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Title: Rationale for development of a synthetic vaccine against plasmodium falciparum malaria
Authors: Zavala, F.
Tam, J.P.
Hollingdale, M.R.
Cochrane, A.H.
Quakyi, I.A.
Nussenzweig, R.S.
Nussenzweig, V.
Keywords: EMTREE drug terms: immunoglobulin g i 125; malaria vaccine; monoclonal antibody; parasite antigen; peptide; radioisotope; unclassified drug
EMTREE medical terms: animal cell; article; drug efficacy; drug resistance; drug therapy; immunity; nonhuman; Plasmodium falciparum; priority journal; protozoon; sporozoite; therapy; vaccine production
MeSH: Adult; Antibodies, Monoclonal; Child; Epitopes; Humans; Malaria; Peptides; Plasmodium falciparum; Vaccines
Issue Date: 1985
Publisher: Science
Citation: Zavala, F., Tam, J. P., Hollingdale, M. R., Cochrane, A. H., Quakyi, I.,Nussenzweig, R. S., &Nussenzweig, V. (1985). Rationale for development of a synthetic vaccine aggainst plasmodium falciparum malaria. Science, 228(4706), 1436-1440
Abstract: Protective immunity against malaria can be obtained by vaccination with irradiated spoorozoites. The protective antigens known as circumsprozoite (CS) proteins, are polypeptides that cover the surface membrane of the parasite. The CS proteins contain species-specific immunodominant epitopes formed by tandem repeated sequences of amino acids. Here it is shown that the dominant epitope of Plasmodium falciparum is contained in the synthetic dodecapeptide Asn-Ala-Asn-Pro-Asn-Ala-Asn-Pro-Asn-Ala-Asn-Pro or (NANP)3. Monoclonal antibodies and most or all polyclonal human antobodies to the sporozoites react with (NANP)3, and polyclonal antibodies raised against the synthetic peptide (NANP)3 react with the surface of the parasite and neutralize its infectivity. Since (NANP)3 repeats are present in CS proteins of P. falciparum from many parts of the world, this epitope is a logical target for vaccine development.
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