Molecular genetic studies of Anopheles stephensi in Pakistan

Show simple item record Ali, N. Hume, J.C. Dadzie, S.K. Donnelly, M.J. 2012-05-03T13:37:02Z 2017-10-16T13:11:22Z 2012-05-03T13:37:02Z 2017-10-16T13:11:22Z 2007
dc.description.abstract Anopheles stephensi Liston s.l. (Diptera: Culicidae) is one of the major vectors of malaria in Pakistan, India, Iran and Afghanistan. In parts of its range this species has shown increases in both relative and absolute abundance in what is hypothesized to be a response to human-mediated environmental change resulting from extensive irrigation. We attempted to detect the molecular genetic signatures of this population instability based on three samples obtained from two villages (149/6R and 111/6R) within an irrigation zone in Punjab Province and from one village (Azakhel) outside the irrigation scheme in Northwest Frontier Province (NWFP), Pakistan, using seven microsatellite loci and 682 basepairs of the mitochondrial CO1 gene. For microsatellite loci, high levels of genetic diversity were observed within populations (mean alleles per locus 10.71-11.57; mean heterozygosity 0.703-0.733). Deviation from Hardy-Weinberg expectations was observed for only two microsatellite loci in 21 tests. No genetic differentiation was observed between populations and average pairwise F(ST) values did not differ significantly from zero for any population pair or either marker system. Tests of population expansion for both mitochondrial and microsatellite loci were inconclusive. en_US
dc.language.iso en en_US
dc.publisher Medical and Veterinary Entomology 21(3): 265-9 en_US
dc.subject Anopheles stephensi en_US
dc.subject Malaria vector en_US
dc.subject Microsatellite loci en_US
dc.subject mtDNA en_US
dc.subject Population structure en_US
dc.subject Pakistan en_US
dc.title Molecular genetic studies of Anopheles stephensi in Pakistan en_US
dc.type Article en_US

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

  • Parasitology Department [253]
    The Department of Parasitology conducts research into parasitic diseases of public health importance with the overall goal of reducing their transmission and the heavy disease burden that they impose on affected populations. The Department maintains focus on parasitic diseases in general. These include major diseases such as malaria, and others listed under the Neglected Tropical Diseases (NTD) control initiative such as, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, trypanosomiasis and leishmaniasis.

Show simple item record

Search UGSpace


My Account