Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/3144
Title: Antibodies to the N-terminal block 2 of plasmodium falciparum merozoite surface protein 1 are associated with protection against clinical malaria.
Authors: Cavanagh, D.R.
Dodoo, D.
Hviid, L.
Kurtzhals, J.A.L.
Theander, T.G.
Akanmori, B.D.
Spencer, P.
Conway, D.J.
Koram, K.A.
McBride, J.S.
Issue Date: 26-Jul-2004
Publisher: Infection and Immunity
Abstract: This longitudinal prospective study shows that antibodies to the N-terminal block 2 region of the Plasmodium falciparum merozoite surface protein 1 (MSP-1) are associated with protection against clinical malaria in an area of stable but seasonal malaria transmission of Ghana. Antibodies to the block 2 region of MSP-1 were measured in a cohort of 280 children before the beginning of the major malaria transmission season. The cohort was then actively monitored for malaria, clinically and parasitologically, over a period of 17 months. Evidence is presented for an association between antibody responses to block 2 and a significantly reduced risk of subsequent clinical malaria. Furthermore, statistical survival analysis provides new information on the duration of the effect over time. The results support a conclusion that the block 2 region of MSP-1 is a target of protective immunity against P. falciparum and, thus, a promising new candidate for the development of a malaria vaccine.
URI: http://hdl.handle.net/123456789/3144
Appears in Collections:Noguchi Memorial Institute for Medical Research

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