Indigofera arrecta: Safety evaluation of an antidiabetic plant extract in non-diabetic human volunteers

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dc.contributor.author Sittie, A.A.
dc.contributor.author Nyarko, A.K.
dc.date.accessioned 2013-06-16T11:53:38Z
dc.date.accessioned 2017-10-16T13:02:46Z
dc.date.available 2013-06-16T11:53:38Z
dc.date.available 2017-10-16T13:02:46Z
dc.date.issued 1998
dc.identifier.citation Sittie, A. A., & Nyarko, A.K. (1998). Indigofera arrecta: Safety evaluation of an antidiabetic plant extract in non-diabetic human volunteers. Phytotherapy Research, 12(1), 52-54. en_US
dc.identifier.uri http://197.255.68.203/handle/123456789/3235
dc.description.abstract In order to exclude the effects of diabetes and its complications on the results, this paper examined the effects of I. arrecta extract in 12 healthy young male adult non-diabetic Ghanaians. Volunteers were given a physical examination before and after the administration of plant extract. Similarly blood pressure (systolic and diastolic, in mmHg) were also taken before and after administration of the extract. Effects of the extract on fasting blood glucose, haematological indices, and liver and kidney functions were investigated. Fasting blood specimens were collected from each subject before, during and after the study. Levels of marker enzymes and metabolites for liver and kidney status, and haematological indices were measured. Urine volume and creatinine content were also measured. I. arrecta extract did not alter the mean systolic and diastolic pressures. Fasting blood glucose also did not change. Serum marker enzymes and metabolites for hepatic and renal functions remained normal. However, Indigofera arrecta extract increased the erythrocyte sedimentation rate (ESR) and decreased lymphocyte concentration in the blood. The data suggest that I. arrecta may not have overt toxic reactions but could affect the immune status of users en_US
dc.language.iso en en_US
dc.publisher Phytotherapy Research en_US
dc.subject Indigofera arrecta en_US
dc.subject Diabetes mellitus en_US
dc.subject Safety en_US
dc.subject Evaluation en_US
dc.title Indigofera arrecta: Safety evaluation of an antidiabetic plant extract in non-diabetic human volunteers en_US
dc.type Article en_US


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  • Clinical Pathology Department [55]
    The Clinical Pathology Department conducts research that contributes to intervention strategies and safeguards of public health in Ghana. In view of this the Department carries out research into plant medicine development, drug interactions and regulation, bio-monitoring and prevention of poisoning from environmental toxicants (e.g. mycotoxins specifically aflatoxins and toxic heavy metals). The Department also provides specialized laboratory services in support of public health programmes.

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