α-d-Glucopyranosyl-(1→2)-[6-O-(l-tryptophanyl)-β-d-fructofuranoside]

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dc.contributor.author Kyeremeh, K.
dc.contributor.author Kwain, S.
dc.contributor.author Tetevi, G.M.
dc.contributor.author Camas, A.S.
dc.contributor.author Camas, M.
dc.contributor.author Dofuor, A.K.
dc.contributor.author Deng, H.
dc.contributor.author Jaspars, M.
dc.date.accessioned 2019-10-01T11:25:03Z
dc.date.available 2019-10-01T11:25:03Z
dc.date.issued 2019-06-14
dc.identifier.other doi:10.3390/M1066
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/32372
dc.description Research Article en_US
dc.description.abstract The Mycobacterium sp. BRS2A-AR2 is an endophyte of the mangrove plant Rhizophora racemosa G. Mey., which grows along the banks of the River Butre, in the Western Region of Ghana. Chemical profiling using 1H-NMR and HRESI-LC-MS of fermentation extracts produced by the strain led to the isolation of the new compound, α-d-Glucopyranosyl-(1→2)-[6-O-(l-tryptophanyl)-β-d–fructofuranoside] or simply tortomycoglycoside (1). Compound 1 is an aminoglycoside consisting of a tryptophan moiety esterified to a disaccharide made up of β-d-fructofuranose and α-d-glucopyranose sugars. The full structure of 1 was determined using UV, IR, 1D, 2D-NMR and HRESI-LC-MS data. When tested against Trypanosoma brucei subsp. brucei, the parasite responsible for Human African Trypanosomiasis in sub-Saharan Africa, 1 (IC50 11.25 µM) was just as effective as Coptis japonica (Thunb.) Makino. (IC50 8.20 µM). The extract of Coptis japonica (Thunb.) Makino. is routinely used as laboratory standard due to its powerful antitrypanosomal activity. It is possible that, compound 1 interferes with the normal uptake and metabolism of tryptophan in the T. brucei subsp. brucei parasite. en_US
dc.description.sponsorship Centre for AfricanWetlands (CAW), University of Ghana.TWAS Research Grant Award, Cambridge-Africa Partnership for Research Excellence (CAPREx), which is funded by the Carnegie Corporation of New York, for a Postdoctoral Fellowship.Cambridge-Africa ALBORADA Research Fund for support and MRC African Research Leaders MR/S00520X/1 Award.Carnegie BANGA-Africa Project Award en_US
dc.language.iso en en_US
dc.publisher Molbank en_US
dc.relation.ispartofseries 2019;2
dc.subject Endophytes en_US
dc.subject Mangroves en_US
dc.subject Glycosides en_US
dc.subject Trypanosomes en_US
dc.subject Antiparasitics en_US
dc.title α-d-Glucopyranosyl-(1→2)-[6-O-(l-tryptophanyl)-β-d-fructofuranoside] en_US
dc.type Article en_US


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