dc.contributor.author |
Afriyie, D.K. |
|
dc.contributor.author |
Asare, G.A. |
|
dc.contributor.author |
Bugyei, K. |
|
dc.contributor.author |
Asiedu-Gyekye, I. |
|
dc.contributor.author |
Gyan, B.A. |
|
dc.contributor.author |
Adjei, S. |
|
dc.contributor.author |
Nyarko, A.K. |
|
dc.date.accessioned |
2013-06-15T10:14:14Z |
|
dc.date.accessioned |
2017-10-16T13:19:55Z |
|
dc.date.available |
2013-06-15T10:14:14Z |
|
dc.date.available |
2017-10-16T13:19:55Z |
|
dc.date.issued |
2013 |
|
dc.identifier.citation |
Afriyie, D. K., Asare, G. A., Bugyei, K., Asiedu-Gyekye, I., Gyan, B. A., Adjei, S., Nyarko, A.K. (2013). Anti-atherogenic and anti-ischemic potentials of croton membranaceus observed during sub-chronic toxicity studies. Pharmacognosy Research, 5(1), 10-16. |
en_US |
dc.identifier.uri |
http://197.255.68.203/handle/123456789/3215 |
|
dc.description.abstract |
Background:
Croton membranaceus (CM) is used for benign prostate hyperplasia treatment.
Objective:
Sub-chronic toxicity studies are non-existent and provided the basis for this study.
Materials and Methods:
90 days oral administration of a low dose (LD) (30 mg/kg b. wt.), medium dose (MD) (150 mg/kg b. wt.), and high dose (HD) (300 mg/kg b. wt.) CM aqueous root extract to 3 groups (n=6 each) of male Sprague-Dawley rats, alongside a control group, was undertaken. Urinalysis, hepato-renal function tests, lipid profile, cardiac enzymes, and routine hematology tests were performed.
Results:
Triglyceride levels (C=1.05±0.19, LD=0.64±0.08, MD=0.55±0.04, HD=0.50±0.02 mmol/L) were significantly reduced (P<0.05). Very low density lipoprotein (C=0.48±0.09, LD=0.29±0.04, MD=0.25±0.02, HD=0.23±0.01 mmol/L) decreased significantly (P<0.05). Cardiac enzymes-creatinine kinase (C=568±172, LD=315±79, MD=441±209, HD=286±81 IU/L) decreased markedly (P<0.05) alongside lactate dehydrogenase (C=2675±875, LD=1667±1229, MD=1186±442, HD=855±239 IU/L) (P<0.05).
Conclusion:
C. membranaceus aqueous root extract is non-toxic but demonstrates anti-atherogenic and anti-ischemic potentials. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Pharmacognosy Research |
en_US |
dc.subject |
Anti-atherogenic |
en_US |
dc.subject |
Anti-ischemic |
en_US |
dc.subject |
Croton membranaceus |
en_US |
dc.subject |
Sub-chronic |
en_US |
dc.subject |
Toxicity |
en_US |
dc.title |
Anti-atherogenic and anti-ischemic potentials of croton membranaceus observed during sub-chronic toxicity studies |
en_US |
dc.type |
Article |
en_US |