Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

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dc.contributor.author Soriano, J.B.
dc.contributor.author Abajobir, A.A.
dc.contributor.author Abate, K.H.
dc.contributor.author Abera, S.F.
dc.contributor.author Agrawal, A.
dc.contributor.author Ahmed, M.B.
dc.contributor.author Aichour, A.N.
dc.contributor.author Aichour, I.
dc.contributor.author Eddine Aichour, M.T.
dc.contributor.author Alam, K.
dc.contributor.author Alam, N.
dc.contributor.author Alkaabi, J.M.
dc.contributor.author Al-Maskari, F.
dc.contributor.author Alvis-Guzman, N.
dc.contributor.author Amberbir, A.
dc.contributor.author Amoako, Y.A.
dc.contributor.author Ansha, M.G.
dc.contributor.author Antó, J.M.
dc.contributor.author Asayesh, H.
dc.contributor.author Atey, T.M.
dc.contributor.author Avokpaho, E.F.G.A.
dc.contributor.author Barac, A.
dc.contributor.author Basu, S.
dc.contributor.author Bedi, N.
dc.contributor.author Bensenor, I.M.
dc.contributor.author Berhane, A.
dc.contributor.author Beyene, A.S.
dc.contributor.author Bhutta, Z.A.
dc.contributor.author Biryukov, S.
dc.contributor.author Boneya, D.J.
dc.contributor.author Brauer, M.
dc.contributor.author Carpenter, D.O.
dc.contributor.author Casey, D.
dc.contributor.author Christopher, D.J.
dc.contributor.author Dandona, L.
dc.contributor.author Dandona, R.
dc.contributor.author Dharmaratne, S.D.
dc.contributor.author Do, H.P.
dc.contributor.author Fischer, F.
dc.contributor.author Gebrehiwot, T.T.
dc.contributor.author Geleto, A.
dc.contributor.author Ghoshal, A.G.
dc.contributor.author Gillum, R.F.
dc.contributor.author Mohamed Ginawi, I.A.
dc.contributor.author Gupta, V.
dc.contributor.author Hay, S.I.
dc.contributor.author Edayati, M.T.
dc.contributor.author Horita, N.
dc.contributor.author Hosgood, H.D.
dc.contributor.author Jakovljevic, M.M.B.
dc.contributor.author James, S.L.
dc.contributor.author Jonas, J.B.
dc.contributor.author Kasaeian, A.
dc.contributor.author Khader, Y.S.
dc.contributor.author Khalil, I.A.
dc.contributor.author Khan, E.A.
dc.contributor.author Khang, Y.-H.
dc.contributor.author Khubchandani, J.
dc.contributor.author Knibbs, L.D.
dc.contributor.author Kosen, S.
dc.contributor.author Koul, P.A.
dc.contributor.author Kumar, G.A.
dc.contributor.author Leshargie, C.T.
dc.contributor.author Liang, X.
dc.contributor.author Magdy Abd El Razek, H.
dc.contributor.author Majeed, A.
dc.contributor.author Malta, D.C.
dc.contributor.author Manhertz, T.
dc.contributor.author Marquez, N.
dc.contributor.author Mehari, A.
dc.contributor.author Mensah, G.A.
dc.contributor.author Miller, T.R.
dc.contributor.author Mohammad, K.A.
dc.contributor.author Mohammed, K.E.
dc.contributor.author Mohammed, S.
dc.contributor.author Mokdad, A.H.
dc.contributor.author Naghavi, M.
dc.contributor.author Nguyen, C.T.
dc.contributor.author Nguyen, G.
dc.contributor.author Nguyen, Q.L.
dc.contributor.author Nguyen, T.H.
dc.contributor.author Ningrum, D.N.A.
dc.contributor.author Nong, V.M.
dc.contributor.author Obi, J.I.
dc.contributor.author Odeyemi, Y.E.
dc.contributor.author Ogbo, F.A.
dc.contributor.author Oren, E.
dc.contributor.author Mahesh, P.A.
dc.contributor.author Park, E.-K.
dc.contributor.author Patton, G.C.
dc.contributor.author Paulson, K.
dc.contributor.author Qorbani, M.
dc.contributor.author Quansah, R.
dc.contributor.author Rafay, A.
dc.contributor.author Rahman, M.H.U.
dc.contributor.author Rai, R.K.
dc.contributor.author Rawaf, S.
dc.contributor.author Reinig, N.
dc.contributor.author Safiri, S.
dc.contributor.author Sarmiento-Suarez, R.
dc.contributor.author Sartorius, B.
dc.contributor.author Savic, M.
dc.contributor.author Sawhney, M.
dc.contributor.author Shigematsu, M.
dc.contributor.author Smith, M.
dc.contributor.author Tadese, F.
dc.contributor.author Thurston, G.D.
dc.contributor.author Topor-Madry, R.
dc.contributor.author Tran, B.X.
dc.contributor.author Ukwaja, K.N.
dc.contributor.author van Boven, J.F.M.
dc.contributor.author Vlassov, V.V.
dc.contributor.author Vollset, S.E.
dc.contributor.author Wan, X.
dc.contributor.author Werdecker, A.
dc.contributor.author Hanson, S.W.
dc.contributor.author Yano, Y.
dc.contributor.author Yimam, H.H.
dc.contributor.author Yonemoto, N.
dc.contributor.author Yu, C.
dc.contributor.author Zaidi, Z.
dc.contributor.author Sayed Zaki, M.E.
dc.contributor.author Lopez, A.D.
dc.contributor.author Murray, C.J.L.
dc.contributor.author Vos, T.
dc.contributor.author GBD 2015 Chronic Respiratory Disease Collaborators
dc.date.accessioned 2019-07-31T15:38:17Z
dc.date.available 2019-07-31T15:38:17Z
dc.date.issued 2017-08
dc.identifier.other DOI:https://doi.org/10.1016/S2213-2600(17)30293-X
dc.identifier.other Vol.5(9)
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/31914
dc.description.abstract BACKGROUND: Chronic obstructive pulmonary disease (COPD) and asthma are common diseases with a heterogeneous distribution worldwide. Here, we present methods and disease and risk estimates for COPD and asthma from the Global Burden of Diseases, Injuries, and Risk Factors (GBD) 2015 study. The GBD study provides annual updates on estimates of deaths, prevalence, and disability-adjusted life years (DALYs), a summary measure of fatal and non-fatal disease outcomes, for over 300 diseases and injuries, for 188 countries from 1990 to the most recent year. METHODS: We estimated numbers of deaths due to COPD and asthma using the GBD Cause of Death Ensemble modelling (CODEm) tool. First, we analysed data from vital registration and verbal autopsy for the aggregate category of all chronic respiratory diseases. Subsequently, models were run for asthma and COPD relying on covariates to predict rates in countries that have incomplete or no vital registration data. Disease estimates for COPD and asthma were based on systematic reviews of published papers, unpublished reports, surveys, and health service encounter data from the USA. We used the Global Initiative of Chronic Obstructive Lung Disease spirometry-based definition as the reference for COPD and a reported diagnosis of asthma with current wheeze as the definition of asthma. We used a Bayesian meta-regression tool, DisMod-MR 2.1, to derive estimates of prevalence and incidence. We estimated population-attributable fractions for risk factors for COPD and asthma from exposure data, relative risks, and a theoretical minimum exposure level. Results were stratified by Socio-demographic Index (SDI), a composite measure of income per capita, mean years of education over the age of 15 years, and total fertility rate. FINDINGS: In 2015, 3·2 million people (95% uncertainty interval [UI] 3·1 million to 3·3 million) died from COPD worldwide, an increase of 11·6% (95% UI 5·3 to 19·8) compared with 1990. There was a decrease in age-standardised death rate of 41·9% (37·7 to 45·1) but this was counteracted by population growth and ageing of the global population. From 1990 to 2015, the prevalence of COPD increased by 44·2% (41·7 to 46·6), whereas age-standardised prevalence decreased by 14·7% (13·5 to 15·9). In 2015, 0·40 million people (0·36 million to 0·44 million) died from asthma, a decrease of 26·7% (-7·2 to 43·7) from 1990, and the age-standardised death rate decreased by 58·8% (39·0 to 69·0). The prevalence of asthma increased by 12·6% (9·0 to 16·4), whereas the age-standardised prevalence decreased by 17·7% (15·1 to 19·9). Age-standardised DALY rates due to COPD increased until the middle range of the SDI before reducing sharply. Age-standardised DALY rates due to asthma in both sexes decreased monotonically with rising SDI. The relation between with SDI and DALY rates due to asthma was attributed to variation in years of life lost (YLLs), whereas DALY rates due to COPD varied similarly for YLLs and years lived with disability across the SDI continuum. Smoking and ambient particulate matter were the main risk factors for COPD followed by household air pollution, occupational particulates, ozone, and secondhand smoke. Together, these risks explained 73·3% (95% UI 65·8 to 80·1) of DALYs due to COPD. Smoking and occupational asthmagens were the only risks quantified for asthma in GBD, accounting for 16·5% (14·6 to 18·7) of DALYs due to asthma. INTERPRETATION: Asthma was the most prevalent chronic respiratory disease worldwide in 2015, with twice the number of cases of COPD. Deaths from COPD were eight times more common than deaths from asthma. In 2015, COPD caused 2·6% of global DALYs and asthma 1·1% of global DALYs. Although there are laudable international collaborative efforts to make surveys of asthma and COPD more comparable, no consensus exists on case definitions and how to measure disease severity for population health measurements like GBD. Comparisons between countries and over time are important, as much of the chronic respiratory burden is either preventable or treatable with affordable interventions. en_US
dc.language.iso en en_US
dc.publisher The Lancet Respiratory Medicine en_US
dc.subject Aging en_US
dc.subject Air Pollution en_US
dc.subject Article en_US
dc.subject Asthma en_US
dc.subject Bayes Theorem en_US
dc.subject Cause Of Death en_US
dc.title Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015 en_US
dc.type Article en_US


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    The Department of Parasitology conducts research into parasitic diseases of public health importance with the overall goal of reducing their transmission and the heavy disease burden that they impose on affected populations. The Department maintains focus on parasitic diseases in general. These include major diseases such as malaria, and others listed under the Neglected Tropical Diseases (NTD) control initiative such as, lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis, trypanosomiasis and leishmaniasis.

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