Abstract:
Objective: Flares of autoimmune rheumatic diseases (AIRDs) following COVID-19 vaccination are a particular concern in vaccine-hesitant individ uals. Therefore, we investigated the incidence, predictors and patterns of flares following vaccination in individuals living with AIRDs, using global
COVID-19 Vaccination in Autoimmune Diseases (COVAD) surveys.
Methods: The COVAD surveys were used to extract data on flare demographics, comorbidities, COVID-19 history, and vaccination details for
patients with AIRDs. Flares following vaccination were identified as patient-reported (a), increased immunosuppression (b), clinical exacerbations
(c) and worsening of PROMIS scores (d). We studied flare characteristics and used regression models to differentiate flares among various
AIRDs.
Results: Of 15 165 total responses, the incidence of flares in 3453 patients with AIRDs was 11.3%, 14.8%, 9.5% and 26.7% by definitions a–d,
respectively. There was moderate agreement between patient-reported and immunosuppression-defined flares (K ¼ 0.403, P ¼ 0.022). Arthritis
(61.6%) and fatigue (58.8%) were the most commonly reported symptoms. Self-reported flares were associated with higher comorbidities
(P ¼ 0.013), mental health disorders (MHDs) (P < 0.001) and autoimmune disease multimorbidity (AIDm) (P < 0.001).
In regression analysis, the presence of AIDm [odds ratio (OR) ¼ 1.4; 95% CI: 1.1, 1.7; P ¼ 0.003), or a MHD (OR ¼ 1.7; 95% CI: 1.1, 2.6;
P ¼ 0.007), or being a Moderna vaccine recipient (OR ¼ 1.5; 95% CI: 1.09, 2.2; P ¼ 0.014) were predictors of flares. Use of MMF (OR ¼ 0.5; 95%
CI: 0.3, 0.8; P ¼ 0.009) and glucocorticoids (OR ¼ 0.6; 95% CI: 0.5, 0.8; P ¼ 0.003) were protective.
A higher frequency of patients with AIRDs reported overall active disease post-vaccination compared with before vaccination (OR ¼ 1.3; 95% CI:
1.1, 1.5; P < 0.001).
Conclusion: Flares occur in nearly 1 in 10 individuals with AIRDs after COVID vaccination; people with comorbidities (especially AIDm), MHDs
and those receiving the Moderna vaccine are particularly vulnerable. Future avenues include exploring flare profiles and optimizing vaccine strate gies for this group
