Abstract:
The an t. i - d i a b&t i c pr oper t ies of f .1 9 von oide: -x 11 a : te :i f roid
B.r.idj!_l.i.a f.&rj:_a￡Li. a p 1 sn t uged 3 1 Ihe 0 en f: r e For Sc 1 ,-n t i f ie
Re s e a r c h I n t o F1 an t Medicine (C S RP M ) t o t r e a. t cl i ab e t e s , were
vvaluated using streptozotocin -induced d iabet io :ni0e 10
represent insulin dependent diabetes mellitus (I DDK; arid
genetically diabetic mice to represent non- ins;.! I in dependent
i i ab e t es ;ri e 11 i t u s (NTDDM ) A 1 s o an a I y z ed wa s the ef f e r_-1 c f
r extra c 1: 0 n t h e re d u c t ion of 1 i v e r m i c r 0 s 0 in a 1 p r 0 t ? :l r 1 f. . . The
possible side■-effeets of the f 1 avon0 id ex1 1 ac-1 01i 1 i ve r and
. Jn ey fun c t i on 5 were also ex am in ed . T he t e- s t an i n; n Is were
.riven intraperitonea 1 injection of the flavonoid extract
dissolved in 0.35% sa 1 in e ,=• o 1 u t i on w l'i i 1 s t t he on t r u 1 s were
• i veri 0.85% saline solution w i t h ou t 11"; e 0x t r ac t . 'j' h e r rju Its
3 h 0 w e d t h a t t h e f 13 v 0 n 0 i d e 11 a c t w a s n 01 i; y p o ,e. 3 y c 3 e m i o a s i t
3.;i no ef f eo t on t he p 1 asraa glucose levels nf n jn • d j abe tic
■nice . A11 h 0 u g h the ext r a c t d i d n o t p r e v en t t h e d e v e ! o p in en t o f
y erglyc s em i a in t he TDDM r.iod e 1 af t er t. he ST1 in j e t i on . i t
' *J r educe the non • f ast ing p 1 asma gIu00se levels si.eni -
i an 11 y . w h erea s s u >:h e f f e c t o n f a s 1: i r j g 10 v ■; 1 w a s a I s n t 01 •
''101 signif ioant. In the cnee of the HIDDH m■: *.• 1 tii^ x '• v3.01
■j e c r e as e d signifies r-1L y t h e n c ■ > s - f a s l.. j r 1 c. y \ .a, :i-; ! 1 <. ^ - f >.•1
. about but thf;i e u n j.c < i,|ie
. ting p J a s rii a g 1 u c o s e . T h e 7- e s u .11 s t I <•> z:; o iv e ■! < b , 1 • i j ' h e
s s t a ri i 111 a 1 s :i 1 j b c I: h ]. DDM u i: d f 11D D f 1 m fit L::: , 1,;--j. , w ≪., ^ /\ [) p f;
y ■'.o0 hr Gine V 3 !>Ci r ed n L a e ar• K i v i I, y an !..!,■;■:?■ i.: •. ! s ,
■. 11 hong h b <:• I: h t e s t ? n - J 0 - j n t r 0 I r- 11 - •' j ■■■ s 11 - -• r 0 !- \ * i \ v e r ; o s o in a 1 p r o I:, e i n o T he re s u 11 s i n d i c a t e t !'i at, the
I avono ids , wh ioh are not hypog1 y c ae m ic , redu c-e pos t pr a n d i a 1
P asEta glucose levels in d iabet ic pa ti en ts . There is also an
indication that t h e y red u c e the ac t i v i t y o f d r ug met ab o J. i s in g
•res, probably the ones involving the cytochrome F450DM
. j.jiryme. t?u toxic side-effects on the liver and kidney were
!' rved.
