Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/4122
Title: Comparison of the sensitivity and specificity of urine cytology, urinary nuclear matrix protein-22 and multitarget fluorescence in situ hybridization assay in the detection of bladder cancer
Authors: Kehinde, E.O.
Al-Mulla, F.
Kapila, K.
Anim, J.T.
Keywords: Bladder cancer
diagnosis
NMP22
urine cytology
UroVysion FISH
Issue Date: Mar-2011
Publisher: Scandinavian Journal of Urology and Nephrology
Citation: Kehinde, E. O., Al-Mulla, F., Kapila, K., & Anim, J. T. (2011). Comparison of the sensitivity and specificity of urine cytology, urinary nuclear matrix protein-22 and multitarget fluorescence in situ hybridization assay in the detection of bladder cancer. Scandinavian Journal of Urology and Nephrology, 45(2), 113-121. Link to full text: http://hinari-gw.who.int/whalecominformahealthcare.com/whalecom0/doi/abs/10.3109/00365599.2010.533694
Abstract: Objective: This study aimed to compare the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of urine cytology, BladderChek nuclear matrix protein-22 (NMP22) and UroVysion™ fluorescence in situ hybridization (FISH) tests in patients with newly diagnosed bladder cancer, those with recurrent bladder cancer, and those with bladder cancer but in remission during surveillance. Material and methods. Voided urine samples obtained from 178 patients with suspected or known bladder cancer about to undergo diagnostic or surveillance cystoscopy and 25 control subjects without the disease were divided into four and used for urine culture and cytology, NMP22 BladderChek and UroVysion FISH tests. The sensitivity, specificity, PPV and NPV for each test were calculated. Comparison was made between the ability of each test to detect bladder cancer in the three category of patients listed. Results. Of the 178 patients with bladder cancer, 43 were newly diagnosed, 58 had recurrent disease and 77 were in remission. The sensitivity of each test in newly diagnosed patients was: urine cytology 28%, NMP22 88% and FISH 80%; and in patients with recurrent disease: urine cytology 33%, NMP22 57% and FISH 85%. The mean specificity for urine cytology, NMP22 and FISH was 95%, 67% and 48%, respectively. Conclusion. Of the tests used in the study for detection of bladder cancer, NMP22 appeared to be most cost-effective and rapid, with relatively high sensitivity and specificity in all categories of patients. The NMP22 test may be considered a new gold standard for the assessment of patients with known or suspected bladder cancer.
URI: http://hdl.handle.net/123456789/4122
ISSN: 00365599
Appears in Collections:Department of Pathology 9

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