Buruli Ulcer: a Review of the Current Knowledge

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dc.contributor.author Yotsu, R.R.
dc.contributor.author Suzuki, K.
dc.contributor.author Simmonds, R.E.
dc.contributor.author Bedimo, R.
dc.contributor.author Ablordey, A.
dc.contributor.author Yeboah-Manu, D.
dc.contributor.author Phillips, R.
dc.contributor.author Asiedu, K.
dc.date.accessioned 2019-06-17T10:50:24Z
dc.date.available 2019-06-17T10:50:24Z
dc.date.issued 2018-12
dc.identifier.other doi: 10.1007/s40475-018-0166-2
dc.identifier.uri http://ugspace.ug.edu.gh/handle/123456789/30822
dc.description.abstract Purpose of the Review Buruli ulcer (BU) is a necrotizing and disabling cutaneous disease caused by Mycobacterium ulcerans, one of the skin-related neglected tropical diseases (skin NTDs). This article aims to review the current knowledge of this disease and challenges ahead. Recent Findings Around 60,000 cases of BU have been reported from over 33 countries between 2002 and 2017. Encouraging findings for development of point-of-care tests for BU are being made, and its treatment is currently in the transition period from rifampicin plus streptomycin (injection) to all-oral regimen. A major recent advance in our understanding of its pathogenesis has been agreement on the mechanism of action of the major virulence toxin mycolactone in host cells, targeting the Sec61 translocon during a major step in protein biogenesis. Summary BU is distributed mainly in West Africa, but cases are also found in other parts of the world. We may be underestimating its true disease burden, due to the limited awareness of this disease. More awareness and more understanding of BU will surely contribute in enhancing our fight against this skin NTD. en_US
dc.language.iso en en_US
dc.publisher Current Tropical Medicine Reports en_US
dc.subject Buruli ulcer en_US
dc.subject Mycobacterium ulcerans en_US
dc.subject Mycolactone en_US
dc.subject Non-tuberculous mycobacterial disease en_US
dc.subject Skin neglected tropical diseases en_US
dc.subject Skin NTDs en_US
dc.title Buruli Ulcer: a Review of the Current Knowledge en_US
dc.type Article en_US

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  • Bacteriology Department [108]
    The Bacteriology Department aims to improve the quality of life first for Ghanaians and the world at large by conducting research into bacterial diseases of public health importance to Ghana and globally. In addition to working on enteric pathogens and sexually transmitted diseases, the department’s current main focus is on the two most important mycobacterial diseases of public health importance to Ghana, namely Buruli ulcer (BU) and tuberculosis (TB).

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