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Title: Mitochondrial ophthalmoplegia with fatigable weakness and elevated acetylcholine receptor antibody
Authors: Behbehani, R.
Sharfuddin, K.
Anim, J.T.
Keywords: Adult
Biological Markers
Diagnosis, Differential
Disease Progression
Eye Movements
Follow-Up Studies
Magnetic Resonance Imaging
Microscopy, Electron
Muscle Fatigue
Oculomotor Muscles
Issue Date: Mar-2007
Publisher: Journal of Neuro-Ophthalmology
Citation: Behbehani, R., Sharfuddin, K., & Anim, J. T. (2007). Mitochondrial ophthalmoplegia with fatigable weakness and elevated acetylcholine receptor antibody. Journal of Neuro-Ophthalmology, 27(1), 41-44. Link to full text:
Abstract: A 25-year-old man with chronically progressive ptosis and bilateral ophthalmoplegia displayed fatigability and fluctuation of ptosis, an abnormal single-fiber electromyogram, and a markedly elevated acetylcholine receptor antibody level. Yet a muscle biopsy showed clear evidence of a mitochondrial cytopathy, and the clinical features did not improve after treatment with prednisone. This case emphasizes the difficulty in differentiating mitochondrial cytopathy from myasthenia gravis and points out that elevated acetylcholine receptor antibody levels may occur in nonmyasthenic conditions.
ISSN: 10708022
Appears in Collections:Department of Pathology 9

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