LOOKING FOR FUNDING? UNIVERSITY June 2019 OF GHANA V 1.2 Turn to * Research Professional ü Thousands of open calls for all disciplines and from over 8,000 funders ü Authoritative news, analysis and comment ü Fast and user-friendly search options TM ü Customisable email alerts ü Tools to help you share information and stay ahead of funding deadlines Insp r n g UG You can use *Research Professional from any computer on the University network. Or register for free to set up your own account so that you can use the service off campus. For further enquiries contact: As a registered user you’ll also enjoy an array of other orid-ppa@ug.edu.gh benefits that help you save time and share information with your colleagues. University of Ghana has a subscription to * Research Professional researchprofessional.com To access the Research Professional porta l, send a request to orid-info@ug.edu.gh FRONT PAGE School of Engineering ORID - Annex Office of Research, Innovation & Development (ORID) - Annex GA-521-3066 Photo credit EPA GHANA Office of Research, Innovation Phone: +233 303 930436 ORID & Development (ORID) Email: orid@ug.edu.gh OFFICE OF RESEARCH, P.O. Box LG 571, University of Ghana, Legon Website: www.orid.ug.edu.gh INNOVATION AND DEVELOPMENT Print: University of Ghana Printing Press, Tel: 030 293 4987 RESEARCH GRANTS AWARDED TH ROUGH ORID The University of Ghana's goal to become a research-int ensive University by 2024, is progressing steadily with an upward trajectory in revenues accruing from funded projects. The Office of Research, Innovation and Development (ORID), UG's office of sponsored research has restructured over the last two and a half years into six teams, the Pre-and Post-Award Services, Research Performance Services, Technology Transfer and Intellectual Property Services, Publication, Dissemination and Translation Services, Capacity Development Services and Human and Animal Research Ethics Services. The Pre- and Post-Award Services (PPA) team comprises about half of the research administration staff of ORID and handles grants and contract management, working closely with the brilliant academics at the University of Ghana. Grant revenues processed through ORID have grown sharply by over 1000% in the last three academic years from a level of $3.4 million in 2015/2016 academic year to $42.5million in the 2018/2019 academic year . (figure 1) Table 1: Research Grants & Contracts reported through ORID (Academic Year) Academic Year No. of Grant Agreements US$ Value of Grant 2015-2016 16 3,414,212 (A student-led initiative under the auspices of the VC’s Green Project) 2016-2017 44 6,249,417 2017-2018 84 15,322,980 2018-2019 96 42,558,915** ** Includes 4 committed Awards of US$ 21.6 million Fi gure 1: Research Grants & Contracts reported through ORID (Academic Year) feteria Central Ca US$ Value of Received Awards US$ Value of Committed Awards No. of Grants AWARDS/APPOINTMENTS EDITORIAL Dr. Kwaku Kyeremeh of the The Director of the Institute for This second issue of 'Inspiring UG' features a compilation of articles that reflect the diversity and Department of Chemistry has been Environment and Sanitation scope of research underway at the University of Ghana (UG). The publication characterizes UG's awarded the prestigious Medical Studies (IESS), Professor Kwasi quest to intensify research and build capacity across all spheres of scientific endeavour. Research Council (MRC)/UK Appeaning Addo has been Department for International appointed a member of the Expert The selection of research in this issue encompasses the humanities, applied sciences and medicine, Development (DFID) African Group of the High Level Panel for a and demonstrates the impact of adding value to basic resources, the benefits of engaging local Research Leader Award 2018 for Sustainable Ocean Economy. communities for solutions to health care challenges and the rooting of religious and behavioural his project 'Development of Novel Therapeutics for The Panel is supported by the United Nations Special Envoy practices in poetry among others. Parasite Infections and Cancer by Multi-step Microbial for the Ocean, and is made up of 14 Heads of Government. Biodiscovery Processes and iChip'. The Panel's recommendations on the Blue Economy, an Our scientists have identified health interventions that remedy the adverse effects of livelihood The African Research Leadership Award is jointly run and emerging concept that advocates improvements in practices to empower and safeguard the fisheries value chain. In the engineering sciences, solutions funded by the MRC and DFID. The Award Scheme aims to management of the ocean, will make the case for change have been proffered to the menace of plastic pollution of water bodies, while agricultural produce is strengthen research leadership across Sub-Saharan Africa and call for international action for the short, medium and being transformed into a therapeutic agent in the biological sciences. (SSA) by attracting and retaining exceptional individuals long term. who will lead high quality research programmes on crucial As competition for research funding intensifies, emphasis on the impact of research outcomes is key global health issues relevant to SSA. Professor Appeaning-Addo will co-author a chapter for the to sustain funding. We seek therefore to present scholarly work in practical ways that speak to Blue Papers that will play a central role in the production of communities and make positive impacts on livelihoods. The West African College of the Panel's Summary of Recommendations on the Blue Physicians and Surgeons has Economy. Publication, Dissemination and Translation (PDT) Team elected Dr. Albert Akpalu of the Department of Medicine and Therapeutics, School of Medicine T he First Lady of the Republic of and Dentistry as its Secretary- Ghana, Her Excellency Mrs Rebecca General. The College, established in Akufo Addo has presented the First 1976, is an association of medical Lady's Excellence Award for the fields of Community Health, Family Medicine, Internal Medicine/Health Care Delivery to Medicine, Laboratory Medicine, Chemical Pathology, Professor Lorna Awo Renner of Haematology, Medical Microbiology, Paediatrics and the Department of Child Health, Psychiatry that aims to promote professional training of HE Mrs. Rebecca Akufo Addo (left) presenting the award to Prof. Renner School of Medicine and Dentistry, physicians and healthcare specialists in West Africa. on International Women's Day. The award is in recognition of her dedication to the diagnosis and treatment of children Professor Dorothy Yeboah-Manu with cancer and the mobilisation of resources to support of the Department of Bacteriology, the care of childhood cancers in Ghana. Noguchi Memorial Institute for Medical Research has received the Royal Society Africa Prize 2018 for her contributions and innovative approaches to understanding Mycobacterium ulcerous and Mycobacterium arcanum microbiology, genetic studies and epidemiology in the areas of her work. The Royal Society Africa Prize, previously the Royal Society Pfizer Award, recognises research scientists in Africa who are making innovative contributions to the biological sciences, including basic medical science, which contribute significantly to capacity building in Africa. 16 Inspir ing Inspir ing 1 C O BUDGET FUNDER UG LEAD ORIGINATING PROJECT TITLE ALLOCATED UNIT TO UG Social Sciences and 3 10 Humanities Research Prof. Kodzo Gavua Department of Improving African Futures CAD 59,500.00Council (SSHRC) through Dr. Wazi Ray Apoh Archaeology and Using Lessons from the Past N Heritage StudiesCassava as a Biomaterial University of VictoriaGarbage-in, Energy-out:Valorising Plastic Waste in Ghana Reinforcement for Tissue Engineering Institute of Prof. Dzodzi Other Universals: Theorizing from The Andrew Mellon W. African Studies R 1,603,436.93 Tsikata Post-colonial Locations on Politics Foundation and Aesthetics Legon Centre for Women and Political Participation in Africa: The Andrew Mellon W. Dr. Jennifer International Affairs A Comparative Study of the Representation USD 500,000.00 Foundation Amanda Coffie T and Diplomacy and Roles of Female Chiefs The Cambridge A Clash of Kingdoms: Isolation of Indigenous Dr. Winfred-Peck Department of Africa-ALBORADA Entomopathogenic Fungi against the Fall Dorleku Biochemistry, Cell and USD 8,787.00 Research Fund Armyworm and Unravlling the Molecular Molecular Biology Signature of Insect-fungus Interactions E The Regents of the Prof. Augustine Department of Strengthening population size estimates USD 40,605.00University of California Ankomah Population, Family and for key populations in Ghana4 Reproduction HealthConventional Drugs, Plant Medicines 8 A Social Affliction: A Social Media The Secretary of State for Health, UK through Prof. Gordon West Africa Centre and Foods: A Complementary Intervention Tackling Infections to Benefit Africa (TIBA) GBP 244,650.00the University Court of the for Cell Biology of Awandare Combination? Infectious Pathogens University of Edinburgh, UK (Amendment 3) (WACCBIP) N UK Research and Innovation GCRF South-South Migration, Inequality and through Coventry University Prof. Joseph Teye Centre for Migration GBP 823,024.006 Literature, Music and Prayer: 12 Antimicrobial Resistance: Studies Development HubRepositories of African Values, Addressing an Emerged Global Spirituality and Theology Problem with Local Solutions Societal Transformation and Climate Universities Canada through Change: Training the next generation of Prof. Yaa Centre for African CAD 3,564.00 7 Empowering Women by Creating 13 An Impact Assessment of Social Carleton University Ntiamoa-Baidu scholars in sub-Saharan Africa and Canada Wetlands (NextGen Climate Change Advanced Scholars) Safeguards against Anemia Marketing in Ghana (IASMG) T 11 Reducing Incidence of Harmful 14 Funding News Institute for World Resources Prof. Kwasi Environment and Managing resilience, restoration USD 50,000.00Organisms in Ghana’s Vegetable Institute Appeaning Addo Sanitation Studies & infrastructure of coastlines. Export Market 16 (IESS)Awards/Appointments West Africa Centre National Institute of Health Prof. Gordon Hearing Impairment Genetic USD 39,443.00 for Cell Biology of S through the University of Awandare Infectious Pathogens Studies in Africa (HI-GENES Africa)Cape Town (WACCBIP) 2 Inspir ing Inspir ing 15 FUNDING NEWS GARBAGE-IN, ENERGY-OUT: ST ST 1 FEBRUARY TO 31 MAY 2019 VALORISING PLASTIC WASTE IN GHANA ORIGINATING UNIT Plastics, which are basically long hydrocarbon- Department of chained compounds synthesized from petroleum Crop Science products, have become very popular because of their unmatched usability, wide range of application, non- degradable nature and low cost. In Ghana, the Department of Population, Family and estimation is that over 1.7 million tonnes of plastics Reproduction Health are used annually. The ever-increasing demand has also resulted in a huge amount of plastic waste, and due to disposal challenges, pose a serious threat to These issues are precisely what preoccupy Department of Marketing and the environment, waterways, water bodies and Dr. David Dodoo-Arhin of the Department of Entrepreneurship farmlands. The greater risk of plastic pollution to Materials Science and Engineering and his general human health has become a major global colleagues, as they explore the conversion of concern. plastic waste into liquid fuel and gas, as well as their potential utilization in light-duty As a result, the implementation of prudent plastic engines. Their early studies, supported by waste management and valorisation systems is the University of Ghana BANGA-Africa seed Department of Economics imperative to minimize these adverse environmental grant fellowship, in collaboration with CNRS impacts. Recycling, reusing, incineration and energy Centré RAPSODEE of Ecole de Mines d'Albi- recovery are the main techniques of plastic waste Carmaux, France, are already yielding very School of Nursing management. Energy recovery is a promising route promising results, as they explore further Midwifery for converting waste material into useful energy funding opportunities to scale up their products; the most commonly used method of research and engage trans-disciplinary energy recovery is thermal cracking (Pyrolysis), approaches to valorising plastic waste in Department of Psychology which produces liquid and gaseous fuel products Ghana. with high energy values. Department of With the exponential growth in industries as well as Economics in population, the demand for energy, which is mostly petroleum-fuel based has likewise increased. Department of Coupled with the ever-increasing world price of Population, Family and Reproduction Health crude oil, the resultant search for alternate energy resources can be mitigated by the recycling and conversion of the infinitely growing plastic waste Office of Research, into energy to diversify the energy resource. Innovation and Development Department of Biological, Environmental and Occupational Health 14 Inspir ing Inspir ing 3 CONVENTIONAL DRUGS, PLANT MEDICINES AN IMPACT ASSESSMENT OF AND FOODS: SOCIAL MARKETING IN GHANA (IASMG) The deleterious effects of smoking are widely known; with Africa the greatest laggard of all world regions and with arguably the lowest level of medical technology to address the associated problems, the question of how to temper the spread of the problem is urgent. Particularly among adolescents, whose life habits are now being shaped and who are susceptible to peer-influence to make choices that are frequently contrary to their own best A Complementary Combination? interests, the problem is immediately salient. Dr. Naa Dodua Dodoo and Dr. Adriana Biney, at the Regional Institute of Population Studies (RIPS), are leading a team at the University of Ghana to partner with collaborators at Tulane University in the USA, on a Bill and Melinda Gates Foundation (BMGF) funded project to investigate how social marketing can help dissuade adolescents from smoking. Plant medicines are patronized by about 80% of Africans and are generally considered safe remedies that may be ingested over long periods of time. For many people, plant medicines are first-line The BMGF Tobacco Control Programme incorporates social marketing as a core activity to highlight policy remedies. Scientific investigations have revealed, however that the concurrent intake of some plant changes and improve Knowledge, Attitudes and Practices (KAP) related to youth smoking. One initiative of the medicines and conventional drugs can result in therapeutic failure or drug toxicity. A classic example programme is a SKY Girls campaign implemented in Botswana, Uganda and Ghana. This initiative is based on the regards the intake of ginseng, which has been reported to increase physical stamina and alertness, understanding that although girls are aware of the health harms of tobacco, social inclusion is everything to them and is linked to a complex process of finding their identity. The project in Ghana therefore centers its principles when taken with several conventional drugs for example, those substrates of a particular catalyst, such around activities that are important to young girls (music and fashion, for example), and on ideals that will keep as Cytochrome P450 3A4 (CYP3A4). Examples of drugs metabolised by CYP3A4 include cyclosporin them grounded and able to make the right choices concerning life in general and smoking in particular. and acetaminophen (paracetamol). When such conventional drugs are taken together with CYP3A4 substrates, it appears to cause a rapid breakdown of the drugs which, in turn, generally translates into The IASMG evaluated the SKY Girls Campaign in Ghana with the following objectives: the therapeutic failure or ineffectiveness of these conventional drugs. This can also result in further Measuring the effectiveness of the combined and individual media interventions of SKY Girls on smoking adverse effects if the broken-down products or newly formed ones are harmful. attitudes, norms, intentions, tobacco use and prevention of smoking uptake Calculating the cost-effectiveness of the different media interventions of SKY Girls relative to other Similarly, consumption of some foods while taking conventional drugs has the potential to also result smoking in adverse outcomes. For instance, eating of cruciferous vegetables such as lettuce, cabbage and prevention and cessation interventions, such as multi-component, community-based interventions, other broccoli, increases the breakdown or biotransformation of acetaminophen; thus, effectiveness of the forms of mass media (e.g., public health messaging, billboards, advertisements), or school-based drug is reduced by eating such foods. interventions, and Enhancing understanding of the links between exposure to communication and behaviour change by clarifying the mechanisms through which the specific health communication activities affect tobacco outcomes. “Advertising campaignshighlight smoking as a sign of affluence. Dr. Naa Dodua Dodoo (third from right) and Dr. Adriana Biney (third from left) Based on an experimental design with a panel of follow-up phone interviews of a sub-sample of the adolescents in areas around the Ayawaso West survey respondents. Wuogon Constituency of Accra (treatment area), Kumasi and Teshie (partial treatment area) and Finally, an endline survey was conducted between Sunyani (control), a baseline survey of 7000 November 2018 and January 2019. Preliminary adolescents was conducted between March and findings indicate that most of the girls who were May, 2017. Subsequently, the various components exposed to the intervention indicated that SKY had of the SKY Girls Campaign were rolled out by a helped them to feel more empowered, aspirational, partner advertising company. This included a bi- socially connected and have a greater sense of future monthly magazine distributed in schools, two orientation. In addition, greater exposure to SKY movies available for free, visits to schools by interventions increased perceptions that smoking various role models popular with young people, shisha is not 'cool' and increased knowledge of the SKY clubs instituted in some schools, a SKY theme health consequences of shisha and tobacco. song, SKY social media channels, a SKY WhatsApp group, a weekly radio programme, a SKY truck that Further analyses of the initiative is continuing in visited various neighborhoods and schools, text order to assess the relative cost-effectiveness of the Prof. Regina Appiah-Opong messages to adolescents, a Vlog, and occasional different media interventions, and promises to SKY parties at various malls. During the campaign, evolve into a scaled-up study of young women's which lasted 18 months, there were bi-monthly empowerment, that clarifies links between communication and behavior change. 4 Inspir ing Inspir ing 13 “ Globally, the pharmaceutical industry is highly regulated with approval regimes for drug therapies subjected to extensive pre-clinical and clinical trials. While the rigorous nature of clinical trials provides a safety net for end users, the use of approved drugs in a particular jurisdiction does not necessarily translate into safe use in other populations. According to Professor Appiah- Opong, these dynamics raise questions about the generalized applicability of drugs approved by authorities in other parts of the world. Morinda Lucida She is also collaborating with colleagues at the University of Ghana and the University of Washington, Bothell, in research on genes of Although the interaction potential of drugs is CYP3A4 drug metabolising enzymes to identify assessed during pre-clinical studies in developed differences in Single Nucleotide Polymorphisms countries, for instance by the Food and Drug (SNPs) between Caucasian and Ghanaian Administration in the USA, this is not typical in many ethnicities, and is seeking funding to extend her developing countries. Neither is the evaluation of the work to different ethnic groups in West Africa with drug-food interaction potential a conventional study the goal of determining: norm of regulatory bodies. It would appear that reports on the drug interaction potential with i. The effect of drugs approved and tested in natural products are hardly requirements of safety other countries on Ghanaians assessments of drug manufacturers. ii. Plant-based medicines and foods that interact with conventional medicines Professor Regina Appiah-Opong, Head of the Department of Clinical Pathology at the Noguchi Ultimately, her goal is to create awareness and Memorial Institute for Medical Research (NMIMR), is establish in Ghana, the means of screening drugs, extremely passionate about this subject and has drug candidates, plant medicines and food for devoted much of her working life to biomedical drug interaction potential. This is to safeguard r e s e a r c h . W o r k i n g i n t h e f i e l d o f public health and support the efforts of toxicology/pharmacology, where drug-metabolizing pharmaceutical industries. She seeks to develop enzymes are employed in evaluating drug candidates appropriate medical protocols for imported drugs and provide education to maximise the effects of as part of pre-clinical studies on these drug drugs and other therapies through nutrition. candidates, Professor Appiah-Opong is exploring the interactions between conventional drugs, herbs and foods. Her particular interest in drug-drug/drug- herb/drug-food interactions, pharmacokinetics, pharmacogenomics, drug discovery, antioxidants and environmental contaminants (heavy metals, aflatoxins), has seen her collaborate extensively with domestic and international partners. Professor Appiah-Opong's current work has focused on anti- cancer and anti-malarial agents, and her collaboration with colleagues in Japan and Ghana has resulted in a filed patent on an anti-typanosomiasis agent. She has played a major role in the construction of a DNA cassette vector that is useful for drug Moringa Oliefera susceptibility testing of anti-HIV protease inhibitor drugs. 12 Inspir ing Inspir ing 5 REDUCING INCIDENCE OF HARMFUL ORGANISMS LITERATURE, MUSIC, AND PRAYER REPERTOIRES AS IN GHANA'S VEGETABLE EXPORT MARKET SOURCES OF AFRICAN VALUES, SPIRITUALITY AND CHRISTIAN THEOLOGY Ghana's vegetable exports experienced several interception notifications between 2012 and 2015, largely due to the presence of harmful organisms, specifically quarantine The argument that Christian faith is not a matter of Thus, literature, music and prayer repertoires are pests; mostly thrips, whiteflies, fruit flies, false codling moth False Moth White Fly opinion, but “a community-building or community- not just tools or avenues for African Christians at (FCM) and eggplant fruit and shoot borer (EFSB) in consignments destined for export to the European Union transformative appropriation of the very deepest the grassroots to theologise, but also, sources of (EU). poetic truth” runs deep in many communities, social mobilisation (religious and/ or social capital) provoking the question of how these traditional for community development. Fruit Fly Thrip spiritual traits and values have survived and These pests are associated with such vegetables as Capsicum modulated within contemporary African (chilli pepper), Solanum (eggplant and aubergine), and the It is therefore important to note that such reflective gourds (luffa, bitter and bottle gourds, i.e, Luffa, Momordica, The pest management protocols involve the use of farm Christianity. or grassroots theology is neither a replacement nor and Lagenaria, respectively). These organisms, although sanitation, mass trapping of pests using appropriate lures and sticky traps for the different species, use of bio-rational competitor for academic theology. Rather, when the they do not pose a threat to human health, can cause severe With a unique focus on the critical role of poetic economic damage by affecting crop yields. Thus, such insecticides (botanicals and microbials) as well as other two function together, theology acquires an elements such as language, literature and oral vegetable produce is banned for export to countries where physically-acting insecticides and less persistent binary authentic character in which scholars and believers forms as repositories and vehicles for such these pests are absent or are present but not widespread and synthetic pesticides. work together within the same context. spirituality and values, Dr. Rose Mary Amenga- are under official control. A survey of existing pest management practices among Etego and colleagues from the University of Ghana vegetable exporters and their cohort of out-growers Within the scope of this project, and as a community engaged in the production value chain was also undertaken, (Dr. Abraham Nana Opare Kwakye), Ebonyi State of theological scholar-practitioners ourselves, Dr. Scientists from the African Regional Postgraduate with two goals: University (Dr. Ngozi Emeka-Nwobia), Canada (Dr Amenga-Etego and her collaborators endeavour to Programme in Insect Science (ARPPIS) have been engaged in Sara Fretheim), and USA (Dr. Paul Onovoh) are elucidate the myriad ways in which African writers, a project titled 'Reducing Incidences of Harmful Pests in i. to develop scientific protocols for the management examining ‘Literature, Music, and Prayer Ghana's Export Vegetable Sector' with the goal of of these pests of quarantine importance; and singers, historians, and lay church people Repertoires as Sources of African Values, addressing the ban on export of vegetables to the EU market. ii. to develop a roadmap for pest reduction in exported theologise. Spirituality, and Christian Theology’ with a grant A team of Entomologists, led by Dr Ken Okwae Fening of the vegetables from Ghana to the UK in order to reverse Soil and Irrigation Research Centre and Dr Maxwell Kelvin from the African Theological Advance programme. the ban. Billah of the Department of Animal Biology and Conservation Science, in partnership with the GhanaVeg The outcomes of this research provided baseline data for Their work bridges theology, social sciences, and Project, the Ghana Association of Vegetable Exporters policy interventions adopted by Ghana's National Plant the arts and seeks to make a creative contribution (GAVEX), and the Ministry of Food and Agriculture (MoFA), Protection Organization (NPPO), which is the Plant have developed interventions to manage these pests of by analyzing selected literary works, gospel songs, Protection and Regulatory Services Directorate (PPRSD) of quarantine importance associated with vegetables from the Ministry of Food and Agriculture (MoFA). It has prayers, archival and oral histories, as well as praise Ghana. With funding from the Centre for Development successfully led to the establishment of a roadmap for pest poetry from selected societies and individuals in Innovation (CDI), Wageningen, Netherlands, the United reduction in vegetables for export, which is the NPPO's Ghana and Nigeria, so as to discern ways in which States Agency for International Development (USAID), the approved set of protocols for producing vegetables for African Christian spirituality and values are Centre for Agriculture and Bioscience International (CABI) export with endorsement from the EU authorities. These perceived and expressed by members of these and the Deutsche Gesellschaft für Internationale communities. Zusammenarbeit GmbH (GIZ), the project aimed to reduce interventions contributed significantly to the lifting of the the incidence of harmful pest tainting vegetable produce, ban on the selected vegetables by the EU, and holds promise which lead to their rejection or interception during export. for the vegetable export sector, and indeed for an overall increase in the volume of agricultural produce from Ghana. The literary, liturgical, musical, archival and historical works that are being analysed in The research team conducted participatory trials in selected combination with interviews, participant exporter out-grower farms in three agro-ecological zones, observation and archival studies raise issues of (i.e., the forest, coastal savanna and forest-savanna transition gender, ethnic i ty, ident i ty, agency, and zones), where most vegetables for export are cultivated, and colonialism/post-colonialism. The team seeks to high pest pressure exists. These are areas designated as hot spots. The research demonstrated that the interventions demonstrate the ways in which these linguistic which they have developed could offer 100% protection works are sources of 'reflective theology' in and of against most of the key pests of quarantine importance themselves, while also elucidating the importance encountered in the field. The Integrated Pest Management of these oral and written forms as resources for protocols, which involved preventive, monitoring and wider theological scholarship. Dr. Sara Fretheim, Dr. Abraham Kwakye & Dr. Rose Mary Amenga-Etego control interventions, were adopted in trials conducted for the most commonly intercepted pests (thrips, whiteflies, fruit flies, FCM and EFSB) on the three critical commodities (eggplant, chillies and gourds). Dr. Fening (right) and Dr. Billah (left) inspecting catches of FCM in a delta trap in a chilli field 6 Inspir ing Inspir ing 11 Cassava as a Biomaterial Reinforcement EMPOWERING WOMEN BY for TISSUE ENGINEERING CREATING SAFEGUARDS AGAINST Anemia Dr. Esi Colecraft Anemia among reproductive-age women persists as a public health problem, putting many of them at risk of adverse health, pregnancy and delivery complications, poor birth outcomes and even death. These outcomes have unfortunate implications for their livelihoods and ability to support their families. With complex and multifaceted causes, resolving the problem requires multi-disciplinary actions, particularly involving the agriculture, infectious disease control and Dr. Elsie Kaufmann nutrition sectors. Since 2016, Dr Esi Colecraft, of the Department of Nutrition and Food Science, has been collaborating with colleagues at the University of Michigan, to address the various and interlocking mechanisms associated with anemia prevention. The Pathways to Anemia Prevention project explored agricultural, nutritional, and infectious disease Tissue Engineering (TE) is the specialized discipline that combines cells, biomaterials, and suitable biochemical pathways to addressing anemia among women, with a focus on the regions with the highest burden of anemia in Ghana: factors to form functional biological substitutes for the restoration, maintenance, or enhancement of tissue the Northern, Volta and Central regions. function. One major component in many TE processes is the use of scaffolds developed from natural or synthetic biomaterials to serve as support for cells as they promote cellular activity and tissue growth. A required critical In 2018, the Pathways project team with collaborators from the University of Michigan, Innovations for Poverty Action property of tissue engineering scaffolds is their ability to provide mechanical strength and structural support for (IPA), Netherlands Development Agency (SNV), and Viamo received additional funding from the Bill and Melinda Gates cells during tissue development. In recent times, natural fibres have become interesting targets as novel Foundation (BMGF) and the Department for International Development (DFID) for a follow-up study titled: The Invisible biomaterials for the development of tissue engineered fibre-reinforced scaffolds due to their low cost, availability, Fishers: Empowering and Safeguarding Women in Fisheries Value Chains in Ghana to Reduce Anemia. eco-friendliness, good mechanical strength, and potential ability to safely degrade inside a living host. This latter study builds on specific key insights from the Pathways project, including the fact that the fisheries value chain Cassava bagasse is a waste by-product of industrial cassava starch extraction. Despite being waste, the bagasse contains a considerable amount of natural cellulose fibres that are a potential novel biomaterial for developing (post-fish landing) in Ghana is dominated by women, although they tissue engineering scaffolds. Before a novel material can be successfully introduced in tissue engineering, however, remain largely invisible. The biomass-based fish-smoking livelihoods it must be characterized to understand, among other things, its mechanical, physicochemical, thermal, and predisposes women to anemia due to changes in iron metabolism microstructural properties. This is one of the objectives of Dr. Elsie Effah Kaufmann's research in the Department associated with chronic smoke inhalation, and that anemia-related of Biomedical Engineering, where she seeks to develop novel biomaterials from waste products, and to social behaviour change education is needed to address knowledge and characterize the fibres in cassava bagasse in order to provide the necessary material properties needed for the cultural barriers to anemia prevention. exploitation of the fibres for use in the fabrication of scaffolds for tissue engineering. The Invisible Fishers project is piloting the feasibility of intervention Dr. Kaufmann and her colleagues have isolated and characterized some material properties (mechanical, thermal, strategies for addressing anemia among women engaged in fish- physicochemical and microstructure) of cassava cellulose fibres and demonstrated the use of these fibres as smoking livelihoods in the Volta and Central regions of Ghana. In each reinforcement in gelatin composite scaffolds. Their recent work has indicated that cassava fibre has reasonable region, six fishing communities were selected, and ten women with mechanical strength and resilience comparable to other natural fibres and further demonstrated an improvement small- to medium-scale fish-smoking enterprises have been chosen in mechanical properties over pure gelatin scaffolds when cassava cellulose microfibres are used as reinforcing (from each of these communities) to participate in the study. biomaterial. For the 120 women fish smokers in the twelve communities, three Their research provides critical data for consideration in the evaluation of new biomaterials to enable biomedical intervention strategies (packages) are being tested, over a nine-month engineers develop mathematical models and biomechanical simulations to predict the behaviour of the cassava cellulose fibres for in vivo applications. The research therefore bridges a knowledge gap regarding the material period: properties of cassava fibres and promotes cassava fibre as a potential biomaterial for applications in biomedical A) anemia-based social behaviour change education delivered via engineering. mobile voice messages; B) discounted micro-loans with entrepreneurship training; and; Given the large quantities of cassava bagasse that typically go to waste in industrial starch manufacturing and the low cost of cassava, this work has potentially significant commercial and economic impact. Dr. Effah Kaufmann’s C) introduction of improved smoking oven technology research also proffers strategies for the use of cassava fibre in wound healing and tissue culture applications. (Ahotor oven) and associated practices. The experimental study randomly assigns the following three package sets to two communities in each region: Group 1: Package A ONLY (education only) Group 2: Package A PLUS Package B (education plus micro- loans with entrepreneurship training) Group 3: Package A PLUS Package C (education plus smoking over technology) The findings from this pilot work are intended to inform a national level study, refining intervention strategies and Cassava Tubers Cassava Fibres Cassava Cellulose-gelatin Composite Scaffold design/implementation of data collection processes for a future full-scale study. 10 Inspir ing Inspir ing 7 A SOCIAL AFFLICTION: A SOCIAL MEDIA INTERVENTION - IMPROVING EARLY CASE DETECTION OF BURULI ULCER IN GHANA AND COTE D'IVOIRE Images of Buruli ulcer sufferers, seen on both local This novel method was presented by the team at the The main research project aims to determine and international media, reveal the devastating March 2019 biennial conference on Buruli ulcer in these unique Buruli ulcer metabolites, which can effects of a disease that affects already vulnerable Geneva. The World Health Organization's (WHO) then be further developed into efficient, field societies. Despite the social stigma attached to the Technical Advisory Committee has made early applicable and easy to use diagnostic tools. disease, interventions to arrest its spread and cure detection and antibiotic treatment a core strategy for patients have been challenged by lack of access and tackling the disease. To confirm the status of the disease from a information for early detection and treatment. suspected Buruli ulcer patient, involves a tedious The work of Dr. Mosi and her colleagues in the two sampling process, followed by the transfer of the Buruli ulcer is caused by a bacterium called most affected countries in West Africa, Ghana and samples to a reference facility. Appropriate Mycobacterium ulcerans and manifests either as a Cote d'Ivoire, received funding from a GCRF-MRC facilities for testing samples are generally absent boil-like lesion called a nodule, or with parts of the grant, with support from the National Buruli ulcer from the communities where patients reside. Less skin being discolored and firm (referred to as control programmes in both Ghana and Côte d'Ivoire. than 50% of samples taken actually reach a plaque). Other manifestations are a non-pitting Dr. Lydia Mosi reference laboratory, and an even lower oedema (i.e., a swelling of mostly the lower or upper During Buruli ulcer infections, it is expected that the proportion of the results from tested samples limbs) that leaves a clear impression when interaction of the pathogen and skin cells will reach a rural health facility to trigger treatment. depressed, and open undermined lesions referred to facilitate the production of specific metabolites. as ulcers. This bacterium uniquely produces a lipid The number of suspected and confirmed cases of toxin (mycolactone) that is responsible for the Buruli ulcer identified in the active case district of progression and extensive destruction of the skin the study showed the prevalence of Buruli ulcer in and soft tissues. In some cases, these ulcers invade up the Amansie Central District in Ghana to be high, to a third of the total body surface of affected but the lack of effective case identification and individuals. confirmation has hampered the identification of these cases. Use of the WhatsApp® group Most Buruli ulcer cases in Ghana are found in remote platform demonstrated that it is possible to and rural parts of the country where appropriate establish a case identification and surveillance care is limited due to an overstretched health system in real time, which can also be used for delivery service. The challenges of health care monitoring case confirmation, treatment and delivery in many developing countries mean that treatment outcomes. interventions to effectively estimate the burden of the disease for measured deployment is lacking. Poor The use of technology will enable health care understanding of the mode of transmission of the providers to reach wider audiences to offer low- pathogen from endemic aquatic environments to cost opportunities to connect through social humans and other mammals in affected communities media platforms with populations on a large scale. compounds the Buruli ulcer menace. Other functional benefits of the use of smart phones include the potential for real-time Dr. Lydia Mosi, Head of the Department of monitoring of the disease, identification and Biochemistry, Cell & Molecular Biology has, for over a feedback of health indicators, real-time usage, and decade, been at the forefront of the charge to data being automatically generated within most understand the epidemiology and biology of this technology platforms all of which are debilitating skin infection. Working with a team of advantageous for evaluation purposes. scientists, on the transmission, pathogenesis and diagnosis of the pathogen and its infections, her goal The use of the WhatsApp is to achieve early laboratory confirmation of the infection in order to facilitate the use of efficient platform on smart phones antibiotics for treatment. Dr. Mosi and her colleagues “ has provided an easy have identified a novel, yet easy and efficient method and efficient method to to detect cases in rural communities using the WhatsApp platform on smart phones. detect cases in rural Sharing and coding of patient lesions on WhatsApp® platforms (Ghana and Cote d'Ivoire) communities. 8 Inspir ing Inspir ing 9 “ A SOCIAL AFFLICTION: A SOCIAL MEDIA INTERVENTION - IMPROVING EARLY CASE DETECTION OF BURULI ULCER IN GHANA AND COTE D'IVOIRE Images of Buruli ulcer sufferers, seen on both local This novel method was presented by the team at the The main research project aims to determine and international media, reveal the devastating March 2019 biennial conference on Buruli ulcer in these unique Buruli ulcer metabolites, which can effects of a disease that affects already vulnerable Geneva. The World Health Organization's (WHO) then be further developed into efficient, field societies. Despite the social stigma attached to the Technical Advisory Committee has made early applicable and easy to use diagnostic tools. disease, interventions to arrest its spread and cure detection and antibiotic treatment a core strategy for patients have been challenged by lack of access and tackling the disease. To confirm the status of the disease from a information for early detection and treatment. suspected Buruli ulcer patient, involves a tedious The work of Dr. Mosi and her colleagues in the two sampling process, followed by the transfer of the Buruli ulcer is caused by a bacterium called most affected countries in West Africa, Ghana and samples to a reference facility. Appropriate Mycobacterium ulcerans and manifests either as a Cote d'Ivoire, received funding from a GCRF-MRC facilities for testing samples are generally absent boil-like lesion called a nodule, or with parts of the grant, with support from the National Buruli ulcer from the communities where patients reside. Less skin being discolored and firm (referred to as control programmes in both Ghana and Côte d'Ivoire. than 50% of samples taken actually reach a plaque). Other manifestations are a non-pitting Dr. Lydia Mosi reference laboratory, and an even lower oedema (i.e., a swelling of mostly the lower or upper During Buruli ulcer infections, it is expected that the proportion of the results from tested samples limbs) that leaves a clear impression when interaction of the pathogen and skin cells will reach a rural health facility to trigger treatment. depressed, and open undermined lesions referred to facilitate the production of specific metabolites. as ulcers. This bacterium uniquely produces a lipid The number of suspected and confirmed cases of toxin (mycolactone) that is responsible for the Buruli ulcer identified in the active case district of progression and extensive destruction of the skin the study showed the prevalence of Buruli ulcer in and soft tissues. In some cases, these ulcers invade up the Amansie Central District in Ghana to be high, to a third of the total body surface of affected but the lack of effective case identification and individuals. confirmation has hampered the identification of these cases. Use of the WhatsApp® group Most Buruli ulcer cases in Ghana are found in remote platform demonstrated that it is possible to and rural parts of the country where appropriate establish a case identification and surveillance care is limited due to an overstretched health system in real time, which can also be used for delivery service. The challenges of health care monitoring case confirmation, treatment and delivery in many developing countries mean that treatment outcomes. interventions to effectively estimate the burden of the disease for measured deployment is lacking. Poor The use of technology will enable health care understanding of the mode of transmission of the providers to reach wider audiences to offer low- pathogen from endemic aquatic environments to cost opportunities to connect through social humans and other mammals in affected communities media platforms with populations on a large scale. compounds the Buruli ulcer menace. Other functional benefits of the use of smart phones include the potential for real-time Dr. Lydia Mosi, Head of the Department of monitoring of the disease, identification and Biochemistry, Cell & Molecular Biology has, for over a feedback of health indicators, real-time usage, and decade, been at the forefront of the charge to data being automatically generated within most understand the epidemiology and biology of this technology platforms all of which are debilitating skin infection. Working with a team of advantageous for evaluation purposes. scientists, on the transmission, pathogenesis and diagnosis of the pathogen and its infections, her goal The use of the WhatsApp is to achieve early laboratory confirmation of the infection in order to facilitate the use of efficient platform on smart phones antibiotics for treatment. Dr. Mosi and her colleagues “ has provided an easy have identified a novel, yet easy and efficient method and efficient method to to detect cases in rural communities using the WhatsApp platform on smart phones. detect cases in rural Sharing and coding of patient lesions on WhatsApp® platforms (Ghana and Cote d'Ivoire) communities. 8 Inspir ing Inspir ing 9 “ Cassava as a Biomaterial Reinforcement EMPOWERING WOMEN BY for TISSUE ENGINEERING CREATING SAFEGUARDS AGAINST Anemia Dr. Esi Colecraft Anemia among reproductive-age women persists as a public health problem, putting many of them at risk of adverse health, pregnancy and delivery complications, poor birth outcomes and even death. These outcomes have unfortunate implications for their livelihoods and ability to support their families. With complex and multifaceted causes, resolving the problem requires multi-disciplinary actions, particularly involving the agriculture, infectious disease control and Dr. Elsie Kaufmann nutrition sectors. Since 2016, Dr Esi Colecraft, of the Department of Nutrition and Food Science, has been collaborating with colleagues at the University of Michigan, to address the various and interlocking mechanisms associated with anemia prevention. The Pathways to Anemia Prevention project explored agricultural, nutritional, and infectious disease Tissue Engineering (TE) is the specialized discipline that combines cells, biomaterials, and suitable biochemical pathways to addressing anemia among women, with a focus on the regions with the highest burden of anemia in Ghana: factors to form functional biological substitutes for the restoration, maintenance, or enhancement of tissue the Northern, Volta and Central regions. function. One major component in many TE processes is the use of scaffolds developed from natural or synthetic biomaterials to serve as support for cells as they promote cellular activity and tissue growth. A required critical In 2018, the Pathways project team with collaborators from the University of Michigan, Innovations for Poverty Action property of tissue engineering scaffolds is their ability to provide mechanical strength and structural support for (IPA), Netherlands Development Agency (SNV), and Viamo received additional funding from the Bill and Melinda Gates cells during tissue development. In recent times, natural fibres have become interesting targets as novel Foundation (BMGF) and the Department for International Development (DFID) for a follow-up study titled: The Invisible biomaterials for the development of tissue engineered fibre-reinforced scaffolds due to their low cost, availability, Fishers: Empowering and Safeguarding Women in Fisheries Value Chains in Ghana to Reduce Anemia. eco-friendliness, good mechanical strength, and potential ability to safely degrade inside a living host. This latter study builds on specific key insights from the Pathways project, including the fact that the fisheries value chain Cassava bagasse is a waste by-product of industrial cassava starch extraction. Despite being waste, the bagasse contains a considerable amount of natural cellulose fibres that are a potential novel biomaterial for developing (post-fish landing) in Ghana is dominated by women, although they tissue engineering scaffolds. Before a novel material can be successfully introduced in tissue engineering, however, remain largely invisible. The biomass-based fish-smoking livelihoods it must be characterized to understand, among other things, its mechanical, physicochemical, thermal, and predisposes women to anemia due to changes in iron metabolism microstructural properties. This is one of the objectives of Dr. Elsie Effah Kaufmann's research in the Department associated with chronic smoke inhalation, and that anemia-related of Biomedical Engineering, where she seeks to develop novel biomaterials from waste products, and to social behaviour change education is needed to address knowledge and characterize the fibres in cassava bagasse in order to provide the necessary material properties needed for the cultural barriers to anemia prevention. exploitation of the fibres for use in the fabrication of scaffolds for tissue engineering. The Invisible Fishers project is piloting the feasibility of intervention Dr. Kaufmann and her colleagues have isolated and characterized some material properties (mechanical, thermal, strategies for addressing anemia among women engaged in fish- physicochemical and microstructure) of cassava cellulose fibres and demonstrated the use of these fibres as smoking livelihoods in the Volta and Central regions of Ghana. In each reinforcement in gelatin composite scaffolds. Their recent work has indicated that cassava fibre has reasonable region, six fishing communities were selected, and ten women with mechanical strength and resilience comparable to other natural fibres and further demonstrated an improvement small- to medium-scale fish-smoking enterprises have been chosen in mechanical properties over pure gelatin scaffolds when cassava cellulose microfibres are used as reinforcing (from each of these communities) to participate in the study. biomaterial. For the 120 women fish smokers in the twelve communities, three Their research provides critical data for consideration in the evaluation of new biomaterials to enable biomedical intervention strategies (packages) are being tested, over a nine-month engineers develop mathematical models and biomechanical simulations to predict the behaviour of the cassava cellulose fibres for in vivo applications. The research therefore bridges a knowledge gap regarding the material period: properties of cassava fibres and promotes cassava fibre as a potential biomaterial for applications in biomedical A) anemia-based social behaviour change education delivered via engineering. mobile voice messages; B) discounted micro-loans with entrepreneurship training; and; Given the large quantities of cassava bagasse that typically go to waste in industrial starch manufacturing and the low cost of cassava, this work has potentially significant commercial and economic impact. Dr. Effah Kaufmann’s C) introduction of improved smoking oven technology research also proffers strategies for the use of cassava fibre in wound healing and tissue culture applications. (Ahotor oven) and associated practices. The experimental study randomly assigns the following three package sets to two communities in each region: Group 1: Package A ONLY (education only) Group 2: Package A PLUS Package B (education plus micro- loans with entrepreneurship training) Group 3: Package A PLUS Package C (education plus smoking over technology) The findings from this pilot work are intended to inform a national level study, refining intervention strategies and Cassava Tubers Cassava Fibres Cassava Cellulose-gelatin Composite Scaffold design/implementation of data collection processes for a future full-scale study. 10 Inspir ing Inspir ing 7 REDUCING INCIDENCE OF HARMFUL ORGANISMS LITERATURE, MUSIC, AND PRAYER REPERTOIRES AS IN GHANA'S VEGETABLE EXPORT MARKET SOURCES OF AFRICAN VALUES, SPIRITUALITY AND CHRISTIAN THEOLOGY Ghana's vegetable exports experienced several interception notifications between 2012 and 2015, largely due to the presence of harmful organisms, specifically quarantine The argument that Christian faith is not a matter of Thus, literature, music and prayer repertoires are pests; mostly thrips, whiteflies, fruit flies, false codling moth False Moth White Fly opinion, but “a community-building or community- not just tools or avenues for African Christians at (FCM) and eggplant fruit and shoot borer (EFSB) in consignments destined for export to the European Union transformative appropriation of the very deepest the grassroots to theologise, but also, sources of (EU). poetic truth” runs deep in many communities, social mobilisation (religious and/ or social capital) provoking the question of how these traditional for community development. Fruit Fly Thrip spiritual traits and values have survived and These pests are associated with such vegetables as Capsicum modulated within contemporary African (chilli pepper), Solanum (eggplant and aubergine), and the It is therefore important to note that such reflective gourds (luffa, bitter and bottle gourds, i.e, Luffa, Momordica, The pest management protocols involve the use of farm Christianity. or grassroots theology is neither a replacement nor and Lagenaria, respectively). These organisms, although sanitation, mass trapping of pests using appropriate lures and sticky traps for the different species, use of bio-rational competitor for academic theology. Rather, when the they do not pose a threat to human health, can cause severe With a unique focus on the critical role of poetic economic damage by affecting crop yields. Thus, such insecticides (botanicals and microbials) as well as other two function together, theology acquires an elements such as language, literature and oral vegetable produce is banned for export to countries where physically-acting insecticides and less persistent binary authentic character in which scholars and believers forms as repositories and vehicles for such these pests are absent or are present but not widespread and synthetic pesticides. work together within the same context. spirituality and values, Dr. Rose Mary Amenga- are under official control. A survey of existing pest management practices among Etego and colleagues from the University of Ghana vegetable exporters and their cohort of out-growers Within the scope of this project, and as a community engaged in the production value chain was also undertaken, (Dr. Abraham Nana Opare Kwakye), Ebonyi State of theological scholar-practitioners ourselves, Dr. Scientists from the African Regional Postgraduate with two goals: University (Dr. Ngozi Emeka-Nwobia), Canada (Dr Amenga-Etego and her collaborators endeavour to Programme in Insect Science (ARPPIS) have been engaged in Sara Fretheim), and USA (Dr. Paul Onovoh) are elucidate the myriad ways in which African writers, a project titled 'Reducing Incidences of Harmful Pests in i. to develop scientific protocols for the management examining ‘Literature, Music, and Prayer Ghana's Export Vegetable Sector' with the goal of of these pests of quarantine importance; and singers, historians, and lay church people Repertoires as Sources of African Values, addressing the ban on export of vegetables to the EU market. ii. to develop a roadmap for pest reduction in exported theologise. Spirituality, and Christian Theology’ with a grant A team of Entomologists, led by Dr Ken Okwae Fening of the vegetables from Ghana to the UK in order to reverse Soil and Irrigation Research Centre and Dr Maxwell Kelvin from the African Theological Advance programme. the ban. Billah of the Department of Animal Biology and Conservation Science, in partnership with the GhanaVeg The outcomes of this research provided baseline data for Their work bridges theology, social sciences, and Project, the Ghana Association of Vegetable Exporters policy interventions adopted by Ghana's National Plant the arts and seeks to make a creative contribution (GAVEX), and the Ministry of Food and Agriculture (MoFA), Protection Organization (NPPO), which is the Plant have developed interventions to manage these pests of by analyzing selected literary works, gospel songs, Protection and Regulatory Services Directorate (PPRSD) of quarantine importance associated with vegetables from the Ministry of Food and Agriculture (MoFA). It has prayers, archival and oral histories, as well as praise Ghana. With funding from the Centre for Development successfully led to the establishment of a roadmap for pest poetry from selected societies and individuals in Innovation (CDI), Wageningen, Netherlands, the United reduction in vegetables for export, which is the NPPO's Ghana and Nigeria, so as to discern ways in which States Agency for International Development (USAID), the approved set of protocols for producing vegetables for African Christian spirituality and values are Centre for Agriculture and Bioscience International (CABI) export with endorsement from the EU authorities. These perceived and expressed by members of these and the Deutsche Gesellschaft für Internationale communities. Zusammenarbeit GmbH (GIZ), the project aimed to reduce interventions contributed significantly to the lifting of the the incidence of harmful pest tainting vegetable produce, ban on the selected vegetables by the EU, and holds promise which lead to their rejection or interception during export. for the vegetable export sector, and indeed for an overall increase in the volume of agricultural produce from Ghana. The literary, liturgical, musical, archival and historical works that are being analysed in The research team conducted participatory trials in selected combination with interviews, participant exporter out-grower farms in three agro-ecological zones, observation and archival studies raise issues of (i.e., the forest, coastal savanna and forest-savanna transition gender, ethnic i ty, ident i ty, agency, and zones), where most vegetables for export are cultivated, and colonialism/post-colonialism. The team seeks to high pest pressure exists. These are areas designated as hot spots. The research demonstrated that the interventions demonstrate the ways in which these linguistic which they have developed could offer 100% protection works are sources of 'reflective theology' in and of against most of the key pests of quarantine importance themselves, while also elucidating the importance encountered in the field. The Integrated Pest Management of these oral and written forms as resources for protocols, which involved preventive, monitoring and wider theological scholarship. Dr. Sara Fretheim, Dr. Abraham Kwakye & Dr. Rose Mary Amenga-Etego control interventions, were adopted in trials conducted for the most commonly intercepted pests (thrips, whiteflies, fruit flies, FCM and EFSB) on the three critical commodities (eggplant, chillies and gourds). Dr. Fening (right) and Dr. Billah (left) inspecting catches of FCM in a delta trap in a chilli field 6 Inspir ing Inspir ing 11 Globally, the pharmaceutical industry is highly regulated with approval regimes for drug therapies subjected to extensive pre-clinical and clinical trials. While the rigorous nature of clinical trials provides a safety net for end users, the use of approved drugs in a particular jurisdiction does not necessarily translate into safe use in other populations. According to Professor Appiah- Opong, these dynamics raise questions about the generalized applicability of drugs approved by authorities in other parts of the world. Morinda Lucida She is also collaborating with colleagues at the University of Ghana and the University of Washington, Bothell, in research on genes of Although the interaction potential of drugs is CYP3A4 drug metabolising enzymes to identify assessed during pre-clinical studies in developed differences in Single Nucleotide Polymorphisms countries, for instance by the Food and Drug (SNPs) between Caucasian and Ghanaian Administration in the USA, this is not typical in many ethnicities, and is seeking funding to extend her developing countries. Neither is the evaluation of the work to different ethnic groups in West Africa with drug-food interaction potential a conventional study the goal of determining: norm of regulatory bodies. It would appear that reports on the drug interaction potential with i. The effect of drugs approved and tested in natural products are hardly requirements of safety other countries on Ghanaians assessments of drug manufacturers. ii. Plant-based medicines and foods that interact with conventional medicines Professor Regina Appiah-Opong, Head of the Department of Clinical Pathology at the Noguchi Ultimately, her goal is to create awareness and Memorial Institute for Medical Research (NMIMR), is establish in Ghana, the means of screening drugs, extremely passionate about this subject and has drug candidates, plant medicines and food for devoted much of her working life to biomedical drug interaction potential. This is to safeguard r e s e a r c h . W o r k i n g i n t h e f i e l d o f public health and support the efforts of toxicology/pharmacology, where drug-metabolizing pharmaceutical industries. She seeks to develop enzymes are employed in evaluating drug candidates appropriate medical protocols for imported drugs and provide education to maximise the effects of as part of pre-clinical studies on these drug drugs and other therapies through nutrition. candidates, Professor Appiah-Opong is exploring the interactions between conventional drugs, herbs and foods. Her particular interest in drug-drug/drug- herb/drug-food interactions, pharmacokinetics, pharmacogenomics, drug discovery, antioxidants and environmental contaminants (heavy metals, aflatoxins), has seen her collaborate extensively with domestic and international partners. Professor Appiah-Opong's current work has focused on anti- cancer and anti-malarial agents, and her collaboration with colleagues in Japan and Ghana has resulted in a filed patent on an anti-typanosomiasis agent. She has played a major role in the construction of a DNA cassette vector that is useful for drug Moringa Oliefera susceptibility testing of anti-HIV protease inhibitor drugs. 12 Inspir ing Inspir ing 5 CONVENTIONAL DRUGS, PLANT MEDICINES AN IMPACT ASSESSMENT OF AND FOODS: SOCIAL MARKETING IN GHANA (IASMG) The deleterious effects of smoking are widely known; with Africa the greatest laggard of all world regions and with arguably the lowest level of medical technology to address the associated problems, the question of how to temper the spread of the problem is urgent. Particularly among adolescents, whose life habits are now being shaped and who are susceptible to peer-influence to make choices that are frequently contrary to their own best A Complementary Combination? interests, the problem is immediately salient. Dr. Naa Dodua Dodoo and Dr. Adriana Biney, at the Regional Institute of Population Studies (RIPS), are leading a team at the University of Ghana to partner with collaborators at Tulane University in the USA, on a Bill and Melinda Gates Foundation (BMGF) funded project to investigate how social marketing can help dissuade adolescents from smoking. Plant medicines are patronized by about 80% of Africans and are generally considered safe remedies that may be ingested over long periods of time. For many people, plant medicines are first-line The BMGF Tobacco Control Programme incorporates social marketing as a core activity to highlight policy remedies. Scientific investigations have revealed, however that the concurrent intake of some plant changes and improve Knowledge, Attitudes and Practices (KAP) related to youth smoking. One initiative of the medicines and conventional drugs can result in therapeutic failure or drug toxicity. A classic example programme is a SKY Girls campaign implemented in Botswana, Uganda and Ghana. This initiative is based on the regards the intake of ginseng, which has been reported to increase physical stamina and alertness, understanding that although girls are aware of the health harms of tobacco, social inclusion is everything to them and is linked to a complex process of finding their identity. The project in Ghana therefore centers its principles when taken with several conventional drugs for example, those substrates of a particular catalyst, such around activities that are important to young girls (music and fashion, for example), and on ideals that will keep as Cytochrome P450 3A4 (CYP3A4). Examples of drugs metabolised by CYP3A4 include cyclosporin them grounded and able to make the right choices concerning life in general and smoking in particular. and acetaminophen (paracetamol). When such conventional drugs are taken together with CYP3A4 substrates, it appears to cause a rapid breakdown of the drugs which, in turn, generally translates into The IASMG evaluated the SKY Girls Campaign in Ghana with the following objectives: the therapeutic failure or ineffectiveness of these conventional drugs. This can also result in further Measuring the effectiveness of the combined and individual media interventions of SKY Girls on smoking adverse effects if the broken-down products or newly formed ones are harmful. attitudes, norms, intentions, tobacco use and prevention of smoking uptake Calculating the cost-effectiveness of the different media interventions of SKY Girls relative to other Similarly, consumption of some foods while taking conventional drugs has the potential to also result smoking in adverse outcomes. For instance, eating of cruciferous vegetables such as lettuce, cabbage and prevention and cessation interventions, such as multi-component, community-based interventions, other broccoli, increases the breakdown or biotransformation of acetaminophen; thus, effectiveness of the forms of mass media (e.g., public health messaging, billboards, advertisements), or school-based drug is reduced by eating such foods. interventions, and Enhancing understanding of the links between exposure to communication and behaviour change by clarifying the mechanisms through which the specific health communication activities affect tobacco outcomes. “Advertising campaignshighlight smoking as a sign of affluence. Dr. Naa Dodua Dodoo (third from right) and Dr. Adriana Biney (third from left) Based on an experimental design with a panel of follow-up phone interviews of a sub-sample of the adolescents in areas around the Ayawaso West survey respondents. Wuogon Constituency of Accra (treatment area), Kumasi and Teshie (partial treatment area) and Finally, an endline survey was conducted between Sunyani (control), a baseline survey of 7000 November 2018 and January 2019. Preliminary adolescents was conducted between March and findings indicate that most of the girls who were May, 2017. Subsequently, the various components exposed to the intervention indicated that SKY had of the SKY Girls Campaign were rolled out by a helped them to feel more empowered, aspirational, partner advertising company. This included a bi- socially connected and have a greater sense of future monthly magazine distributed in schools, two orientation. In addition, greater exposure to SKY movies available for free, visits to schools by interventions increased perceptions that smoking various role models popular with young people, shisha is not 'cool' and increased knowledge of the SKY clubs instituted in some schools, a SKY theme health consequences of shisha and tobacco. song, SKY social media channels, a SKY WhatsApp group, a weekly radio programme, a SKY truck that Further analyses of the initiative is continuing in visited various neighborhoods and schools, text order to assess the relative cost-effectiveness of the Prof. Regina Appiah-Opong messages to adolescents, a Vlog, and occasional different media interventions, and promises to SKY parties at various malls. During the campaign, evolve into a scaled-up study of young women's which lasted 18 months, there were bi-monthly empowerment, that clarifies links between communication and behavior change. 4 Inspir ing Inspir ing 13 “ FUNDING NEWS GARBAGE-IN, ENERGY-OUT: ST ST 1 FEBRUARY TO 31 MAY 2019 VALORISING PLASTIC WASTE IN GHANA ORIGINATING UNIT Plastics, which are basically long hydrocarbon- Department of chained compounds synthesized from petroleum Crop Science products, have become very popular because of their unmatched usability, wide range of application, non- degradable nature and low cost. In Ghana, the Department of Population, Family and estimation is that over 1.7 million tonnes of plastics Reproduction Health are used annually. The ever-increasing demand has also resulted in a huge amount of plastic waste, and due to disposal challenges, pose a serious threat to These issues are precisely what preoccupy Department of Marketing and the environment, waterways, water bodies and Dr. David Dodoo-Arhin of the Department of Entrepreneurship farmlands. The greater risk of plastic pollution to Materials Science and Engineering and his general human health has become a major global colleagues, as they explore the conversion of concern. plastic waste into liquid fuel and gas, as well as their potential utilization in light-duty As a result, the implementation of prudent plastic engines. Their early studies, supported by waste management and valorisation systems is the University of Ghana BANGA-Africa seed Department of Economics imperative to minimize these adverse environmental grant fellowship, in collaboration with CNRS impacts. Recycling, reusing, incineration and energy Centré RAPSODEE of Ecole de Mines d'Albi- recovery are the main techniques of plastic waste Carmaux, France, are already yielding very School of Nursing management. Energy recovery is a promising route promising results, as they explore further Midwifery for converting waste material into useful energy funding opportunities to scale up their products; the most commonly used method of research and engage trans-disciplinary energy recovery is thermal cracking (Pyrolysis), approaches to valorising plastic waste in Department of Psychology which produces liquid and gaseous fuel products Ghana. with high energy values. Department of With the exponential growth in industries as well as Economics in population, the demand for energy, which is mostly petroleum-fuel based has likewise increased. Department of Coupled with the ever-increasing world price of Population, Family and Reproduction Health crude oil, the resultant search for alternate energy resources can be mitigated by the recycling and conversion of the infinitely growing plastic waste Office of Research, into energy to diversify the energy resource. Innovation and Development Department of Biological, Environmental and Occupational Health 14 Inspir ing Inspir ing 3 C O BUDGET FUNDER UG LEAD ORIGINATING PROJECT TITLE ALLOCATED UNIT TO UG Social Sciences and 3 10 Humanities Research Prof. Kodzo Gavua Department of Improving African Futures CAD 59,500.00Council (SSHRC) through Dr. Wazi Ray Apoh Archaeology and Using Lessons from the Past N Heritage StudiesCassava as a Biomaterial University of VictoriaGarbage-in, Energy-out:Valorising Plastic Waste in Ghana Reinforcement for Tissue Engineering Institute of Prof. Dzodzi Other Universals: Theorizing from The Andrew Mellon W. African Studies R 1,603,436.93 Tsikata Post-colonial Locations on Politics Foundation and Aesthetics Legon Centre for Women and Political Participation in Africa: The Andrew Mellon W. Dr. Jennifer International Affairs A Comparative Study of the Representation USD 500,000.00 Foundation Amanda Coffie T and Diplomacy and Roles of Female Chiefs The Cambridge A Clash of Kingdoms: Isolation of Indigenous Dr. Winfred-Peck Department of Africa-ALBORADA Entomopathogenic Fungi against the Fall Dorleku Biochemistry, Cell and USD 8,787.00 Research Fund Armyworm and Unravlling the Molecular Molecular Biology Signature of Insect-fungus Interactions E The Regents of the Prof. Augustine Department of Strengthening population size estimates USD 40,605.00University of California Ankomah Population, Family and for key populations in Ghana4 Reproduction HealthConventional Drugs, Plant Medicines 8 A Social Affliction: A Social Media The Secretary of State for Health, UK through Prof. Gordon West Africa Centre and Foods: A Complementary Intervention Tackling Infections to Benefit Africa (TIBA) GBP 244,650.00the University Court of the for Cell Biology of Awandare Combination? Infectious Pathogens University of Edinburgh, UK (Amendment 3) (WACCBIP) N UK Research and Innovation GCRF South-South Migration, Inequality and through Coventry University Prof. Joseph Teye Centre for Migration GBP 823,024.006 Literature, Music and Prayer: 12 Antimicrobial Resistance: Studies Development HubRepositories of African Values, Addressing an Emerged Global Spirituality and Theology Problem with Local Solutions Societal Transformation and Climate Universities Canada through Change: Training the next generation of Prof. Yaa Centre for African CAD 3,564.00 7 Empowering Women by Creating 13 An Impact Assessment of Social Carleton University Ntiamoa-Baidu scholars in sub-Saharan Africa and Canada Wetlands (NextGen Climate Change Advanced Scholars) Safeguards against Anemia Marketing in Ghana (IASMG) T 11 Reducing Incidence of Harmful 14 Funding News Institute for World Resources Prof. Kwasi Environment and Managing resilience, restoration USD 50,000.00Organisms in Ghana’s Vegetable Institute Appeaning Addo Sanitation Studies & infrastructure of coastlines. Export Market 16 (IESS)Awards/Appointments West Africa Centre National Institute of Health Prof. Gordon Hearing Impairment Genetic USD 39,443.00 for Cell Biology of S through the University of Awandare Infectious Pathogens Studies in Africa (HI-GENES Africa)Cape Town (WACCBIP) 2 Inspir ing Inspir ing 15 AWARDS/APPOINTMENTS EDITORIAL Dr. Kwaku Kyeremeh of the The Director of the Institute for This second issue of 'Inspiring UG' features a compilation of articles that reflect the diversity and Department of Chemistry has been Environment and Sanitation scope of research underway at the University of Ghana (UG). The publication characterizes UG's awarded the prestigious Medical Studies (IESS), Professor Kwasi quest to intensify research and build capacity across all spheres of scientific endeavour. Research Council (MRC)/UK Appeaning Addo has been Department for International appointed a member of the Expert The selection of research in this issue encompasses the humanities, applied sciences and medicine, Development (DFID) African Group of the High Level Panel for a and demonstrates the impact of adding value to basic resources, the benefits of engaging local Research Leader Award 2018 for Sustainable Ocean Economy. communities for solutions to health care challenges and the rooting of religious and behavioural his project 'Development of Novel Therapeutics for The Panel is supported by the United Nations Special Envoy practices in poetry among others. Parasite Infections and Cancer by Multi-step Microbial for the Ocean, and is made up of 14 Heads of Government. Biodiscovery Processes and iChip'. The Panel's recommendations on the Blue Economy, an Our scientists have identified health interventions that remedy the adverse effects of livelihood The African Research Leadership Award is jointly run and emerging concept that advocates improvements in practices to empower and safeguard the fisheries value chain. In the engineering sciences, solutions funded by the MRC and DFID. The Award Scheme aims to management of the ocean, will make the case for change have been proffered to the menace of plastic pollution of water bodies, while agricultural produce is strengthen research leadership across Sub-Saharan Africa and call for international action for the short, medium and being transformed into a therapeutic agent in the biological sciences. (SSA) by attracting and retaining exceptional individuals long term. who will lead high quality research programmes on crucial As competition for research funding intensifies, emphasis on the impact of research outcomes is key global health issues relevant to SSA. Professor Appeaning-Addo will co-author a chapter for the to sustain funding. We seek therefore to present scholarly work in practical ways that speak to Blue Papers that will play a central role in the production of communities and make positive impacts on livelihoods. The West African College of the Panel's Summary of Recommendations on the Blue Physicians and Surgeons has Economy. Publication, Dissemination and Translation (PDT) Team elected Dr. Albert Akpalu of the Department of Medicine and Therapeutics, School of Medicine T he First Lady of the Republic of and Dentistry as its Secretary- Ghana, Her Excellency Mrs Rebecca General. The College, established in Akufo Addo has presented the First 1976, is an association of medical Lady's Excellence Award for the fields of Community Health, Family Medicine, Internal Medicine/Health Care Delivery to Medicine, Laboratory Medicine, Chemical Pathology, Professor Lorna Awo Renner of Haematology, Medical Microbiology, Paediatrics and the Department of Child Health, Psychiatry that aims to promote professional training of HE Mrs. Rebecca Akufo Addo (left) presenting the award to Prof. Renner School of Medicine and Dentistry, physicians and healthcare specialists in West Africa. on International Women's Day. The award is in recognition of her dedication to the diagnosis and treatment of children Professor Dorothy Yeboah-Manu with cancer and the mobilisation of resources to support of the Department of Bacteriology, the care of childhood cancers in Ghana. Noguchi Memorial Institute for Medical Research has received the Royal Society Africa Prize 2018 for her contributions and innovative approaches to understanding Mycobacterium ulcerous and Mycobacterium arcanum microbiology, genetic studies and epidemiology in the areas of her work. The Royal Society Africa Prize, previously the Royal Society Pfizer Award, recognises research scientists in Africa who are making innovative contributions to the biological sciences, including basic medical science, which contribute significantly to capacity building in Africa. 16 Inspir ing Inspir ing 1 RESEARCH GRANTS AWARDED TH ROUGH ORID The University of Ghana's goal to become a research-int ensive University by 2024, is progressing steadily with an upward trajectory in revenues accruing from funded projects. The Office of Research, Innovation and Development (ORID), UG's office of sponsored research has restructured over the last two and a half years into six teams, the Pre-and Post-Award Services, Research Performance Services, Technology Transfer and Intellectual Property Services, Publication, Dissemination and Translation Services, Capacity Development Services and Human and Animal Research Ethics Services. The Pre- and Post-Award Services (PPA) team comprises about half of the research administration staff of ORID and handles grants and contract management, working closely with the brilliant academics at the University of Ghana. Grant revenues processed through ORID have grown sharply by over 1000% in the last three academic years from a level of $3.4 million in 2015/2016 academic year to $42.5million in the 2018/2019 academic year . (figure 1) Table 1: Research Grants & Contracts reported through ORID (Academic Year) Academic Year No. of Grant Agreements US$ Value of Grant 2015-2016 16 3,414,212 (A student-led initiative under the auspices of the VC’s Green Project) 2016-2017 44 6,249,417 2017-2018 84 15,322,980 2018-2019 96 42,558,915** ** Includes 4 committed Awards of US$ 21.6 million Fi gure 1: Research Grants & Contracts reported through ORID (Academic Year) feteria Central Ca US$ Value of Received Awards US$ Value of Committed Awards No. of Grants LOOKING FOR FUNDING? UNIVERSITY June 2019 OF GHANA V 1.2 Turn to * Research Professional ü Thousands of open calls for all disciplines and from over 8,000 funders ü Authoritative news, analysis and comment ü Fast and user-friendly search options TM ü Customisable email alerts ü Tools to help you share information and stay ahead of funding deadlines Insp r n g UG You can use *Research Professional from any computer on the University network. Or register for free to set up your own account so that you can use the service off campus. For further enquiries contact: As a registered user you’ll also enjoy an array of other orid-ppa@ug.edu.gh benefits that help you save time and share information with your colleagues. University of Ghana has a subscription to * Research Professional researchprofessional.com To access the Research Professional porta l, send a request to orid-info@ug.edu.gh FRONT PAGE School of Engineering ORID - Annex Office of Research, Innovation & Development (ORID) - Annex GA-521-3066 Photo credit EPA GHANA Office of Research, Innovation Phone: +233 303 930436 ORID & Development (ORID) Email: orid@ug.edu.gh OFFICE OF RESEARCH, P.O. Box LG 571, University of Ghana, Legon Website: www.orid.ug.edu.gh INNOVATION AND DEVELOPMENT Print: University of Ghana Printing Press, Tel: 030 293 4987