Calpain-10 gene polymorphisms and type 2 diabetes in West Africans: The Africa America Diabetes Mellitus (AADM) Study

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dc.contributor.author Chen, Y.
dc.contributor.author Kittles, R.
dc.contributor.author Zhou, J.
dc.contributor.author Chen, G.
dc.contributor.author Adeyemo, A.
dc.contributor.author Panguluri, R.K.
dc.contributor.author Chen, W.
dc.contributor.author Amoah, A.
dc.contributor.author Opoku, V.
dc.contributor.author Acheampong, J.
dc.contributor.author Agyenim-Boateng, K.
dc.contributor.author Eghan Jr., B.A.
dc.contributor.author Nyantaki, A.
dc.contributor.author Oli, J.
dc.contributor.author Okafor, G.
dc.contributor.author Ofeogbu, E.
dc.contributor.author Osotimehin, B.
dc.contributor.author Abbiyesuku, F.
dc.contributor.author Johnson, T.
dc.contributor.author Fasanmade, O.
dc.contributor.author Rufus, T.
dc.contributor.author Furbert-Harris, P.
dc.contributor.author Daniel, H.I.
dc.contributor.author Berg, K.A.
dc.contributor.author Collins, F.S.
dc.contributor.author Dunston, G.M.
dc.contributor.author Rotimi, C.N.
dc.date.accessioned 2013-06-26T21:17:04Z
dc.date.accessioned 2017-10-19T11:59:17Z
dc.date.available 2013-06-26T21:17:04Z
dc.date.available 2017-10-19T11:59:17Z
dc.date.issued 2005-02
dc.identifier.citation Chen, Y., Kittles, R., Zhou, J., Chen, G., Amaoh, A. G., Panguluri, R. K., . . . Rotimi, C. N. (2005). Calpain-10 gene polymorphisms and type 2 diabetes in west africans: The africa america diabetes mellitus (AADM) study. Annals of Epidemiology, 15(2), 153-159 en_US
dc.identifier.issn 10472797
dc.identifier.uri http://197.255.68.203/handle/123456789/4235
dc.description.abstract To investigate whether the three single nucleotide polymorphisms (SNPs), SNP-43, -56, and -63 of CAPN10 were associated with type 2 diabetes in a West African cohort. A total of 347 diabetic subjects and 148 unaffected controls from four ethnic groups in two West African countries were enrolled in this study. After genotyping three SNPs of CAPN10 and one SNP from CYP19, the allele, genotype, and haplotype frequencies as well as the odds ratios were calculated to test their association with type 2 diabetes. None of the alleles or genotypes was associated with type 2 diabetes. Although statistical analysis indicated that haplotype 221 was associated with type 2 diabetes (OR, 3.765; 95% CI, 1.577-8.989) in the two ethnic groups of Nigeria, the same haplotype did not show any association with type 2 diabetes in the two ethnic groups in Ghana (OR, 0.906; 95% CI, 0.322-2.552). Considering the relatively low frequency of haplotype 221 and that none of the haplotypes including 221 was associated with any of the diabetes-related quantitative traits tested, it is concluded that SNP-43, -56, and -63 of the CAPN10 gene variants may play a limited role in the risk of type 2 diabetes risks in this cohort of West Africans. en_US
dc.language.iso en en_US
dc.publisher Annals of Epidemiology en_US
dc.subject Calpain-10 en_US
dc.subject Insulin en_US
dc.subject SNP-43 en_US
dc.subject Type 2 Diabetes en_US
dc.subject West Africa en_US
dc.title Calpain-10 gene polymorphisms and type 2 diabetes in West Africans: The Africa America Diabetes Mellitus (AADM) Study en_US
dc.type Article en_US


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