Influence of morbidity on serum retinol of children in a community-based study in northern Ghana

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dc.contributor.author Filteau, S.M.
dc.contributor.author Morris, S.S.
dc.contributor.author Abbott, R.A.
dc.contributor.author Tomkins, A.M.
dc.contributor.author Kirkwood, B.R.
dc.contributor.author Arthur, P.
dc.contributor.author Ross, D.A.
dc.contributor.author Gyapong, J.O.
dc.contributor.author Raynes, J.G.
dc.date.accessioned 2013-09-27T12:06:12Z
dc.date.accessioned 2017-10-16T12:30:55Z
dc.date.available 2013-09-27T12:06:12Z
dc.date.available 2017-10-16T12:30:55Z
dc.date.issued 1993
dc.identifier.citation Filteau, S. M., Morris, S. S., Abbott, R. A., Tomkins, A. M., Kirkwood, B. R., Arthur, P., . . . Raynes, J. G. (1993). Influence of morbidity on serum retinol of children in a community-based study in northern ghana. American Journal of Clinical Nutrition, 58(2), 192-197. en_US
dc.identifier.issn 00029165
dc.identifier.uri http://197.255.68.203/handle/123456789/4390
dc.description.abstract Serum retinol concentrations decrease during illness and thus may not accurately reflect the vitamin A status of populations with a high prevalence of illness. To quantify the contribution of illness to low serum retinol in a field study of children aged 6-59 mo in northern Ghana, serum retinol values were compared with two indicators of recent illness: symptoms reported by parents and acute-phase protein concentrations in serum. Serum retinol was not associated with symptoms of illness but showed a significant negative correlation with both α 1-acid glycoprotein (AGP) and serum amyloid A (SAA). Elevated AGP was associated with a 24% decrease in mean serum retinol. A large proportion of asymptomatic children had elevated AGP or SAA concentrations, suggesting that subclinical infections may have had important effects on serum retinol. A significant negative correlation between malaria parasite density and serum retinol indicated that malaria may have been one of the subclinical infections responsible. Measurement of AGP may improve interpretation of serum retinol data from populations with a high prevalence of morbidity. en_US
dc.language.iso en en_US
dc.subject EMTREE drug terms: orosomucoid; retinol; serum amyloid a en_US
dc.subject EMTREE medical terms: article; human; infant; infection; major clinical study; malaria; morbidity; nutritional status; parasitemia; population research; preschool child; prevalence; priority journal; retinol deficiency; symptomatology; vitamin blood level; vitamin intake en_US
dc.subject MeSH: Amyloid Protein SAA; Child, Preschool; Double-Blind Method; Fever; Ghana; Health Status; Human; Infant; Infection; Malaria; Morbidity; Orosomucoid; Prevalence; Rural Population; Support, Non-U.S. Gov't; Vitamin A; Vitamin A Deficiency; Vomiting en_US
dc.title Influence of morbidity on serum retinol of children in a community-based study in northern Ghana en_US
dc.type Article en_US


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