Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.

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dc.contributor.advisor
dc.contributor.author Haiman, C. A.
dc.contributor.author Chen, G. K.
dc.contributor.author Tettey, Y.
dc.contributor.author Strom, S. S.
dc.contributor.author Berndt, S. I.
dc.contributor.author Kittles, R. A.
dc.contributor.author Isaacs, W.B.
dc.contributor.author Ingles, S.A.
dc.contributor.author Stanford, J.L.
dc.contributor.author Diver, W.R.
dc.contributor.author Witte, J.S.
dc.contributor.author Hsing, A.W.
dc.contributor.author Nemesure, B.
dc.contributor.author Rebbeck, T.R.
dc.contributor.author Cooney, K.A.
dc.contributor.author Xu, J.
dc.contributor.author Kibel, A.S.
dc.contributor.author Hu, J.J.
dc.contributor.author John, E.M.
dc.contributor.author Gueye, S.M.
dc.contributor.author Watya, S.
dc.contributor.author Signorello, L.B.
dc.contributor.author Hayes, R.B.
dc.contributor.author Wang, Z.
dc.contributor.author Yeboah, E.
dc.contributor.author Tettey, Y.
dc.contributor.author Cai, Q.
dc.contributor.author Kolb, S.
dc.contributor.author Ostrander, E.A.
dc.contributor.author Zeigler-Johnson, C.
dc.contributor.author Yamamura, Y.
dc.contributor.author Neslund-Dudas, C.
dc.contributor.author Haslag-Minoff, J.
dc.contributor.author Wu, W.
dc.contributor.author Thomas, V.
dc.contributor.author Allen, G.O.
dc.contributor.author Murphy, A.
dc.contributor.author Chang, B.L.
dc.contributor.author Zheng, S.L.
dc.contributor.author Leske, M.C.
dc.contributor.author Wu, S.Y.
dc.contributor.author Ray, A.M.
dc.contributor.author Hennis, A.J.
dc.contributor.author Thun, M.J.
dc.contributor.author Carpten, J.
dc.contributor.author Casey, G.
dc.contributor.author Carter, E.N.
dc.contributor.author Duarte, E.R.
dc.contributor.author Xia, L.Y.
dc.contributor.author Sheng, X.
dc.contributor.author Wan, P.
dc.contributor.author Pooler, L.C.
dc.contributor.author Cheng, I.
dc.contributor.author Monroe, K.R.
dc.contributor.author Schumacher, F.
dc.contributor.author Le Marchand, L.
dc.contributor.author Kolonel, L.N.
dc.contributor.author Van Den Berg, D.
dc.contributor.author Chanock, S.J.
dc.contributor.author Stram, D.O.
dc.contributor.author Henderson, B.E.
dc.date.accessioned 2013-06-21T15:46:55Z
dc.date.accessioned 2017-10-19T12:42:11Z
dc.date.available 2013-06-21T15:46:55Z
dc.date.available 2017-10-19T12:42:11Z
dc.date.issued 2011-05-22
dc.identifier.citation 14. Haiman, C. A., Chen, G. K., Tettey, Y., Strom, S. S., Berndt, S. I., Kittles, R. A., . . . Henderson, B. E. (2011). Genome-wide association study of prostate cancer in men of african ancestry identifies a susceptibility locus at 17q21. Nature Genetics, 43(6), 570-573. en_US
dc.identifier.uri http://197.255.68.203/handle/123456789/3881
dc.description.abstract In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10(-13)). The frequency of the risk allele is ∼5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations. en_US
dc.title Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. en_US


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