Research Articles
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A research article reports the results of original research, assesses its contribution to the body of knowledge in a given area, and is published in a peer-reviewed scholarly journal. The faculty publications through published and on-going articles/researches are captured in this community
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Item Local iatrogenic complications in nasopharyngeal rhinoscleroma(Journal of Laryngology and Otology, 1988) Dawlatly, E.E.; Anim, J.T.; Baraka, M.E.The possible role of surgical manipulation in inducing local spread and cicatricial complications in rhinoscleroma is illustrated by the three cases discussed in this paper. This is especially so where its occasional presentation as polypoid lesions of the lower respiratory tract may mimic other more sinister lesions and lead to unwarranted invasive procedures by the unsuspecting clinician. The infective nature of the lesions must be appreciated and confirmed microbiologically for appropriate drug treatment to be used. The benefits of minimal surgical intervention are illustrated in the third case.Item Fistula-in-ano: A pathological study(Annals of Saudi Medicine, 1991) Anim, J.T.; Sowayan, S.A.; Grant, C.S.; Al-Breiki, H.A review of 229 cass of fistula-in-ano in our institution has shown that nonspecific inflammatory tissue lines the majority of tracts. Epithelial lining was present in 50 cases and was encountered proportionately more frequently in subjects under 10 years of age, thus supporting a congenital origin as well as infection of anal glands, earlier proposed by other workers. Intestinal contents may have a role in the foreign body response seen in many cases. Locally endemic infectious conditions do not appear to play a significant role in the cause of the disease.Item Breast cancer as seen in King Fahd University Hospital, Al-Khobar, 1983-1986(Journal of the Royal College of Surgeons of Edinburgh, 1989) Anim, J.T.; Sohaibani, M.O.; Grant, C.S.; Tamimi, D.No abstract available]Item Hyperplastic, premalignant and malignant lesions of the prostate gland(Annals of Saudi Medicine, 1999-07) Anim, J.T.; Sathar, S.A.; Bhatti, M.E.No abstract availableItem Nasopharyngeal carcinoma. A comparative study(Tropical and Geographical Medicine, 1991) Anim, J.T.; Kutty, M.K.; Sowayan, S.; Al-Sohaibani, M.O.No abstract availableItem Hypertension, cerebral vascular changes and stroke in Ghana. 1. Microaneurysm formation and stroke(Journal of Pathology, 1984) Anim, J.T.; Kofi, A.D.A modification of the post-mortem arteriographic technique of Ross Russell was used to study the brains of 284 consecutive autopsy cases dying from non-traumatic causes; and made up of 159 hypertensives and 125 normotensives. Microaneurysms were demonstrated in 30.8 per cent of the hypertensives compared with 9.6 per cent normotensives. Haemorrhagic stroke was the cause of death in 37.6 per cent of the hypertensives, the majority of which were in younger age groups compared with hypertensive strokes in whites. The much lower incidence of microaneurysms in the brain of black hypertensives (even those with haemorrhagic strokes) compared with that found by workers among white hypertensives further emphasized the different nature of hypertension in blacks. It is suggested that, in the absence of significant structural differences in the cerebral vasculature between blacks and whites, the high incidence of haemorrhagic strokes occurring in the relatively younger subjects in Ghana may be due to the direct effect of high blood pressures on small intracerebral vessels and that microaneurysm formation may not be as important as in the much older white subjects dying of haemorrhagic strokes.Item Benign disorders of the prostate: A histopathological study(Annals of Saudi Medicine, 1998) Anim, J.T.; Ebrahim, B.H.; Sathar, S.A.Although the medical literature contains adequate accounts of the pathophysiology of various benign prostatic disorders, it is often necessary to revisit these lesions, to reexamine the relationships between known benign lesions and more sinister, malignant disorders, in the light of new advances in our understanding of the processes. We carried out a histopathological review of prostatic surgical pathology material seen over a seven-year period in our hospital. Our findings show that benign enlargement of the prostate or benign prostatic hyperplasia (BPH) is initially fibromuscular in many cases, becoming glandulostromal with advancing age. While we found no relationship between prostatitis and age, individual gland necrosis tended to occur relatively early and correlated well with stromal repair, which we believe forms the basis of fibromuscular hyperplasia. Epithelial hyperplasia may result from glandular regeneration, and basal cell hyperplasia, papillary hyperplasia and cribriform hyperplasia all showed significant correlation with prostatic intraepithelial neoplasia (PIN). On the other hand, only cribriform hyperplasia showed correlation with atypical adenomatous hyperplasia (AAH), and also demonstrated an increase in incidence with advancing age. Our findings underline the positive relationships between benign events such as glandular necrosis with repair and epithelial hyperplasia, which may itself predispose to recognized premalignant lesions such as PIN.Item Tuberculosis of the tonsil revisited(West African Journal of Medicine, 1991) Anim, J.T.; Dawlatly, E.E.With the advent of effective antituberculous therapy and pasteurisation of cow's milk, there has been considerable reduction in the worldwide prevalence of tuberculosis. Although tuberculosis of the tonsil is now an uncommon finding, tonsillar granulomata are occasionally seen by histopathologists and rarely, some contain tuberculous organisms. One such case has prompted us to examine the tonsils of seventeen cases of open pulmonary tuberculosis complaining of sore throat, dysphagia or other pharyngeal symptoms. No granulomata were demonstrated in fourteen who yielded representative tonsillar tissue, underlining the rarity of association between secondary pulmonary tuberculosis and tonsillar involvement.Item Morphological alterations in the nasal mucosa in heat stroke(Journal of Environmental Pathology, Toxicology and Oncology, 1988) Anim, J.T.; Baraka, M.E.; Al-Gamdi, S.; Sohaibani, M.O.A preliminary histomorphological examination of the nasal mucosa of 8 heatstroke patients who presented without epistaxis, showed stromal vascular damage and degenerative changes in the basal lamina of the overlying epithelium, severe enough in two cases to indicate impending epistaxis, even in the absence of disseminated intravascular coagulation (DIC). It is suggested that direct damage by the extreme heat to mucosal structures, especially the prominent, thin-walled blood vessels, plays an important role in the genesis of epistaxis in heatstroke even in the absence of DIC.Item Pattern of atherosclerosis in a Ghanaian adult population: An autopsy study(African Journal of Medicine and Medical Sciences, 1987) Anim, J.T.A qualitative assessment of the degree of atherosclerotic involvement of six major arteries in 310 autopsies of Ghanaian adults revealed that atherosclerosis is less severe in Ghanaians compared to Caucasians. Atherosclerosis increases with age, more so in hypertensives, but severe lesions are not common in cerebral vessels in spite of the high mortality from haemorrhagic stroke in the adult Ghanaian. Severe atherosclerosis is, therefore, not important in the causation of cerebral haemorrhage. The small number of cerebral infarcts (six) is in keeping with the absence of severe atherosclerotic lesions in both extra cranial and intracranial large arteries. Absence of severe coronary lesions also parallels the low incidence of myocardial infarction and ischaemic heart disease in Ghanaians. Diabetes mellitus in combination with hypertension results in more severe atherosclerosis of the aorta and coronary arteries but the effect of diabetes mellitus alone requires further study.