Department of Philosophy and Classics
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Item WHO guidance on COVID-19 vaccine trial designs in the context of authorized COVID-19 vaccines and expanding global access: Ethical considerations(Vaccine, 2022) Singh, J.A.; Kochhar, S.; Wolff, J.; Atuire, C.; Bhan, A.; Emanuel, E.; Faden, R.; Ghimire, P.; Greco, D.; Ho, C.; Moon, S.; Shamsi-Gooshki, E.; Touré, A.; Thomé, B.; Smith, M.J.; Upshur, R.E.G.While the degree of COVID-19 vaccine accessibility and uptake varies at both national and global levels, increasing vaccination coverage raises questions regarding the standard of prevention that ought to apply to different settings where COVID-19 vaccine trials are hosted. A WHO Expert Group has developed guidance on the ethical implications of conducting placebo-controlled trials in the context of expanding global COVID-19 vaccine coverage. The guidance also considers alternative trial designs to placebo controlled trials in the context of prototype vaccines, modified vaccines, and next generation vaccines