Impact of treating young children with antimalarials with or without antibiotics on morbidity: A cluster-randomized controlled trial in ghana

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dc.contributor.author Chinbuah, M.A.
dc.contributor.author Adjuik, M.
dc.contributor.author Cobelens, F.
dc.contributor.author Koram, K.A.
dc.contributor.author Abbey, M.
dc.contributor.author Gyapong, M.
dc.contributor.author Kager, P.A.
dc.contributor.author Gyapong, J.O.
dc.date.accessioned 2013-10-09T13:53:11Z
dc.date.accessioned 2017-10-16T12:35:35Z
dc.date.available 2013-10-09T13:53:11Z
dc.date.available 2017-10-16T12:35:35Z
dc.date.issued 2013-09
dc.identifier.citation Chinbuah, M. A., Adjuik, M., Cobelens, F., Koram, K. A., Abbey, M., Gyapong, M., . . . Gyapong, J. O. (2013). Impact of treating young children with antimalarials with or without antibiotics on morbidity: A cluster-randomized controlled trial in ghana. International Health, 5(3), 228-235. en_US
dc.identifier.issn 18763413
dc.identifier.uri http://197.255.68.203/handle/123456789/4419
dc.description.abstract Background: Community health workers in Dangme-West district, Ghana, treated children aged 2-59 months with fever with either artesunate-amodiaquine (AAQ) or AAQ plus amoxicillin (AAQ + AMX) within a clusterrandomized controlled trial (registration no. TDR/UNDP Trial registration A: 20189). The intervention was introduced in a stepped-wedge manner. The aim of the study was reduction of mortality. This paper reports on the reduction of morbidity, notably anaemia, severe anaemia and severe illness. Clusters of 100 children were randomized in to AAQ, AAQ + AMX and pre-intervention arms. Six months later the pre-intervention clusters were randomized in to the AAQ and AAQ + AMX arms. Methods: Data were collected in eight cross-sectional surveys. Using stratified sampling, 10 clusters were randomly selected per survey. Blood samples were taken to assess haemoglobin. Caregivers were interviewed about diseases (signs and symptoms) among their children in the preceding 14 days. Multivariate logistic regression analysis was used to determine the impact on anaemia, severe anaemia and severe illness. Results: Compared with the pre-intervention clusters, anaemia was reduced in the AAQ (OR=0.20, 95% CI 0.12-0.33) and AAQ+ AMX (OR=0.23, 95% CI 0.15-0.36) clusters, severe anaemia was reduced in the AAQ (OR=0.20, 95% CI 0.09-0.45) and AAQ+ AMX (OR=0.12, 95% CI 0.04-0.31) clusters and severe illness was reduced in the AAQ (OR=0.46, 95% CI 0.26-0.80) and AAQ+ AMX (OR= 0.38, 95% CI 0.22-0.63) clusters. No significant differences were found in outcome variables between the AAQ and AAQ+ AMX clusters. Conclusions: Treating fever with antimalarials significantly reduced the prevalence of anaemia, severe anaemia and severe illness.We found no significant reduction in outcomes when the AAQ and AAQ+AMX clusters were compared. en_US
dc.language.iso en en_US
dc.publisher Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. en_US
dc.subject Amoxicillin; Anaemia; Artesunate; Children; Community; Fever en_US
dc.title Impact of treating young children with antimalarials with or without antibiotics on morbidity: A cluster-randomized controlled trial in ghana en_US
dc.type Article en_US


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