In search of susceptibility genes for type 2 diabetes in west africa: The design and results of the first phase of the AADM study

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dc.contributor.author Rotimi, C.N.
dc.contributor.author Dunston, G.M.
dc.contributor.author Berg, K.
dc.contributor.author Akinsete, O.
dc.contributor.author Amoah, A.
dc.contributor.author Owusu, S.
dc.contributor.author Acheampong, J.
dc.contributor.author Boateng, K.
dc.contributor.author Oli, J.
dc.contributor.author Okafor, G.
dc.contributor.author Onyenekwe, B.
dc.contributor.author Osotimehin, B.
dc.contributor.author Abbiyesuku, F.
dc.contributor.author Johnson, T.
dc.contributor.author Fasanmade, O.
dc.contributor.author Furbert-Harris, P.
dc.contributor.author Kittles, R.
dc.contributor.author Vekich, M.
dc.contributor.author Adegoke, O.
dc.contributor.author Bonney, G.
dc.contributor.author Collins, F.
dc.date.accessioned 2013-06-27T12:20:23Z
dc.date.accessioned 2017-10-19T11:57:53Z
dc.date.available 2013-06-27T12:20:23Z
dc.date.available 2017-10-19T11:57:53Z
dc.date.issued 2001
dc.identifier.citation Rotimi, C. N., Dunston, G. M., Berg, K., Akinsete, O., Amoah, A., Owusu, S., . . . Collins, F. (2001). In search of susceptibility genes for type 2 diabetes in west africa: The design and results of the first phase of the AADM study. Annals of Epidemiology, 11(1), 51-58 en_US
dc.identifier.issn 10472797
dc.identifier.uri http://197.255.68.203/handle/123456789/4258
dc.description.abstract PURPOSE: The purpose of this study is to map type 2 diabetes susceptibility genes in West African ancestral populations of African-Americans, through an international collaboration between West African and US investigators. DESIGN AND METHODS: Affected sib-pairs (ASP) along with unaffected spouse controls are being enrolled and examined in West Africa, with two sites established in Ghana (Accra and Kumasi) and three in Nigeria (Enugu, Ibadan, and Lagos). Eligible participants are invited to study clinics to obtain detailed epidemiologic, family, and medical history information. Blood samples are drawn from each participant to measure glucose, insulin, C-peptide, total cholesterol, LDL, HDL, triglycerides, albumin, creatinine, urea, uric acid, total calcium and to detect autoantibodies to glutamic acid decarboxylase (GAD). DNA is isolated from frozen white blood cells obtained from 20 ml of EDTA whole blood samples. RESULTS: With full informed consent, 162 individuals from 78 families have been enrolled and examined since the Africa America Diabetes Mellitus (AADM) study began in June of 1997. Logistics of field examinations and specimen shipping have been successfully established. At the end of the third year of field activity (September 2000) the AADM study will have enrolled and performed comprehensive examination on 400 ASP with type 2 diabetes, for a minimum of 800 cases and 200 controls from Ghana and Nigeria. At the current participation rate, the goal of 400 sib-pairs and 200 controls will be met before the scheduled closing date. CONCLUSIONS: The AADM study will create a comprehensive epidemiologic and genetic resource that will facilitate a powerful genome-wide search for West African susceptibility genes to type 2 diabetes. en_US
dc.language.iso en en_US
dc.publisher Annals of Epidemiology en_US
dc.subject Genes en_US
dc.subject Linkage en_US
dc.subject Sib-Pairs en_US
dc.subject Type 2 diabetes en_US
dc.subject West Africa en_US
dc.title In search of susceptibility genes for type 2 diabetes in west africa: The design and results of the first phase of the AADM study en_US
dc.type Article en_US


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