Abstract:
CD4+helper T cells play a central role in the development of malaria immune responses and a large number of epitopes from the sporozoite, sexual, and asexual stage of malaria proteins have been tabulated in both mice and humans (1-8). It is clear that the incorporation of antigenic determinants stimulating helper T cells is important for the induction of antibody responses (9-11) and cytotoxic T cell responses (12-15) stimulated by peptide or subunit vaccines. Helper T cells (Th) also may act as effectors themselves, by secreting cytokines that may significantly influence the clinical course following infection.
