Research Articles

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A research article reports the results of original research, assesses its contribution to the body of knowledge in a given area, and is published in a peer-reviewed scholarly journal. The faculty publications through published and on-going articles/researches are captured in this community

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Now showing 1 - 10 of 38
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    Carcinoma of the pancreas: A review of autopsy material at the Korle Bu Teaching Hospital for the period 1972-1981.
    (Ghana Medical Journal, 1988-06) Dankwa, K.E.; Anim, J.T.
    A retrospective study of autopsies has been carried out and this shows the death rate from pancreatic carcinoma to be 5.8% of all cancer deaths in the Korle Bu Teaching Hospital Mortuary between the period 1972-1981. This relatively high incidence would lend support to findings of other studies which indicate that the disease is more common in US blacks and some parts of Africa. The high case fatality rate as found in our hospital-based cancer registry coupled with the increasing trend in females in recent years indicate that the disease requires a closer study from the point of view of aetiology and natural history in Ghana. The greater preference to the head of the pancreas would obviously pose problems to effective management
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    Percutaneous pericardial biopsy: Technique, efficacy, safety, and value in the management of pericardial effusion in children and adolescents
    (Pediatric Cardiology, 1997-11) Uthaman, B.; Endrys, J.; Abushaban, L.; Khan, S.; Anim, J.T.
    This study describes our technique of nonsurgical percutaneous pericardial biopsy (PPB) its efficacy and safety, and its diagnostic and therapeutic usefulness in the management of pericardial effusion (PE) in children and adolescents. In an 8-year period, 19 selected patients, aged 2 to 20 years, had PPB for evaluation and treatment of PE. Using this procedure we procured multiple biopsy specimens from various areas of the thickened parietal pericardium, and also procured pericardial fluid for investigation. The biopsy material helped establish a specific etiologic diagnosis in 63% and helped II exclude tuberculosis and malignancy in the rest (37%). The histopathologic diagnoses were tuberculous pericarditis (37%) uremic pericarditis (16%) radiation pericarditis (5%), connective tissue disease (5%), and idiopathic pericarditis (37%). In tuberculous pericarditis, the biopsy specimen provided an immediate histopathologic diagnosis and a higher culture positivity (71%) than pericardial fluid (29%). In addition the procedure was therapeutically effective in relieving tamponade and in treating effusion. Our experience indicates that the PPB procedure has both diagnostic and therapeutic value and it can be performed easily, safely, and without complications even in small children.
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    Atrophic gastritis and intestinal metaplasia in helicobacter pylori-associated antral gastritis
    (Medical Principles and Practice, 1996-02) Sakar, C.; Anim, J.T.; Ibrahim, B.H.
    Although the causal relationship between Helicobacter pylori (H. pylori) infection and chronic gastritis and peptic ulcer disease appears established, the relationship between the organism and gastric carcinoma remains tenuous. We have reviewed 268 gastric antral biopsies from the Department of Pathology, Mubarak Al-Kabeer Hospital, Kuwait, in an attempt to assess the relationship between H. pylori colonizations and the presence of atrophic gastritis and intestinal metaplasia, recognized premalignant lesions of the stomach. H. pylori were found in 219 (81.7%) patients of which 62 (28.3%) had atrophic gastritis and 33 (15.1%) intestinal metaplasia. Both atrophic gastritis and intestinal metaplasia increased with age. The mean age of patients with intestinal metaplasia was about 8 years older than that of patients without intestinal metaplasia. Higher prevalences of both lesions were associated with lower density H. pylori colonization as well as an increasing grade of chronic inflammation. Our results confirm previous findings of a probable causal relationship between H. pylori infection and both atrophic gastritis and intestinal metaplasia. The higher prevalence of these premalignant lesions in older subjects would suggest progressive changes associated with persistent H. pylori infection.
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    Cancer of the breast in Accra
    (Ghana Medical Journal, 1980) Quartey-Papafio, J.B.; Anim, J.T.
    No abstract available
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    The dialysed patient with both Castleman disease and Kaposi sarcoma
    (Nephrology Dialysis Transplantation, 1998-09) Nampoory, M.R.N.; Johny, K.V.; Sakar, C.; Al-Masry, I.; Al-Hilali, N.; Anim, J.T.
    No abstract available
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    Histiocytic necrotising lymphadenitis (Kikuchi-Fujimoto disease) in Saudi Arabia
    (Tropical and Geographical Medicine, 1991) Kutty, M.K.; Anim, J.T.; Sowayan, S.
    No abstract available
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    Schonlein-henoch syndrome and acute appendicitis in childhood
    (Journal of the Royal College of Surgeons of Edinburgh, 1988) Knox-Macaulay, H.; Grant, C.S.; Salem, A.; Anim, J.T.
    No abstract available
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    Endocarditis due to aspergillus flavus
    (Mycoses, 1997) Khan, Z.U.; Sanyal, S.C.; Mokaddas, E.; Vislocky, I.; Anim, J.T.; Salama, A.L.; Shuhaiber, H.
    Fungal endocarditis has emerged as an important complication of patients undergoing cardiovascular surgery. Our patient had no past history of cardiac surgery, intravenous drug abuse or immunosuppressive therapy. He had received broad-spectrum antibiotics for varying periods, which might have predisposed him to this infection. The diagnosis was based on the demonstration of hyaline, septate branched fungal elements in the infected valvular tissue and isolation of Aspergillus flavus in culture. The delay in establishing the ante-mortem diagnosis because of repeatedly negative blood cultures, presence of disseminated intravascular coagulopathy and rapidly deteriorating kidney function were the major factors contributing to his poor prognosis and death, despite surgical removal of infected valves and antifungal therapy. This is the first report of endocarditis due to A. flavus from the Middle East.
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    Abdominal tuberculosis: A frequent diagnostic challenge
    (Annals of Tropical Medicine and Parasitology, 1985-04) Ibrahim, E.M.; Anim, J.T.; Al-Idrissi, H.; Al Mohaya, S.; Al Dossary, J.; Grant, C.S.
    In recent years, abdominal tuberculosis has become rare in many countries even where pulmonary tuberculosis still exists. A case of abdominal tuberculosis is described in a young male who presented with non-specific symptoms together with CT scan findings that simulated abdominal lymphoma. Diagnosis was established during abdominal exploration. The frequency of various presenting manifestations of abdominal tuberculosis are discussed. The report emphasizes the need for a high index of suspicion to save patients unnecessary exploratory laparatomy.
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    Helicobacter pylori-associated chronic antral gastritis in Kuwait - A histopathological study
    (Annals of Saudi Medicine, 1995) Ibrahim, B.H.; Anim, J.T.; Sakar, C.
    In order to study the causal relationship between Helicobacter pylori (HP) and various inflammatory reactions in gastric antral mucosa, we have reviewed 268 endoscopic gastric biopsies in the Department of Pathology of Mubarak Al-Kabeer Teaching Hospital in Kuwait. Of the 219 HP-positive biopsies, 95.4% showed chronic gastritis (CG), 59.8% active chronic gastritis (ACG) and 78.5% lymphoid hyperplasia (LH). The prevalence of LH, CG or ACG, either alone or in combination, increased with increasing density (grade) of HP colonization, assuming statistical significance for LH and ACG (P < 0.05), especially when these changes in Grade 1 HP cases were compared to those of Grades 2 and 3 combined. Moreover, the grade of LH by itself also showed statistically significant correlation (P < 0.01) with the grade of inflammation. Our results confirm a causal relationship between HP colonization of gastric mucosa and the various forms of gastritis, and also provide evidence in support of induction of mucosa-associated lymphoid tissue (MALT) by HP, an observation which may have significance in the genesis of gastric MALTomas.