A genome wide quantitative trait linkage analysis for serum lipids in type 2 diabetes in an African population

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dc.contributor.author Adeyemo, A.A.
dc.contributor.author Johnson, T.
dc.contributor.author Acheampong, J.
dc.contributor.author Oli, J.
dc.contributor.author Okafor, G.
dc.contributor.author Amoah, A.
dc.contributor.author Owusu, S.
dc.contributor.author Agyenim-Boateng, K.
dc.contributor.author Eghan Jr., B.A.
dc.contributor.author Abbiyesuku, F.
dc.contributor.author Fasanmade, O.
dc.contributor.author Rufus, T.
dc.contributor.author Doumatey, A.
dc.contributor.author Chen, G.
dc.contributor.author Zhou, J.
dc.contributor.author Chen, Y.
dc.contributor.author Furbert-Harris, P.
dc.contributor.author Dunston, G.
dc.contributor.author Collins, F.
dc.contributor.author Rotimi, C.
dc.date.accessioned 2013-06-26T20:12:28Z
dc.date.accessioned 2017-10-19T11:58:53Z
dc.date.available 2013-06-26T20:12:28Z
dc.date.available 2017-10-19T11:58:53Z
dc.date.issued 2005-08
dc.identifier.citation Adeyemo, A. A., Johnson, T., Acheampong, J., Oli, J., Okafor, G., Amoah, A., . . . Rotimi, C. (2005). A genome wide quantitative trait linkage analysis for serum lipids in type 2 diabetes in an African population. Atherosclerosis, 181(2), 389-397 en_US
dc.identifier.issn 00219150
dc.description.abstract Lipid abnormalities are strongly linked with coronary heart disease and are common in type 2 diabetes. However, little is known about the genetic determinants of serum lipids in African populations. An autosomal genome scan was performed for linkage to five plasma lipid phenotypes (total cholesterol, triglycerides (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C) and VLDL-cholesterol (VLDL-C)) in the Africa-America Diabetes Mellitus (AADM) study. Two hundred and ninety-five affected sibling pairs with type 2 diabetes mellitus enrolled from Ghana and Nigeria were genotyped for 390 microsatellite markers with an average inter-marker distance of 9 cM. Multipoint variance components linkage analysis showed that HDL-C had a LOD score of 4.34 near marker D7S3061 and 3.00 near marker D7S513. Some clustering of linkage evidence to several lipid phenotypes was observed on chromosomes 5 (LDL-C, total cholesterol, VLDL-C), chromosome 7 (HDL-C, TG) and chromosome 19 (total cholesterol, LDL-C, TG). Principal component analysis of the five phenotypes yielded two factors, one (TG, HDL-C and VLDL) of which was linked to QTLs on chromosomes 2, 5 and 7, while the other (total cholesterol and LDL-C) was linked to a different set of QTLs on chromosomes 2, 5 and 18. Several of these regions have been reported to be linked to lipids in other studies. Follow up investigations are warranted in view of the central role serum lipids play in the aetiopathogenesis of cardiovascular disease. © 2005 Elsevier Ireland Ltd. All rights reserved. en_US
dc.language.iso en en_US
dc.publisher Atherosclerosis en_US
dc.subject Africa en_US
dc.subject Cholesterol en_US
dc.subject Genome scan en_US
dc.subject Lipids en_US
dc.subject Type 2 diabetes en_US
dc.title A genome wide quantitative trait linkage analysis for serum lipids in type 2 diabetes in an African population en_US
dc.type Article en_US

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