TMPRSS2:ERG Gene Fusions in Prostate Cancer of West African Men and Ameta-Analysis of Racial Differences

Show simple item record

dc.contributor.author Zhou, C.K.
dc.contributor.author Young, D.
dc.contributor.author Yeboah, E.D.
dc.contributor.author Coburn, S.B.
dc.contributor.author Tettey, Y.
dc.contributor.author Biritwum, R.B.
dc.contributor.author Adjei, A.A.
dc.contributor.author Tay, E.
dc.contributor.author Niwa, S.
dc.contributor.author Truelove, A.
dc.contributor.author Welsh, J.
dc.contributor.author Mensah, J.E.
dc.contributor.author Hoover, R.N.
dc.contributor.author Sesterhenn, I.A.
dc.contributor.author Hsing, A.W.
dc.contributor.author Srivastava, S.
dc.contributor.author Cook, M.B.
dc.date.accessioned 2019-07-26T10:15:59Z
dc.date.available 2019-07-26T10:15:59Z
dc.date.issued 2017-06
dc.identifier.other Vol. 186 (12)
dc.identifier.other DOI: 10.1093/aje/kwx235
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/31798
dc.description.abstract The prevalence of TMPRSS2-ERG fusions in prostate cancer varies by race. However, such somatic aberration and its association with prognostic factors have neither been studied in a West African population nor been systematically reviewed in the context of racial differences. We used immunohistochemistry to assess ERG expression as the established surrogate of ERG fusion genes among 262 prostate cancer biopsies from the Ghana Prostate Study. Poisson regression with robust variance estimation provided prevalence ratios and 95% confidence intervals of ERG expression in relation to patients' characteristics. We found 47 of 262 (18%) prostate cancers were ERG-positive, and negative ERG staining was associated with higher Gleason score. We further conducted a systematic review and meta-analysis of TMPRSS2-ERG fusions in relation to race, Gleason score, and tumor stage, combining results from Ghana with 40 additional studies. Meta-analysis showed the prevalence of TMPRSS2-ERG fusions in prostate cancer to be highest in men of European descent (49%) followed by Asian (27%) and then African (25%). The lower prevalence of TMPRSS2-ERG fusions in men of African descent implies that alternative genomic mechanisms might explain the disproportionately high prostate cancer burden in such populations. en_US
dc.language.iso en en_US
dc.publisher American Journal of Epidemiology en_US
dc.subject Tmprss2:Erg en_US
dc.subject West Africa en_US
dc.subject Prostatic Neoplasms en_US
dc.subject Racial Differences en_US
dc.subject Systematic Review en_US
dc.title TMPRSS2:ERG Gene Fusions in Prostate Cancer of West African Men and Ameta-Analysis of Racial Differences en_US
dc.type Article en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search UGSpace


Browse

My Account