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Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated plasmodium falciparum malaria.

Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated plasmodium falciparum malaria.

Jensen, A. T. R.; Zornig, H. D.; Buhmann, C.; Salanti, A.; Koram, K. A.; Riley, E. M.; Theander, T.G.; Hviid, L.; Staalsoe, T.
URI: http://197.255.68.203/handle/123456789/4219
Date: 2003-07

Abstract:

Gender-specific and parity-dependent acquired antibody recognition is characteristic of variant surface antigens (VSA) expressed by chondroitin sulfate A (CSA)-adherent Plasmodium falciparum involved in pregnancy-associated malaria (PAM). However, antibody recognition of recombinant products of a specific VSA gene (2O2var1) implicated in PAM and transcribed by a CSA-adhering parasite line did not have these characteristics. Furthermore, we could not demonstrate preferential transcription of 2O2var1 in the CSA-adhering line versus the unselected, parental isolate. Our data call for circumspection regarding the molecular identity of the parasite ligand mediating adhesion to CSA in PAM.

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  • Epidemiology Department [281]
    The Epidemiology Department contributes to the mission of the institute through basic and applied epidemiological research on, but not limited to, malaria and other diseases of public health importance. It is also home to the Social Science Unit of the Institute, including the Health Support Centre for HIV/AIDS and other communicable and noncommunicable health problems.

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