Department of Medical Biochemistry 9

Department of Medical Biochemistry 9

 

Recent Submissions

  • Yan, F.; Lartey, M.; Damodaran, K.; Albenze, E.; Thompson, R.L.; Kim, J.; Haranczyk, M.; Nulwala, H.B.; Luebke, D.R.; Smit, B. (2013-03-07)
    Ionic liquids are an emerging class of materials with applications in a variety of fields. Steady progress has been made in the creation of ionic liquids tailored to specific applications. However, the understanding of the ...
  • Sumner, A.E.; Zhou, J.; Doumatey, A.; Imoisili, O.E.; Amoah, A.; Acheampong, J.; Oli, J.; Johnson, T.; Adebamowo, C.; Rotimi, C.N. (CVD Prevention and Control, 2010-09)
    Background: Although designed to predict cardiovascular disease and type 2 diabetes mellitus, the Metabolic Syndrome (MetSyn) under-predicts these conditions in African Americans (AA). Failure of MetSyn in AA is often ...
  • Rotimi, C.N.; Dunston, G.M.; Berg, K.; Akinsete, O.; Amoah, A.; Owusu, S.; Acheampong, J.; Boateng, K.; Oli, J.; Okafor, G.; Onyenekwe, B.; Osotimehin, B.; Abbiyesuku, F.; Johnson, T.; Fasanmade, O.; Furbert-Harris, P.; Kittles, R.; Vekich, M.; Adegoke, O.; Bonney, G.; Collins, F. (Annals of Epidemiology, 2001)
    PURPOSE: The purpose of this study is to map type 2 diabetes susceptibility genes in West African ancestral populations of African-Americans, through an international collaboration between West African and US investigators. ...
  • Rotimi, C.; Daniel, H.; Zhou, J.; Obisesan, A.; Chen, G.; Chen, Y.; Amoah, A.; Opoku, V.; Acheampong, J.; Agyenim-Boateng, K.; Eghan Jr., B.A.; Oli, J.; Okafor, G.; Ofeogbu, E.; Osotimehin, B.; Abbiyesuku, F.; Johnson, T.; Fasanmade, O.; Doumatey, A.; Aje, T.; Collins, F.; Dunston, G. (Ethnicity and Disease, 2003-06)
    Objective: To quantify the prevalence of, and risk factors for, diabetic retinopathy and cataracts in patients with type 2 diabetes, and their spouse controls, enrolled from 5 centers in 2 West African countries (Ghana and ...
  • Mayosi, B.; Robertson, K.; Volmink, J.; Adebo, W.; Akinyore, K.; Amoah, A.; Bannerman, C.; Biesman-Simons, S.; Carpetis, J.; Cilliers, A.; Commerford, P.; Croasdale, A.; Damasceno, A.; Dean, J.; Dean, M.; de Souza, R.; Filipe, A.; Hugo-Hamman, C.; Jurgens-Clur, S.A.; Kombila-Koumba, P.; Kotzenberg, C.; Lawrenson, J.; Manga, P.; Matenga, J.; Mathivha, T.; Mntla, P.; Mocumbi, A.; Mokone, T.; Ogola, E.; Omokhodion, S.; Palweni, C.; Pearce, A.; Salo, A.; Thomas, B.; Walker, K.; Wiysonge, C.; Zaher, S. (South African Medical Journal, 2006-03)
  • Doumatey, A.P.; Zhou, J.; Huang, H.; Adeleye, J.; Balogun, W.; Fasanmade, O.; Johnson, T.; Oli, J.; Okafor, G.; Amoah, A.; Eghan, B.; Agyenim-Boateng, K.; Acheampong, J.; Adebamowo, C.; Adeyemo, A.; Rotimi, C.N. (International Journal of Nephrology, 2012)
    Adiponectin, a protein secreted by adipose tissue, has been associated with renal dysfunction. However, these observations have not been adequately investigated in large epidemiological studies of healthy individuals in ...
  • Doumatey, A.P.; Lashley, K.S.; Huang, H.; Zhou, J.; Chen, G.; Amoah, A.; Agyenim-Boateng, K.; Oli, J.; Fasanmade, O.; Adebamowo, C.A.; Adeyemo, A.A.; Rotimi, C.N. (Obesity, 2010-03)
    Several research studies in different populations indicate that inflammation may be the link between obesity and insulin resistance (IR). However, this relationship has not been adequately explored among African Americans, ...
  • Doumatey, A.P.; Chen, G.; Ayele, F.T.; Zhou, J.; Erdos, M.; Shriner, D.; Huang, H.; Adeleye, J.; Balogun, W.; Fasanmade, O.; Johnson, T.; Oli, J.; Okafor, G.; Amoah, A.; Eghan, B.A.; Agyenim-Boateng, K.; Acheampong, J.; Adebamowo, C.; Gerry, N.P.; Christman, M.F.; Adeyemo, A.; Rotimi, C.N. (Human Molecular Genetics, 2012-07)
    C-reactive protein (CRP) is an acute phase reactant protein produced primarily by the liver. Circulating CRP levels are influenced by genetic and non-genetic factors, including infection and obesity. Genome-wide association ...
  • Chen, Y.; Kittles, R.; Zhou, J.; Chen, G.; Adeyemo, A.; Panguluri, R.K.; Chen, W.; Amoah, A.; Opoku, V.; Acheampong, J.; Agyenim-Boateng, K.; Eghan Jr., B.A.; Nyantaki, A.; Oli, J.; Okafor, G.; Ofeogbu, E.; Osotimehin, B.; Abbiyesuku, F.; Johnson, T.; Fasanmade, O.; Rufus, T.; Furbert-Harris, P.; Daniel, H.I.; Berg, K.A.; Collins, F.S.; Dunston, G.M.; Rotimi, C.N. (Annals of Epidemiology, 2005-02)
    To investigate whether the three single nucleotide polymorphisms (SNPs), SNP-43, -56, and -63 of CAPN10 were associated with type 2 diabetes in a West African cohort. A total of 347 diabetic subjects and 148 unaffected ...
  • Chen, G.; Adeyemo, A.A.; Zhou, J.; Chen, Y.; Doumatey, A.; Lashley, K.; Huang, H.; Amoah, A.; Agyenim-Boateng, K.; Eghan Jr., B.A.; Okafor, G.; Acheampong, J.; Oli, J.; Fasanmade, O.; Johnson, T.; Rotimi, C. (American Journal of Kidney Diseases, 2007-03)
    Background: Reduced renal function often is a major consequence of diabetes and hypertension. Although several indices of renal function (eg, creatinine clearance) are clearly heritable and show linkage to several genomic ...
  • Chen, G.; Adeyemo, A.A.; Johnson, T.; Zhou, J.; Amoah, A.; Owusu, S.; Acheampong, J.; Agyenim-Boateng, K.; Eghan Jr., B.A.; Oli, J.; Okafor, G.; Abbiyesuku, F.; Dunston, G.M.; Chen, Y.; Collins, F.; Rotimi, C. (International Journal of Obesity, 2005-03)
    OBJECTIVE: To identify quantitative trait loci (QTL) for three obesity phenotypes: body mass index (BMI), fat mass (FM) and percent body fat (PBF) in West Africans with type 2 diabetes (T2DM). DESIGN: An affected sibling ...
  • Chen, G.; Adeyemo, A.; Zhou, J.; Chen, Y.; Huang, H.; Doumatey, A.; Lashley, K.; Agyenim-Boateng, K.; Eghan Jr., B.A.; Acheampong, J.; Fasanmade, O.; Johnson, T.; Okafor, G.; Oli, J.; Amoah, A.; Rotimi, C. (Diabetes Research and Clinical Practice, 2007-12)
    C-peptide is a substance that the pancreas releases into the circulation in equimolar amounts to insulin and has demonstrated important physiological effects which relate to the vascular field, in particular the microcirculation. ...
  • Bonilla, C.; Panguluri, R.K.; Taliaferro-Smith, L.; Argyropoulos, G.; Chen, G.; Adeyemo, A.A.; Amoah, A.; Owusu, S.; Acheampong, J.; Agyenim-Boateng, K.; Eghan Jr., B.A.; Oli, J.; Okafor, G.; Abbiyesuku, F.; Johnson, T.; Rufus, T.; Fasanmade, O.; Chen, Y.; Collins, F.S.; Dunston, G.M.; Rotimi, C.; Kittles, R.A. (International Journal of Obesity, 2006-04)
    Objective: The role of the central melanocortin system in the development of obesity has been extensively studied. Single-nucleotide polymorphisms (SNPs) within several candidate genes have been associated with food intake ...
  • Bentley, A.R.; Doumatey, A.P.; Chen, G.; Huang, H.; Zhou, J.; Shriner, D.; Jiang, C.; Zhang, Z.; Liu, G.; Fasanmade, O.; Johnson, T.; Oli, J.; Okafor, G.; Eghan, B.A.; Agyenim-Boateng, K.; Adeleye, J.; Balogun, W.; Adebamowo, C.; Amoah, A.; Acheampong, J.; Adeyemo, A.; Rotimi, C.N. (International Journal of Nephrology, 2012)
    Low levels of high-density cholesterol (HDLc) accompany chronic kidney disease, but the association between HDLc and the estimated glomerular filtration rate (eGFR) in the general population is unclear. We investigated the ...
  • Ayele, F.T.; Doumatey, A.; Huang, H.; Zhou, J.; Charles, B.; Erdos, M.; Adeleye, J.; Balogun, W.; Fasanmade, O.; Johnson, T.; Oli, J.; Okafor, G.; Amoah, A.; Eghan Jr., B.A.; Agyenim-Boateng, K.; Acheampong, J.; Adebamowo, C.A.; Herbert, A.; Gerry, N.; Christman, M.; Chen, G.; Shriner, D.; Adeyemo, A.; Rotimi, C.N. (Immunogenetics, 2012-05)
    Interleukins (ILs) are key mediators of the immune response and inflammatory process. Plasma levels of IL-10, IL-1Ra, and IL-6 are associated with metabolic conditions, show large inter-individual variations, and are under ...
  • Adeyemo, A.A.; Johnson, T.; Acheampong, J.; Oli, J.; Okafor, G.; Amoah, A.; Owusu, S.; Agyenim-Boateng, K.; Eghan Jr., B.A.; Abbiyesuku, F.; Fasanmade, O.; Rufus, T.; Doumatey, A.; Chen, G.; Zhou, J.; Chen, Y.; Furbert-Harris, P.; Dunston, G.; Collins, F.; Rotimi, C. (Atherosclerosis, 2005-08)
    Lipid abnormalities are strongly linked with coronary heart disease and are common in type 2 diabetes. However, little is known about the genetic determinants of serum lipids in African populations. An autosomal genome ...
  • Amoah, A.G.; Owusu, S.K.; Adjei, S. (Diabetes Research and Clinical Practice, 2002)
    Data on the prevalence of diabetes in Ghana is scanty and unreliable. In the present study we have ascertained the prevalence of diabetes, impaired fasting glycaemia (IFG) and impaired glucose tolerance (IGT) in a random ...
  • Amoah, A.G. (Ethnicity & Disease, 2003-06)
    Objectives: To determine the prevalence of hypertension, and the extent to which it is treated and controlled, among adult Ghanaians. Design: 6300 adults, aged 25 years and older, were selected by random cluster sampling, ...
  • Amoah, A.G. (Ethnicity & Disease, 2003-06)
    Objectives: To determine the prevalence of obesity in Ghanaian adults. Design: 6300 adults, aged 25 years and older, were selected by random cluster sampling using electoral enumeration areas and listings of adults. Setting: ...
  • Addo, J.; Amoah, A.G.; Koram, K.A. (Ethnicity & Disease, 2006-09)
    Objective: To determine the prevalence, distribution and risk factors of hypertension among rural residents in Ghana. Design and Setting: Cross sectional study in four rural communities in the Ga District of Ghana. Subjects ...

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