Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/4092
Title: Mitochondrial ophthalmoplegia with fatigable weakness and elevated acetylcholine receptor antibody
Authors: Behbehani, R.
Sharfuddin, K.
Anim, J.T.
Keywords: Adult
Antibodies
Biological Markers
Biopsy
Diagnosis, Differential
Disease Progression
Electromyography
Electroretinography
Eye Movements
Follow-Up Studies
Humans
Magnetic Resonance Imaging
Male
Microscopy, Electron
Muscle Fatigue
Oculomotor Muscles
Issue Date: Mar-2007
Publisher: Journal of Neuro-Ophthalmology
Citation: Behbehani, R., Sharfuddin, K., & Anim, J. T. (2007). Mitochondrial ophthalmoplegia with fatigable weakness and elevated acetylcholine receptor antibody. Journal of Neuro-Ophthalmology, 27(1), 41-44. Link to full text: http://hinari-gw.who.int/whalecomovidsp.tx.ovid.com/whalecom0/sp-3.8.0b/ovidweb.cgi?T=JS&PAGE=fulltext&D=ovft&AN=00041327-200703000-00009&NEWS=N&CSC=Y&CHANNEL=PubMed
Abstract: A 25-year-old man with chronically progressive ptosis and bilateral ophthalmoplegia displayed fatigability and fluctuation of ptosis, an abnormal single-fiber electromyogram, and a markedly elevated acetylcholine receptor antibody level. Yet a muscle biopsy showed clear evidence of a mitochondrial cytopathy, and the clinical features did not improve after treatment with prednisone. This case emphasizes the difficulty in differentiating mitochondrial cytopathy from myasthenia gravis and points out that elevated acetylcholine receptor antibody levels may occur in nonmyasthenic conditions.
URI: http://hdl.handle.net/123456789/4092
ISSN: 10708022
Appears in Collections:Department of Pathology 9

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