Genome-wide search for susceptibility genes to type 2 diabetes in West Africans: Potential role of C-peptide

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dc.contributor.author Chen, G.
dc.contributor.author Adeyemo, A.
dc.contributor.author Zhou, J.
dc.contributor.author Chen, Y.
dc.contributor.author Huang, H.
dc.contributor.author Doumatey, A.
dc.contributor.author Lashley, K.
dc.contributor.author Agyenim-Boateng, K.
dc.contributor.author Eghan Jr., B.A.
dc.contributor.author Acheampong, J.
dc.contributor.author Fasanmade, O.
dc.contributor.author Johnson, T.
dc.contributor.author Okafor, G.
dc.contributor.author Oli, J.
dc.contributor.author Amoah, A.
dc.contributor.author Rotimi, C.
dc.date.accessioned 2013-06-26T20:49:22Z
dc.date.accessioned 2017-10-19T11:59:11Z
dc.date.available 2013-06-26T20:49:22Z
dc.date.available 2017-10-19T11:59:11Z
dc.date.issued 2007-12
dc.identifier.citation Chen, G., Adeyemo, A., Amoah, A., Chen, Y., Huang, H., Doumatey, A., . . . Rotimi, C. (2007). Genome-wide search for susceptibility genes to type 2 diabetes in west africans: Potential role of C-peptide. Diabetes Research and Clinical Practice, 78(3), e1-e6 en_US
dc.identifier.issn 01688227
dc.identifier.uri http://197.255.68.203/handle/123456789/4232
dc.description.abstract C-peptide is a substance that the pancreas releases into the circulation in equimolar amounts to insulin and has demonstrated important physiological effects which relate to the vascular field, in particular the microcirculation. For this analysis, we included 321 full and 36 half sibling pairs affected with type 2 diabetes (T2D) from West Africa. A genome-wide panel of 390 tri-nucleotide and tetra-nucleotide repeats with an average distance of 8.9 cM was performed on a total of 691 persons. Variance components based on multipoint linkage approach as implemented in SOLAR were performed for log C-peptide. Significant linkage evidences were observed on 10q23 at D10S2327 with a LOD score of 4.04 (nominal p-value = 0.000008, empirical p-value = 0.0004); and on 4p15 at D4S2632 with a LOD score of 3.48 (nominal p-value = 0.000031, empirical p-value = 0.0013). Other suggestive evidence of linkage were observed on 15q14 at D15S659 with a LOD score 2.41 (nominal p-value = 0.000435, empirical p-value = 0.0068), and on 18p11 near D18S976 with a LOD score 2.18 (nominal p-value = 0.000771 and empirical p-value = 0.0094). Interestingly, five positional candidate genes for diabetes and related complications are located in our linkage region (the pituitary adenylate cyclase activating polypeptide (PACAP in 18p11); the peroxisome proliferator-activated receptor gamma coactivator 1 (PPARGC1 in 4p15); PTEN, PPP1R5, and IDE located in 10q23. In conclusion, we identified four major genetic loci (10q23, 4p15, 15q14, and 18p11) influencing C-peptide concentration in West Africans with T2D. en_US
dc.language.iso en en_US
dc.publisher Diabetes Research and Clinical Practice en_US
dc.subject C-peptide en_US
dc.subject Genome scan en_US
dc.subject Type 2 diabetes en_US
dc.subject West Africa en_US
dc.title Genome-wide search for susceptibility genes to type 2 diabetes in West Africans: Potential role of C-peptide en_US
dc.type Article en_US


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