Comparison of the sensitivity and specificity of urine cytology, urinary nuclear matrix protein-22 and multitarget fluorescence in situ hybridization assay in the detection of bladder cancer

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dc.contributor.author Kehinde, E.O.
dc.contributor.author Al-Mulla, F.
dc.contributor.author Kapila, K.
dc.contributor.author Anim, J.T.
dc.date.accessioned 2013-06-25T19:09:59Z
dc.date.accessioned 2017-10-19T12:37:13Z
dc.date.available 2013-06-25T19:09:59Z
dc.date.available 2017-10-19T12:37:13Z
dc.date.issued 2011-03
dc.identifier.citation Kehinde, E. O., Al-Mulla, F., Kapila, K., & Anim, J. T. (2011). Comparison of the sensitivity and specificity of urine cytology, urinary nuclear matrix protein-22 and multitarget fluorescence in situ hybridization assay in the detection of bladder cancer. Scandinavian Journal of Urology and Nephrology, 45(2), 113-121. Link to full text: http://hinari-gw.who.int/whalecominformahealthcare.com/whalecom0/doi/abs/10.3109/00365599.2010.533694 en_US
dc.identifier.issn 00365599
dc.identifier.uri http://197.255.68.203/handle/123456789/4122
dc.description.abstract Objective: This study aimed to compare the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of urine cytology, BladderChek nuclear matrix protein-22 (NMP22) and UroVysion™ fluorescence in situ hybridization (FISH) tests in patients with newly diagnosed bladder cancer, those with recurrent bladder cancer, and those with bladder cancer but in remission during surveillance. Material and methods. Voided urine samples obtained from 178 patients with suspected or known bladder cancer about to undergo diagnostic or surveillance cystoscopy and 25 control subjects without the disease were divided into four and used for urine culture and cytology, NMP22 BladderChek and UroVysion FISH tests. The sensitivity, specificity, PPV and NPV for each test were calculated. Comparison was made between the ability of each test to detect bladder cancer in the three category of patients listed. Results. Of the 178 patients with bladder cancer, 43 were newly diagnosed, 58 had recurrent disease and 77 were in remission. The sensitivity of each test in newly diagnosed patients was: urine cytology 28%, NMP22 88% and FISH 80%; and in patients with recurrent disease: urine cytology 33%, NMP22 57% and FISH 85%. The mean specificity for urine cytology, NMP22 and FISH was 95%, 67% and 48%, respectively. Conclusion. Of the tests used in the study for detection of bladder cancer, NMP22 appeared to be most cost-effective and rapid, with relatively high sensitivity and specificity in all categories of patients. The NMP22 test may be considered a new gold standard for the assessment of patients with known or suspected bladder cancer. en_US
dc.language.iso en en_US
dc.publisher Scandinavian Journal of Urology and Nephrology en_US
dc.subject Bladder cancer en_US
dc.subject diagnosis en_US
dc.subject NMP22 en_US
dc.subject urine cytology en_US
dc.subject UroVysion FISH en_US
dc.title Comparison of the sensitivity and specificity of urine cytology, urinary nuclear matrix protein-22 and multitarget fluorescence in situ hybridization assay in the detection of bladder cancer en_US
dc.type Article en_US


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