Overall and abdominal obesity and prostate cancer risk in a West African population: An analysis of the Ghana Prostate Study

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dc.contributor.author Yeboah, E.D.
dc.contributor.author Hurwitz, L.M.
dc.contributor.author Biritwum, R.B.
dc.contributor.author Tettey, Y.
dc.contributor.author Adjei, A.A.
dc.contributor.author Mensah, J.E.
dc.contributor.author Tay, E.
dc.contributor.author Okyne, V.
dc.contributor.author Truelove, A.
dc.contributor.author Kelly, S.P.
dc.contributor.author Zhou, C.K.
dc.contributor.author Butler, E.N.
dc.contributor.author Hoover, R.N.
dc.contributor.author Hsing, A.W.
dc.contributor.author Cook, M.B.
dc.date.accessioned 2020-06-29T14:02:47Z
dc.date.available 2020-06-29T14:02:47Z
dc.date.issued 2020-03-11
dc.identifier.other DOI: 10.1002/ijc.33026
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/35388
dc.description Research Article en_US
dc.description.abstract Obesity has been associated with an increased risk of advanced prostate cancer. However, most studies have been conducted among North American and European populations. Prostate cancer mortality appears elevated in West Africa, yet risk factors for prostate cancer in this region are unknown. We thus examined the relationship between obesity and prostate cancer using a case-control study conducted in Accra, Ghana in 2004 to 2012. Cases and controls were drawn from a populationbased sample of 1037 men screened for prostate cancer, yielding 73 cases and 964 controls. An additional 493 incident cases were recruited from the Korle-Bu Teaching Hospital. Anthropometric measurements were taken at enrollment. We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR) and prostate cancer, adjusting for potential confounders. The mean BMI was 25.1 kg/m2 for cases and 24.3 kg/m2 for controls. After adjustment, men with BMI ≥ 30 kg/m2 had an increased risk of prostate cancer relative to men with BMI < 25 kg/m2 (OR 1.86, 95% CI 1.11-3.13). Elevated WC (OR 1.76, 95% CI 1.24-2.51) and WHR (OR 1.46, 95% CI 0.99-2.16) were also associated with prostate cancer. Associations were not modified by smoking status and were evident for low- and high-grade disease. These findings indicate that overall and abdominal obesity are positively associated with prostate cancer among men in Ghana, implicating obesity as a potentially modifiable risk factor for prostate cancer in this region. en_US
dc.description.sponsorship National Cancer Institute, Grant/Award Number: ZIA CP010180 en_US
dc.language.iso en en_US
dc.publisher International Journal of Cancer en_US
dc.relation.ispartofseries 2020;1-8
dc.subject body-mass index en_US
dc.subject obesity en_US
dc.subject prostate cancer en_US
dc.subject West Africa en_US
dc.title Overall and abdominal obesity and prostate cancer risk in a West African population: An analysis of the Ghana Prostate Study en_US
dc.type Article en_US

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