Research Articles
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A research article reports the results of original research, assesses its contribution to the body of knowledge in a given area, and is published in a peer-reviewed scholarly journal. The faculty publications through published and on-going articles/researches are captured in this community
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Item High dose cyclophosphamide in drug resistant and relapsing Burkitt's lymphoma.(Ghana Medical Journal, 1979) Nkrumah, F.K.; Biggar, R.J.Item Acute infectious lymphocytosis.(Lancet, 1973) Nkrumah, F.K.; Addy, P.A.Item Presenting clinical features of Burkitt's lymphoma in Ghana, West Africa.(Journal of Tropical Pediatrics and Environmental Child Health, 1979) Biggar, R.J.; Nkrumah, F.K.; Perkins, I.V.Item Severe intestinal haemorrhage due to hookworm infection.(Ghana Medical Journal, 1976) Annobil, S.H.; Nkrumah, F.K.Item Haemoglobin K Woolwich (alpha 2, beta 2 132 lysine leads to glutamine) in Ghana.(Acta Haematologica, 1971) Ringelhann, B.; Konotey-Ahulu, F.I.; Talapatra, N.C.; Nkrumah, F.K.; Wiltshire, B.G.; Lehmann, H.A fast moving haemoglobin, K Woolwich, was found in patients admitted to Korle Bu Teaching Hospital, Accra, and in members of 2 tribes which live in different regions of Ghana and differ linguistically and ethnically. Although haemoglobin K Woolwich is the third most common abnormal haemoglobin in Ghana, it has not yet been found except in these tribes. This is possibly due to the difficulty in detecting the haemoglobin variant in the presence of haemoglobin A. It would be interesting to examine the amino-acid sequence of cases of ‘haemoglobin K’ reported from other parts of West and North Africa, in order to determine whether they are cases of haemoglobin K Woolwich. This may throw light on genetic links and migration routes of tribes in West Africa.Item Immunity to plasmodium berghei yoelii in mice. II. specific and nonspecific cellular and humoral responses during the course of infection(Journal of Immunology, 1978) Weinbaum, F.I.; Weintraub, J; Nkrumah, F.K.; Evans, C.B.; Tigelaar, R.E.; Rosenberg, Y.J.The kinetics of various specific and nonspecific immunologic responses were examined in BALB/c mice infected with 17X nonlethal Plasmodium berghei yoelii (a self-limiting infection). The sequence of events after infection was characterized by rapid sensitization of splenic T cells to malaria antigen and polyclonal B cell activation, followed by a period of depressed splenic proliferative responses in vitro to mitogens (PHA and LPS) and malaria (specific) antigen. At the same time, suppressed primary in vitro splenic PFC responses to trinitrophenyl-aminoethylcarbamylmethyl-Ficoll (TNP-F) were seen. This suppression was an active process requiring adherent cells. During this period, levels of antimalarial antibody also increased exponentially. As the infection was cleared, splenic malaria antigen-specific proliferative responses were again observed and splenic PFC and in vitro mitogen responses returned to preinfection levels after variable periods of time. Both splenic proliferative responses to malaria antigen and antimalarial antibody responses remained persistently elevated. In addition, some responses were examined in mice infected with 17X lethal P.b. yoelii (a fatal infection); in comparison to the early responses of mice infected with the nonlethal substrain, there was a decrease and delay in the development of a splenic T cell response to malaria antigen and a blunted antimalarial antibody response.Item Survival of burkitt's lymphoma patients in Ghana(British Journal of Cancer, 1971) Wosornu, J.L.; Nkrumah, F.K.; Perkins, I.V.Of 141 suspected cases of Burkitt's lymphoma referred from all over Ghana between November 1965 and June 30, 1969, the diagnosis of Burkitt's lymphoma was confirmed histologically in 60. This report deals with survival of all 50 treated and evaluable cases. The overall estimated long term survival rate was 38·5% calculated actuarially. It was 63·2% for Stage I (10 of 18); 20·0% for Stage II (2 of 10); and 25·4% for Stages III and IV combined (3 of 22), thus confirming the value of staging as a rough guide to prognosis. Six Stage I patients who died all had large tumors. These results have been compared with a similar study by Morrow et al. (1967) from Uganda.Item Evaluation of CCNU (NSC 79037) used for the prevention of CNS involvement in burkitt's lymphoma(Cancer chemotherapy reports, 1975) Ziegler, J.L.; Magrath, I.T.; Nkrumah, F.K.; Perkins, I.V.; Simon, RItem Fibrin-degradation products in cerebral malaria.(Lancet, 1972) Reid, H.A.; Nkrumah, F.K.The serum concentrations of fibrin-degradation products (F.D.P.) were estimated in twenty-five patients with falciparum malaria. Cerebral features were present in nine of the seventeen Ghanaian children studied in Accra, and in one of eight adults observed in England. High levels of F.D.P. were found in all ten patients with cerebral malaria; in the fifteen patients without cerebral symptoms, F.D.P. levels were usually normal.Item Variable clinical expression of homozygous beta thalassaemia in a Ghanaian family.(Ghana Medical Journal, 1975) Nkrumah, F.K.; Yawson, G.I.In spite of the relatively high frequency of beta thalassemia genes in some African populations, reported cases of homozygous beta thalassemia are rare. A Ghanaian family is presented in which 3 siblings have the hematological findings and the necessary genetic background compatible with the diagnosis of homozygous beta thalassemia. The propositus has a clinically severe disease with transfusion dependency (thalassemia major) while the disease in the other 2 siblings appears to be clinically much milder (thalassemia intermedia). It is suggested that other genetic factors may be responsible for the variable clinical expression of the disease in this family. Documentation and follow up of more cases of homozygous beta thalassemia will greatly help to delineate the clinical and genetic patterns of the disease in Africa.
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