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Title: Differential non-responsiveness in humans of candidate plasmodium falciparum vaccine antigens
Authors: Quakyi, I.A.
Otoo, L.N.
Pombo, D.
Sugars, L.Y.
Menon, A.
DeGroot, A.S.
Good, M.F.
Keywords: EMTREE drug terms: malaria vaccine; parasite antigen
EMTREE medical terms: human; human experiment; immunization; malaria; plasmodium falciparum; priority journal; protozoon
MeSH: Adult; Animal; Antibodies, Protozoan; Antibody Specificity; Antigens, Protozoan; Child; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Gambia; HLA Antigens; Human; Lymphocytes; Malaria; Plasmodium falciparum; Precipitin Tests; Rural Population; Support, Non-U.S. Gov't; Support, U.S. Gov't, Non-P.H.S.; Support, U.S. Gov't, P.H.S.; Vaccines; Vaccines, Synthetic
Issue Date: 1989
Publisher: American Journal of Tropical Medicine and Hygiene
Citation: Quakyi, I. A., Otoo, L. N., Pombo, D., Sugars, L. Y., Menon, A., DeGroot, A. S., . . . Good, M. F. (1989). Differential non-responsiveness in humans of candidate plasmodium falciparum vaccine antigens. American Journal of Tropical Medicine and Hygiene, 41(2), 125-134.
Abstract: Synthetic subunit vaccines to sporozoites, merozoites, and gametes are being developed for malaria. The vaccine strategy assumes that the population to be immunized will respond favorably to these vaccine antigens. Using sera of 35 adults and 50 children from the The Gambia, West Africa, where Plasmodium falciparum is highly endemic, we examined the humoral immune response to candidate malaria vaccine antigens from sporozoites, merozoites, and gametes. We observed widespread restricted immunogenicity to defined parasite antigens in children and adults. HLA typing of adult lymphocytes demonstrated a marked diversity in HLA haplotypes in this population. Our results and those from our studies in mice suggest that genetic factors may partly explain the immunological non-responsiveness. This may necessitate re-evaluation of the malaria vaccine strategy.
ISSN: 00029637
Appears in Collections:School of Public Health 9

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