The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC

Show simple item record Ghansah, A. Verity, R. Aydemir, O. Brazeau, N.F. Watson, O.J. Hathaway, N.J. Mwandagalirwa, M.K. Marsh, P.W. Thwai, K. Fulton, T. Denton, M. Morgan, A.P. Parr, J.B. Tumwebaze, P.K. Conrad, M. Rosenthal, P.J. Ishengoma, D.S. Ngondi, J. Gutman, J. Mulenga, M. Norris, D.E. Moss, W.J. Mensah, B.A. Myers-Hansen, J.L. Tshefu, A.K. Ghani, A.C. Meshnick, S.R. Bailey, J.A. Juliano, J.J. 2020-07-29T12:40:40Z 2020-07-29T12:40:40Z 2020-04-30
dc.identifier.citation Verity, R., Aydemir, O., Brazeau, N.F. et al. The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC. Nat Commun 11, 2107 (2020). en_US
dc.description Research Article en_US
dc.description.abstract The Democratic Republic of the Congo (DRC) harbors 11% of global malaria cases, yet little is known about the spatial and genetic structure of the parasite population in that country. We sequence 2537 Plasmodium falciparum infections, including a nationally representative population sample from DRC and samples from surrounding countries, using molecular inversion probes - a high-throughput genotyping tool. We identify an east-west divide in haplotypes known to confer resistance to chloroquine and sulfadoxine-pyrimethamine. Furthermore, we identify highly related parasites over large geographic distances, indicative of gene flow and migration. Our results are consistent with a background of isolation by distance combined with the effects of selection for antimalarial drug resistance. This study provides a high-resolution view of parasite genetic structure across a large country in Africa and provides a baseline to study how implementation programs may impact parasite populations. en_US
dc.description.sponsorship National Institutes of Health (R01AI107949, R01AI139520, K24AI134990, R21AI121465, F30AI143172, U19AI089680). R.V is funded by a Skills Development Fellowship: this award is jointly funded by the UK Medical Research Council (MRC) and the UK Department for International Development (DFID) under the MRC/DFID Concordat agreement and is also part of the EDCTP2 programme supported by the European Union en_US
dc.language.iso en en_US
dc.publisher Nature Communications en_US
dc.relation.ispartofseries 11;
dc.subject Democratic Republic of the Congo (DRC) en_US
dc.subject malaria en_US
dc.subject Plasmodium falciparum infections en_US
dc.subject sulfadoxine-pyrimethamine en_US
dc.title The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC en_US
dc.type Article en_US

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  • Parasitology Department [253]
    The Department of Parasitology conducts research into parasitic diseases of public health importance with the overall goal of reducing their transmission and the heavy disease burden that they impose on affected populations. The Department maintains focus on parasitic diseases in general. These include major diseases such as malaria, and others listed under the Neglected Tropical Diseases (NTD) control initiative such as, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, trypanosomiasis and leishmaniasis.

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