.55E-16 0.0076 330.714 341 107.143 1.98E-16 0.0113 387.857 341 107.143 3.95E-17 0.0202 45 415 107.143 3.22E-19 0.2776 102.143 415 107.143 9.16E-17 0.018 159.286 415 107.143 6.40E-17 0.0204 216.429 415 107.143 3.27E-17 0.0325 273.571 415 107.143 1.22E-16 0.0146 330.714 415 107.143 1.16E-16 0.0155 387.857 415 107.143 2.94E-17 0.025 45 489 107.143 1.27E-19 0.3534 102.143 489 107.143 5.49E-17 0.0241 159.286 489 107.143 4.22E-17 0.0266 216.429 489 107.143 3.35E-17 0.0293 273.571 489 107.143 6.07E-17 0.0224 330.714 489 107.143 6.76E-17 0.0221 387.857 489 107.143 1.80E-17 0.0344 45 563 107.143 2.18E-19 0.3932 102.143 563 107.143 3.65E-17 0.0309 159.286 563 107.143 3.53E-17 0.0308 135 University of Ghana http://ugspace.ug.edu.gh 216.429 563 107.143 3.77E-17 0.0299 273.571 563 107.143 3.93E-17 0.0294 330.714 563 107.143 4.24E-17 0.0288 387.857 563 107.143 1.31E-17 0.0428 45 637 107.143 1.47E-19 0.5278 102.143 637 107.143 2.80E-17 0.0366 159.286 637 107.143 2.58E-17 0.0369 216.429 637 107.143 2.79E-17 0.0367 273.571 637 107.143 2.65E-17 0.0362 330.714 637 107.143 2.92E-17 0.0366 387.857 637 107.143 8.30E-18 0.0549 45 711 107.143 6.45E-20 0.4556 102.143 711 107.143 1.94E-17 0.0447 159.286 711 107.143 2.04E-17 0.0436 216.429 711 107.143 2.10E-17 0.0423 273.571 711 107.143 2.17E-17 0.0423 330.714 711 107.143 2.06E-17 0.0431 387.857 711 107.143 6.92E-18 0.0674 45 45 150 1.05E-19 0.5779 102.143 45 150 1.11E-16 0.0157 159.286 45 150 2.20E-16 0.0107 216.429 45 150 5.90E-16 0.0053 273.571 45 150 3.26E-16 0.0083 330.714 45 150 1.43E-16 0.0136 387.857 45 150 7.81E-17 0.0191 45 119 150 3.79E-17 0.0277 102.143 119 150 1.55E-16 0.0132 159.286 119 150 3.29E-16 0.0088 216.429 119 150 3.25E-14 0.0009 273.571 119 150 4.10E-15 0.0024 330.714 119 150 2.02E-16 0.0113 387.857 119 150 8.01E-17 0.0175 45 193 150 3.34E-17 0.0282 102.143 193 150 1.33E-16 0.0141 159.286 193 150 2.14E-16 0.0109 216.429 193 150 1.63E-14 0.0011 273.571 193 150 1.98E-15 0.0032 330.714 193 150 2.11E-16 0.0108 387.857 193 150 4.72E-17 0.0185 45 267 150 8.45E-18 0.0549 102.143 267 150 1.14E-16 0.0152 159.286 267 150 1.05E-16 0.0167 216.429 267 150 1.35E-16 0.0147 136 University of Ghana http://ugspace.ug.edu.gh 273.571 267 150 2.29E-16 0.0101 330.714 267 150 2.14E-16 0.0103 387.857 267 150 4.61E-17 0.0188 45 341 150 9.36E-19 0.1539 102.143 341 150 8.66E-17 0.0176 159.286 341 150 6.27E-17 0.0222 216.429 341 150 6.37E-17 0.0229 273.571 341 150 1.62E-16 0.0118 330.714 341 150 1.73E-16 0.0113 387.857 341 150 3.70E-17 0.0212 45 415 150 2.19E-19 0.3128 102.143 415 150 5.92E-17 0.022 159.286 415 150 4.08E-17 0.0288 216.429 415 150 3.94E-17 0.0292 273.571 415 150 7.43E-17 0.019 330.714 415 150 9.93E-17 0.0158 387.857 415 150 2.61E-17 0.0263 45 489 150 2.04E-19 0.3276 102.143 489 150 3.79E-17 0.0283 159.286 489 150 2.77E-17 0.0346 216.429 489 150 2.79E-17 0.0352 273.571 489 150 3.85E-17 0.0279 330.714 489 150 5.44E-17 0.0225 387.857 489 150 1.68E-17 0.0351 45 563 150 4.65E-20 0.6719 102.143 563 150 2.74E-17 0.0351 159.286 563 150 2.09E-17 0.0396 216.429 563 150 2.13E-17 0.0389 273.571 563 150 2.60E-17 0.0349 330.714 563 150 3.66E-17 0.0294 387.857 563 150 1.07E-17 0.0453 45 637 150 3.37E-20 0.5678 102.143 637 150 2.10E-17 0.0399 159.286 637 150 2.00E-17 0.0406 216.429 637 150 2.13E-17 0.0397 273.571 637 150 2.39E-17 0.0387 330.714 637 150 2.49E-17 0.0367 387.857 637 150 7.85E-18 0.0551 45 711 150 7.89E-20 0.7259 102.143 711 150 1.58E-17 0.0463 159.286 711 150 1.70E-17 0.0459 216.429 711 150 1.79E-17 0.0448 273.571 711 150 1.99E-17 0.0429 137 University of Ghana http://ugspace.ug.edu.gh 330.714 711 150 1.92E-17 0.0435 387.857 711 150 6.80E-18 0.0663 45 45 171.429 2.05E-20 0.5354 102.143 45 171.429 1.24E-16 0.0149 159.286 45 171.429 2.85E-16 0.0093 216.429 45 171.429 9.82E-15 0.0016 273.571 45 171.429 2.20E-15 0.0033 330.714 45 171.429 1.70E-16 0.0124 387.857 45 171.429 8.52E-17 0.0182 45 119 171.429 4.09E-17 0.0272 102.143 119 171.429 1.61E-16 0.013 159.286 119 171.429 3.59E-16 0.0084 216.429 119 171.429 3.46E-14 0.0008 273.571 119 171.429 6.72E-15 0.0019 330.714 119 171.429 2.18E-16 0.0109 387.857 119 171.429 8.18E-17 0.0176 45 193 171.429 3.59E-17 0.0288 102.143 193 171.429 1.18E-16 0.0154 159.286 193 171.429 1.61E-16 0.013 216.429 193 171.429 1.34E-15 0.0028 273.571 193 171.429 4.15E-16 0.0066 330.714 193 171.429 2.11E-16 0.0107 387.857 193 171.429 4.78E-17 0.0187 45 267 171.429 8.92E-18 0.0563 102.143 267 171.429 9.32E-17 0.0176 159.286 267 171.429 9.80E-17 0.0175 216.429 267 171.429 1.14E-16 0.016 273.571 267 171.429 1.62E-16 0.0125 330.714 267 171.429 2.11E-16 0.0103 387.857 267 171.429 4.40E-17 0.0191 45 341 171.429 1.19E-18 0.1427 102.143 341 171.429 6.75E-17 0.0207 159.286 341 171.429 6.03E-17 0.0234 216.429 341 171.429 6.17E-17 0.023 273.571 341 171.429 1.08E-16 0.0151 330.714 341 171.429 1.64E-16 0.0114 387.857 341 171.429 3.49E-17 0.0221 45 415 171.429 4.55E-19 0.268 102.143 415 171.429 4.77E-17 0.0251 159.286 415 171.429 3.78E-17 0.0295 216.429 415 171.429 3.79E-17 0.0299 273.571 415 171.429 5.59E-17 0.0224 330.714 415 171.429 9.36E-17 0.0161 138 University of Ghana http://ugspace.ug.edu.gh 387.857 415 171.429 2.42E-17 0.0274 45 489 171.429 1.19E-19 0.328 102.143 489 171.429 3.16E-17 0.0319 159.286 489 171.429 2.63E-17 0.0356 216.429 489 171.429 2.58E-17 0.036 273.571 489 171.429 3.33E-17 0.0313 330.714 489 171.429 5.08E-17 0.0231 387.857 489 171.429 1.70E-17 0.0353 45 563 171.429 7.93E-20 0.4561 102.143 563 171.429 2.14E-17 0.0385 159.286 563 171.429 1.87E-17 0.0423 216.429 563 171.429 1.92E-17 0.0419 273.571 563 171.429 2.24E-17 0.0388 330.714 563 171.429 3.38E-17 0.0301 387.857 563 171.429 1.07E-17 0.0457 45 637 171.429 6.79E-20 0.6706 102.143 637 171.429 1.80E-17 0.0429 159.286 637 171.429 1.55E-17 0.0461 216.429 637 171.429 1.74E-17 0.0431 273.571 637 171.429 1.96E-17 0.0425 330.714 637 171.429 2.35E-17 0.038 387.857 637 171.429 8.14E-18 0.0562 45 711 171.429 5.62E-21 1 102.143 711 171.429 1.60E-17 0.0476 159.286 711 171.429 1.54E-17 0.0463 216.429 711 171.429 1.62E-17 0.0476 273.571 711 171.429 1.64E-17 0.0465 330.714 711 171.429 1.77E-17 0.0453 387.857 711 171.429 6.17E-18 0.0668 2. Distribution at the tube position LAO 30° at 163.6 cm from the floor X Y Value /Sv/h/particle 45 45 1.30E-25 102.143 45 3.90E-20 159.286 45 2.49E-20 216.429 45 2.56E-20 273.571 45 3.01E-20 330.714 45 6.84E-21 387.857 45 3.61E-24 45 119 1.40E-24 102.143 119 1.09E-19 139 University of Ghana http://ugspace.ug.edu.gh 159.286 119 7.24E-20 216.429 119 6.89E-20 273.571 119 6.06E-20 330.714 119 1.16E-20 387.857 119 8.20E-24 45 193 1.70E-24 102.143 193 4.67E-19 159.286 193 2.72E-20 216.429 193 8.99E-21 273.571 193 1.38E-20 330.714 193 1.39E-20 387.857 193 3.85E-21 45 267 1.20E-24 102.143 267 1.38E-18 159.286 267 1.70E-20 216.429 267 9.52E-21 273.571 267 5.70E-20 330.714 267 3.41E-20 387.857 267 8.93E-21 45 341 8.80E-24 102.143 341 1.77E-18 159.286 341 3.61E-20 216.429 341 1.24E-20 273.571 341 7.74E-20 330.714 341 4.93E-20 387.857 341 5.76E-21 45 415 3.70E-24 102.143 415 1.17E-18 159.286 415 3.46E-20 216.429 415 2.39E-20 273.571 415 4.81E-20 330.714 415 3.97E-20 387.857 415 2.13E-21 45 489 9.10E-24 102.143 489 3.25E-19 159.286 489 2.31E-20 216.429 489 4.54E-21 273.571 489 1.26E-20 330.714 489 2.44E-20 387.857 489 8.62E-21 45 563 7.80E-23 102.143 563 4.97E-20 159.286 563 8.70E-22 140 University of Ghana http://ugspace.ug.edu.gh 216.429 563 2.67E-20 273.571 563 4.49E-21 330.714 563 1.80E-20 387.857 563 2.24E-21 45 637 5.50E-24 102.143 637 2.72E-20 159.286 637 1.82E-20 216.429 637 1.49E-20 273.571 637 6.78E-21 330.714 637 1.55E-20 387.857 637 5.50E-24 45 711 4.30E-23 102.143 711 1.53E-20 159.286 711 8.44E-21 216.429 711 2.20E-21 273.571 711 1.50E-24 330.714 711 3.50E-21 387.857 711 6.29E-22 3. Distribution at the tube position RAO 30° at 171 cm from the floor X Y Value /Sv/h/particle 45 45 2.55E-18 102.143 45 2.80E-16 159.286 45 3.60E-16 216.429 45 4.56E-16 273.571 45 5.69E-16 330.714 45 6.60E-16 387.857 45 5.69E-16 45 119 2.30E-16 102.143 119 3.53E-16 159.286 119 4.83E-16 216.429 119 6.73E-16 273.571 119 9.39E-16 330.714 119 3.11E-15 387.857 119 3.80E-15 45 193 1.51E-16 102.143 193 4.06E-16 159.286 193 5.42E-16 216.429 193 8.32E-16 273.571 193 1.59E-14 141 University of Ghana http://ugspace.ug.edu.gh 330.714 193 6.78E-14 387.857 193 2.09E-14 45 267 7.77E-17 102.143 267 4.83E-16 159.286 267 6.65E-16 216.429 267 1.15E-15 273.571 267 3.21E-14 330.714 267 1.05E-13 387.857 267 2.80E-14 45 341 3.36E-17 102.143 341 5.09E-16 159.286 341 7.15E-16 216.429 341 1.29E-15 273.571 341 3.72E-14 330.714 341 1.18E-13 387.857 341 3.09E-14 45 415 1.57E-17 102.143 415 4.56E-16 159.286 415 6.22E-16 216.429 415 1.07E-15 273.571 415 2.97E-14 330.714 415 9.83E-14 387.857 415 2.66E-14 45 489 9.18E-18 102.143 489 3.68E-16 159.286 489 4.75E-16 216.429 489 7.19E-16 273.571 489 1.07E-14 330.714 489 5.14E-14 387.857 489 1.85E-14 45 563 5.10E-18 102.143 563 2.69E-16 159.286 563 3.38E-16 216.429 563 4.63E-16 273.571 563 6.92E-16 330.714 563 1.01E-15 387.857 563 8.36E-16 45 637 3.51E-18 102.143 637 2.10E-16 159.286 637 2.59E-16 216.429 637 3.31E-16 273.571 637 4.20E-16 330.714 637 4.91E-16 142 University of Ghana http://ugspace.ug.edu.gh 387.857 637 1.60E-16 45 711 2.60E-18 102.143 711 1.70E-16 159.286 711 2.03E-16 216.429 711 2.39E-16 273.571 711 2.75E-16 330.714 711 2.99E-16 387.857 711 9.56E-17 143