Research Articles
Permanent URI for this communityhttp://197.255.125.131:4000/handle/123456789/22010
A research article reports the results of original research, assesses its contribution to the body of knowledge in a given area, and is published in a peer-reviewed scholarly journal. The faculty publications through published and on-going articles/researches are captured in this community
Browse
5 results
Search Results
Item Epilepsy in the Freeman Sheldon Syndrome.(J Child Neurol, 1995-07-01) Sackey, A.H.; Coulter, B.; Fryer, A.; van Velzen, D.The Freeman Sheldon Syndrome, also known as whistling face syndrome, is rare congenital disorder characterized by a small mouth, immobile face and distal arthrogryposis.Item Interval between Insulin Injection and Breakfast in Diabetes.(Arch Dis Child, 1994) Sackey, A.H.; Jefferson, I.G.The relationship between the insulin-breakfast interval, postprandial increase in blood glucose, and glycaemic control was studied in 58 children with diabetes. Patients recorded insulin-breakfast intervals in a home diary over a seven day period, and during a 24 hour period at the weekend provided eight serial capillary dried blood spots for glucose analysis. The highest mean blood glucose value occurred two hours after breakfast and showed a significant correlation with fructosamine concentrations. Weekend insulin-breakfast intervals ranged from 2-30 minutes, with 70% reporting intervals of less than 15 minutes. There was a significant correlation between the weekend insulin-breakfast interval and the after breakfast increase in blood glucose with a mean increment of 0.4 mmol/l in the 30 minute group and 7.2 mmol/l in the 2 minute group. Over the whole study period, children with mean insulin-breakfast intervals of two to 12 minutes had a mean fructosamine concentration of 376 mumol/l compared with 341 mumol/l in those with intervals of 15-35 minutes. This study has shown that the interval between insulin injection and breakfast significantly influences the morning postprandial rise in blood glucose and consequently short term glycaemic control. It is therefore important that patients are encouraged to leave an interval of about 30 minutes between insulin injection and breakfast.Item Vitamin A Administration in Neonates: A Continuing Problem.(Paediatrics Today, 1994-01) Shaw, N.J.; Harrison, C.; Sackey, A.H.; Hughes, A.Vitamin A Administration in Neonates: A Continuing Problem.Item How many inpatient paediatric units do we need?(Archives of disease in childhood, 1995) Carter, P.E.; Precious, S.H.; Sackey, A.H.; Paynter, A.H. et.alIn his article on paediatric inpatient units, Professor Taylor claims that many present paediatric units are too small to provide safe and cost effective care, do not meet required standards, and should combine into larger units providing specialist children's services.' We would disagree with him, at least with regard to rural communities. In many small district general hospitals a very high standard of care is offered, frequently directly by the consultant and often at great personal cost. The service shares many of the better aspects of primary care delivered by staff who know the families and their backgrounds. Professor Taylor stresses the value of a good relationship with the tertiary centres; where this exists children can be referred to superspecialists when indicated. He does, however, make a good case for continuing update and education for all staff and the need for clinical commitments to be such that study and development of appropriate skills are possibleItem Anaemia after Enalapril in a Child with Nephrotic Syndrome(The Lancet, 1998-07-25) Sackey, A.H.A girl aged 7 years with focal segmental glomerulosclerosis and nephrotic syndrome failed to respond to prednisolone for 7 weeks, and to prednisolone with cyclophosphamide for a further 8 weeks Blood pressure was normal and oedema was controlled with diuretics Creatinine had increased from 30 μmol/L to 50 μmol/L, and the urine protein/creatinine ratio from 2400 mg/mmol to 4000 mg/mmol From week 10 to week 40, creatinine rose from 30 μmol/L to 85 μmol/L and the urine albumin/creatinine ratio fluctuated between 2000 mg/mmol and 4000 mg/mmol She was started on enalapril 2·5 mg twice daily After 3 months, enalapril was discontinued because her haemoglobin had fallen from 127 g/L to 62 g/L with haematocrit of 0·16, but with normal ferritin, folate, and vitamin B12 There is a relation between onset of anaemia and use of enalapril (figure) A weaker relation was seen with prednisolone withdrawal.