Abstract:
The minimum dose of thiopentone required to induce anaesthesia was determined bygiving thiopentone incrementally until verbal counting and eyelash reflexes wereabolished. Males required 2.75 mg/kg (±0.11 SE) and females 2.16 mg/kg ( + 0.10 SE)to abolish verbal counting. Thiopentone requirement correlated positively with haemo-globin concentration (P<0.001) but not with plasma albumin, Ol globulin, total globulinor A/G ratio. The presence of sickle-cell haemoglobins did not influence thiopentonerequirements. It is suggested that this result may have clinical importance
