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Zoonotic tuberculosis—a call for an open One Health debate

Zoonotic tuberculosis—a call for an open One Health debate

Yeboah-Manu, D.; Zumla, A.; Michel, A.L.; Azhar, E.I.; Torrelles, J.B.; Cadmus, S.II.; Kendall, S.L.; Chakaya, J.M.; Marais, B.; kock, R.
URI: http://ugspace.ug.edu.gh/handle/123456789/35606
Date: 2020-02-23

Abstract:

Tuberculosis is caused by bacteria of the Mycobacterium tuberculosis complex (MTBC) and affects both human and animal populations. Animal-adapted MTBC threatens the wellbeing of humans, animals, and their livelihoods. The 2019 WHO annual tuberculosis report1 estimated that there were 143 000 new human cases of zoonotic tuberculosis with 12 300 deaths caused by Mycobacterium bovis globally in 2018. Prevalence estimates of zoonotic tuberculosis are inaccurate, however, because routine laboratory tests cannot differentiate between infections caused by the humanadapted and animal-adapted species of MTBC, including newer members such as Mycobacterium orygis.2 Thus, the true effect of zoonotic tuberculosis on the human tuberculosis epidemic remains unclear. Accurate disease differentiation is also important given that M bovis isuniversally resistant to pyrazinamide, a key first-line tuberculosis drug.

Description:

Research Article

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  • Bacteriology Department [133]
    The Bacteriology Department aims to improve the quality of life first for Ghanaians and the world at large by conducting research into bacterial diseases of public health importance to Ghana and globally. In addition to working on enteric pathogens and sexually transmitted diseases, the department’s current main focus is on the two most important mycobacterial diseases of public health importance to Ghana, namely Buruli ulcer (BU) and tuberculosis (TB).

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