dc.contributor.author | Owusu, S. | |
dc.contributor.author | Adeyemo, A.A. | |
dc.contributor.author | Zaghloul, N.A. | |
dc.contributor.author | Chen, G. | |
dc.contributor.author | Doumatey, A.P. | |
dc.contributor.author | Leitch, C.C. | |
dc.contributor.author | Hostelley, T.L. | |
dc.contributor.author | Nesmith, J.E. | |
dc.contributor.author | Zhou, J. | |
dc.contributor.author | Bentley, A.R. | |
dc.contributor.author | Shriner, D. | |
dc.contributor.author | Fasanmade, O. | |
dc.contributor.author | Okafor, G. | |
dc.contributor.author | Eghan, B.J. | |
dc.contributor.author | Agyenim-Boateng, K. | |
dc.contributor.author | Chandrasekharappa, S. | |
dc.contributor.author | Adeleye, J. | |
dc.contributor.author | Balogun, W. | |
dc.contributor.author | Owusu, S. | |
dc.contributor.author | Amoah, A. | |
dc.contributor.author | Acheampong, J. | |
dc.contributor.author | Johnson, T. | |
dc.contributor.author | Oli, J. | |
dc.contributor.author | Adebamowo, C. | |
dc.contributor.author | Collins, F. | |
dc.contributor.author | Dunston, G. | |
dc.contributor.author | Rotimi, C.N. | |
dc.date.accessioned | 2019-09-09T16:10:29Z | |
dc.date.available | 2019-09-09T16:10:29Z | |
dc.date.issued | 2019-06-11 | |
dc.identifier.other | https://doi.org/10.1038/s41467- 019-10967-7. | |
dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/32102 | |
dc.description | Research Article | en_US |
dc.description.abstract | Genome analysis of diverse human populations has contributed to the identification of novel genomic loci for diseases of major clinical and public health impact. Here, we report a genome-wide analysis of type 2 diabetes (T2D) in sub-Saharan Africans, an understudied ancestral group. We analyze ~18 million autosomal SNPs in 5,231 individuals from Nigeria, Ghana and Kenya. We identify a previously-unreported genome-wide significant locus: ZRANB3 (Zinc Finger RANBP2-Type Containing 3, lead SNP p = 2.831 × 10−9). Knockdown or genomic knockout of the zebrafish ortholog results in reduction in pancreatic β-cell number which we demonstrate to be due to increased apoptosis in islets. siRNA transfection of murine Zranb3 in MIN6 β-cells results in impaired insulin secretion in response to high glucose, implicating Zranb3 in β-cell functional response to high glucose conditions. We also show transferability in our study of 32 established T2D loci. Our findings advance understanding of the genetics of T2D in non-European ancestry populations. | en_US |
dc.language.iso | en | en_US |
dc.publisher | nature communications | en_US |
dc.relation.ispartofseries | ;2019 | |
dc.subject | ZRANB3 | en_US |
dc.subject | diabetes | en_US |
dc.subject | insulin | en_US |
dc.subject | beta-cell | en_US |
dc.subject | locus | en_US |
dc.title | ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response | en_US |
dc.type | Article | en_US |