Expression of estrogen receptor α and estrogen receptor β in fine needle aspirates of breast carcinoma

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dc.contributor.author Kapila, K.
dc.contributor.author Anim, J.T.
dc.contributor.author Francis, I.M.
dc.contributor.author Al-Mulla, F.
dc.contributor.author George, S.S.
dc.contributor.author Behbehani, A.I.F.
dc.date.accessioned 2013-06-25T18:53:30Z
dc.date.accessioned 2017-10-19T12:33:01Z
dc.date.available 2013-06-25T18:53:30Z
dc.date.available 2017-10-19T12:33:01Z
dc.date.issued 2010-01
dc.identifier.citation 61. Kapila, K., Anim, J. T., Francis, I. M., Al-Mulla, F., George, S. S., & Behbehani, A. I. F. (2010). Expression of estrogen receptor α and estrogen receptor β in fine needle aspirates of breast carcinoma. Acta Cytologica, 54(1), 25-30. en_US
dc.identifier.issn 00015547
dc.identifier.uri http://197.255.68.203/handle/123456789/4119
dc.description.abstract Objective: To evaluate the expression of estrogen receptor β (ERβ) in fine needle aspirates (FNAs) and correlate the findings with its expression in tissue sections. Study Design: In 38 cases of breast carcinoma, expression of estrogen receptor α (ERα) and ERβ in aspirates and tissue sections was correlated with the cytologic and histologic grade of the tumor. Results: ERα and ERβ were expressed as nuclear staining in 80% and 90% of the cases in tissue sections and 47% and 45% of the cases in aspirates, respectively. Tissue expression of ERα (grade 1, 81%; grade 2, 100%) and ERβ (grade 1, 94%; grade 2, 100%) was greater than in grade 3 tumors (ERα, 50%; ERβ, 70%). In FNAs they were equally distributed in the different cytologic grades. In aspirates 30% of ERα negative tumors were positive for ERβ, while in tissues 75% of ERα-negative tumors were positive for ERβ (p=0.007). Conclusion: Demonstration of ERβ on FNA smears is feasible. It helps identify the specific subcohort of ERβ-positive tumors in ERα-negative breast cancers; that may have therapeutic importance. en_US
dc.language.iso en en_US
dc.publisher Acta Cytologica en_US
dc.subject Aspirations biopsy en_US
dc.subject Breast cancer en_US
dc.subject Estrogen receptor α en_US
dc.subject Estrogen receptor β en_US
dc.subject Fine-needle en_US
dc.title Expression of estrogen receptor α and estrogen receptor β in fine needle aspirates of breast carcinoma en_US
dc.type Article en_US


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