HLA-DRB1*04 allele is associated with severe malaria in northern Ghana.

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dc.contributor.author Osafo-Addo, A.D.
dc.contributor.author Koram, K.A.
dc.contributor.author Oduro, A.R.
dc.contributor.author Wilson, M.
dc.contributor.author Hodgson, A.
dc.contributor.author Rogers, W.O.
dc.date.accessioned 2013-06-27T10:41:54Z
dc.date.accessioned 2017-10-16T13:03:49Z
dc.date.available 2013-06-27T10:41:54Z
dc.date.available 2017-10-16T13:03:49Z
dc.date.issued 2008
dc.identifier.citation Osafo-Addo, A. D., Koram, K. A., Oduro, A. R., Wilson, M., Hodgson, A., & Rogers, W. O. (2008). HLA-DRB1*04 allele is associated with severe malaria in northern Ghana. American Journal of Tropical Medicine and Hygiene, 78(2), 251-255. en_US
dc.description.abstract Several associations between specific HLA alleles and susceptibility or resistance to Plasmodium falciparum malaria have been previously reported, but no associations have been confirmed in multiple populations. We studied associations between HLA-A, -B, and DRB1 alleles and severe malaria in northern Ghana. We analyzed HLA-DRB1*04 in 4,032 subjects from a severe malaria case-control study, 790 severe malaria cases, 1,611 mild malaria controls, and 1631 asymptomatic controls. The presence of HLA-DRB1*04 was associated with severe malaria (OR = 2.42, 95% CI = 1.64, 3.58). The allele frequency of DRB1*04 was similar in the two major ethnic groups in the study population, Kassem (4.4%) and Nankam (4.7%), and the OR for the association between DRB1*04 and severe malaria was similar in both ethnic groups. These findings are consistent with results from Gabon suggesting that DRB1*04 is a risk factor for severe malaria. en_US
dc.language.iso en en_US
dc.title HLA-DRB1*04 allele is associated with severe malaria in northern Ghana. en_US
dc.type Article en_US

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  • Epidemiology Department [262]
    The Epidemiology Department contributes to the mission of the institute through basic and applied epidemiological research on, but not limited to, malaria and other diseases of public health importance. It is also home to the Social Science Unit of the Institute, including the Health Support Centre for HIV/AIDS and other communicable and noncommunicable health problems.

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