Functional Characterization of Plasmodium falciparum Surface Related Antigen (PfSRA) as a Potential Blood-Stage Vaccine Target

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dc.contributor.author Amlabu, E.
dc.contributor.author Mensah-Brown, H.
dc.contributor.author Nyarko, P.B.
dc.contributor.author Akuh, O.A.
dc.contributor.author Opoku, G.
dc.contributor.author Ilani, P.
dc.contributor.author Oyagbenro, R.
dc.contributor.author Asiedu, K.
dc.contributor.author Aniweh, Y.
dc.contributor.author Awandare, G.A.
dc.date.accessioned 2019-07-22T12:05:01Z
dc.date.available 2019-07-22T12:05:01Z
dc.date.issued 2018-04
dc.identifier.other DOI: 10.1093/infdis/jiy222
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/31610
dc.description.abstract Plasmodium falciparum erythrocyte invasion is a multistep process that involves a spectrum of interactions that are not well characterized. We have characterized a 113-kDa immunogenic protein, PF3D7_1431400 (PF14_0293), that possesses coiled-coil structures. The protein is localized on the surfaces of both merozoites and gametocytes, hence the name Plasmodium falciparum surface-related antigen (PfSRA). The processed 32-kDa fragment of PfSRA binds normal human erythrocytes with different sensitivities to enzyme treatments. Temporal imaging from initial attachment to internalization of viable merozoites revealed that a fragment of PfSRA, along with PfMSP119, is internalized after invasion. Moreover, parasite growth inhibition assays showed that PfSRA P1 antibodies potently inhibited erythrocyte invasion of both sialic acid–dependent and –independent parasite strains. Also, immunoepidemiological studies show that malaria-infected populations have naturally acquired antibodies against PfSRA. Overall, the results demonstrate that PfSRA has the structural and functional characteristics of a very promising target for vaccine development. en_US
dc.language.iso en en_US
dc.publisher Journal of Infectious Diseases en_US
dc.subject Plasmodium falciparum en_US
dc.subject Malaria vaccine en_US
dc.subject Erythrocyte invasion en_US
dc.subject Novel antigens en_US
dc.subject Naturally acquired immunity en_US
dc.title Functional Characterization of Plasmodium falciparum Surface Related Antigen (PfSRA) as a Potential Blood-Stage Vaccine Target en_US
dc.type Article en_US


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