Antigenicity and immune correlate assessment of seven Plasmodium falciparum antigens in a longitudinal infant cohort from northern Ghana

Show simple item record Kusi, K.A. Aguiar, J. Kumordjie, S. Aggor, F. Bolton, J. Renner, A. Kyei-Baafour, E. Puplampu, N. Belmonte, M. Dodoo, D. Gyan, B.A. Ofori, M.F. Oduro, R.A. Atuguba, F. Koram, K.A. Adams, N. Letizia, A. Villasante, E. Sedegah, M. 2019-08-20T16:37:31Z 2019-08-20T16:37:31Z 2019
dc.identifier.other vol.9(1):8621
dc.identifier.other DOI:10.1038/s41598-019-45092-4
dc.description.abstract The current global malaria control and elimination agenda requires development of additional effective disease intervention tools. Discovery and characterization of relevant parasite antigens is important for the development of new diagnostics and transmission monitoring tools and for subunit vaccine development. This study assessed the natural antibody response profile of seven novel Plasmodium falciparum pre-erythrocytic antigens and their potential association with protection against clinical malaria. Antigen-specific antibody levels in plasma collected at six time points from a longitudinal cohort of one-to-five year old children resident in a seasonal malaria transmission area of northern Ghana were assessed by ELISA. Antibody levels were compared between parasite-positive and parasite-negative individuals and the association of antibody levels with malaria risk assessed using a regression model. Plasma antibody levels against five of the seven antigens were significantly higher in parasite-positive children compared to parasite-negative children, especially during low transmission periods. None of the antigen-specific antibodies showed an association with protection against clinical malaria. The study identified five of the seven antigens as markers of exposure to malaria, and these will have relevance for the development of disease diagnostic and monitoring tools. The vaccine potential of these antigens requires further assessment. © 2019, The Author(s). en_US
dc.language.iso en en_US
dc.publisher Scientific Reports en_US
dc.title Antigenicity and immune correlate assessment of seven Plasmodium falciparum antigens in a longitudinal infant cohort from northern Ghana en_US
dc.type Article en_US

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  • Immunology Department [184]
    The Department of Immunology conducts research in the field of immunology of infectious and non-infectious diseases. The Department has the overall goal of contributing knowledge to better diagnosis, management, control and prevention of infectious and non-infectious diseases in Ghana and worldwide. This is consistent with the overall strategy of the Noguchi Memorial Institute for Medical Research (NMIMR) and in line with the strategy of the College of Health Sciences of the University of Ghana.

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