Please use this identifier to cite or link to this item:
Title: Benign disorders of the prostate: A histopathological study
Authors: Anim, J.T.
Ebrahim, B.H.
Sathar, S.A.
Keywords: Adult
Basal cell
Cell hyperplasia
Fibromuscular dysplasia
Human tissue
Major clinical study
Priority journal
Prostate hypertrophy
Prostatic intraepithelial neoplasia
Tissue regeneration
Issue Date: 1998
Publisher: Annals of Saudi Medicine
Citation: Anim, J. T., Ebrahim, B. H., & Sathar, S. A. (1998). Benign disorders of the prostate: A histopathological study. Annals of Saudi Medicine, 18(1), 22-27.
Abstract: Although the medical literature contains adequate accounts of the pathophysiology of various benign prostatic disorders, it is often necessary to revisit these lesions, to reexamine the relationships between known benign lesions and more sinister, malignant disorders, in the light of new advances in our understanding of the processes. We carried out a histopathological review of prostatic surgical pathology material seen over a seven-year period in our hospital. Our findings show that benign enlargement of the prostate or benign prostatic hyperplasia (BPH) is initially fibromuscular in many cases, becoming glandulostromal with advancing age. While we found no relationship between prostatitis and age, individual gland necrosis tended to occur relatively early and correlated well with stromal repair, which we believe forms the basis of fibromuscular hyperplasia. Epithelial hyperplasia may result from glandular regeneration, and basal cell hyperplasia, papillary hyperplasia and cribriform hyperplasia all showed significant correlation with prostatic intraepithelial neoplasia (PIN). On the other hand, only cribriform hyperplasia showed correlation with atypical adenomatous hyperplasia (AAH), and also demonstrated an increase in incidence with advancing age. Our findings underline the positive relationships between benign events such as glandular necrosis with repair and epithelial hyperplasia, which may itself predispose to recognized premalignant lesions such as PIN.
ISSN: 02564947
Appears in Collections:Department of Pathology 9

Files in This Item:
There are no files associated with this item.

Items in UGSpace are protected by copyright, with all rights reserved, unless otherwise indicated.