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Title: Assessing CD4+ helper T-lymphocyte responses by lymphoproliferation
Authors: Quakyi, I.A.
Ahlers, J.D.
Keywords: EMTREE drug terms: antigen; epitope; interleukin 2; malaria vaccine; peptide; recombinant vaccine
EMTREE medical terms: animal; article; Bagg albino mouse; biosynthesis; C3H mouse; C57BL mouse; helper cell; human; immunization; immunology; lymphocyte activation; methodology; mouse; mouse strain; Plasmodium falciparum; vaccination
MeSH: Animals; Antigens; Epitopes; Humans; Immunization; Interleukin-2; Lymphocyte Activation; Malaria Vaccines; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred Strains; Peptides; Plasmodium falciparum; T-Lymphocytes, Helper-Inducer; Vaccination; Vaccines, Synthetic
Issue Date: 2002
Publisher: Methods in Molecular Medicine
Citation: Quakyi, I. A., &Ahlers, J. D. (2002). Assessing CD4+ helper T-lymphocyte responses by lymphoproliferation. Methods in Molecular Medicine, 72, 369-383.
Abstract: CD4+helper T cells play a central role in the development of malaria immune responses and a large number of epitopes from the sporozoite, sexual, and asexual stage of malaria proteins have been tabulated in both mice and humans (1-8). It is clear that the incorporation of antigenic determinants stimulating helper T cells is important for the induction of antibody responses (9-11) and cytotoxic T cell responses (12-15) stimulated by peptide or subunit vaccines. Helper T cells (Th) also may act as effectors themselves, by secreting cytokines that may significantly influence the clinical course following infection.
Appears in Collections:School of Public Health 9

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