Virulence potential of Staphylococcus aureus isolates from Buruli ulcer patients

Show simple item record Amissah, N.A. Chlebowicz, M.A. Ablordey, A. Tetteh, C.S. Prah, I. van der werf, T.S. Friedrich, A.W. Van Dijl, J.M. Stienstra, Y. Rossen, J.W. 2019-07-29T15:57:15Z 2019-07-29T15:57:15Z 2017
dc.identifier.other vol.307(4):pp223-232
dc.identifier.other DOI:10.1016/j.ijmm.2017.04.002
dc.description.abstract Buruli ulcer (BU) is a necrotizing infection of the skin and subcutaneous tissue caused by Mycobacterium ulcerans. BU wounds may also be colonized with other microorganisms including Staphylococcus aureus. This study aimed to characterize the virulence factors of S. aureus isolated from BU patients. Previously sequenced genomes of 21 S. aureus isolates from BU patients were screened for the presence of virulence genes. The results show that all S. aureus isolates harbored on their core genomes genes for known virulence factors like α-hemolysin, and the α- and β-phenol soluble modulins. Besides the core genome virulence genes, mobile genetic elements (MGEs), i.e. prophages, genomic islands, pathogenicity islands and a Staphylococcal cassette chromosome (SCC) were found to carry different combinations of virulence factors, among them genes that are known to encode factors that promote immune evasion, superantigens and Panton-Valentine Leucocidin. The present observations imply that the S. aureus isolates from BU patients harbor a diverse repertoire of virulence genes that may enhance bacterial survival and persistence in the wound environment and potentially contribute to delayed wound healing. © 2017 The Authors en_US
dc.language.iso en en_US
dc.publisher International Journal of Medical Microbiology en_US
dc.subject binomial tree; discontinuous drift; Skew Vasicek model; trinomial tree en_US
dc.title Virulence potential of Staphylococcus aureus isolates from Buruli ulcer patients en_US
dc.type Article en_US

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  • Bacteriology Department [105]
    The Bacteriology Department aims to improve the quality of life first for Ghanaians and the world at large by conducting research into bacterial diseases of public health importance to Ghana and globally. In addition to working on enteric pathogens and sexually transmitted diseases, the department’s current main focus is on the two most important mycobacterial diseases of public health importance to Ghana, namely Buruli ulcer (BU) and tuberculosis (TB).

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