An extract of Synedrella nodiflora (L) Gaertn exhibits antidepressant properties through monoaminergic mechanisms

Show simple item record Amoateng, P. Kukuia, K.K.E. Mensah, J.A. Osei-Safo, D. Adjei, S. Eklemet, A.A. Vinyo, E.A. Karikari, T.K. 2019-07-02T09:18:39Z 2019-07-02T09:18:39Z 2018-08
dc.identifier.citation Amoateng, P., Kukuia, K.K.E., Mensah, J.A. et al. Metab Brain Dis (2018) 33: 1359. en_US
dc.identifier.other Volume 33, Issue 4, pp 1359–1368
dc.description.abstract Synedrella nodiflora (SNE) has been used traditionally for many neurological conditions and some of these neuroactive effects have been scientifically substantiated. The usefulness of SNE in depression has however not been investigated despite the availability of data in other disease models indicating it may be useful. The present study therefore examined the effect of SNE in acute murine models of depression and the possible mechanisms mediating its activities in these models. Preliminary qualitative phytochemical and high performance liquid chromatography (HPLC) screening were conducted on SNE. The behavioural effects of SNE (100, 300 and 1000 mg/kg) pre-treated mice were examined in the forced swimming (FST) and tail suspension (TST) tests. Behavioural events such as mobility (swimming, climbing, curling and climbing), and immobility, were scored. The possible involvement of monoamines in the effects of SNE was assessed in the TST by pre-treating mice with α-methyldopa, reserpine and para-chlorophenylalanine (pCPA) in separate experiments. Flavonoids, tannins, saponins, alkaloids, cardiac glycosides, coumarins, triterpenes, sterols, anthraquinones and phenolic compounds were present in SNE. HPLC analysis revealed the presence of two major constituents observed at retention times 42.56 and 46.51 min, with percentage composition of 45.72% and 36.88% respectively. SNE significantly reduced immobility scores in both FST and TST, suggesting antidepressant effects. The antidepressant properties of SNE were reversed by the pre-treatment of α-methyldopa, reserpine and pCPA, suggesting a possible involvement of monoamines (noradrenaline and serotonin) in its mechanism(s) of actions. SNE exhibits antidepressant effects, possibly mediated through an interplay of enhancement of noradrenergic and serotoninergic mechanisms. © 2018, Springer Science+Business Media, LLC, part of Springer Nature. en_US
dc.language.iso en en_US
dc.publisher Metabolic Brain Disease en_US
dc.subject Antidepressant en_US
dc.subject Forced swimming en_US
dc.subject Monoamines en_US
dc.subject Synedrella nodiflora en_US
dc.subject Tail suspension en_US
dc.title An extract of Synedrella nodiflora (L) Gaertn exhibits antidepressant properties through monoaminergic mechanisms en_US
dc.type Article en_US

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